RESUMO
Objective: To detect the expression of γ-synuclein in primary osteosarcoma, so as to assess the diagnostic value of γ-synuclein in diagnosis of primary osteosarcoma. Methods: The expression of γ-synuclein in 31 primary osteosarcoma specimens(from 31 patients in our department from Jan. 2004 to Dec. 2005) and 10 benign bone tumor specimens were investigated by tissue array and immunohistochemical method. Results: The expression or overexpression of γ-synuclein was found in 30 of the 31 osteosarcoma specimens; only one female patient's specinmen was negative of it, with a positive rate of 96.8%. All the benign bone tumor specimens had negative expression of γ-synuclein. The positive rate of γ-synuclein was not correlated with age or gender of patients. Conclusion: The γ-synuclein may serve as a marker for osteosarcoma and may be valuable in diagnosis, typing, and prognosis of primary osteosarcoma.
