New Techniques for Assessing Critical Raw Material Aspects in Energy and Other Technologies.

Transitioning to more sustainable energy technologies is a vital step in the move toward reducing global greenhouse gas emissions. However, several physical constraints could hinder the implementation of these technologies, and many of the raw materials required to produce new infrastructure are scarce, nonrenewable, and nonsubstitutable. Various factors relating to material extraction and processing activities may also affect the security and sociopolitical aspects of future supply lines. Here, we introduce methods for quantifying three key indicators relating to raw material supplies for specific production processes: (1) overall supply risk, (2) environmental impacts from sourcing raw materials, and (3) environmental justice threats at sourcing locations. The use of the proposed methods is demonstrated via an exploratory case study examining projected electricity production scenarios within the European Union. Results suggest that renewable sources of electricity─particularly wind, solar, and geothermal technologies─are more likely to exacerbate supply risks and environmental issues than other technologies. Furthermore, projected expansions of wind and solar technologies mean that all three indicators appear likely to rise significantly systemwide by 2050. Ultimately, the methods represent a much-needed first attempt at providing practitioners with simple and robust approaches for integrating factors relating specifically to raw material supply into energy modeling and other applications.

Advances in exploring the therapeutic potential of marine natural products.

Marine natural products represent novel and diverse chemotypes that serve as templates for the discovery and development of therapeutic agents with distinct mechanisms of action. These genetically encoded compounds produced by an evolutionary optimized biosynthetic machinery are usually quite complex and can be difficult to recreate in the laboratory. The isolation from the source organism results in limited amount of material; however, the development of advanced NMR technologies and dereplication strategies has enabled the structure elucidation on small scale. In order to rigorously explore the therapeutic potential of marine natural products and advance them further, the biological characterization has to keep pace with the chemical characterization. The limited marine natural product supply has been a serious challenge for thorough investigation of the biological targets. Several marine drugs have reached the markets or are in clinical trials, where those challenges have been overcome, including through the development of scalable syntheses. However, the identification of mechanisms of action of marine natural products early in the discovery process is potentially game changing, since effectively linking marine natural products to potential therapeutic applications in turn triggers motivation to tackle challenging syntheses and solve the supply problem. An increasing number of sensitive technologies and methods have been developed in recent years, some of which have been successfully applied to marine natural products, increasing the value of these compounds with respect to their biomedical utility. In this review, we discuss advances in overcoming the bottlenecks in marine natural product research, emphasizing on the development and advances of diverse target identification technologies applicable for marine natural product research.

Application of third party logistics for hospital material supply / 中华医院管理杂志

Third party custody system at the Second Affiliated Hospital ot Zhejiang University has reduced hospital costs,raised efficiency and optimized resources.The standardized management system featuring 5S+ 1 achieved such outcomes as +5 and -5,and 0 inventory.A three-year review of the economic performance at the hospital has saved three million yuan of costs,proving that the system can help build an effective material supply system for contemporary general hospitals.