Advancements in genetically modified insect pest-resistant crops in India.

MAIN CONCLUSION: The review offers insights into the current state of research on insect pest-resistant GM crops and the regulations governing the cultivation of GM crops in India. India has a rich crop diversity of more than 160 major and minor crops through its diverse agroclimatic conditions. Insect pests alone cause around USD 36 billion in crop loss annually in India. The last two decades witnessed considerable progress in managing insect pests by adopting innovative techniques including transgenics. In research, significant advancement has been brought in insect pest-resistant transgenics in India since its inception in 2002. However, any events have not been endorsed owing to biosafety impediments, except Bt cotton reaching the commercial release stage. A landmark decision to exempt certain types of gene-edited plants from genetically modified organism (GMO) regulations offers great promise for developing novel insect-resistant crops in India. The article reviews the current research on insect pest-resistant transgenics and its regulations in India.

A review on fungal-based biopesticides and biofertilizers production.

The escalating use of inorganic fertilizers and pesticides to boost crop production has led to the depletion of natural resources, contamination of water sources, and environmental crises. In response, the scientific community is exploring eco-friendly alternatives, such as fungal-based biofertilizers and biopesticides, which have proven effectiveness in enhancing plant health and growth while sustainably managing plant diseases and pests. This review article examines the production methodologies of these bioproducts, highlighting their role in sustainable agriculture and advancing our understanding of soil microorganisms. Despite their increasing demand, their global market presence remains limited compared to traditional chemical counterparts. The article addresses: 1) the production of biofertilizers and biopesticides, 2) their contribution to crop productivity, 3) their environmental impact and regulations, and 4) current production technologies. This comprehensive approach aims to promote the transition towards more sustainable agricultural practices.

Microplastic Pollution in Aquatic Ecosystem: A Review of Existing Policies and Regulations.

Environmental pollution due to plastic waste is a global challenge causing adverse impacts on the ecosystem and public health. Microplastic (MP) originates at the upstream processes such as industrial and household activities; however, their existence is affecting the downstream environment. Even though many governments and non- government organizations have taken technological and regulatory steps, these current efforts and strategies are insufficient to prevent the MP release in the environment. Thus, a multidisciplinary global approach is required, which must prioritize the reducing of plastic inputs to the environment. To regulate MP levels in the environment, worldwide reformative and preventive strategies are required because the issue is not limited to a single nation or region. In relation to marine plastic waste, a number of multilateral agreements and measures exist at global level. Several regulatory measures have been examined by regulatory bodies with the intention of safeguarding the environment from excessive MP contamination. However, neither of the frameworks in place is specifically made to stop the increased MP pollution in the environment. Therefore, this review focused on the preventive measures taken by the government and non-government organizations for MP control through legislations. The study also critically discussed MP-related policies aiming to increase the viability and efficiency of implementing future plastic management. This review is expected to provide the basic guidelines for formulating MP standards in the environment.

Uncovering the functions and mechanisms of regulatory elements-associated non-coding RNAs.

Over the past decade, regulatory non-coding RNAs (ncRNAs) produced by RNA Pol II have been revealed as meaningful players in various essential cellular functions. In particular, thousands of ncRNAs are produced at transcriptional regulatory elements such as enhancers and promoters, where they may exert multiple functions to regulate proper development, cellular programming, transcription or genomic stability. Here, we review the mechanisms involving these regulatory element-associated ncRNAs, and particularly enhancer RNAs (eRNAs) and PROMoter uPstream Transcripts (PROMPTs). We contextualize the mechanisms described to the processing and degradation of these short lived RNAs. We summarize recent findings explaining how ncRNAs operate locally at promoters and enhancers, or further away, either shortly after their production by RNA Pol II, or through post-transcriptional stabilization. Such discoveries lead to a converging model accounting for how ncRNAs influence cellular fate, by acting on transcription and chromatin structure, which may further involve factors participating to 3D nuclear organization.

Understanding the secondary outcomes of international travel measures during the covid-19 pandemic: a scoping review of social impact evidence.

