Histiocitoma fibroso maligno no tornozelo: relato de caso / Malignant fibrous histiocytoma in ankle: case report

Histiocitoma fibroso maligno (MFH) ou sarcoma pleomórfico indiferenciado (UPS) é um sarcoma moderadamente agressivo, capaz de invadir estruturas adjacentes. Trata-se de neoplasia mesenquimal que predomina em homens entre a sexta e sétima décadas de vida. Localiza-se, principalmente, nos membros inferiores, podendo acometer cabeça e pescoço, tronco e retroperitônio, com tendência à recorrência e à metástase local. O presente relato tem como objetivo apresentar um caso de MFH no tornozelo de uma mulher de 49 anos, com invasão óssea adjacente, que evoluiu com amputação transtibial. São abordados aspectos clínicos, radiológicos, histopatológicos e terapêuticos, salientando-se a importância do diagnóstico precoce.

Malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma (UPS) is a sarcoma capable of invading adjacent structures. It is a mesenchymal neoplasia that predominates in men between the sixth and seventh decades of life. It is located mainly in the lower limbs and may affect the head and neck, trunk, and retroperitoneum, presenting a tendency to recurrence and local metastasis. This report aims to present a case of MFH in the ankle of a 49-year-old woman with an adjacent bone invasion, which evolved with transtibial amputation. Clinical, radiological, histopathological, and therapeutic aspects were addressed, highlighting the importance of early diagnosis

Undifferentiated pleomorphic sarcoma of the mandible.

Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindlecell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.

Rapidly Progressive Malignant Fibrous Histiocytoma of Right Atrium: a Rare Case Report.

We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right ventricle, causing functional tricuspid valve stenosis. The tumor was completely resected and the patient had an uneventful postoperative period. Histopathological examination reported malignant fibrous histiocytoma. The patient presented to the emergency department five weeks after discharge with dyspnea and palpitation. Echocardiography and magnetic resonance imaging revealed recurrent right atrial tumor mass. His clinical status has worsened, with syncope and acute renal failure. On the repeated echocardiography, suspected tumor recurrence was observed in left atrium, which probably caused systemic embolization. Considering the aggressive nature of the tumor and systemic involvement, our Heart Council decided to provide palliative treatment by nonsurgical management. His status deteriorated for the next few days and the patient succumbed to a cardiac arrest on the 4th day.

Rapidly progressive malignant fibrous histiocytoma of right atrium: a rare case report

Abstract We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right ventricle, causing functional tricuspid valve stenosis. The tumor was completely resected and the patient had an uneventful postoperative period. Histopathological examination reported malignant fibrous histiocytoma. The patient presented to the emergency department five weeks after discharge with dyspnea and palpitation. Echocardiography and magnetic resonance imaging revealed recurrent right atrial tumor mass. His clinical status has worsened, with syncope and acute renal failure. On the repeated echocardiography, suspected tumor recurrence was observed in left atrium, which probably caused systemic embolization. Considering the aggressive nature of the tumor and systemic involvement, our Heart Council decided to provide palliative treatment by nonsurgical management. His status deteriorated for the next few days and the patient succumbed to a cardiac arrest on the 4th day.

Histiocitoma fibroso maligno metastásico en estómago / Metastatic malignant fibrous histiocytoma in the stomach

El histiocitoma fibroso maligno es el sarcoma de partes blandas más frecuente de la adultez tardía. Se desarrolla habitualmente en los miembros inferiores y en el retroperitoneo. Su pronóstico es malo, la recidiva local y las metástasis a distancia. Se presenta el caso de un paciente con metástasis en el estómago de un histiocitoma fibroso maligno. El objetivo de esta publicación es la presentación de una forma poco común de diseminación metastásica del histiocitoma fibroso maligno(AU)

Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life. It usually develops in the lower extremities and in the retroperitonium. Prognosis is fairly poor; local relapse and distant metastasis are the common natural history. The is presented of a patient with stomach metastasis of malignant fibrous histiocytoma. This paper is aimed at presenting a rare way of metastatic dissemination of the malignant fibrous histiocytoma(AU)

Histiocitoma fibroso maligno metastásico en estómago / Metastatic malignant fibrous histiocytoma in the stomach

El histiocitoma fibroso maligno es el sarcoma de partes blandas más frecuente de la adultez tardía. Se desarrolla habitualmente en los miembros inferiores y en el retroperitoneo. Su pronóstico es malo, la recidiva local y las metástasis a distancia. Se presenta el caso de un paciente con metástasis en el estómago de un histiocitoma fibroso maligno. El objetivo de esta publicación es la presentación de una forma poco común de diseminación metastásica del histiocitoma fibroso maligno(AU)

Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life. It usually develops in the lower extremities and in the retroperitonium. Prognosis is fairly poor; local relapse and distant metastasis are the common natural history. The is presented of a patient with stomach metastasis of malignant fibrous histiocytoma. This paper is aimed at presenting a rare way of metastatic dissemination of the malignant fibrous histiocytoma(AU)

Malignant fibrous histiocytoma in the right portion of the mandible with metastasis in pancreas.

