Extramedullary Plasmacytoma of the Penis as a First Manifestation of Multiple Myeloma: A Case Report.

INTRODUCTION: Plasmacytoma is a rare plasma-cell neoplasm, which includes bone and extramedullary types. While most cases occur in the head and neck, our report presents an unusual case of extramedullary plasmacytoma (EMP) in the penis, emphasizing the diverse locations of this condition. CASE PRESENTATION: An 88-year-old man, post-hydrocelectomy, presented with a palpable penile mass causing urinary symptoms. CT scans revealed a tumor with extracapsular spread and potential urethral involvement. Biopsy confirmed lymphoma, later identified as extramedullary plasmacytoma. A follow-up whole-body CT scan was performed, revealing multiple areas of bone rarefaction of the dens of the axis. His diagnosis has been further specified as multiple myeloma. Treatment with lenalidomide, bortezomib, and dexamethasone led to significant penile tumor reduction and improved voiding symptoms after three cycles. CONCLUSION: A rare case of primary EMP in the penis is reported, with only two documented cases of EMP in this location. The etiology of EMP remains unclear, possibly linked to chronic infection, irritation, or inflammation. EMP typically occurs in soft tissues, commonly in the head and neck, presenting as submucosal masses with symptoms in individuals aged 50-70. Diagnosis requires demonstrating monoclonal plasma cell infiltration and excluding multiple myeloma. While EMPs are often treated with radiotherapy, a patient with bone rarefaction suggestive of multiple myeloma requires first-line chemotherapy. This case highlights the importance of recognizing myeloma-defining events for appropriate treatment.

Bilateral Pedicled Scrotal Flaps as an Alternative to Skin Graft in Penile Shaft Defects Repair.

OBJECTIVE: To analyze surgical and functional outcomes of bilateral pedicled scrotal flaps for penile shaft reconstruction. MATERIALS AND METHODS: A retrospective analysis was performed on 22 patients who underwent penile shaft reconstruction with bilateral pedicled scrotal flaps between 2009 and 2017. Demographics, peri-operative data, and surgical complications were collected. Functional outcomes were analyzed using a questionnaire made of the erection hardness score, the patient and observer scar assessment scale, and a 10-point Likert scale measuring patients... satisfaction about their skin coloration, sensitivity, elasticity and thickness, penile size, scrotal volume, erection quality, penetration ability, pain, sexual satisfaction, body image, masculinity, self-esteem, and global satisfaction. RESULTS: Patients exhibited a wide range of indications, including buried penis (27.2%), or subcutaneous injections of foreign material (27.2%). Early complications were suture dehiscence (31.8%), infection (13.6%) and hematoma (4.6%), associated with 9.1% of surgical revisions. Late complications were skin retraction (27.3%), testicular ascension (22.7%), pyramidal shape (4.6%) or shortening (13.6%) of the penis, associated with 27.3% of surgical revisions. For the 12 patients who answered the questionnaire, median erection hardness score and patient and observer scar assessment scale score [IQR] were 3.5 out of 4 [2.5-4] and 11.5 out of 60 [9.5-22], respectively. The patients reported a positive impact of the surgery on their psychological condition, with a median score of global satisfaction of 8 [IQR 7.5-9.5]. CONCLUSION: Bilateral pedicled scrotal flaps seem.ßto be a safe alternative for shaft defects reconstruction despite a potential need of surgical revision, providing satisfactory functional outcomes.

Colgajo fasciocutáneo pudendo bilateral para cobertura de tronco del pene: nuevo diseño e indicación / Bilateral pudendal thigh flap for penile shaft coverage: new indication and design

La Gangrena de Fournier es una forma poco frecuente de fascitis necrotizante que puede llegar a ser fatal si no es tratada adecuadamente. Las áreas habitualmente afectadas son el periné y los genitales externos y con frecuencia requieren amplios desbridamientos quirúrgicos que pueden dejar defectos de cobertura extensos.La reconstrucción del tronco del pene requiere una reparación libre de tensión que permita mantener la capacidad eréctil del tejido y evite la formación de una cicatriz retráctil. La viabilidad de la técnica empleada, su resultado estético y el grosor del pene reconstruido son otros factores a tener en cuenta. Las principales opciones para proporcionar cobertura son los colgajos pediculados locales y los injertos de piel de espesor parcial o total.El colgajo fasciocutáneo pudendo se emplea comúnmente en la cirugía reparadora de periné y vagina pero, de acuerdo con lo observado en la literatura, apenas existen 2 casos descritos de su uso en reconstrucción del tronco del pene, con variaciones respecto al diseño tradicional del colgajo. Describimos una secuela de Gangrena de Fournier en la que logramos con éxito la cobertura del tronco del pene gracias a una novedosa modificación en el diseño del colgajo fasciocutáneo pudendo. (AU)