BACKGROUND: Assessment of the effective use of international travel measures during the COVID-19 pandemic has focused on public health goals, namely limiting virus introduction and onward transmission. However, risk-based approaches includes the weighing of public health goals against potential social, economic and other secondary impacts. Advancing risk-based approaches thus requires fuller understanding of available evidence on such impacts. METHODS: We conducted a scoping review of existing studies of the social impacts of international travel measures during the COVID-19 pandemic. Applying a standardized typology of travel measures, and five categories of social impact, we searched 9 databases across multiple disciplines spanning public health and the social sciences. We identified 26 studies for inclusion and reviewed their scope, methods, type of travel measure, and social impacts analysed. RESULTS: The studies cover a diverse range of national settings with a strong focus on high-income countries. A broad range of populations are studied, hindered in their outbound or inbound travel. Most studies focus on 2020 when travel restrictions were widely introduced, but limited attention is given to the broader effects of their prolonged use. Studies primarily used qualitative or mixed methods, with adaptations to comply with public health measures. Most studies focused on travel restrictions, as one type of travel measure, often combined with domestic public health measures, making it difficult to determine their specific social impacts. All five categories of social impacts were observed although there was a strong emphasis on negative social impacts including family separation, decreased work opportunities, reduced quality of life, and inability to meet cultural needs. A small number of countries identified positive social impacts such as restored work-life balance and an increase in perceptions of safety and security. CONCLUSIONS: While international travel measures were among the most controversial interventions applied during the COVID-19 pandemic, given their prolonged use and widespread impacts on individuals and populations, there remains limited study of their secondary impacts. If risk-based approaches are to be advanced, involving informed choices between public health and other policy goals, there is a need to better understand such impacts, including their differential impacts across diverse populations and settings.

Occurrence of aflatoxin M1 in cheese products commonly available in Sri Lankan market.

Aflatoxins (AFs) are a group of mycotoxins produced by certain fungi of Aspergillus spp. AFs of major concern are B1 (AFB1), B2 (AFB2), G1 (AFG1), G2 (AFG2), and M1 (AFM1). AFM1 is a hydroxylated metabolite of AFB1 formed inside the animal's body which is excreted into milk of cows that consumed AFB1 contaminated feed. Consumption of AFM1-contaminated milk and subsequent dairy products causes negative health effects in consumers. This study was conducted to determine the occurrence and levels of AFM1 in cheese products available in the Sri Lankan market where AFM1 is not regularly monitored in milk while having an outdated regulatory limit of 1 ppb established for dairy products. Processed cheese (n = 28), hard cheese (n = 14), semi-hard cheese (n = 5), and soft cheese (n = 3) representing seven popular brands were collected. The samples were analyzed by Ultra High-Performance Liquid Chromatography Fluorescence Detection. AFM1 was detected in 40 samples (80 %), while 17 (34 %) and 37 (74 %) of the samples had AFM1 levels exceeding the maximum permitted limit set by Codex Alimentarius Commission (0.5 ppb) and the Netherlands (0.2 ppb). Further, 10 samples violated the Sri Lankan maximum limit of 1 ppb. Thirteen out of the 14 hard cheese (92.9 %, 0.11-14.43 ppb) and all semi-hard cheese samples (100 %, 0.29-0.65 ppb) contained AFM1. Most of the soft (66.7 %, 0.35-0.45 ppb) and processed (71.4 %, 0.11-1.35 ppb) cheese samples had AFM1. Most of the locally manufactured cheese products in Sri Lankan market may pose health risks to consumers. The results highlight the significance of regular monitoring of AFM1 in dairy products and the importance of updating regulations on par with international standards concurrently to ensure consumer safety.

Racial, ethnic, and neighborhood socioeconomic disparities in local cannabis retail policy in California.

