Progressive supranuclear palsy, a case report.

Progressive Supranuclear Palsy (PSP), also known as Steele-Richardson-Olszewski syndrome, is a rare neurodegenerative disease characterized by a variety of motor and neuro-ophthalmological symptoms. We present the case of a 73-year-old male patient with a history of type 2 diabetes and high blood pressure, who consulted for gait disorders, tremors in the extremities, and difficulty controlling conjugate gaze. During physical examination, findings consistent with PSP were noted, including hypomimia, muscle rigidity, and abnormal movements. The initial misdiagnosis of Parkinson's disease and subsequent administration of levodopa highlight the importance of accurate diagnosis in complex neurological conditions. This clinical case highlights the need for a thorough evaluation of neuro-ophthalmological symptoms and signs to ensure an appropriate therapeutic approach and improve the quality of life of patients.

Partial regression of peripapillary myelinated nerve fibers after non-arteritic anterior ischemic optic neuropathy / Regressão parcial das fibras nervosas peripapilares mielinizadas após neuropatia óptica isquêmica anterior não arterítica

ABSTRACT A 71-year-old woman presented a non-arteritic anterior ischemic optic neuropathy in an optic nerve with previously registered superonasal peripapillary myelinated nerve fibers. Her past medical history was significant for controlled systemic hypertension, hyperlipidemia, and diabetes mellitus. The physiologic cup was absent in both optic discs. Non-arteritic anterior ischemic optic neuropathy mainly affected the temporal and inferior sectors of the peripapillary retinal nerve fiber layer, as could be demonstrated by retinal nerve fiber layer optical coherence tomography and optic disc optical coherence tomography angiography. Unlike other published reports, just a slight regression of the myelinated nerve fibers was observed after 1 year of follow-up. This occurred because ischemia mainly affected the temporal and inferior peripapillary sectors, whereas myelinated nerve fibers were superonasal to the optic disc.

RESUMO Uma mulher de 71 anos de idade apresentou neuropatia óptica isquêmica anterior não arterítica no nervo óptico com fibras nervosas peripapilares mielinizadas previamente registradas. Seu histórico médico foi significativo para hipertensão arterial sistêmica controlada, hiperlipidemia e diabetes mellitus. Em ambos os discos ópticos, a tacícula fisiológica esteve ausente. A neuropatia óptica isquêmica anterior não arterítica afetou principalmente os setores temporal e inferior da camada de fibras nervosas da retina peripapilar, como demonstrado pela tomografia de coerência óptica da camada de fibras nervosas da retina e pela angiotomografia de coerência óptica do disco óptico. Ao contrário de outros relatórios publicados, apenas uma ligeira regressão das fibras nervosas mielinizadas foi observada após um ano de acompanhamento. Isto pode ser explicado pelo fato da isquemia ter afetado principalmente os setores temporal e inferior peripapilares, enquanto as fibras nervosas de mielina eram nasal superior ao disco óptico.

Características epidemiológicas y clínicas de pacientes con glaucoma crónico simple / Epidemiologic and clinic characteristics of patients with chronic simple glaucoma i: en

Introducción: El glaucoma es una de las enfermedades oculares de mayor prevalencia a escala mundial y se caracteriza por presión intraocular elevada, cambios en la papila y alteraciones en el campo visual. Objetivo: Caracterizar a pacientes con glaucoma crónico simple según variables epidemiológicas y clínicas. Método: Se realizó un estudio observacional, descriptivo y transversal de 96 pacientes con glaucoma primario de ángulo abierto, quienes fueron atendidos en la consulta de oftalmología del Policlínico Docente Alberto Fernández Montes de Oca del municipio de San Luis, en la provincia de Santiago de Cuba, desde enero hasta julio del 2019. Resultados: En la serie prevalecieron el sexo masculino, el grupo etario de 60 a 69 años y los pacientes de piel negra, además de la hipertensión arterial y ocular como factores de riesgo asociados. Por otra parte, la mayoría de los afectados presentaron agudeza visual entre 1,0-0,6, cifras de presión intraocular entre 16-21 mmHg y excavación papilar entre 0,6-0,7, con daños importantes en el campo visual. Conclusiones: Las características epidemiológicas y clínicas de los pacientes con glaucoma primario de ángulo abierto resultaron útiles para establecer el pronóstico y trazar pautas terapéuticas efectivas, a fin de evitar la fase avanzada de la enfermedad y los daños irreversibles que se producen en el nervio óptico.

