Total Margin Control Is Superior to Traditional Margin Assessment for Treatment of Low-Stage Penile Squamous Cell Carcinoma.

PURPOSE: Penile cancer is rare, with significant morbidity and limited literature assessing utility of peripheral and deep en face margin assessment (PDEMA) vs traditional margin assessment (vertical sections) on treatment outcomes. MATERIALS AND METHODS: This was a 32-year retrospective multicenter cohort study at 3 academic tertiary care centers. The cohort consisted of 189 patients with histologic diagnosis of in situ or T1a cutaneous squamous cell carcinoma of the penis at Brigham and Women's, Massachusetts General Hospital (1988-2020), and Memorial Sloan Kettering Cancer Center (1995-2020) treated with PDEMA surgical excision, excision/circumcision, or penectomy/glansectomy. Local recurrence, metastasis, and disease-specific death were assessed via multivariable Cox proportional hazard models. RESULTS: The cohort consisted of 189 patients. Median age at diagnosis was 62 years. Median tumor diameter was 1.3 cm. The following outcomes of interest occurred: 30 local recurrences, 13 metastases, and 5 disease-specific deaths. Primary tumors were excised with PDEMA (N = 30), excision/circumcision (N = 110), or penectomy/glansectomy (N = 49). Of patients treated with traditional margin assessment (non-PDEMA), 12% had narrow or positive margins. Five-year proportions were as follows with respect to local recurrence-free survival, metastasis-free survival, and disease-specific survival/progression-free survival, respectively: 100%, 100%, and 100% following PDEMA; 82%, 96%, and 99% following excision/circumcision; 83%, 91%, and 95% following penectomy/glansectomy. A limitation is that this multi-institutional cohort study was not externally validated. CONCLUSIONS: Initial results are encouraging that PDEMA surgical management effectively controls early-stage penile squamous cell carcinoma.

Penis Girth Augmentation Using SEPA Flap and Dermofat Grafts.

Background: Men of various ages feel that an increase in penile size would give them and their sexual partners an increased confidence. There are a variety of methods for increasing penile girth, such as injection therapies and surgery. All of these methods have a high complication rate which must be emphasized to the patients. In this article, the techniques used for increasing penile girth using dermofat grafts and SEPA (superior external pudendal artery) flaps are highlighted along with their complications and their management thereof. Patients and Methods: Ten patients were operated for penile girth augmentation between June 2016 and March 2022. Of these, six patients had augmentation using dermofat grafts and four patients had SEPA flaps. Patients were chosen as per the Augmentation Phalloplasty Patient Selection and Satisfaction Inventory (APPSSI) score which was between 2 and 6 in the pre-operative period. The age range of the patients were between 25 and 57 years. The mid-penile girth in the flaccid state ranged from 8.8 to 12.3 cm. Results: Post-operatively, after 6 months, the final girth increase varied from 1.9 to 2.6 cm. The complication rate was 50% and included skin loss, urinary obstruction, fat necrosis, and so on. The post-operative APPSSI score ranged from 2 to 12. Complications were more in uncircumcised patients and in those who desired excessive augmentation. Conclusion: Penis girth augmentation using SEPA flaps and dermofat grafts is indicated in patients who fulfill the criteria and give appreciable girth increase, but patients need to be aware of the potential complications of these surgeries.

Masculinidades e rupturas após a penectomia / Masculinidades y rupturas después de la penectomía / Masculinities and ruptures after penectomy