BACKGROUND: Policies governing legal cannabis commerce can vary widely within a U.S. state when local control exists. Disproportionate distribution of policies allowing retail sale, protecting public health, or promoting equity in licensing may contribute to differences in health and economic outcomes between sociodemographic subgroups. This cross-sectional study jointly examined racial, ethnic, and neighborhood socioeconomic characteristics of Californians subject to specific local cannabis policies to identify such disparities. METHODS: Local laws in effect January 1, 2020, governing retail cannabis sales (bans, expanding buffers from youth-serving sites, restricting advertising, promoting equity in licensing, and capping outlets) were determined for California's 539 jurisdictions. The number of Asian, Black, Latinx, and white residents in socioeconomic advantaged versus disadvantaged neighborhoods (Census block groups) was determined using 2015-2019 American Community Survey data. We estimated proportions of the sociodemographic subpopulations covered by specific policies based on the block group's jurisdiction. To ascertain disparities in coverage proportions were compared across subgroups using Z-tests with the Bonferroni correction. RESULTS: Residents of socioeconomically advantaged neighborhoods were more likely to live in jurisdictions allowing retail cannabis commerce than those in disadvantaged neighborhoods (61.7 % versus 54.8 %). Black residents in advantaged neighborhoods were most likely to live where retailing was allowed (69 %), and white residents in disadvantaged neighborhoods least likely (49 %). Latinx and Black populations from disadvantaged neighborhoods were most likely to live in jurisdictions with stronger advertising restrictions (66 %). Equity in licensing policy was more prevalent for Black residents living in advantaged neighborhoods (57 %) than disadvantaged neighborhoods (49 %). CONCLUSIONS: Local cannabis policies potentially protecting public health and social equity are unequally distributed across race, ethnicity, and socioeconomic characteristics in California. Research examining whether differential policy exposure reduces, creates, or perpetuates cannabis-related health and socioeconomic disparities is needed.

Essential/precursor chemical control research: Giommoni's review, understanding multi-replication interrupted time series analysis, and next steps.

Controls on essential/precursor chemicals from commercial companies have been associated with many large downturns in illicit drug markets and attendant problems. My colleagues and I brought this to light in the studies that are the subject of Giommoni's review. McKetin et al. in an earlier review considered several of our studies on chemical controls for methamphetamine, all centered in North America. Giommoni discusses not only those studies but also our later work on chemical controls for cocaine and heroin. This later work evaluates US essential/precursor chemical policies targeting illicit drug producers outside of North America, and it examines impacts on illicit drug availability and use (the studies reviewed by McKetin et al. predominantly focused on outcomes such as drug-related hospitalizations, arrests, and treatment). Giommoni's review is a new resource that will help make the varied topics in essential/precursor chemical control research more accessible to many readers. After noting this, I discuss some common methodological misconceptions about our studies. For example, our studies generally used multi-replication interrupted time series analysis, a research design among the most powerful of all quasi-experimental designs. Authors, however, typically discuss the studies as if they used single-intervention interrupted time series analysis, a less powerful design. Multi-replication and single-intervention interrupted time series analyses also differ regarding likely confounders; awareness of this is critical to accurately assessing our findings and critiquing alternative explanations. Finally, I note that commercial chemical companies function as the silent, albeit usually unwitting, partners in the large-scale production of several illicit drugs, including fentanyl. And many governments are implementing essential/precursor chemical controls to help stymie this partnership. But they are doing so largely without evaluation and study-a poor policy practice. To remedy this, I suggest establishing multi-disciplinary applied research teams to help assess, guide and improve essential/precursor chemical control efforts.

The Elusive Truth of Cannabinoids for Rheumatic Pain.

PURPOSE OF REVIEW: Medical cannabis (MC) has entered mainstream medicine by a unique route. Regulatory acceptance as a medical product in many jurisdictions has bypassed the traditional evidence-based pathway required for therapies. Easier access to MC, especially related to recreational legalization of cannabis, has led to widespread use by patients for symptom relief of a variety of medical conditions and often without medical oversight. Musculoskeletal pain remains the most common reason for MC use. This review examines real-world issues pertaining to MC and offers some guidance for clinical care of patients with rheumatic diseases being treated with MC. RECENT FINDINGS: Controlled clinical studies of cannabis products in patients with rheumatic diseases have been small and tested a range of compounds, routes of administration, and clinical populations, limiting our ability to generate conclusions on MC's effectiveness in this population. Observational cohort studies and surveys suggest that use of MC and related products in patients with rheumatic diseases improves pain and associated symptoms but is commonly accompanied by mild to moderate side effects. Conflicting evidence contributes to practitioner and patient uncertainty regarding the use of MC for rheumatic disease-related pain. Despite promising preclinical and observational evidence that MC and cannabis-derived compounds are useful in the management of rheumatic disease-related pain, there remains limited high-quality clinical evidence to substantiate these findings. There are a significant number of clinical trials on this topic currently planned or underway, however, suggesting the next decade may yield more clarity. Nevertheless, given that many people with rheumatic diseases are using cannabis products, healthcare professionals must remain apprised of the evidence pertaining to cannabinoids, communicate such evidence to patients in a meaningful way that is free from personal bias and stigma, and maintain strong collaborative clinical care pertaining to MC.