BACKGROUND: Malignant fibrous histiocytoma is a sarcoma of uncertain origin that can be found both in soft tissues and in bones. It is currently called undifferentiated pleomorphic sarcoma not otherwise specified and it represents a final common pathway in several tumors that are subject to the progress of dedifferentiation. Local recurrence of the tumor in the same location where it was originated occurs in 20-30% of the total number of soft tissue sarcomas. It is less frequent in limbs and more likely to recur in retroperitoneal sarcomas and in head and neck. Most tumors grow during the first two years after treatment. Most sarcoma metastases, especially those in the head and neck (including malignant fibrous histiocytoma) present as a lung disease (90%). Extrapulmonary diseases are not frequent and can occur in lymph nodes (10%), bones (8%) and in the liver (1%). CASE REPORT: 61 years old woman with history of malignant fibrous histiocytoma in the right portion of the mandible, resected four years ago. Subsequent checkups did not show any disease. The patient reports a constant abdominal pain not diagnosed, related to a pancreatic nodule. CONCLUSION: Malignant fibrous histiocytoma is a potentially curable disease. The most important part of the treatment is complete surgical removal, usually followed by adjuvant radiation therapy. Chemotherapy is a treatment usually used only on those patients with higher recurrence risk or on those showingrecurrence or who have already showed recurrence.

Benign fibrous histiocytoma of the tongue: a case report / Histiocitoma fibroso benigno em língua: relato de caso

The fibrous histiocytoma is a soft tissue neoplasm that affects the dermis and the subcutaneous tissue, rarely is found in the oral cavity and perioral regions, and is originated from the proliferation of fibroblasts and histiocytes. The objective of this paper is to report a case of Benign Fibrous Histiocytoma in a 30-year-old male patient, complaining of a painless nodule in the tongue for about six months. With diagnostic clinical hypotheses of Fibrous Hyperplasia, Neurofibroma, Traumatic Neuroma, Fibrous Histiocytoma, Granular Cell Tumor or Ectomesenchymal Chondromyxoid Tumor a excisional biopsy was performed. The histopathological examination revealed a non-encapsulated proliferation of spindle cells with some giant multinucleated cells in the periphery of the lesion. Immunohistochemical reactions were performed, staining only for vimentin in the spindle cells and for CD68 in the multinucleated giant cells. According to these characteristics, the final diagnosis was Benign Fibrous Histiocytoma. The correct diagnosis of spindle shaped cell neoplasia must be performed with the aid of histopathological analysis and immunohistochemistry, mainly because the morphological similarities with other benign and malignant lesions. (AU)

O Histiocitoma Fibroso é uma neoplasia de partes moles que acomete a derme e o tecido subcutâneo, raramente é encontrado na cavidade oral e regiões periorais, e tem origem a partir da proliferação de fibroblastos ou histiócitos. O objetivo deste artigo é relatar um caso de Histiocitoma Fibroso Benigno em um paciente masculino, 30 anos de idade, com um nódulo indolor, bem delimitado, com duração de cerca de seis meses, localizado no dorso anterior da língua. Com as hipóteses clínicas diagnósticas de Hiperplasia Fibrosa, Neurofibroma, Neuroma Traumático, Histiocitoma Fibroso, Tumor de Células Granulares e Tumor Condromixoide Ectomesenquimal uma biópsia foi realizada sob anestesia local e a lesão foi fixada em formol a 10% e enviada para análise histopatológica. O exame histopatológico revelou uma proliferação não-encapsulada de células fusiformes com algumas células gigantes multinucleadas na periferia da lesão. A marcação imunohistoquímica foi positiva para CD68 nas células gigantes multinucleadas e para vimentina nas células fusiformes. O diagnóstico final foi de Histiocitoma Fibroso Benigno. Para um diagnóstico correto, este deve ser feito correlacionando características clínicas, análise histopatológica e imunohistoquímica devido à similaridade microscópica do Histiocitoma Fibroso com outras lesões com aspecto fusocelular, assim como similaridade clínica com outras lesões benignas e malignas.(AU)

Fibrohistiocitoma maligno mamario: descripción de un caso

El fibrohistiocitoma maligno de mama es una entidad muy poco frecuente que debuta como un nódulo mamario de reciente aparición y de crecimiento relativamente rápido. El diagnóstico debe establecerse mediante una muestra histológica, debido a que las pruebas de imagen suelen ser inespecíficas. El tratamiento habitual es la mastectomía con o sin vaciamiento axilar y la terapia adyuvante (quimioterapia y radioterapia) suele tener poca efectividad en esta patología.

