Test for abnormal niacin response syndrome in schizophrenia: reclaiming the oral route / Prueba de síndrome de respuesta a niacina anormal en pacientes con diagnóstico de esquizofrenia: reivindicando la vía oral.

Introduction: Although there is an abnormal presentation of Niacin Response Syndrome (ANRS) in schizophrenic patients (SZ) compared to subjects with other psychiatric illnesses and with healthy individuals. However, most of the literature is based on studies that have used tests of niacin topical administration, observing, on the other hand, less scientific production of its oral administration. The objective was to determine the sensitivity of the oral niacin test as a method of detecting ASRN in EZ. Methods: A non-randomized clinical trial was carried out. Two groups were formed, the experimental or SZ, with 21 patients diagnosed with schizophrenia according to DSM-IV-TR SZ or schizoaffective disorder, and the HC group, made up of 20 healthy controls. Both groups were exposed to an oral niacin test and clinical-semiological tools were applied to evaluate the NRS. Results: 90.5% of the SZ group presented ANRS. In contrast, no participant in the HC group presented ANRS (0%). Conclusions: Oral niacin administration was sensitive to the detection of ASRN in schizophrenia. Likewise, ASRN could be a gradual phenomenon and its prevalence could be dose-dependent, being lower the lower the dose of oral niacin used. Further trials with larger and randomized samples will be needed.

Introducción: En pacientes esquizofrénicos (EZ) existe un síndrome de respuesta a niacina (ASRN) anormal en comparación con sujetos con otras enfermedades psiquiátricas y con individuos sanos. Sin embargo, la mayor parte de la literatura se basa en estudios que han utilizado pruebas de niacina por vía tópica, observándose, en cambio, menor cantidad de ensayos utilizando su administración por vía oral, a pesar de existir algunas ventajas comparativas con el uso de esta última vía. El objetivo fue determinar la sensibilidad de la prueba de niacina por vía oral como método de detección del ASRN en EZ. Metodología: Se realizó un ensayo clínico no aleatorizado, conformando dos grupos, el grupo experimental o EZ, con 21 pacientes con diagnóstico de esquizofrenia según DSM-IV-TR SZ o trastorno esquizoafectivo, y el grupo CS, constituido por 20 controles sanos. Ambos grupos fueron expuestos a la prueba de niacina por vía oral y se aplicaron herramientas clínico-semiológicas para evaluar el SRN. Resultados: La prevalencia de ASRN fue del 90,5% en el grupo EZ, mientras que en el grupo CS fue nula (0%). Conclusiones: La administración oral de niacina fue sensible a la detección de ASRN en la esquizofrenia. Asimismo, la ASRN podría ser un fenómeno gradual y su prevalencia podría ser dosis-dependiente, siendo menor cuanto menor sea la dosis de niacina oral utilizada. Se necesitarán ensayos adicionales con muestras de mayor tamaño y aleatorizadas.

A espera na "Era da pre(s)sa" / The wait in the "Rush era" / La espera en la "Era de la pri(e)sa" / Attendre à « l'Ère de la hâte (et de la proie) ¼

Na "Era da pre(s)sa", o mundo transborda de imagens e excessos, com a sensação do tempo em aceleração que impele respostas velozes aos sujeitos para que tudo aconteça no "já". Pensando na espera como constituinte do psiquismo, a autora desenvolve as relações entre o paradoxo excesso e ausência, bem como a necessidade de preservação de intervalos temporais que possibilitam a elaboração e o trabalho psíquico. O objetivo deste artigo é propor reflexões sobre a análise virtual na "Era da pre(s)sa", seus desafios e impasses, agravados pelo cenário atual de pandemia (covid-19).

At the "Rush era", the world overflows with images and excesses, with the time perception in acceleration demanding quick answers so everything happens immediately. Addressing the wait as the constituent of the psyche, I will develop the relations regarding the excess/absence paradox, as well as the need to preserve time intervals that allow the elaboration and construction of the psychic work. This article's goal is to propose reflections about the virtual analysis at the "Rush era", how humans get trapped within it, its challenges and deadlocks, which are aggravated by the current pandemic scenario.

En la "Era de la pri(e)sa", el mundo se desborda con imágenes y excesos, con la percepción del tiempo en aceleración demandando respuestas rápidas, para que todo se pase en el ya (ahora). Pensando en la espera como algo que constituye la psique humana, la autora desarrolla las relaciones de la paradoja del exceso y de la ausencia, así como la necesidad de preservación de intervalos temporales que hacen posible la elaboración y el trabajo psíquico. El objetivo de ese artículo es proponer reflexiones acerca del análisis (terapia) virtual en la Era de la Pri(e)sa, sus desafíos y dificultades, que son agravados por el escenario actual de la pandemia (covid-19).