Which works better? Comparing the multiple effects of heterogeneous environmental regulations on urban green economic transformation in China.

The coordination of heterogeneous environmental regulations (HER) is crucial for promoting regional green synergistic development. The primary objective of this study is to evaluate the impact of various heterogeneous environmental regulations (HER) on the green economic transformation (GET) of cities in China. We developed a comprehensive index system to measure the GET across three dimensions: the level of economic green development, the capacity for resource and environmental support, and the level of support for green transformation. This study examines 284 Chinese cities during the period from 2011 to 2020. Applying a dynamic panel model, a dynamic Durbin model, and a synergy model, we explore direct effects, spatial effects, and asymmetry of synergistic effects of HER on the GET of Chinese cities. We find that, in terms of direct effects, all environmental regulations can promote urban GET, though the magnitude of effects is heterogeneous. In terms of spatial spillover effects, market-incentive and public-participation environmental policies in a given region inhibit green transformation in neighboring regions, while overall environmental regulation and command-and-control regulation have significant positive effects on neighboring regions' green transformation. Furthermore, the total short-term effect of HER is significantly higher than the total long-term effect. The synergistic effect of HER is positive for the Beijing-Tianjin-Hebei city cluster and the Yangtze River Delta city cluster. This study can provide valuable policy implications for regional coordinated development with a low-carbon focus.

Environmental productivity growth, regulation and types of pollutants: Evidence from European firms.

European manufacturing firms have to cope with the new regulations that advocate a greener and more sustainable future with less emissions and at the same time enhance or at least maintain their productivity levels. A unique dataset is constructed by combining information on different firms' pollutants with their financial information during the 2011-2017 period. A non-radial directional distance function analysis is adopted with desirable and undesirable outputs to estimate environmental productivity growth and its components, which addresses the problem of heterogeneity. A regulatory impact indicator that provides information about the loss of outputs resulting from new policies is also computed. Finally, the impact of environmental regulations on productivity growth is explored using a panel vector autoregressive method. Our findings showcase different average values of productivity for each pollutant group. Moreover, results indicate that increasing the index of regulations by 1%, increases environmental productivity by 0.24% and 0.44% for heavy metals and greenhouse gases groups, respectively. Finally, results support the "weak" Porter Hypothesis, which attests that welldesigned environmental regulations can exert a positive effect on environmental innovation.

Assessing the influence of environmental regulation on carbon sequestration in China: Towards a sustainable future.

Carbon sequestration is vital to maintaining carbon neutrality and mitigating climate change's impact on humans and the environment. As the government's role in eco-advocacy is primarily designed to safeguard the environment, this paper discusses the impact of government environmental regulations on carbon sequestration. By analyzing 286 cities from 2000 to 2019 in China, we propose that government environmental regulation can lead to a 0.77% increase in carbon sequestration. Additionally, industrial agglomeration and industrial structure advancement are regarded as viable channels. As a result of the differences in city types, government intervention, and public concern across different cities, the impact is likely to vary as well.

The impact of economic growth targets on the level of green development-A perspective on officials' promotion incentives and environmental regulations.

Currently, China is at a critical stage of accelerating the green transformation of its economic development model, with considerable attention being paid to achieving this transformation while maintaining moderate economic growth. This study uses 271 prefecture-level cities in China from 2006 to 2020 to examine the impact of local government economic growth target constraints on the level of green economic development and to elucidate the underlying mechanisms. The results show that economic growth targets significantly inhibit the level of urban green development, with this effect being more pronounced in the economically developed eastern regions of China. Hard constraints on economic growth targets have a greater inhibitory effect on green development than soft constraints. The greater the promotion pressure on local officials, the stronger the inhibitory effect of economic growth target constraints on green development. The test of the mediation effect model reveals that economic growth targets can inhibit green development by affecting the degree of regional marketization, leading to mismatches in the capital and labor markets. Moreover, environmental regulations can mitigate the inhibitory effect of economic growth targets on green development levels. The conclusions of this study provide useful insights for local governments to optimize economic development target constraint mechanisms and accelerate high-quality green economic development.

Multifaceted strategies for alleviating Pseudomonas aeruginosa infection by targeting protease activity: Natural and synthetic molecules.