Malignant fibrous histiocytoma of the breast is arare entity that debuts as a breast lump of recent onset and relatively fast growth. Diagnosis is by histology because imaging tests are often nonspecific. Usual treatment is mastectomywith orwithout axillary dissection; acjuvant therapy (chemotherapy and radiotherapy) often have limited effectiveness in this pathology.

Neoplasmas em suínos: 37 casos / Neoplasia in swine: 37 cases

Neoplasmas em suínos são raros. Esse trabalho descreve os neoplasmas encontrados em suínos na rotina diagnóstica de um laboratório de patologia veterinária localizado na Região Central do Rio Grande do Sul. Durante um período de 49 anos, 2.266 casos de várias afecções em suínos foram encontrados, dos quais 37 (1,6%) eram neoplasmas. Em ordem decrescente de frequência, os seguintes neoplasmas foram encontrados: Linfoma (11/37), nefroblastoma (11/37), melanoma (8/37) e papiloma (2/37). Adicionalmente, um caso de cada um dos seguintes tumores foi observado: Adenoma hepatocelular, carcinoma hepatocelular, colangiocarcinoma, histiocitoma fibroso maligno e sarcoma granulocítico. O aspecto macroscópico e histológico desses tumores é descrito e a sua epidemiologia é comparada com os dados disponíveis na literatura para neoplasia suína.(AU)

Neoplasms in swine are rare. This paper describes neoplasms found in swine in the diagnostic routine of a veterinary pathology laboratory in the Central Region of Rio Grande do Sul, Brazil during a 49-year period, during which 2,266 cases of the various affections in swine were diagnosed. Of those 37 cases (1.6%) were neoplasms. In decreasing order of prevalence, the following neoplasms were found: lymphoma (11 out of 37 cases), nephroblastoma (11/37), melanoma (8/37), and papilloma (2/37). Adenoma hepatocelular, carcinoma hepatocelular, cholangiocarcinoma, malignant fibrous histiocytoma, granulocytic sarcoma were each found in one case out of the 37 cases. The gross and histological aspects of these tumors are described and their epidemiology is compared with the data available in the literature for neoplasia in swine.(AU)

Neoplasmas em suínos: 37 casos / Neoplasia in swine: 37 cases

Neoplasmas em suínos são raros. Esse trabalho descreve os neoplasmas encontrados em suínos na rotina diagnóstica de um laboratório de patologia veterinária localizado na Região Central do Rio Grande do Sul. Durante um período de 49 anos, 2.266 casos de várias afecções em suínos foram encontrados, dos quais 37 (1,6%) eram neoplasmas. Em ordem decrescente de frequência, os seguintes neoplasmas foram encontrados: Linfoma (11/37), nefroblastoma (11/37), melanoma (8/37) e papiloma (2/37). Adicionalmente, um caso de cada um dos seguintes tumores foi observado: Adenoma hepatocelular, carcinoma hepatocelular, colangiocarcinoma, histiocitoma fibroso maligno e sarcoma granulocítico. O aspecto macroscópico e histológico desses tumores é descrito e a sua epidemiologia é comparada com os dados disponíveis na literatura para neoplasia suína.

Neoplasms in swine are rare. This paper describes neoplasms found in swine in the diagnostic routine of a veterinary pathology laboratory in the Central Region of Rio Grande do Sul, Brazil during a 49-year period, during which 2,266 cases of the various affections in swine were diagnosed. Of those 37 cases (1.6%) were neoplasms. In decreasing order of prevalence, the following neoplasms were found: lymphoma (11 out of 37 cases), nephroblastoma (11/37), melanoma (8/37), and papilloma (2/37). Adenoma hepatocelular, carcinoma hepatocelular, cholangiocarcinoma, malignant fibrous histiocytoma, granulocytic sarcoma were each found in one case out of the 37 cases. The gross and histological aspects of these tumors are described and their epidemiology is compared with the data available in the literature for neoplasia in swine.