Introduction: Glaucoma is one of the most prevalent eye diseases worldwide and is characterized by high intraocular pressure, changes in the papilla and visual field alterations. Objective: To characterize patients with chronic simple glaucoma according to epidemiologic and clinical variables. Methods: An observational, descriptive and cross-sectional study of 96 patients with primary open-angle glaucoma was carried out, who were assisted in the Ophthalmology Service of Alberto Fernández Montes de Oca Teaching Polyclinic of San Luis municipality, in Santiago de Cuba province, from January to July, 2019. Results: In the series there was a prevalence of the male sex, the 60 to 69 age group, and dark-skinned patients, besides hypertension and ocular hypertension as associated risk factors. On the other hand, most of those affected presented visual acuteness between 1.0-0.6, intraocular pressure figures between 16-21 mmHg and papillary excavation between 0.6-0.7, with important damage in the visual field. Conclusions: The epidemiologic and clinical characteristics of patients with primary open-angle glaucoma were useful to establish the prognosis and trace effective therapeutic guidelines, in order to avoid the advanced phase of the disease and the irreversible damage that occurs in the optic nerve.

Factor de crecimiento nervioso en neuropatía óptica traumática

La neuropatía óptica traumática (TON) es una entidad asociada al trauma facial y craneal, y constituye una causa importante para el desarrollo de la ceguera; es una complicación grave del trauma craneofacial que daña directa (dTON) o indirectamente (iTON) el nervio óptico (ON), cuya incidencia global de TON es de 0,7 a 2,5 %. El objetivo del presente estudio es presentar el caso de un paciente que padecía de TON y a la vez de una afección bilateral asimétrica, y que fue tratado con el factor de crecimiento nervioso mNGF. Este medicamento fue el primero que se descubrió y demostró eficacia en mantener la supervivencia de las neuronas centrales y periféricas y facilitar su crecimiento, diferenciación y regeneración. Se trata de un paciente de 13 años, sexo masculino, quien acude a la emergencia del Instituto Nacional de Ciencias Neurológicas y, posteriormente, su seguimiento clínico es por consultorio de Neuroftalmología, con un cuadro de amaurosis traumática, producto de un traumatismo encéfalo craneano con hematoma epidural, que recibió dos ciclos de tratamiento con factor de crecimiento nervioso. Luego del primer ciclo de tratamiento, se evidenció hiporreactividad de ambos ojos; al finalizar el segundo ciclo de tratamiento, se observó un aumento considerable de la agudeza visual. El mNGF está aprobado y comercializado en China desde el año 2015 y es un producto que ha demostrado su eficacia y seguridad en varios ensayos clínicos. Por ello, el presente estudio pretende convertir al factor de crecimiento nervioso como el tratamiento prometedor de iTON; en ese sentido, se necesita de amplias investigaciones clínicas en este caso en particular.

Traumatic optic neuropathy (TON) is an entity associated with facial and cranial trauma, and a leading cause of blindness. It is a severe complication of craniofacial trauma that directly (DTON) or indirectly (ITON) damages the optic nerve (ON) and whose global incidence is 0.7 to 2.5 %. The objective of this study is to present the case of a patient who suffered from TON and, at the same time, an asymmetrical bilateral condition, and was treated with nerve growth factor (NGF). This drug was the first to be discovered and demonstrate efficacy in maintaining the survival of central and peripheral neurons and facilitating their growth, differentiation and regeneration. A 13-year-old male patient attended the emergency room of Instituto Nacional de Ciencias Neurológicas and was later followed up at the Neuro-Ophthalmology Service. He was diagnosed with post-traumatic amaurosis caused by traumatic brain injury and epidural hematoma, and received two treatment cycles of NGF. After the first treatment cycle, hyporeactivity of both eyes occurred. And, at the end of the second treatment cycle, visual acuity improved significantly. NGF has been approved and marketed in China since 2015 and is a product that has demonstrated its efficacy and safety in several clinical trials. Therefore, this study aims to make NGF a promising ITON treatment; in that sense, further clinical research is needed in this particular case.