A « l'Ère de la hâte (et de la proie) ¼, le monde déborde d'images et d'excès, avec la sensation d'accélération du temps, ce qui pousse des réponses rapides aux sujets pour que tout se passe dans le « maintenant ¼. En pensant à l'attente comme constituant du psychisme, l'auteur développe la relation entre le paradoxe de l'excès et de l'absence, ainsi que la nécessité de préserver des intervalles de temps qui rendent possible l'élaboration et le travail psychiques. Le but de cet article est de proposer des réflexions sur l'analyse virtuelle à « l'Ere de la hâte (et de la proie) ¼, ses défis et impasses, aggravés par le scénario pandémique actuel (covid-19).

Ascorbic acid increases SVCT2 localization at the plasma membrane by accelerating its trafficking from early secretory compartments and through the endocytic-recycling pathway.

Ascorbic acid (Asc) is an antioxidant molecule essential for physiological functions. The concentration of extracellular Asc increases during synaptic transmission and renal reabsorption. These phenomena induce an increase of the Sodium-dependent-Vitamin-C-transporter 2 (SVCT2) at plasma membrane (PM) localization, as we previously demonstrated in neuronal and non-neuronal cells. Hence, the aim of this study was to evaluate intracellular SVCT2 trafficking kinetics in response to Asc. We observed two peaks of SVCT2 localization and function at the PM (at 5-10 min, "acute response", and 30-60 min, "post-acute response") when cells were incubated with Asc. We defined that the post-acute response was dependent on SVCT2 located in early secretory compartments, and its trafficking was abolished with Tunicamycin and Brefeldin A treatment. Moreover, using the RUSH system to retain and synchronize cargo secretion through the secretory pathway we demonstrated that the post-acute response increases SVCT2 trafficking kinetics from the ER to the PM suggesting the retention of SVCT2 at the early secretory pathway when Asc is absent. However, these observations do not explain the increased SVCT2 levels at the PM during the "acute" response, suggesting the involvement of a faster mechanism in close proximity with the PM. To investigate the possible role of endosomal compartments, we tested the effect of endocytosis inhibition. Expression of dominant-negative (DN) versions of the GTPase-dynamin II and clathrin-accessory protein AP180 showed a significant increase in SVCT2 levels at the PM. Moreover, expression of Rab11-DN, a GTPase implicated in cargo protein recycling from endosomes to the PM showed a similar outcome, strongly indicating that Asc impacts SVCT2 trafficking during the acute response. Therefore, our results revealed two mechanisms by which Asc modulates SVCT2 levels at the PM, one at the early secretory pathway and another at the endocytic compartments. We propose that these two mechanisms have key protective implications in the homeostasis of metabolically active and specialized tissues.

Propagule pressure, genetic structure, and geographic origins of Chondrilla juncea (Asteraceae): an apomictic invader on three continents.

PREMISE OF THE STUDY: Assessing propagule pressure and geographic origins of invasive species provides insight into the invasion process. Rush skeletonweed (Chondrilla juncea; Asteraceae) is an apomictic, perennial plant that is invasive in Australia, South America (Argentina), and North America (Canada and the United States). This study comprehensively compares propagule pressure and geographic structure of genotypes to improve our understanding of a clonal invasion and enhance management strategies. • METHODS: We analyzed 1056 native range plants from Eurasia and 1156 plants from three invaded continents using amplified fragment length polymorphism (AFLP) techniques. We used measures of diversity (Simpson's D) and evenness (E), analysis of molecular variance, and Mantel tests to compare invasions, and genotype similarity to determine origins of invasive genotypes. • KEY RESULTS: We found 682 unique genotypes in the native range, but only 13 in the invaded regions. Each invaded region contained distinct AFLP genotypes, suggesting independent introduction events, probably with different geographic origins. Relatively low propagule pressure was associated with each introduction around the globe, but levels of among-population variation differed. We found exact AFLP genotype matches between the native and invaded ranges for five of the 13 invasive genotypes. • CONCLUSIONS: Invasion dynamics can vary across invaded ranges within a species. Intensive sampling for molecular analyses can provide insight for understanding intraspecific invasion dynamics, which can hold significance for the management of plant species, especially by finding origins and distributions of invasive genotypes for classical biological control efforts.