Resumo Objetivo Analisar os significados das masculinidades durante a vivência do câncer peniano e seus tratamentos. Métodos Abordagem qualitativa de pesquisa amparada em referencial teórico da antropologia médica e das masculinidades, com o emprego do método narrativo. Foram entrevistados em profundidade 18 homens com neoplasia peniana em um hospital referência em uro-oncologia do estado de São Paulo. Cada participante foi entrevistado com roteiro de investigação, em média três vezes, sendo as entrevistas audiogravadas, transcritas e analisadas conforme a análise temática indutiva. Resultados Seis participantes realizaram a penectomia parcial e 12 total. Em relação ao estado civil, participaram dois viúvos, dois solteiros, três divorciados e 11 casados, com média de idade de 54 anos. A extirpação do pênis promoveu mudanças significativas na forma como os homens performavam suas masculinidades, sobretudo a hegemônica. Portanto, essa experiência lhes permitiu reinterpretar suas condições de saúde na tentativa de identificar outros elementos hegemônicos que sustentassem suas imagens masculinas. Para alguns foi possível representar um homem inteiro, porém outros se consideram agora meio-homens. Conclusão O adoecimento rompeu com o fluxo biográfico dos participantes, pois antes do câncer peniano a hegemonia os representava como masculinos, entretanto, após a penectomia, eles perdem um órgão que socialmente traz atributos como força, poder, trabalho e virilidade, situação que lhes trouxe a necessidade de reinterpretar o ser masculino em suas culturas. A enfermagem, para promover o cuidado integral ao homem, deve considerar que as masculinidades interferem no processo saúde e doença.

Resumen Objetivo Analizar los significados de las masculinidades durante la vivencia del cáncer de pene y sus tratamientos. Métodos Enfoque cualitativo de investigación respaldado en el marco referencial teórico de la antropología médica y de las masculinidades, con el uso del método narrativo. Fueron entrevistados en profundidad 18 hombres con neoplasia de pene en un hospital de referencia en urología oncológica del estado de São Paulo. Cada participante fue entrevistado con guion de investigación, tres veces en promedio. Las entrevistas fueron grabadas, transcriptas y analizadas de acuerdo con el análisis temático inductivo. Resultados Seis participantes realizaron penectomía parcial y 12 total. Respecto al estado civil, participaron dos viudos, dos solteros, tres divorciados y 11 casados, con un promedio de edad de 54 años. La extirpación del pene generó cambios significativos en la forma como los hombres practicaban su masculinidad, sobre todo la hegemónica. Por lo tanto, esta experiencia les permitió interpretar sus condiciones de salud en el intento de identificar otros elementos hegemónicos que sostengan su imagen masculina. Para algunos fue posible representar un hombre entero, pero otros ahora se consideran medio hombres. Conclusión La enfermedad rompió con el flujo biográfico de los participantes, ya que antes del cáncer de pene, la hegemonía los representaba como masculinos; sin embargo, después de la penectomía, perdieron un órgano que socialmente trae atributos como fuerza, poder, trabajo y virilidad, situación que les produjo la necesidad de reinterpretar el ser masculino en su cultura. Para promover el cuidado integral del hombre, la enfermería debe considerar que las masculinidades interfieren en el proceso salud y enfermedad.

Abstract Objective To analyze masculinity meanings during penile cancer experience and its treatments. Methods Qualitative approach supported in the theoretical framework of medical anthropology and masculinities, with the use of the narrative method. We interviewed in-depth 18 men with penile cancer in a referential Urologic Oncology hospital from the state of São Paulo. Each participant was interviewed on average three times, with a structured script, being the interviews audio-recorded, transcribed, and analyzed according to the inductive thematic analysis. Results Six patients were submitted to the partial penectomy and 12 to the total penectomy. Regarding the marital status, six were widowers, two single, three divorced, and 11 married, with an average age of 54 years old. The penis extirpation fostered significant change in the way men performed their masculinities, even the hegemonic. Thus, this experience allowed them to reinterpret their health conditions to identify other hegemonic elements that sustained their masculine images. For a few, it was possible to represent a full man however, others considered themselves half-men. Conclusion The illness broke the participant's biographic flow because, before penile cancer, the hegemony represented them as masculines, however, after the penectomy, they have lost an organ that is socially related to attributes such as strength, power, work, and virility, situation that brought them the necessity to reinterpret being masculine in their culture. To promote integrality of care to man the nursing must consider that masculinities interfere in the process of health and disease.

A 10-year Audit of Penile Prosthesis Insertion.