Histiocitoma fibroso maligno em um cão relato de caso / Malignant fibrous histiocytom a in a dog: a case report

Um canino macho, de aproximadamente cinco anos de idade, da raça Pinscher, foi diagnosticado comum histiocitoma fibroso maligno nos cornetos nasais. A neoplasia é do tipo mesenquimal maligno, que sedesenvolve nos tecidos moles e abrange a derme e o tecido subcutâneo. O caso foi analisado com auxíliode exames radiográficos da cabeça, além do citopatológico, para maior precisão no prognóstico clínico.Diante da situação foi indicada a remoção cirúrgica do histiocitoma, e sendo esta uma das formas maisraras de neoplasias, se torna relevante a sua apresentação aos clínicos médicos veterinários.(AU)

A male dog, about five years old, Pinscher, was diagnosed with a malignant fibrous histiocytomaof the nasal turbinates. The tumor is malignant mesenchymal type, which develops in the soft tissueand covers the dermis and subcutaneous tissue. The casewas analyzed with the aid of X-rayexaminations of the head, in addition to cytology,for greater accuracy in clinical prognosis. Giventhe situation was nominated forsurgical removal of histiocytoma, and this being one of the rarestforms of cancer, it becomes relevant to their clinical presentation to veterinarians.(AU)

Histiocitoma fibroso maligno em um cão – relato de caso / Malignant fibrous histiocytom a in a dog: a case report

Um canino macho, de aproximadamente cinco anos de idade, da raça Pinscher, foi diagnosticado comum histiocitoma fibroso maligno nos cornetos nasais. A neoplasia é do tipo mesenquimal maligno, que sedesenvolve nos tecidos moles e abrange a derme e o tecido subcutâneo. O caso foi analisado com auxíliode exames radiográficos da cabeça, além do citopatológico, para maior precisão no prognóstico clínico.Diante da situação foi indicada a remoção cirúrgica do histiocitoma, e sendo esta uma das formas maisraras de neoplasias, se torna relevante a sua apresentação aos clínicos médicos veterinários.

A male dog, about five years old, Pinscher, was diagnosed with a malignant fibrous histiocytomaof the nasal turbinates. The tumor is malignant mesenchymal type, which develops in the soft tissueand covers the dermis and subcutaneous tissue. The casewas analyzed with the aid of X-rayexaminations of the head, in addition to cytology,for greater accuracy in clinical prognosis. Giventhe situation was nominated forsurgical removal of histiocytoma, and this being one of the rarestforms of cancer, it becomes relevant to their clinical presentation to veterinarians.

Recurrence of atypical fibroxanthoma. Diagnosis and treatment

Introduction: The soft tissue sarcomas (SPM) accounts for only 1% of malignant tumors of the adult population. The SPM is the most frequent malignant fibrous histiocytoma (MFH) that exhibits behavior characterized by the tendency to invasion of adjacent tissue and metastatic spread early. One of its variants is the atypical fibroxanthoma (FA). Objective: To describe a case of probable recurrence of AF underwent surgical treatment and presentation of a literature review. Case report: Patient female, 63 years, presenting with a mass in the face about four inches and a history of prior resection of the lesion in the same topography. The patient underwent surgical resection with a diagnosis of AF. Conclusion: The FA is a rare tumor histological diagnosis difficult. The correct histological diagnosis and patient follow-up are essential...

Histiocitoma fibroso maligno / Malignant fibrous histiocytoma

Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 porciento de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente Roberto Rodríguez Fernández de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico(AU)

Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 percent of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, treatment and course of this tumor in study case and treated in Roberto Rodríguez Fernández Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure(AU)

Histiocitoma fibroso maligno / Malignant fibrous histiocytoma

Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 porciento de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente Roberto Rodríguez Fernández de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico

Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 percent of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, treatment and course of this tumor in study case and treated in Roberto Rodríguez Fernández Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure

Recurrence of atypical fibroxanthoma. Diagnosis and treatment.

INTRODUCTION: The soft tissue sarcomas (SPM) accounts for only 1% of malignant tumors of the adult population. The SPM is the most frequent malignant fibrous histiocytoma (MFH) that exhibits behavior characterized by the tendency to invasion of adjacent tissue and metastatic spread early. One of its variants is the atypical fibroxanthoma (FA). OBJECTIVE: To describe a case of probable recurrence of AF underwent surgical treatment and presentation of a literature review. CASE REPORT: Patient female, 63 years, presenting with a mass in the face about four inches and a history of prior resection of the lesion in the same topography. The patient underwent surgical resection with a diagnosis of AF. CONCLUSION: The FA is a rare tumor histological diagnosis difficult. The correct histological diagnosis and patient follow-up are essential.