Autoimmune optic neuropathy as the differential diagnosis of neuromyelitis optica spectrum disorders / Neuropatia óptica autoimune como diagnóstico diferencial do espectro da neuromielite óptica

ABSTRACT Optic neuritis is an important cause of decreased vision due to inflammation of the optic nerve. In view of its complex etiology, a thorough clinical evaluation is essential. Autoimmune optic neuropathy, a rare form of optic neuritis, is associated with progressive, painless, and severe visual loss. Severity depends on the inflammatory and ischemic components of the condition. Autoimmune optic neuropathy is ideally diagnosed with autoimmune disease markers (usually elevated levels of antinuclear antibodies). The treatment is immunosuppression with high doses of corticosteroids. Corticoid dependence is a characteristic of autoimmune optic neuropathy. In this report, we describe a patient with autoimmune optic neuropathy and discuss the importance of laboratory parameters and magnetic resonance imaging findings in the diagnosis of the disease.

RESUMO A Neurite óptica é uma importante causa de diminuição da visão devido à inflamação do nervo óptico. Por apresentar diversas etiologias faz-se necessário ampla investigação. A neuropatia óptica autoimune corresponde a uma doença rara que se manifesta com perda visual aguda, indolor e grave. A gravidade está associada a sua fisiopatogenia com componentes inflamatório e isquêmico. A positividade para marcadores de doenças autoimunes, mais comumente a elevação da titulação de anticorpos antinucleares, são fatores determinantes para o diagnóstico da neuropatia óptica autoimune. O tratamento é feito através de imunossupressão, com necessidade de altas doses de corticoide. Neste relato iremos descrever um paciente com neuropatia óptica autoimune. Discutiremos sobre a importância dos parâmetros laboratoriais e os achados de imagem da ressonância magnética para o diagnóstico.

Validation of the color graduation scale in the optical nerve photograph, an alternative for qualitative classification.

BACKGROUND: To validate objectively the proposed Teherán-Morales's color grading scale, comparing to the subjective readings of specialists in optic nerve photography. METHODS: Concordance study and diagnostic tests, in which 150 photographs of the optic nerve were evaluated, from three groups, glaucomatous neuropathy, neuropathy of other origin and control group with the Teherán-Morales's color scale and the analysis of three experts in optic nerve. Spearman's Rho correlation was performed between both analysis methods. RESULTS: In the analysis of all the photographs using Spearman's Rho, we found moderate correlations that were statistically significant P < 0.0001, the highest was in the temporal quadrant by observer 1 (r = 0.650 95% CI 0.546-0.733). In photographs of optic neuropathy, the correlations become moderately high, and statistically significant P < 0.0001, the highest correlation was for the temporal quadrant by observer 1 (r = 0.772 95% CI 0.626-0.865). In the glaucoma and normal eyes groups, there were moderate to low correlations with statistical significance P < 0.05. CONCLUSIONS: The Teherán-Morales's scale, for color grading, is useful in detecting color, correlates moderately with the subjective assessment of experts in the optic nerve having its best performance in optic neuropathy with very pale discs. However, in normal or glaucomatous optic discs, it has a low correlation, compared to the subjective clinical assessment.

Validación de la escala de graduación del color en la fotografía del nervio óptico, una alternativa para la clasificación cualitativa / Validation of the color graduation scale in the optical nerve photograph, an alternative for qualitative classification

