RESUMO
ObjectiveTo explore the clinical application law and provide literature support and development ideas for the modern application of fresh Plantaginis Herba. MethodThe literature about the application of fresh Plantaginis Herba was retrieved from the fifth edition of Chinese medical dictionary， China national knowledge infrastructure （CNKI）， VIP， Wanfang data， and Chinese medical journals and analyzed. ResultFresh Plantaginis Herba appeared frequently in ancient books， with the effects of clearing heat， cooling blood， promoting urination， and relieving stranguria. It was used for the treatment of stranguria， urine retention， bloody urine， sore and carbuncle， epistaxis， red and swelling eye， suppurative inflammation in the throat， and gynecological and pediatric diseases. According to modern medical publications， fresh Plantaginis Herba is mainly used to treated diseases in the kidney， five sense organs， spleen， stomach， lung， liver， gallbladder， and skin and gynecological and pediatric diseases. Specifically， it is mainly used to treat the syndrome of dampness and heat in kidney and skin diseases caused by the accumulation of dampness and heat toxin， with the effects of clearing heat， removing toxin， promoting urination， and relieving stranguria. Since ancient times， there have been reports of using fresh Plantaginis Herbausing for food and health care. ConclusionFresh Plantaginis Herba is widely used in clinical practice and has a high medical value and economic value. However， its modern application lags behind， so it is necessary to promote the development of fresh Plantaginis Herba from the aspects of medicinal material production， storage， transportation， preparation research and development， and clinical application.
RESUMO
CE methods are valuable tools for medicinal plant quality management, screening, and analysis. Therefore, the aim of the current study was to optimize and validate a CE-MEKC method for simultaneous quantification of four chief bioactive metabolites from Plantago species. The two most important secondary metabolite groups were aimed to be separated. Different electrolyte and surfactant types were tested. Surfactant concentration, BGE pH, electrolyte concentration, and buffering capacity were optimized. The final BGE consisted of 15 mM sodium tetraborate, 20 mM TAPS, and 250 mM DOC at pH 8.50. Acceptable precision, good stability, and accuracy were achieved, with high resolution for phenylethanoid glycosides. Analytes were separated within 20 min. The method was shown to be suitable for the quantification of the iridoid glycosides aucubin and catalpol, and the phenylethanoid glycosides acteoside (verbascoside) and plantamajoside from water extracts of different samples. The method was shown to be applicable to leaf extracts of Plantago lanceolata, Plantago major, and Plantago asiatica, the main species with therapeutic applications, and a biotechnological product, plant tissue cultures (calli) of P. lanceolata. Baseline separation of the main constituents from minor peaks was achieved, regardless of the matrix type.