Introduction Penile prosthesis (PP) insertion is the gold standard surgical treatment option for men with refractory Erectile Dysfunction (ED). PP insertion is considered effective but has a well-documented array of complications. Our aim was to assess outcomes following single-surgeon insertion of PP for ED within an Irish cohort. Methods Following review of the Hospital In-Patient Enquiry (HIPE) system, a retrospective chart review of all patients who underwent PP insertion over a 10-year period from 2008-2017 inclusive was performed, and an electronic database was analysed for results. Results One-hundred-and-eleven PPs were inserted in 96 patients. The most common aetiology for ED in our cohort was post-prostatectomy, affecting 25 (26%) patients. The most frequently implanted device was a 3-piece inflatable PP (3p-IPP) (AMS 700TM; American Medical Systems Inc., Minnesota, USA) and the peno-scrotal approach was utilised in the majority of patients (86, 77.5%). No intraoperative complications were recorded. Twelve (12.5%) patients developed peri-operative complications. Thirteen (13.5%) patients required device revision, the majority for device failure. Of the 71 patient satisfaction responses, 61 (85.9%) patients were satisfied with their PP. Conclusions This single-surgeon retrospective audit of PP surgery demonstrates complication rates in-line with internationally published data. Patients should be adequately counselled regarding possible complications, including device failure and erosion. PP insertion should be considered for suitable patients with refractory ED.

Dorsal penile curvature and megameatus intact prepuce hypospadias: A common association in a rare variant of hypospadias.

BACKGROUND: Megameatus intact prepuce (MIP) is a rare variant of hypospadias. Unlike the hooded ventrally absent prepuce in non-MIP hypospadias, the prepuce in MIP hypospadias is fully circumferential and intact. The distal urethra remains wide with a deep glanular groove. While ventral curvature is a common finding in non-MIP hypospadias, neither ventral nor dorsal penile curvature has been reported in MIP hypospadias. OBJECTIVE: To assess the association of the MIP hypospadias variant with penile curvature. STUDY DESIGN: We retrospectively reviewed the medical records of all children who underwent hypospadias repair and identified those who were documented as having the MIP variant of hypospadias and operated in our center from January 1998 to June 2020. The patients were considered as having MIP hypospadias if no hypospadias had been evident before circumcision, if a circumferential circumcision scar was present (instead of the inverted V-shaped scar in the ventral aspect of the penis following circumcision of the hooded prepuce associated with non-MIP hypospadias), and if there was a wide meatus. Penile curvature was diagnosed intraoperatively by an artificial erection test that uses saline solution for injection. Patients were considered surgical candidates if the degree of curvature was equal to or greater than 30°. RESULTS: The study cohort consisted of 118 male children who were identified as having the MIP hypospadias variant according to the inclusion criteria. The median age at repair was 1.1 years (interquartile range 8 months to 1.6 years). Penile curvature was found in 29 children (24%), of whom 23 had dorsal curvatures (19%) and 6 had ventral curvatures (5%). DISCUSSION: MIP hypospadias is associated with penile curvature, and more frequently with dorsal than ventral curvature. This study is retrospective and does now identify specific features of MIP associated with penile curvature. We encourage pediatric urologists to perform an artificial erection test intraoperatively in children with the MIP variant and repair associated curvatures. CONCLUSIONS: A dorsal curvature was found in 19% of patients with a MIP variant of hypospadias, and most of them (86%) required ventral plication due to the severity of the curvature.

Non-invasive and surgical penile enhancement interventions for aesthetic or therapeutic purposes: a systematic review.

OBJECTIVE: To systematically review the literature in order to investigate the efficacy and safety of surgical and non-invasive penile enhancement procedures for aesthetic and therapeutic purposes. METHODS: A systematic search for papers investigating penile enhancement procedures was performed using the MEDLINE database. Articles published from January 2010 to December 2019, written in English, including >10 cases, and reporting objective length and/or girth outcomes, were included. Studies without primary data and conference abstracts were excluded. The main outcome measure was objective length and/or girth improvement. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. RESULTS: Out of 220 unique records, a total of 57 were reviewed. Eighteen studies assessed interventions for penile enhancement in 1764 healthy men complaining of small penis. Thirty-nine studies investigated 2587 men with concomitant pathologies consisting mostly of Peyronie's disease and erectile dysfunction. Twenty-five studies evaluated non-invasive interventions and 32 studies assessed surgical interventions, for a total of 2192 and 2159 men, respectively. Non-invasive interventions, including traction therapies and injection of fillers, were safe and mostly efficacious, whereas surgical interventions were associated with minor complications and mostly increased penile dimensions and/or corrected penile curvature. Overall, the quality of studies was low, and standardized criteria to evaluate and report efficacy and safety of procedures, as well as patient satisfaction, were missing. CONCLUSION: The quality of the studies on penile enhancement procedures published in the last decade is still low. This prevents us from establishing recommendations based on scientific evidence regarding the efficacy and safety of interventions that are performed to increase the penis size for aesthetic or therapeutic indications.