ObjetivoValidar de forma objetiva la escala de graduación del color Teherán-Morales propuesta, comparándola con las lecturas subjetivas de especialistas en lectura de fotografías del nervio óptico.Material y métodosEstudio de concordancia y pruebas diagnósticas, en el que 150 fotografías del nervio óptico fueron evaluadas, distribuidas en tres grupos, neuropatía glaucomatosa, neuropatía de otro origen y grupo control los cuales se sometieron a evaluación mediante la escala de color Teherán-Morales por parte de 3 expertos en nervio óptico independientes. Se realizó correlación Rho de Spearman entre ambos métodos de análisis.ResultadosEn el análisis de todas las fotografías mediante la rho de Spearman, encontramos correlaciones moderadas que fueron estadísticamente significativas P <0,0001, la mayor de ellas fue por el observador 1 (r=0,650 IC 95% 0,546 a 0,733) en el cuadrante temporal. En fotografías de neuropatía óptica, las correlaciones pasan a ser moderadas altas, y estadísticamente significativas P<0,0001, siendo la correlación más alta para el cuadrante temporal por el observador 1 (r=0,772 IC 95% 0,626 a 0,865). En los grupos de glaucoma y ojos normales, hubo correlaciones moderadas a bajas con significación estadística P <0,05.ConclusionesLa escala Teherán-Morales, para la graduación del color es útil en la detección del color, correlacionándose moderadamente con la valoración subjetiva de expertos en nervio óptico, teniendo su mejor desempeño en neuropatía óptica con discos muy pálidos. Sin embargo, en discos ópticos normales o glaucomatosos, tiene baja correlación, comparada con la valoración clínica subjetiva. (AU)

BackgroundTo validate objectively the proposed Teherán-Morales's color grading scale, comparing to the subjective readings of specialists in optic nerve photography.MethodsConcordance study and diagnostic tests, in which 150 photographs of the optic nerve were evaluated, from three groups, glaucomatous neuropathy, neuropathy of other origin and control group with the Teherán-Morales's color scale and the analysis of three experts in optic nerve. Spearman's Rho correlation was performed between both analysis methods.ResultsIn the analysis of all the photographs using Spearman's Rho, we found moderate correlations that were statistically significant P <.0001, the highest was in the temporal quadrant by observer 1 (r=0.650 95% CI 0.546 to 0.733). In photographs of optic neuropathy, the correlations become moderately high, and statistically significant P <.0001, the highest correlation was for the temporal quadrant by observer 1 (r=0.772 95% CI 0.626 to 0.865). In the glaucoma and normal eyes groups, there were moderate to low correlations with statistical significance P <.05.ConclusionsThe Teherán-Morales's scale, for color grading, is useful in detecting color, correlates moderately with the subjective assessment of experts in the optic nerve having its best performance in optic neuropathy with very pale discs. However, in normal or glaucomatous optic discs, it has a low correlation, compared to the subjective clinical assessment. (AU)

Síndromes paraneoplásicos en oftalmología / Paraneoplastic syndromes in ophthalmology

Los síndromes paraneoplásicos consisten en la afectación de órganos y tejidos alejados de un tumor primario, y que no son consecuencia directa de la invasión tumoral ni de sus metástasis. Se sabe que en su fisiopatología desempeñan un papel importante la autoinmunidad y la síntesis de autoanticuerpos debido a un proceso de mimetismo molecular. Los síndromes paraneoplásicos de afectación oftalmológica son una enfermedad poco frecuente, pero es importante reconocerlos clínicamente debido a que en algunas ocasiones los síntomas derivados preceden al diagnóstico de la neoplasia de base. El tumor más frecuentemente relacionado con esta enfermedad es el carcinoma microcítico pulmonar, pero también existe relación con otras etiologías tumorales como el timoma, los tumores ginecológicos o el neuroblastoma en niños. Los síndromes paraneoplásicos de afectación oftalmológica pueden dividirse entre los que afectan a la vía visual aferente, como la retinopatía asociada al cáncer, la retinopatía asociada al melanoma o la neuropatía óptica paraneoplásica; o a la vía visual eferente, como las pupilas tónicas bilaterales, la miastenia gravis, el síndrome de Lambert-Eaton o la degeneración cerebelosa paraneoplásica. Cada vez se conocen más autoanticuerpos relacionados y su positividad es de ayuda en la práctica clínica, pero la negatividad no excluye el diagnóstico. Aunque su evolución y pronóstico va ligado al de la enfermedad causal, en algunos casos el tratamiento específico, habitualmente mediante terapia inmunosupresora puede ayudar a mejorar la calidad de vida de estos pacientes (AU)

