Dependence of radioactive iodine-131 capture by the lacrimal ducts on the tear production level.

Purpose: Secondary acquired lacrimal duct obstruction (SALDO) is one of the complications of radioiodine therapy. SALDO is formed a few months after therapy if there is a sufficient uptake of radioactive iodine by the nasolacrimal duct. To date, risk factors leading to SALDO are unclear. The objective was to determine the correlation between the tear production level and radioactive iodine-131 uptake in the lacrimal ducts. Methods: Basal and reflex tear production was studied in 64 eyes prior to the therapy with radioactive iodine-131 after drug-induced hypothyroidism. The condition of the ocular surface was assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Seventy-two hours after the radioactive iodine therapy, scintigraphy was performed, which determined the presence or absence of iodine-131 in the lacrimal ducts. T-statistics and the Mann-Whitney criterion were used to identify the differences between the groups. The differences were considered significant at P ≤ 0.05. The current tear production level in patients receiving radioiodine therapy was determined using a mathematical model. Results: A statistically significant difference between the basal (p = 0.044) and reflex (p = 0.015) tear production levels was found in cases with and without iodine-131 uptake by the lacrimal ducts. The probable current tear production level corresponds to the sum of basal and 10-20% of reflex tear production. The uptake of iodine-131 was found regardless of the OSDI results. Conclusion: The probability of iodine-131 uptake by the lacrimal ducts rises as the tear production level increases.

Complete resolution of a large squamous cell carcinoma of the lacrimal duct in a young African American male after non-surgical management.

PURPOSE: The following case describes a 28-year old African American male who presented with squamous cell carcinoma of the lacrimal duct. Despite its size and location, his tumor showed complete resolution with non-surgical treatment. OBSERVATIONS: The patient presented with a 4-month history of dacryocystitis-like symptoms in the right eye, with no prior medical history and a history of tobacco smoking. Pathology indicated that SCC arose as nests within a benign sinonasal inverted papilloma. He received cisplatin chemotherapy and radiotherapy with tumor resolution in 4 months. Several months after the end of treatment, he experienced irreversible visual deterioration which led to enucleation of the right eye. The patient has remained in remission for 4 years following the treatment. CONCLUSIONS: The complete resolution of the mass with non-surgical management supports the most recent literature endorsing a multidisciplinary approach for localized tumors. Our patient is the only African American identified in the literature and the youngest reported patient to present with this tumor. Most case studies have not emphasized race, ethnicity and demographics, although it is known that morbidity in malignancy is impacted by these factors.

Massa paranasal congênita - dacriocistocele: relato de caso clínico e revisão de literatura / Congenital paranasal mass – dacryocystocele: case report and literature review

O edema facial em criança é uma condição clínica comum, podendo ser progressivoou não, de causas congênitas e/ou adquiridas. Lesões não-progressivas e congênitas do epicanto medial se restringem a: dacriocistocele, menigoencefalocele frontoetmoidal e cisto dermoide. Relata-se o caso de um paciente com dacriocistocele congênita, descrevendo-se as características da lesão, suas manifestações clínicas e aspectos de imagem. Apresenta-se, ainda, breve revisão da literatura relevante.

The facial swelling in children is a common clinical condition and may be progressive or not, from congenital or acquired causes. Medial epicanthus non-progressive and congenital lesions are restricted to: dacryocystocele, menigoencefalocele frontoethmoidal and dermoid cyst. This is a case report of a patient with congenital dacryocystocele, describing the lesion characteristics, its clinical manifestations and image aspects. There is also a brief review of the relevant literature.