Effect of surgical repair of acquired buried penis on sexual function in adults.

PURPOSE: This study was performed to investigate the effect of surgical repair of acquired buried penis on sexual function in adults and provide a reference for clinical treatment. METHODS: Thirty-two adult patients who underwent surgical treatment of buried penis from August 2010 to August 2017 were selected as the study group. The basic operative method was penile lengthening. Suprapubic liposuction, suspensory ligament release, and preputial plasty were performed according to the clinical manifestations. The changes in erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction sexual function were evaluated according to the International Index of Erectile Function (IIEF) before and after treatment. RESULTS: All 32 patients were analyzed by the IIEF before and after the operation. The results showed statistically significant differences in sexual function before and after the operation (P < 0.05). CONCLUSION: Surgical repair of acquired buried penis in adults can significantly improve patients' sexual function.

[Single-repair for primary proximal hypospadias. Lessons learned after 196 primary repairs]. / Hipospadias proximales reparados en un único tiempo. Lecciones aprendidas tras 196 intervenciones primarias.

PURPOSE: Proximal, scrotal and perineal hypospadias challenge the surgeon. After 40 years devoted to hypospadias surgery, the senior author summarizes her experience, share her tricks and shows that almost any hypospadias can be fully repaired in one surgery. METHODS: Retrospective review and discussions of a large series of consecutive proximal hypospadias treated in one surgery by the same team from 1999 to 2016. RESULTS: 196 patients were operated. 68% of all patients were successfully repaired after the surgery. All hypospadias were treated using one of the following techniques: onlay double flap, tubularized preputial flap or mucosal grafts (only until 2005). Urethrocutaneous fistula was present in 25% of cases, but only 13% of patients needed other further surgical procedures. CONCLUSION: Cutaneous incisions design is fundamental in hypospadias repair. When the incisions follow the natural folds that appear in penile and scrotal skin, it's possible to obtain optimal flaps for both urethroplasty and skin coverage (even avoiding the need for mucosal grafts). Consequently, almost all kinds of hypospadias can be repaired in one surgery with very good long-term results.

INTRODUCCION Y OBJETIVO: Los hipospadias peneanos proximales, escrotales y perineales son un reto para el cirujano. Tras toda una carrera dedicada a los hipospadias, la autora principal del trabajo resume su experiencia y demuestra que prácticamente cualquier tipo de hipospadias puede ser resuelto completamente en un único tiempo. METODO: Se trata de una revisión retrospectiva y la discusión de una serie de hipospadias proximales consecutivos tratados en una única intervención por el mismo equipo quirúrgico entre 1999 y 2016. RESULTADOS: 196 pacientes fueron intervenidos. El 68% de los casos quedaron satisfactoriamente resueltos tras la operación. Todos los hipospadias fueron reparados con una de las siguientes técnicas: onlay, colgajo prepucial tubularizado (Duckett) o injertos de mucosa. Los injertos se utilizaron solo hasta 2005; posteriormente, el refinamiento de las técnicas quirúrgicas expuestas permitió que cualquier hipospadias fuera reparado con las técnicas de onlay o Duckett. Solo un 13% de los casos necesitó algún tipo de procedimiento quirúrgico adicional, más allá del cierre de una fístula uretral puntiforme (presente en el 25% de los pacientes). CONCLUSION: El diseño de las incisiones cutáneas es fundamental en la reparación de los hipospadias. Cuando las incisiones siguen las líneas que de forma natural se forman en la piel del pene y escroto se obtiene como resultado un colgajo óptimo para realizar una neouretra y recubrirla con piel, evitando incluso los injertos de mucosa. Estas modificaciones permiten que cualquier tipo de hipospadias sea reparado en un único tiempo con muy buenos resultados a largo plazo.