Paraneoplastic syndromes consist on systemic manifestations associated with certain cancers which are not a direct consequence of tumor invasion or its metastases. It is known that autoimmunity and autoantibody synthesis play an important role in its pathophysiology due to a process of molecular mimicry. Paraneoplastic syndromes in ophthalmology are rare, but it is important to recognize them clinically because in some cases symptoms preceded the diagnosis of an underlying neoplasia. Most frequently involved cancer is small cell lung carcinoma, but there is also a relationship with other tumor etiologies such as thymoma, gynecological tumors or neuroblastoma in children. Paraneoplastic syndromes with ocular involvement can be divided into those that affect the afferent visual pathway, such as cancer-associated retinopathy, melanoma-associated retinopathy, or paraneoplastic optic neuropathy; and the ones that affect the efferent visual pathway, such as bilateral tonic pupils, Myasthenia Gravis, Lambert-Eaton syndrome or paraneoplastic cerebellar degeneration. The presence of autoantibodies is helpful in clinical practice but negativity does not exclude this diagnosis. Although evolution and prognosis is linked to primary disease, in some cases specific treatment, usually immunosuppressive therapy, can help improving patients quality of life (AU)

Paraneoplastic syndromes in ophthalmology.

Paraneoplastic syndromes consist on systemic manifestations associated with certain cancers which are not a direct consequence of tumor invasion or its metastases. It is known that autoimmunity and autoantibody synthesis play an important role in its pathophysiology due to a process of molecular mimicry. Paraneoplastic syndromes in ophthalmology are rare, but it is important to recognize them clinically because in some cases symptoms preceded the diagnosis of an underlying neoplasia. Most frequently involved cancer is small cell lung carcinoma, but there is also a relationship with other tumor etiologies such as thymoma, gynecological tumors or neuroblastoma in children. Paraneoplastic syndromes with ocular involvement can be divided into those that affect the afferent visual pathway, such as cancer-associated retinopathy, melanoma-associated retinopathy, or paraneoplastic optic neuropathy; and the ones that affect the efferent visual pathway, such as bilateral tonic pupils, Myasthenia Gravis, Lambert-Eaton syndrome or paraneoplastic cerebellar degeneration. The presence of autoantibodies is helpful in clinical practice but negativity does not exclude this diagnosis. Although evolution and prognosis is linked to primary disease, in some cases specific treatment, usually immunosuppressive therapy, can help improving patients quality of life.

Choroidopathy and optic neuropathy in systemic lupus erythematosus, a case report.

Although the associated ocular pathology to systemic lupus erythematosus is not infrequent, its manifestations and importance can be overlooked by rheumatologists and ophthalmologists. We present the case of a 44-year-old male with a history of systemic lupus erythematosus whose disease started with metamorphopsia and subjective alteration of the visual fields of both eyes, with a marked decrease in visual acuity, secondary to bilateral serous retinal detachment and optic neuropathy. He received systemic corticosteroids, biological therapy and posterior subtenon triamcinolone acetonide injections, showing an improvement in visual acuity. Ophthalmic manifestations should be considered a sign of systemic lupus erythematosus activity, therefore the treatment is essentially systemic, in combinationed with local coadjutant treatment.

Optic neuropathy by ethambutol in a patient with multiple sclerosis.

We present the clinical case of a patient who developed a toxic optic neuropathy due to ethambutol in the context of a tuberculosis reactivation and who also had a personal history of multiple sclerosis. The objective is to highlight the importance of making a good differential diagnosis of this adverse effect and of knowing its main clinical, campimetric and tomographic manifestations and characteristics. Furthermore, since the reversibility of damage is still discussed in the literature, early diagnosis is essential. For this purpose, it is important to inform the patient of the possible symptoms and to carry out an ophthalmological examination and colour tests before starting treatment to assess whether there is progression.

Coroidopatía y neuropatía óptica en lupus eritematoso sistémico, reporte de caso / Choroidopathy and optic neuropathy in systemic lupus erythematosus, a case report

Si bien la patología ocular asociada a lupus eritematoso sistémico no es infrecuente, sus manifestaciones e importancia pueden ser a veces pasadas por alto por reumatólogos y oftalmólogos. Se describe el caso de un varón de 44 años con antecedente de lupus eritematoso sistémico que inicia enfermedad con metamorfopsias y alteración subjetiva de campos visuales de ambos ojos, presentando disminución marcada de agudeza visual secundaria a desprendimiento de retina seroso bilateral y neuropatía óptica. Recibió tratamiento con corticoides sistémicos, terapia biológica e inyecciones subtenonianas posteriores de triamcinolona, presentando mejoría de la agudeza visual. Las manifestaciones oftálmicas deben ser consideradas como signo de actividad del lupus eritematoso sistémico, por ese motivo el tratamiento es esencialmente sistémico, asociado a tratamiento coadyuvante local.