Pseudomonas aeruginosa has become a top-priority pathogen in the health sector because it is ubiquitous, has high metabolic/genetic versatility, and is identified as an opportunistic pathogen. The production of numerous virulence factors by P. aeruginosa was reported to act individually or cooperatively to make them robots invasion, adherences, persistence, proliferation, and protection against host immune systems. P. aeruginosa produces various kinds of extracellular proteases such as alkaline protease, protease IV, elastase A, elastase B, large protease A, Pseudomonas small protease, P. aeruginosa aminopeptidase, and MucD. These proteases effectively allow the cells to invade and destroy host cells. Thus, inhibiting these protease activities has been recognized as a promising approach to controlling the infection caused by P. aeruginosa. The present review discussed in detail the characteristics of these proteases and their role in infection to the host system. The second part of the review discussed the recent updates on the multiple strategies for attenuating or inhibiting protease activity. These strategies include the application of natural and synthetic molecules, as well as metallic/polymeric nanomaterials. It has also been reported that a propeptide present in the middle domain of protease IV also attenuates the virulence properties and infection ability of P. aeruginosa.

Overview of online pharmacy regulations in Saudi Arabia and the Gulf cooperation council countries and their impact on online pharmacy service providers in Saudi Arabia: a qualitative analysis.

Background: Laws and regulations are needed to regulate the growing online pharmacy (OP) services. The main objective of this work was to provide an overview of the laws and regulations for OP services in the Gulf Cooperation Council (GCC) countries. In addition, the perception of how these laws and regulations in Saudi Arabia (SA) affect the online ordering of medications and health-related products from national and international OPs was explored. Methods: A secondary data collection through emails and a qualitative descriptive analysis was used to gain insight into the OP regulations in the GCC countries. Then, a qualitative study was carried out with semi-structured interviews to investigate the impact of these regulations on the practice and the market from the OP service providers' perspective. The interviews were carried out with a sample of major OP service providers in SA, to represent the GCC countries. During the interviews, multiple open-ended questions were used to explore opinions about the OP regulations and how these regulations affected the practice. The interviews were then transcribed and thematically analysed. Results: Responses were mainly received from regulators in SA, Bahrain, Oman and United Arab Emirates (UAE). SA and UAE allow for offering of OP services as add-on service for existing community pharmacy, while UAE also allows for standalone OP providers. SA, Bahrain, and Oman allow online ordering of both over-the-counter (OTC) and prescription-only medications (POM) from international OP; a prescription is required for POM and quantities allowed should be no more than 3 months' supply in case of SA and Oman while this was not specified in case of Bahrain. Invoice of purchase was also required for any POM to be released from customs in SA and Bahrain but not in Oman and UAE. Controlled medications were prohibited to be ordered online in SA, UAE, and Bahrain while it was allowed in Oman if the prescription was issued within 6-month, and the quantity dispensed was for 1 month only. Apart from online ordering of medications in these countries, no specific regulations existed to regulate ordering of other health-related products from local or international OPs. Whether Kwait and Qatar have regulations for OP could not be established due to lack of response. Two of the four interviewed representatives of OP service providers in SA were not aware of the existence of specific regulations for OP services. The representatives who were aware of these regulations were satisfied with them and found them beneficial for their business and for the patients at the same time. However, representatives raised concerns regarding the enforcement of regulations on international OP providers. Conclusion: The existing regulations for online ordering of medications are somewhat comparable between the GCC countries, with no specific regulations for ordering of other health-related products from local or international OPs. In SA, there is limited awareness of the existing regulations for OP services by providers. Nevertheless, the need for detailed regulations on certain aspects of OP services was highlighted, such as regulations for international OPs and importing medications for personal use.

[The development of regulation of pharmaceuticals turn-over in EU and the USA in 1992-2020. Report 2. Development of normative legal base of pharmaceuticals turn-over in EU in 1992-2001].

The article continues to consider problem of regulation of pharmaceuticals turn-over in the EU and the USA in 1992-2020. The history of development of European pharmaceutical legislation in 1992-2001 is considered. This stage is characterized by passing Directives (laws of indirect action) that were obligatory for implementation through their inclusion into national normative legal bases. In 2001 the passed laws were compiled into EU Pharmaceutical Code (Directive 2001/83) that regulates main sections of pharmaceuticals turn-over from their production to pharmaceutical control. The adoption of Code laid the foundation for EU legislation in the field of medications.

[The issues of development and functioning of common market of medical equipment and articles within the framework of the Eurasian Economic Union].

