The research progress of kallkrein 4 / 中国基层医药

Objective Kallikrein 4(KLK4) is a glycosylated,chymotrypsin-like serine protease.KLK4 was first isolated from developing enamel by Japanese scientists,later it was discovered that was expressed in the normal and cancerous tissues.Its main function is to play a role in process of the protein hydrosis,resulting in a normal devel-oping or abnormal pathological changes of the organization.This article reviewed the structure,expression,functions, related disease of KLK4 and other aspects.