Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop.

Biologic aging reflects the genetic, molecular, and cellular changes underlying the development of morbidity and mortality with advancing chronological age. As several potential mechanisms have been identified, there is a growing interest in developing robust measures of biologic age that can better reflect the underlying biology of aging and predict age-related outcomes. To support this endeavor, the Research Centers Collaborative Network (RCCN) conducted a workshop in January 2022 to discuss emerging concepts in the field and identify opportunities to move the science forward. This paper presents workshop proceedings and summarizes the identified research needs, priorities, and recommendations for measuring biologic age. The highest priorities identified were the need for more robust measures, longitudinal studies, multidisciplinary collaborations, and translational approaches.

A multicenter paper-based and web-based system for collecting patient-reported outcome measures in patients undergoing local treatment for prostate cancer: first experiences.

PURPOSE: To give an overview of the multicenter Prostate Cancer Outcomes (PCO) study, involving paper-based and web-based collection of patient-reported outcome measures (PROM) in patients undergoing local treatment for prostate cancer in certified centers in Germany. The PCO study is part of the larger Movember-funded TrueNTH Global Registry. The article reports on the study's design and provides a brief progress report after the first 2 years of data collection. METHODS: Prostate cancer centers (PCCs) certified according to German Cancer Society requirements were invited to participate in collecting patient-reported information on symptoms and function before and at least once (at 12 months) after treatment. The data were matched with disease and treatment information. This report describes progress in patient inclusion, response rate, and variations between centers relative to online/paper use, and also data quality, including recruitment variations relative to treatment in the first participating PCCs. RESULTS: PCC participation increased over time; 44 centers had transferred data for 3094 patients at the time of this report. Patient recruitment varied widely across centers. Recruitment was highest among patients undergoing radical prostatectomy. The completeness of the data was good, except for comorbidity information. CONCLUSIONS: The PCO study benefits from a quality improvement system first established over 10 years ago, requiring collection and harmonization of a predefined clinical dataset across centers. Nevertheless, establishing a PROM routine requires substantial effort on the part of providers and constant monitoring in order to achieve high-quality data. The findings reported here may be useful for guiding implementation in similar initiatives.

Healthy Indoor Environments: The Need for a Holistic Approach.

Indoor environments have a large impact on health and well-being, so it is important to understand what makes them healthy and sustainable. There is substantial knowledge on individual factors and their effects, though understanding how factors interact and what role occupants play in these interactions (both causative and receptive) is lacking. We aimed to: (i) explore interactions between factors and potential risks if these are not considered from holistic perspective; and (ii) identify components needed to advance research on indoor environments. The paper is based on collaboration between researchers from disciplines covering technical, behavioural, and medical perspectives. Outcomes were identified through literature reviews, discussions and workshops with invited experts and representatives from various stakeholder groups. Four themes emerged and were discussed with an emphasis on occupant health: (a) the bio-psycho-social aspects of health; (b) interaction between occupants, buildings and indoor environment; (c) climate change and its impact on indoor environment quality, thermal comfort and health; and (d) energy efficiency measures and indoor environment. To advance the relevant research, the indoor environment must be considered a dynamic and complex system with multiple interactions. This calls for a transdisciplinary and holistic approach and effective collaboration with various stakeholders.

Ontologias para a Teoria TRIZ: uma necessidade? / Ontologies to Teoria TRIZ: a need?

A Ciência da Informação surgiu há aproximadamente quarenta anos, é multidisciplinar por natureza e uma de suas contribuições é o planejamento e a organização de Sistemas de Conhecimento com o uso de computador. Os cientistas da informação são profissionais formados em diversas áreas e se utilizam das ontologias para organizar o conhecimento. Um dos desafios é o uso de ontologias para sistemas de conhecimento contido nas bases de patentes. O presente ensaio aborda aspectos relacionados à necessidade de uso de ontologias no campo de domínio da Teoria da Resolução de Problemas Inventivos para a construção de Sistemas de Conhecimento capazes de oferecer soluções na prática da Inovação Sistemática; analisa a literatura disponível sobre o assunto; esclarece questões a respeito da Teoria TRIZ; e questiona se o uso de Ontologias contribui na aplicação do desenvolvimento dos métodos da TRIZ. As reflexões finais deixam em aberto o campo de estudos que envolvam ontologias, TRIZ e Sistemas de Conhecimento, como proposta de objeto de estudo a parti r da Ciência da Informação e da Engenharia do Conhecimento (AU)