Although the associated ocular pathology to systemic lupus erythematosus is not infrequent, its manifestations and importance can be overlooked by rheumatologists and ophthalmologists. We present the case of a 44-year-old male with a history of systemic lupus erythematosus whose disease started with metamorphopsia and subjective alteration of the visual fields of both eyes, with a marked decrease in visual acuity, secondary to bilateral serous retinal detachment and optic neuropathy. He received systemic corticosteroids, biological therapy and posterior subtenon triamcinolone acetonide injections, showing an improvement in visual acuity. Ophthalmic manifestations should be considered a sign of systemic lupus erythematosus activity, therefore the treatment is essentially systemic, in combinationed with local coadjutant treatment.

Neuropatía óptica por etambutol en paciente con esclerosis múltiple / Optic neuropathy by ethambutol in a patient with multiple sclerosis

Presentamos el caso clínico de una paciente que desarrolló una neuropatía óptica tóxica por etambutol en el contexto de una reactivación tuberculosa y que, además, presentaba como antecedentes personales una esclerosis múltiple. El objetivo es destacar la importancia de realizar un buen diagnóstico diferencial de este efecto adverso y de conocer sus manifestaciones y características clínicas, campimétricas y tomográficas principales. Además, dado que la reversibilidad del daño sigue siendo discutida en la bibliografía, es esencial el diagnóstico precoz para lo que es importante informar al paciente de los posibles síntomas, así como llevar a cabo una exploración oftalmológica y test cromáticos antes de comenzar el tratamiento para valorar si hay progresión.

We present the clinical case of a patient who developed a toxic optic neuropathy due to ethambutol in the context of a tuberculosis reactivation and who also had a personal history of multiple sclerosis. The objective is to highlight the importance of making a good differential diagnosis of this adverse effect and of knowing its main clinical, campimetric and tomographic manifestations and characteristics. Furthermore, since the reversibility of damage is still discussed in the literature, early diagnosis is essential. For this purpose, it is important to inform the patient of the possible symptoms and to carry out an ophthalmological examination and colour tests before starting treatment to assess whether there is progression.

Ocular toxicity after inadvertent overdose of intracameral cefuroxime during cataract surgery.

PURPOSE: To describe intracameral toxic effects of cefuroxime at a higher dose than recommended in cataract surgery. METHODS: Retrospective study of 8 eyes of 8 patients who inadvertently received 12.5 mg/0.1 ml of intracameral cefuroxime due to a dilution error, at the end of the cataract surgery. All patients underwent a strict ophthalmology follow-up for 6 months. RESULTS: All patients presented with a marked anterior segment inflammation with corneal oedema that resolved completely in all cases (between 5 days and 3 months). At 6 months of follow-up a statistically significant difference was found in the corneal endothelial cell density when compared with the fellow eye (P = .038), being <1000 cells/mm2 in 3 cases. Three patients (37.5%) showed early macular oedema, with subfoveal ellipsoid layer disruption in one case as a permanent sequel. One patient developed an optic neuropathy with associated afferent pupillary defect. CONCLUSIONS: Although 1 mg/0.1 ml of intracameral cefuroxime has been shown to reduce the incidence of endophthalmitis, its overdose can have potentially toxic eye effects in both anterior and posterior segments.

Toxicidad ocular tras sobredosificación accidental de cefuroxima intracameral en cirugía de catarata / Ocular toxicity after inadvertent overdose of intracameral cefuroxime during cataract surgery