Traumatic brain injury due to bull assault in a girl: a case report.

ABSTRACT: Traumatic brain injury is a common condition in the emergency services, affecting the pediatric and adult population significantly. Patterns of head injury as well as management principles in children are important differences compared to adults. Traumatic brain injury by bull rush is usually seen in adults but has not been described in children-report a pediatric cranial trauma present bull rush, which to our knowledge is the first report in the literature of this nature.

Alergia a veneno de himenópteros na criança / Hymenoptera venom allergy in children

Objetivos: A alergia a veneno de himenópteros pode condicionar a vida da criança de forma significativa. Pretende-se, com a exposição de dois casos clínicos e uma breve revisão do tema, salientar a importância da referenciação dessas crianças a consultas especializadas, para início de dessensibilização.Descrição dos casos: Duas crianças, aos três e aos seis anos, tiveram anafilaxia a picada de vespa e abelha, respectivamente. Em ambas, após a determinação de IgE específica e confirmação alergológica, iniciou-se dessen-sibilização com veneno de himenópteros em esquema ultra-rush, sem intercorrências relevantes, apenas edema no local da injeção. Após doze meses de injeções a cada quatro semanas, recebem agora manutenção com injeções a cada seis semanas. No primeiro caso, a criança foi picada por vespa aos dez meses de imunoterapia, desencadeando apenas reação local diminuta.Conclusões: Em ambos os casos, a imunoterapia específica subcutânea com veneno em esquema ultra-rush foisegura e eficaz, oferecendo o conforto de um menor número de injeções e de deslocamentos ao hospital na fasede indução. A manutenção da terapêutica já demonstrou efeito protetor na reexposição ao veneno em uma dascrianças.

clinical cases and a brief review on the topic, emphasizing the importance of referral of these children to specialized care for early desensitization.Cases description: Two children, at three and six years, had anaphylactic reaction to wasp and bee stings, respectively. In both cases, after the determination of specific IgE and allergologic confirmation, desensitization with hymenoptera venom in ultra-rush regimen was done, without relevant side effect apart from swelling at the injection site. After twelve months of injections every four weeks, the children are now receiving maintenance injections every six weeks. In the first case, the child was stung by wasp at ten months of immunotherapy, triggering only small localreaction.Conclusions: In both cases, the subcutaneous venom immunotherapy with ultra-rush regimen was safe and effective, providing the comfort of a smaller number of injections and hospital visits during the induction phase. Maintenance therapy has demonstrated a protective effect on re-exposure to the poison in one child.

Larva migrans cutánea a propósito de un caso / Cutaneous larva migrans taking into consideration a case

Introducción: la Larva migrans cutánea (LMC) es una enfermedad muy común en regiones tropicales, por lo que Cuba no está exenta de este tipo de infestación. Objetivo: relatar un caso de Larva migrans cutánea en un recién nacido de 18 días, visto durante estancia en Mozambique. Presentación del Caso: se presenta el caso de un recién nacido de 18 días, quien ingresa en el Servicio Infeccioso del Hospital Central de Beira, Provincia de Mozambique, con el posible diagnóstico de Meningoencefalitis y al que se le encuentra al examen físico lesiones eritematosas de trayecto lineal tortuosas a nivel de la región pre auricular, tórax y región glútea derecha, después de descartar otras entidades nosológicas. Conclusiones: se trata de una Larva migrans cutánea para lo que se impone tratamiento con cloruro de etilo y tiabendazol local. Presentó una evolución satisfactoria(AU)

Introduction: cutaneous larva migrans is a very common disease in tropical regions that's why Cuba is included in the coontries in which this illness is present. Objective: talk about a cutaneous larva migrans case in an 18 days newborn, seen during the stay in Mozambique. Case Presentation: there is the case of a new born of 18 days who is addmited in the contagioos or infective Service of Beira Central Hospital, Mozambike province, with the possible diagnosis of the Meningoencephalitis, and within physical exam, physical lessions are found of the rind of erythematous of a acute lineal way at the level of the pre auricular region, thorax and de right buttock region. After discoonting others nosological entities. Conclussions: we are in the pressence of cutaneous Larva migrans and the local tiabendazol with cloruro of etilo tretment is impossed finding a notorioos satisfactory evolution after this(AU)

Larva migrans cutánea a propósito de un caso / Cutaneous larva migrans taking into consideration a case