Phalloplasty: techniques and outcomes.

Phalloplasty is an exceptionally complicated reconstructive procedure that attempts to create a structure that is penis-like. As patient goals vary widely, it is helpful to think about phalloplasty as a modular set of procedures that can be combined, mixed and matched to meet the needs of each individual patient while also taking into account their anatomy. Each module-but particularly the shaft and penile urethra-can be performed using a variety of techniques. To date, there is no consensus among surgeons regarding the optimum staging of the reconstructive steps. Our primary goal is to outline the most frequently performed and reported options in phallic reconstruction and outline the various considerations that go into choosing a given sequence of procedures for the specific patient. The secondary goal of this article is to describe the complications common to each of those modules and how they interact when combined.

[Impact of organ sparing therapy in penile carcinoma on sexual and erectile function]. / Impacto da terapêutica conservadora de órgão do carcinoma do pénis na função sexual e erétil.

INTRODUCTION: Penile carcinoma is one of the less frequent tumors of the genitourinary system, however its effect on the patients' sex life and quality of life is of great impact. Studies about the influence on patients' sex life are scarce. OBJECTIVES: To characterize sexual activity with penetration of patients with penile carcinoma who underwent different conservative therapeutic approaches and to evaluate pre and post treatment erectile function. Secondarily, to compare the results between the patients who underwent partial penectomy to those subjected to other conservative therapies. MATERIAL AND METHODS: Review of patients' records diagnosed with penile carcinoma and observed at the Portuguese Institute of Oncology of Oporto between 2005 and 2015, to obtain demographic, clinical and histopathological data. Telephone interviews for the completion of the International Index of Erectile Function-5 (IIEF-5) questionnaire to patients undergoing treatment in that period. RESULTS: 16 out of the 107 patients met the inclusion criteria (n=16), with an average IIEF-5 score of 23.44 (10-25), lowering this value to 16.56 (5-25) after therapy, p<0,05. Fifteen out of the 16 patients kept sexual activity (93.8%) and one (6.25%) suspended due to erectile dysfunction. IIEF-5 score after treatment in the subgroup that underwent partial penectomy was lower when compared to the other subgroup of patients subjected to others conservative therapies, without statistical significance. CONCLUSION: Although penile carcinoma treatment has an impact in erectile function with statistical significance, the majority of patients keeps an active sexual life with penetration after treatment. It's not possible to conclude that less invasive therapies are associated with better erectile function.

[Self-amputation of the penis treated immediately: Case report and review of the literature]. / Auto-amputation de verge traitée par réparation d'emblée: à propos d'un cas et revue de la littérature.

Self-amputation of the penis treated immediately: case report and review of the literature. Self-amputation of the penis is rare in urological practice. It occurs more often in a context psychotic disease. It can also be secondary to alcohol or drugs abuse. Treatment and care vary according on the severity of the injury, the delay of consultation and the patient's mental state. The authors report a case of self-amputation of the penis in an alcoholic context. The authors analyze the etiological and urological aspects of this trauma.

Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients.