Objetivo Describir los efectos de la inyección de cefuroxima intracameral a una dosis más alta de la recomendada en cirugía de catarata. Métodos Estudio retrospectivo de 8 ojos de 8 pacientes operados de catarata en un mismo día que recibieron 12,5mg/0,1ml de cefuroxima intracameral de forma inadvertida al finalizar la cirugía, por un error en la dilución. A todos los pacientes se les realizó un seguimiento oftalmológico estrecho durante 6 meses. Resultado Todos los pacientes presentaron una inflamación marcada del segmento anterior con edema corneal que se resolvió en todos los casos (entre 5 días y 3 meses). A los 6 meses de seguimiento se constató una diferencia significativa en el recuento endotelial corneal de dichos ojos al compararlo con el ojo contralateral (p=0,038), siendo<1000cels/mm2 en 3 casos. Tres pacientes (37,5%) presentaron un edema macular precoz, dejando como secuela permanente la disrupción de la capa elipsoidal a nivel subfoveal en uno de los casos. Uno de los pacientes desarrolló una neuropatía óptica con defecto pupilar aferente asociado. Conclusiones Aunque la inyección de cefuroxima en cámara anterior a dosis de 1mg/0,1ml ha demostrado disminuir la incidencia de endoftalmitis, su sobredosificación puede tener efectos oculares potencialmente perjudiciales tanto en el segmento anterior como en el posterior (AU)

Purpose To describe intracameral toxic effects of cefuroxime at a higher dose than recommended in cataract surgery. Methods Retrospective study of 8 eyes of 8 patients who inadvertently received 12.5mg/0.1ml of intracameral cefuroxime due to a dilution error, at the end of the cataract surgery. All patients underwent a strict ophthalmology follow-up for 6 months. Results All patients presented with a marked anterior segment inflammation with corneal oedema that resolved completely in all cases (between 5 days and 3 months). At 6 months of follow-up a statistically significant difference was found in the corneal endothelial cell density when compared with the fellow eye (P=.038), being<1000 cells/mm2 in 3 cases. Three patients (37.5%) showed early macular oedema, with subfoveal ellipsoid layer disruption in one case as a permanent sequel. One patient developed an optic neuropathy with associated afferent pupillary defect. Conclusions Although 1mg/0.1ml of intracameral cefuroxime has been shown to reduce the incidence of endophthalmitis, its overdose can have potentially toxic eye effects in both anterior and posterior segments (AU)

Neuropatía óptica isquémica no arterítica como lesión de órgano diana en la hipertensión arterial / Non-arteritic ischaemic optic neuropathy as a target organ lesion in arterial hypertension

Varón de 39 años, de raza negra que consultó por pérdida de visión súbita e indolora del ojo derecho en el contexto de una crisis hipertensiva. Antecedente de hipertensión arterial esencial, sin control domiciliario por falta de adherencia terapéutica y con afectación de órganos diana: infarto lacunar, retinopatía hipertensiva grado IV e hipertrofia concéntrica del ventrículo izquierdo. La función renal era normal, sin albuminuria. El cuadro clínico se etiquetó de neuropatía óptica isquémica no arterítica tras descartarse enfermedad vascular, traumática, infecciosa o autoinmune. Presentó una discreta mejoría del déficit visual con el control de la presión arterial. Dados los antecedentes y las pruebas complementarias, se concluyó que la neuropatía óptica isquémica fue debida a malignización de su hipertensión arterial. (AU)

A 39-year-old black male who consulted with sudden and painless loss of vision in his right eye in the context of a hypertensive crisis. A history of essential arterial hypertension uncontrolled at home due to lack of therapeutic adherence and with target organ involvement: lacunar infarct, grade IV hypertensive retinopathy and left ventricular concentric hypertrophy. Renal function was normal, without albuminuria. The clinical picture was classified as non-arteritic ischaemic optic neuropathy after ruling out vascular, traumatic, infectious and autoimmune disease. The patient presented discrete improvement of the visual deficit with the control of blood pressure. From his history and complementary tests, it was concluded that the ischaemic optic neuropathy was due to malignization of his arterial hypertension. (AU)

Neuropatía óptica compresiva. No todo lo que progresa es glaucoma / Compressive optic neuropathy. Not everything that progresses is glaucoma