Fournier ́s Gangrene is an uncommon form of necrotizing fasciitis, which can be fatal if inadequately treated. Perineum and external genitalia are the most commonly affected areas. Urgent radical surgical debridement is often required, which results in extensive soft tissue damage.Reparation of penis shaft must be tension-free, preserving erectile capacity, and avoiding retractile scar formation. Viability of the technique, aesthetic outcome, and thickness of the reconstructed penis should be also beard in mind. Local pedicled flaps, and split or full-thickness skin grafts are the main options for providing coverage.The pudendal thigh fasciocutaneous flap is one of the workhorse flaps of choice for perineal and vaginal reconstructive surgery but, to the best of our knowledge, it has only been used for penile shaft reconstruction in 2 single case studies, in which modifications to the classical design were performed. We report the case of a sequel of Fournier's Gangrene, in which penile shaft coverage was successfully accomplished with an innovative modification in the design of the pudendal thigh fasciocutaneous flap. (AU)

The Characteristics and Distribution of Nerve Plexuses in the Dartos Fascia From Concealed Penis Children.

The purpose of this study is to analyze the nerve plexus distribution in dartos fascia of concealed penis (CP). A total of 28 CP patients met ASA categories I and II were included, with median age of 3.5 years (8 months-5 years). During the surgery, tissue samples of dartos fascia at points 3, 6, 9, and 12 o'clock of the penile shaft were collected. Standard hematoxylin and eosin (H&E) staining and S-100 immunohistochemical staining were used to analyze the nerve plexus distribution among different positions. The number of nerve plexuses in superficial fascia collected at the 6 o'clock position of the penile shaft was the most abundant among four positions (median 7.25, range 1-24). The abundant nerve plexuses in the dartos fascia of CP patients, especially at the 6 o'clock position, indicate that the surgery on the preputial frenulum should avoid damage to the dartos fascia, as it might be related to maintain the erection and sexual function in adolescence.

Severe penile erosion secondary to penile strangulation for 10 years, a reconstructive urological challenge

@#Complications arising from simple surgical procedures such as circumcision are uncommon. When a person devoid of surgical training performs these procedures, severe problems usually occur. This is a rare case of a 23-year-old, Filipino male with severe penile shaft erosion secondary to chronicpenile strangulation from complications of circumcision. A two-stage procedure was planned for this patient involving removal of the constricting object, debridement and anastomosis of the penile shaft. Postoperatively, there was good penile erectile function and an aesthetically acceptable form.

A modified onlay island flap vs. Mathieu urethroplasty for distal hypospadias repair: A prospective randomised study.

OBJECTIVE: To compare the outcome of a modified onlay island flap (MOIF) with that of the Mathieu urethroplasty for distal hypospadias repair. PATIENTS AND METHODS: In a prospective randomised study, 60 patients with coronal, subcoronal and distal penile hypospadias, with a urethral plate width of ⩽6 mm, and minimal or no chordee, underwent either MOIF using a midline longitudinal outer preputial skin flap passed ventrally by penile buttonholing through dartos fascia incision, or a Mathieu urethroplasty. Closed envelopes were used for randomly selecting patients for each procedure. The operative duration, complications, cosmetic outcome, urinary stream and relatives' satisfaction were reported for each procedure. RESULTS: Preoperative data (patients' age and site of urethral meatus) and operative duration were insignificantly different between the groups (P = 0.653, 0.786 and 0.710, respectively). There were no intraoperative complications in either group. The duration of follow-up was insignificantly different between the groups. Patients treated with the MOIF had a statistically significant lower complication rate (P = 0.036), and a better cosmetic outcome, urinary stream and relatives' satisfaction (P < 0.001 for all). CONCLUSIONS: The MOIF urethroplasty seemed to be better than the Mathieu urethroplasty in patients with distal hypospadias and narrow urethral plates. Further studies including more patients, and a longer follow-up with an objective evaluation of functional outcome should be encouraged to confirm these early results.

Sebaceous Hyperplasia of the Penile Shaft in a Young Male / 대한피부과학회지

Sebaceous hyperplasia usually presents as solitary or multiple, small, yellowish papules on the face, particularly on the forehead. It occurs most commonly in middle-aged individuals and rarely in early adult life. It has also been reported in the vulva, penis, and areola. Histological examination reveals a single greatly enlarged sebaceous gland composed of numerous lobules grouped around a centrally located, wide sebaceous duct. We report a case of a 26-year-old man with sebaceous hyperplasia in the ventral surface of the distal penile shaft, an unusual site.

Fordyce's Spots on the Penile Shaft: An Unusual Localization / 대한피부과학회지

Fordyce's spots are ectopically located sebaceous glands, and these are clinically characterized by multiple pinhead- sized whitish or yellowish papules. Although the condition is not generally considered to be pathological, there are some problematic cases that have significant cosmetic concerns. These spots are usually located at different sites inside the oral cavity, and mainly at the upper lip and buccal mucosa. However, they occasionally occur on the areola, glans penis and labia minor. We herein report on a case of Fordyce's spots on the penile shaft because this condition should be considered in the differential diagnosis of lichen nitidus.