INTRODUCTION: Peyronie's disease is an acquired penile deformity with a variety of presentations, caused by the formation of fibrous plaques within the tunica albuginea, leading to bio-mechanical and vascular abnormalities. The objective is to investigate the 18 years outcome of patients with Peyronie's disease treated with penile corporoplasty (Yachia technique) in our department. MATERIALS AND METHODS: One hundred and seventeen patients underwent surgical treatment for PD between 1991 and 2009 and were retrospectively evaluated. We used the Levine and Lenting's algorithm for surgical treatment. Data was obtained from medical records, clinical evaluation, and telephone interview. Post-operative follow-up was at 6 weeks and 12 months. The mean time of follow-up was 14 months (12-19 months). MAIN OUTCOME MEASURES: Patient demographic, co-morbidities, erectile function, penile curvature, and surgical intervention were documented. The main outcome measures of this study are postoperative complications, surgical purpose, and patients and partner's satisfaction rates. RESULTS: Surgical aim was obtained in 106 patients (success rate of 94.6%). Complications occurred in 4.5% of patients, but most of these were mild. At 6 weeks, complete straightening of the penis was achieved in 57 patients (50.9%), and partial straightening which allow sexual intercourse in 49 patients (43.7%). Nine patients report gland hypoesthesia and almost all report subjective perception of penis shortening (0.5 cm to 5 cm). Twenty-two patients developed recurrent deformity at 12 months follow-up, with compromise of sexual intercourse in 7 patients. Patients' responses to our questionnaire showed that overall 88.4% of the patients and partners were satisfied with the surgical results. CONCLUSION: According to the results of this long-term, retrospective study, surgical correction, using the Yachia technique, is an excellent option for patients with functional impairment from their Peyronie's disease, especially.

Two-stage complex hypospadias repair when urethral plate has to be divided: ventral corporoplasty using a tunica vaginalis flap.

OBJECTIVE: To demonstrate ventral corporoplasty, with tunica vaginalis flap to reconstruct the corpora cavernosa, in a two-stage strategy for proximal hypospadias surgery. METHODS: Assessment of residual curvature after complete urethral plate division and transverse superficial cuts in albuginea. Ventral incision of tunica albuginea to elongate the ventral surface of the penis and use of a tunica vaginalis flap to reconstruct the defect in corpora cavernosa. Dorsal preputial island flap was used to cover the penile ventral surface, to be tubularized in a second stage, together with the original urethral plate. RESULTS: Patient had an uneventful follow-up. Penile aspect was very satisfactory with no residual curvature. CONCLUSION: Tunica vaginalis is an attractive alternative for ventral corporoplasty in hypospadia repair and has the advantages of prompt disposability, autologous use, and does not represent an extra cost for treatment.

Fratura peniana: diagnóstico e tratamento / Penile fracture: diagnosis and treatment

A fratura do pênis é definida como a ruptura da túnica albugínea do corpo cavernoso que ocorre exclusivamente durante a ereção. O principal mecanismo de trauma é o intercurso sexual traumático. Devido ao baixo número de casos, alguns pontos do tratamento ainda são controversos, entretanto, é recomendada a intervenção cirúrgica imediata. Este estudo retrospectivo observacional realizado entre abril de 2006 e abril de 2008 descreve os resultados da abordagem cirúrgica em 11 pacientes com fratura peniana tratados no Hospital Alberto Cavalcanti - FHEMIG. Foram avaliadas as características dos pacientes, o mecanismo do trauma, o tipo da lesão e as complicações no per e no pós-operatório imediato.

Objectives: To review the diagnostic and therapeutic options in patients with penile fracture and describe our experience. Patients & Methods: From April 2006 through April 2008, eleven consecutive men with diagnosis of penile fracture were treated at "AlbertoCavalcanti" Hospital. The etiology, interval from injury to presentation, presence of associated injuries and immediate postoperative complications were evaluated. Results: All patients were submitted to surgical intervention and nine had the diagnosis confirmed.None of them had per-operative complications. One patient had skin infection in the post-operative period. Conclusions: Penile fracture can be clinically diagnosticated, the management should be surgical and immediate.

Diagnosis and Treatment of Concealed Penis in Children: a 16 Case Report / 中国康复理论与实践

@#ObjectiveTo explore the diagnosis and the surgical operation of concealed penis, and raise the therapeutic efficacy.Methods16 cases of concealed penis were reviewed retrospectively.ResultsAll 16 cases were treated by Devine surgery and got the satisfactory effect, the penis recovered to its good external appearance. All 16 cases had been followed up for four months to two years. The revelation of penis and its external appearance were all satisfied. No complications such as hydrophallus, skin ischemia, haematoma and erection ache occurred.ConclusionThe real concealed penis should be strictly distinguished from buried penis, microphallus and redundant prepuce, and suitable operation pattern can obtain satisfactory effect.