The Science of the Information appeared there are approximately forty years, it is by nature multidisciplinary, and one of your contributions is the planning and the organization of Systems of Knowledge with the computer use. The cientists of the information are professional formed in severalareas and they are used of the ontologies to organize knowledge. One of the challenges is the ontologies use for knowledge systems contained in the basesof patents.The present empirical text approaches aspects related to the need of ontologies use in the field of domain of the Theory of the Resolution of Inventive Problems to the construction of Systemsof Knowledge that it capable off ering solutions in practice of the Systematic Innovation. It analyzes the available literature about subject, and it’s clears regarding about the TRIZ Theory, and the use of Ontologies is questioned if they contribute in the application of the development of the methods of TRIZ. The final reflections leave in open the field of studies of ontologies, TRIZ and Systems of Knowledge, as proposal of study object starting from the Science of the Information and of the Engineering of the Knowledge (AU)

Ontologias para a Teoria TRIZ: uma necessidade? / Ontologies to Teoria TRIZ: a need?

A Ciência da Informação surgiu há aproximadamente quarenta anos, é multidisciplinar por natureza e uma de suas contribuições é o planejamento e a organização de Sistemas de Conhecimento com o uso de computador. Os cientistas da informação são profissionais formados em diversas áreas e se utilizam das ontologias para organizar o conhecimento. Um dos desafios é o uso de ontologias para sistemas de conhecimento contido nas bases de patentes. O presente ensaio aborda aspectos relacionados à necessidade de uso de ontologias no campo de domínio da Teoria da Resolução de Problemas Inventivos para a construção de Sistemas de Conhecimento capazes de oferecer soluções na prática da Inovação Sistemática; analisa a literatura disponível sobre o assunto; esclarece questões a respeito da Teoria TRIZ; e questiona se o uso de Ontologias contribui na aplicação do desenvolvimento dos métodos da TRIZ. As reflexões finais deixam em aberto o campo de estudos que envolvam ontologias, TRIZ e Sistemas de Conhecimento, como proposta de objeto de estudo a parti r da Ciência da Informação e da Engenharia do Conhecimento

The Science of the Information appeared there are approximately forty years, it is by nature multidisciplinary, and one of your contributions is the planning and the organization of Systems of Knowledge with the computer use. The cientists of the information are professional formed in severalareas and they are used of the ontologies to organize knowledge. One of the challenges is the ontologies use for knowledge systems contained in the basesof patents.The present empirical text approaches aspects related to the need of ontologies use in the field of domain of the Theory of the Resolution of Inventive Problems to the construction of Systemsof Knowledge that it capable off ering solutions in practice of the Systematic Innovation. It analyzes the available literature about subject, and it's clears regarding about the TRIZ Theory, and the use of Ontologies is questioned if they contribute in the application of the development of the methods of TRIZ. The final reflections leave in open the field of studies of ontologies, TRIZ and Systems of Knowledge, as proposal of study object starting from the Science of the Information and of the Engineering of the Knowledge

International Observatory of Human Capabilities, Development and Public Policy: studies and analysis 2 / Observatório Internacional de Capacidades Humanas, Desenvolvimento e Políticas Públicas: estudos e análises 2 / Observatorio Internacional de Capacidades Humanas, Desarollo y Políticas Públicas: estudos y análisis 2

The intention of the coordinators of the editorial project is to explore new perspectives on the discussions that followed the inaugural publication of these studies and analyzes2 . The organization and the release of this publication in a seminar that brings together the authors for the presentation and discussion of their work with special guests confirm the willingness of the Center of Studies on Bioethics and Diplomacy in Health of Fiocruz and the Observatory of Human Resources of UnB to proceed in the consolidation of the International Observatory of Human Capabilities, Development and Public Policy. This collection of texts aims to strengthen this debate, focusing again on two issues raised in the presentation of the previous issue: the vocation of capitalist development, as occurs in Latin America and other continents to inevitably impose certain standardized and controlled styles to live in society, were there is not the unveiling of the horizon of freedom promised by Sen's theory; and the impression that often this horizon of freedom is definitely made not viable by the type of development imposed unilaterally by the State, a phenomenon that can occur in both contexts of authoritarian as democratic regimes.Concluding this presentation, remains the hope that the preparation and dissemination of this publication will contribute to better understand, evaluate and guide decisions about the problems that are part of the debate on international relations, helping to clear up topics relevant to the future of humanity health, in the case in question, diseases and chronic conditions.