Se presentan 3 casos clínicos de neuropatía óptica compresiva secundaria a meningiomas de diferente localización, diagnosticados inicialmente de glaucoma de tensión normal. Todas las pacientes eran mujeres de edad media, con excavación papilar, así como defectos en el campo visual asimétricos, rápidamente progresivos y deterioro de la agudeza visual, a pesar de presentar cifras de presión intraocular correctamente controladas con tratamiento hipotensor tópico. Debido a la evolución atípica de la enfermedad glaucomatosa, y sospechando una lesión compresiva del nervio óptico, se realizaron pruebas de neuroimagen, con las que se llegó al diagnóstico correcto. En casos de glaucoma de tensión normal hay que tener en cuenta como diagnóstico diferencial la neuropatía óptica compresiva. Diferenciar ambas afecciones constituye un reto diagnóstico que se debe sospechar ante la disminución atípica de la agudeza visual y deterioro de las pruebas, tanto funcionales como estructurales, de manera asimétrica y pese a las cifras de presión intraocular normales (AU)

Three clinical cases are presented of compressive optic neuropathy secondary to meningiomas of different locations, initially diagnosed with normal tension glaucoma (NTG). All patients were middle-aged women, with optic disc excavation, as well as asymmetric, rapidly progressive defects in the visual field (VF), and deterioration of the visual acuity (VA), despite presenting with intraocular pressure (IOP) correctly controlled with topical hypotensive therapy. Due to the atypical progression of the glaucoma disease, and suspecting a compressive lesion of the optic nerve, neuroimaging tests were performed, with which the correct diagnosis was reached. In cases of NTG, it is necessary to take into account compressive optic neuropathy as a differential diagnosis. Differentiating both pathologies is a diagnostic challenge that should be suspected due to the atypical decrease of the VA and deterioration of both functional and structural tests, and asymmetrically, despite the normal IOP (AU)

Ocular toxicity after inadvertent overdose of intracameral cefuroxime during cataract surgery. / Toxicidad ocular tras sobredosificación accidental de cefuroxima intracameral en cirugía de catarata.

PURPOSE: To describe intracameral toxic effects of cefuroxime at a higher dose than recommended in cataract surgery. METHODS: Retrospective study of 8 eyes of 8 patients who inadvertently received 12.5mg/0.1ml of intracameral cefuroxime due to a dilution error, at the end of the cataract surgery. All patients underwent a strict ophthalmology follow-up for 6 months. RESULTS: All patients presented with a marked anterior segment inflammation with corneal oedema that resolved completely in all cases (between 5 days and 3 months). At 6 months of follow-up a statistically significant difference was found in the corneal endothelial cell density when compared with the fellow eye (P=.038), being<1000 cells/mm2 in 3 cases. Three patients (37.5%) showed early macular oedema, with subfoveal ellipsoid layer disruption in one case as a permanent sequel. One patient developed an optic neuropathy with associated afferent pupillary defect. CONCLUSIONS: Although 1mg/0.1ml of intracameral cefuroxime has been shown to reduce the incidence of endophthalmitis, its overdose can have potentially toxic eye effects in both anterior and posterior segments.

Optic neuropathy by ethambutol in a patient with multiple sclerosis. / Neuropatía óptica por etambutol en paciente con esclerosis múltiple.

We present the clinical case of a patient who developed a toxic optic neuropathy due to ethambutol in the context of a tuberculosis reactivation and who also had a personal history of multiple sclerosis. The objective is to highlight the importance of making a good differential diagnosis of this adverse effect and of knowing its main clinical, campimetric and tomographic manifestations and characteristics. Furthermore, since the reversibility of damage is still discussed in the literature, early diagnosis is essential. For this purpose, it is important to inform the patient of the possible symptoms and to carry out an ophthalmological examination and colour tests before starting treatment to assess whether there is progression.

[Non-arteritic ischaemic optic neuropathy as a target organ lesion in arterial hypertension]. / Neuropatía óptica isquémica no arterítica como lesión de órgano diana en la hipertensión arterial.

A 39-year-old black male who consulted with sudden and painless loss of vision in his right eye in the context of a hypertensive crisis. A history of essential arterial hypertension uncontrolled at home due to lack of therapeutic adherence and with target organ involvement: lacunar infarct, grade IV hypertensive retinopathy and left ventricular concentric hypertrophy. Renal function was normal, without albuminuria. The clinical picture was classified as non-arteritic ischaemic optic neuropathy after ruling out vascular, traumatic, infectious and autoimmune disease. The patient presented discrete improvement of the visual deficit with the control of blood pressure. From his history and complementary tests, it was concluded that the ischaemic optic neuropathy was due to malignization of his arterial hypertension.