The usefulness of latissimus dorsi transfer for reconstruction for malignant fibrous histiocytoma in the infraspinatus muscle region: a case report / Utilidad de la transferencia del latissimus dorsi en la reconstrucción por histiocitoma fibroso maligno en la región muscular infraespinosa: reporte de un caso

Malignant fibrous histiocytoma (MFH) is a type of highly malignant soft tissue sarcoma with a predilection for the extremities of adults. We report a patient with MFH in the infraspinatus muscle for which wide resection including total resection of the infraspinatus muscle was performed, followed by transfer of the latissimus dorsi muscle for shoulder reconstruction in a onestage operation with good postoperative function.

El histiocitoma fibroso maligno (HFM) es un tipo de sarcoma del tejido suave, altamente maligno, con predilección por las extremidades de los adultos. Reportamos el caso de un paciente con HFM en el músculo infraespinoso, al cual se le hizo una amplia resección que incluyó la resección total del músculo infraespinoso, seguida de una transferencia del músculo latissimus dorsi para la reconstrucción del hombro, en una operación de una sola etapa con buena función postoperatoria.

Aspectos clinicopatológicos e imunoistoquímicis do histocitoma fibroso maligno estoriforme-pleomórfico em um cão / Clinicopathological and immunohistochemical features of storiform-pleomorphic malignant fibrous histiocytoma in a dog

Histiocitoma fibroso maligno (MFH) é um neoplasma pleocelular de origem incerta e prognóstico sombrio. O correto diagnóstico através de exames imunoistoquímicos é difícil e, na maioria das vezes, inconsistente. Descreve-se os aspectos clinicopatológicos e imunoistoquímicos de um caso de MFH em um cão Rottweiler, macho, de seis anos. O neoplasma foi testado para tricômico de Masson, citoqueratina, vimentina, lisozima, proteína S100 GFAP e NSE. A positividade para vimentina, lisozima e proteína S100 nas células redondas e multinucleadas são características dos histiócitos. Resultados negativos foram observados para os demais anticorpos. Com base nos resultados, diagnósticos diferenciais foram discutidos e a origem histiocítica ou de células pluripotenciais ds células tumoriais pôde ser sugerida. O MFH ainda permanece um desafio diagnóstico em animais e humanos(AU)

Malignant fibrous histiocytoma (MFH) is a pleocellular neoplasm of uncertain cellular origin and poor prognosis. The right diagnosis through immunohistochemical test is difficult and most of the time inconsistent. Clinicopathological features of a MFH in a six-year-old male Rottweiler were described. Additional immunohistochemical data were also provided for diagnosis. The tumor was tested for Masson trichrome, cytokeratin, vimentin, lysozyme, S100 protein, GFAP and NSE. Positive results for vimentin, lyzozyme and S100 protein observed in round and multinucleated cells are characteristic of histiocytes. The result allowed the distinction between the differential diagnosis and suggested an histicytic or pluripotential cell origin. The MFH still remains a diagnostic challenge in dogs and humans(AU)

Aspectos clinicopatológicos e imunoistoquímicis do histocitoma fibroso maligno estoriforme-pleomórfico em um cão / Clinicopathological and immunohistochemical features of storiform-pleomorphic malignant fibrous histiocytoma in a dog

Histiocitoma fibroso maligno (MFH) é um neoplasma pleocelular de origem incerta e prognóstico sombrio. O correto diagnóstico através de exames imunoistoquímicos é difícil e, na maioria das vezes, inconsistente. Descreve-se os aspectos clinicopatológicos e imunoistoquímicos de um caso de MFH em um cão Rottweiler, macho, de seis anos. O neoplasma foi testado para tricômico de Masson, citoqueratina, vimentina, lisozima, proteína S100 GFAP e NSE. A positividade para vimentina, lisozima e proteína S100 nas células redondas e multinucleadas são características dos histiócitos. Resultados negativos foram observados para os demais anticorpos. Com base nos resultados, diagnósticos diferenciais foram discutidos e a origem histiocítica ou de células pluripotenciais ds células tumoriais pôde ser sugerida. O MFH ainda permanece um desafio diagnóstico em animais e humanos

Malignant fibrous histiocytoma (MFH) is a pleocellular neoplasm of uncertain cellular origin and poor prognosis. The right diagnosis through immunohistochemical test is difficult and most of the time inconsistent. Clinicopathological features of a MFH in a six-year-old male Rottweiler were described. Additional immunohistochemical data were also provided for diagnosis. The tumor was tested for Masson trichrome, cytokeratin, vimentin, lysozyme, S100 protein, GFAP and NSE. Positive results for vimentin, lyzozyme and S100 protein observed in round and multinucleated cells are characteristic of histiocytes. The result allowed the distinction between the differential diagnosis and suggested an histicytic or pluripotential cell origin. The MFH still remains a diagnostic challenge in dogs and humans