RESUMO
Thyroid cancer is an excellent model for studying tumor immune microenvironment, as it often shows local signs of an immune response. The tumor immune microenvironment of thyroid cancer is the heterogeneous histological space in which tumor cells coexist with host cells. The final composition of this cellular aggregate is associated with the clinical aggressiveness characteristics of the neoplasm. High-performance multiplex technologies suggest that specific genetic signatures of the tumor immune microenvironment may provide data for the delineation of a robust prognostic model. Several proposals integrate clinic, pathologic and immunological information in an attempt to translate the knowledge gained from molecular science into a more personalized approach for the treatment strategy of patients with thyroid cancer. In addition, the tumor immune microenvironment displays multiple molecular connections between cells, revealing complex crosstalk. This interesting network generates several molecular nodes that can be used as targets for immunotherapy. In this scenario, immunotherapy emerges as a promising weapon, mainly for patients with advanced thyroid cancer, both medullary and follicular cell-derived. In fact, although most patients with thyroid cancer have an excellent prognosis with current therapies, around 30% of cases evolve in an unfavorable way, leading to the urgent need to improve immunotherapy for high-risk patients. Preclinical and early clinical investigations are providing optimistic prospects, but more studies are needed to make immunotherapy a more viable and efficient tool for years to come.
Assuntos
Neoplasias da Glândula Tireoide , Humanos , Imunoterapia , Prognóstico , Neoplasias da Glândula Tireoide/genética , Neoplasias da Glândula Tireoide/terapia , Microambiente TumoralRESUMO
La reumatología continental se halla en una época de grandes y acelerados cambios a tono con el mundo actual, vinculados con el mejor conocimiento de los mecanismos patogénicos desde el nivel molecular, el impetuoso desarrollo de la ingeniería genética, los anticuerpos monoclonales, y desarrollo de la industria farmacéutica todo ello en consonancia con el descubrimiento de nuevos blancos terapéuticos y nuevas formas de dirigir las estrategias de diagnóstico y tratamiento para el adecuado manejo de las afecciones autoinmunes reumáticas
The continental rheumatology is in a time of great and rapid changes in tune with today's world, linked to the better understanding of the pathogenic mechanisms from the molecular level, the rapid development of genetic engineering, monoclonal antibodies, and development pharmaceutical industry all in keeping with the discovery of new therapeutics and new ways of running the diagnostic and treatment strategies for the proper management of rheumatic autoimmune conditions whites
RESUMO
La presente investigación surgió como parte de la colaboración que existe entre la Universidad de las Ciencias Informáticas y el Centro de Inmunología Molecular. El objetivo fue desarrollar un procedimiento que contribuyera al almacenamiento y análisis de los ensayos clínicos y que facilitara la aplicación integral de la inteligencia de negocios en esta actividad. Se realizó una propuesta de procedimiento para conducir el desarrollo de soluciones de inteligencia de negocios en el centro. El procedimiento fue evaluado a partir del método de experto Delphi y se obtuvo el resultado de Muy adecuado. Se contó además con un aval del centro cliente, donde se valoró de satisfactorio el trabajo realizado. La implementación de este procedimiento permitirá almacenar toda la información que se gestiona, de manera íntegra y estándar, con lo que se logrará viabilizar los análisis estadísticos que se necesitan realizar por parte de los especialistas de la institución
Present paper appeared as part of cooperation existing between the Information Sciences University and the Center of Molecular Immunology. The aim was to develop a procedure contributing to storage and analysis of clinical trials and to integral application of business intelligence service in this activity. A procedure proposal was made to manage the development of solutions in business intelligence in our center. Procedure was assessed from the method of the Delphi expert method obtaining a result qualified as very appropriate. Implementation of this procedure will allows storing all information managed in an integral and standard way, thus achieving to make viable the statistic analyses needed to be performed by the specialists of the institution