The market of medical devices within the framework of the Eurasian Economic Union is regulated by special legislation that ensures formation of common market and compliance of products with all necessary requirements. This allows to ensure high level of quality of medical equipment and articles that contributes into improving safety and efficiency of medical procedures. The development of uniform requirements, considering world practices, is an important step, since it allows to guarantee high standards not only at level of single states, but also at level of the entire Union. This approach facilitates reinforcement of confidence to medical production of manufacturers from he Eurasian Economic Union countries. The article examines normative legal base regulating issues of formation and functioning of common market of medical equipment and articles within the framework of the Eurasian Economic Union. The analysis of normative legal base of the Russian Federation in section related to medical articles market was carried out. The analysis of the regulatory framework of the Russian Federation in terms of issues related to the market of medical devices was also carried out. The corresponding conclusions were made based on the study results.

The Chemical Residues in Secondary Beekeeping Products of Environmental Origin.

Natural products of bee origin, despite their complex composition and difficulties in standardization, have been of high interest among scientists representing various disciplines from basic sciences to industrial and practical implementation. As long as their use is monitored and they do not impact human health, they can be considered valuable sources of many chemical compounds and are potentially useful in medicine, food processing, nutrition, etc. However, apart from honey, the general turnover of bee products lacks precise and detailed legal requirements ensuring their quality. The different residues in these products constitute a problem, which has been reported in numerous studies. All products derived from beekeeping are made by bees, but they are also influenced by the environment. Such a dual pathway requires detailed surveillance of hazards stemming from outside and inside the apiary. This should be ensured via harmonized requirements arising from the binding legal acts, especially in international and intercontinental trade zones.

Evaluating the effects of safety incentives on worker safety behavior control through image-based activity classification.

Introduction: Construction worker safety remains a major concern even as task automation increases. Although safety incentives have been introduced to encourage safety compliance, it is still difficult to accurately measure the effectiveness of these measures. A simple count of accident rates and lower numbers do not necessarily mean that workers are properly complying with safety regulations. To address this problem, this study proposes an image-based approach to monitor moment-by-moment worker safety behavior and evaluate the effects of different safety incentive scenarios. Methods: By capturing workers' safety behaviors using a model integrated with OpenPose and spatiotemporal graph convolutional network, this study evaluated the effects of safety-incentive scenarios on workers' compliance with rules while on the job. The safety incentive scenarios in this study were designed as 1) varying the type (i.e., providing rewards and penalties) of incentives and 2) varying the frequency of feedback about ones' own compliance status during tasks. The effects of the scenarios were compared to the average compliance rates of three safety regulations (i.e., personal protective equipment self-monitoring hazard avoidance, and arranging the safety hook) for each scenario. Results: The results show that 1) rewarding a good-compliance is more effective when there is no feedback on compliance status, and 2) penalizing non-compliance is more effective when there are three feedbacks during the tasks. Discussion: This study provides a more accurate assessment of safety incentives and their effectiveness by focusing on safe behaviors to promote safety compliance among construction workers.

[DOG-EyeTeacher: a response by the Teaching Association to the medical study restructuring]. / DOG-EyeTeacher: eine Antwort der Arbeitsgemeinschaft Lehre auf die Umstrukturierungen im Medizinstudium.

BACKGROUND: The Masterplan Medicine 2020 adopted in 2017 entails many changes to the medical studies curriculum. The new structure affects the content of the coursework and its main focus. A major goal of this masterplan is to prepare young physicians by teaching the skills that are essential for the future profession. The National Competence-Based Learning Objectives Catalog for Medicine (NKLM) provides the basis for the teaching content. METHODS: The Working Group Teaching of the German Society of Ophthalmology (Arbeitsgemeinschaft Lehre der DOG) actively supports this transformation. In cross-site collaboration, teaching materials for various teaching formats have been compiled by relying on the NKLM (e.g., recordings of operations, slides for small group instruction, image galleries, case studies). An online library named the DOG-EyeTeacher was then created. RESULTS: The aim of the DOG-EyeTeacher is to relieve the training clinics and to establish basic standards in teaching materials, thereby enabling the necessary focus on medical education. The provision of these teaching materials should deepen the interest in ophthalmology among future doctors. CONCLUSION: The DOG-EyeTeacher is our response to the challenges associated with the planned restructuring of the medical curriculum. Since October 2023, any DOG member involved in teaching can create an account free of charge to use our materials.