RESUMO
Objective To investigate the effect of the Qingjin-Huazhuo prescription on the fractional exhaled nitric oxide (FeNO) in the patients with phlegm heat accumulation of lung syndrome in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 72 patients with phlegm heat accumulation of lung syndrome in AECOPD who met the criteria were included were randomly divided into two groups,36 in each group.The control group received the conventional western medicine treatment,and the observation group received the additional Qingjin-Huazhuo prescription on the basis of the western medicine treatment.The duration of treatment was 10 days.The changes of TCM syndromes,FeNO and pulmonary function (FEV 1％,FVC％,FEV 1/FVC) on both two groups before and after treatment were recorded and compared.Results The improvement of cough,phlegm,wheeze and total score of TCM syndrome in the observation group were significantly better than the control group (t=3.091,2.303,3.063,2.412,P＜0.05).The improvement of FeNO in the observation group was significantly better than the control group (9.81 ± 12.10 ppb vs.3.42 ± 14.78 ppb,t=2.007) (P＜0.05).As for the pulmonary function,the improvement of FEV1％,FVC％,FEV1/FVC in the observation group were better than the control group (t=1.295,1.187,0.829,P=-0.200,0.240,0.411),but the differences were not significantly.Conclusions The Qingjin-Huazhuo prescription on the basis of conventional western medicine treatment for patientswith phlegm heat accumulation of lung syndrome in AECOPD,showed the improvement of symptoms,inhibit the inflammation in the respiratory tract and improve the ventilation function.
RESUMO
Objective To observe the efficacy and acute inflammatory reactionof Qingjin Huazhuo Prescription combined with Western medicine therapy for treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Totally 60 hospitalized patients with AECOPD (Grade Ⅱ) and acute exacerbation course≤1 week were enrolled in this study. The patients were randomly divided into two groups, with 30 cases in each group. The control group was treated with conventional Western medicine. The observation group was treated with conventional Western medicine and oral administration of Qingjin Huazhuo Prescription for 10 days, once a day. TCM syndrome and dyspnea grading (mMRC score), white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT) and partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), were measured before and after the treatment. Results The total scores of TCM syndromes and cough, expectoration, wheezing, fever, and cyanosis in the two groups decreased significantly (P<0.05). The improving degrees of cough and expectoration were better in the observation group than in the control group (P<0.05). The scores of mMRC in the two groups were better than before treatment (P<0.05). The levels of WBC, CRP and PaCO2 in the two groups were lower than those before treatment (P<0.05). The decreased degrees of CRP and PaCO2 in the observation group were better than those in the control group (P<0.05, P<0.01). Conclusion Qingjin Huazhuo Prescription combined with Western medicine therapy can relieve clinical symptoms, reduce the acute inflammatory reaction of AECOPD patients and improve respiration.
