RESUMO
La quinzième Réunion des ministres de la Santé du Pacifique a rassemblé, du 20 au 22 septembre 2023, les responsables de la santé de l’ensemble du Pacifique sous les auspices du gouvernement du Royaume des Tonga et avec le concours de l’Organisation mondiale de la Santé (OMS) et de la Communauté du Pacifique (CPS).
Les débats se sont concentrés sur quatre principaux points de l’ordre du jour : 1) repenser les ressources humaines pour la santé ; 2) s’attaquer aux facteurs d’obésité, en particulier chez les enfants et les jeunes ; 3) faire progresser l’information sanitaire et la transformation numérique dans le secteur de la santé ; et 4) renforcer la résilience des systèmes de santé.
Le présent document expose les engagements pris par les ministres ayant participé à la réunion.
Assuntos
Programas Gente Saudável , Ilhas do PacíficoRESUMO
The Fifteenth Pacific Health Ministers Meeting brought together health leaders from across the Pacific, hosted by the Government of the Kingdom of Tonga with support from the World Health Organization (WHO) and the Pacific Community (SPC) from 20-22 September 2023.
The event focused on four main agenda items: (1) rethinking human resources for health; (2)tackling the drivers of obesity, particularly for children and young people; (3) advancing health information and digital transformation in the health sector; and, (4) strengthening health system resilience.
This document outlines the commitments made by the ministers who attended the event.
Assuntos
Programas Gente Saudável , Ilhas do PacíficoRESUMO
RNA viruses are abundant and highly diverse and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of RNA virus species have been catalogued. To cost-effectively expand the diversity of known RNA virus sequences, we mined publicly available transcriptomic data sets. We developed 77 family-level Hidden Markov Model profiles for the viral RNA-dependent RNA polymerase (RdRp)-the only universal "hallmark" gene of RNA viruses. By using these to search the National Center for Biotechnology Information Transcriptome Shotgun Assembly database, we identified 5,867 contigs encoding RNA virus RdRps or fragments thereof and analyzed their diversity, taxonomic classification, phylogeny, and host associations. Our study expands the known diversity of RNA viruses, and the 77 curated RdRp Profile Hidden Markov Models provide a useful resource for the virus discovery community.
Assuntos
Vírus de RNA , Transcriptoma , Vírus de RNA/genética , RNA Polimerase Dependente de RNA/genética , RNA Polimerase Dependente de RNA/metabolismo , Filogenia , RNA Viral , Genoma ViralRESUMO
The Fifteenth Pacific Health Ministers Meeting brought together health leaders from across the Pacific, hosted by the Government of the Kingdom of Tonga with support from the World Health Organization (WHO) and the Pacific Community (SPC) from 20-22 September 2023.
The event focused on four main agenda items: (1) Rethinking human resources for health; (2) Tackling the drivers of obesity, particularly for children and young people; (3) Advancing health information and digital transformation in the health sector; and, (4) Strengthening health system resilience.
Assuntos
Programas Gente Saudável , Ilhas do Pacífico , Regionalização da SaúdeRESUMO
The Fourteenth Pacific Health Ministers Meeting was hosted by Tuvalu on 22–24 March 2022 with support from the World Health Organization (WHO) and the Pacific Community (SPC). It was held as a fully virtual event for the first time due to the ongoing COVID-19 pandemic.
The meeting focused on three main agenda items: (1) Leveraging the COVID-19 pandemic to build sustainable systems and advance universal health coverage; (2) Putting health at the centre of the climate change discussion; and (3) Accelerating action on noncommunicable diseases.
This document outlines the commitments made by the ministers who attended the event.
Assuntos
Programas Gente Saudável , Ilhas do Pacífico , Regionalização da SaúdeRESUMO
RNA sequencing (RNA-Seq) allows for the identification of novel exon-exon junctions and quantification of gene expression levels. We show that from RNA-Seq data one may also detect utilization of alternative polyadenylation (APA) in 3' untranslated regions (3' UTRs) known to play a critical role in the regulation of mRNA stability, cellular localization and translation efficiency. Given the dynamic nature of APA, it is desirable to examine the APA on a sample by sample basis. We used a Poisson hidden Markov model (PHMM) of RNA-Seq data to identify potential APA in human liver and brain cortex tissues leading to shortened 3' UTRs. Over three hundred transcripts with shortened 3' UTRs were detected with sensitivity >75% and specificity >60%. Tissue-specific 3' UTR shortening was observed for 32 genes with a q-value ≤ 0.1. When compared to alternative isoforms detected by Cufflinks or MISO, our PHMM method agreed on over 100 transcripts with shortened 3' UTRs. Given the increasing usage of RNA-Seq for gene expression profiling, using PHMM to investigate sample-specific 3' UTR shortening could be an added benefit from this emerging technology.