Introducción: la Larva migrans cutánea (LMC) es una enfermedad muy común en regiones tropicales, por lo que Cuba no está exenta de este tipo de infestación. Objetivo: relatar un caso de Larva migrans cutánea en un recién nacido de 18 días, visto durante estancia en Mozambique. Presentación del Caso: se presenta el caso de un recién nacido de 18 días, quien ingresa en el Servicio Infeccioso del Hospital Central de Beira, Provincia de Mozambique, con el posible diagnóstico de Meningoencefalitis y al que se le encuentra al examen físico lesiones eritematosas de trayecto lineal tortuosas a nivel de la región pre auricular, tórax y región glútea derecha, después de descartar otras entidades nosológicas. Conclusiones: se trata de una Larva migrans cutánea para lo que se impone tratamiento con cloruro de etilo y tiabendazol local. Presentó una evolución satisfactoria.

Introduction: cutaneous larva migrans is a very common disease in tropical regions that's why Cuba is included in the coontries in which this illness is present. Objective: talk about a cutaneous larva migrans case in an 18 days newborn, seen during the stay in Mozambique. Case Presentation: there is the case of a new born of 18 days who is addmited in the contagioos or infective Service of Beira Central Hospital, Mozambike province, with the possible diagnosis of the Meningoencephalitis, and within physical exam, physical lessions are found of the rind of erythematous of a acute lineal way at the level of the pre auricular region, thorax and de right buttock region. After discoonting others nosological entities. Conclussions: we are in the pressence of cutaneous Larva migrans and the local tiabendazol with cloruro of etilo tretment is impossed finding a notorioos satisfactory evolution after this.

Tamizaje fitoquímico de Cassia uniflora Mill / Phytochemical screening of Cassia uniflora Mill

Introducción: Cassia uniflora Mill se emplea en el control aleloquímico de Parthenium hysterophorus; se ha reportado que presenta actividad larvicida frente a Aedes aegypti. Tradicionalmente se ha usado como antiespasmódico y para el tratamiento de erupciones cutáneas. Objetivo: realizar un tamizaje fitoquímico a los extractos etéreo, alcohólico y acuoso de la especie Cassia uniflora Mill para conocer los metabolitos secundarios que sean de interés biológico en la terapéutica. Métodos: se recolectaron partes aéreas y subterráneas de la planta, se lavaron, desinfectaron, secaron, pulverizaron y se sometieron a extracciones sucesivas con solventes de polaridad creciente. Los extractos se filtraron y se realizaron ensayos fitoquímicos de identificación. Resultados: el tamizaje fitoquímico, efectuado a los extractos etéreo, alcohólico y acuoso de las hojas, tallos, cáscaras de los frutos, semillas y raíces, demostró la existencia de varias familias de metabolitos secundarios de interés biológico y farmacológico, entre los que se destacan, por su significativa presencia, las quinonas y las coumarinas. Conclusiones: de acuerdo con la diversidad de metabolitos secundarios presentes en las partes evaluadas de C. uniflora, así como los efectos biológicos reportados para la especie, sería interesante realizar nuevos estudios que aporten evidencias sobre su eficacia y seguridad, como forma de avalar su empleo tradicional.(AU)

Introduction: Cassia uniflora Mill is used for the allelochemical control of Parthenium hysterophorus; and its larvicidal activity on Aedes aegypti has been reported. It has also been applied as antispasmodic agent and as treatment of cutaneous rash. Objective: to perform a phytochemical screening on alcoholic, ethereal and aqueous extracts from the Cassia uniflora Mill species to identify the secondary metabolites of biological interest in therapeutics. Methods: aerial and underground parts of the plant were harvested, washed, disinfected, dried, powdered and subjected to successive extractions with solvents of increasing polarity. The extracts were filtered to carry out phytochemical tests for identification. Results: the phytochemical screening of ethereal, alcoholic and aqueous extracts from leaves, stems, fruit peels, seeds and roots, confirmed the existence of several families of secondary metabolites of biological and pharmacological interest such as quinones and coumarins that stand out because of their significance presence. Conclusions: according to the diversity of secondary metabolites in the tested parts of Cassia uniflora Mill, as well as the biological effects reported for this species, it would be interesting to conduct new studies to find pieces of evidence on its effectiveness and safety, as a way of supporting traditional use of this plant.(AU)

Tamizaje fitoquímico de Cassia uniflora Mill / Phytochemical screening of Cassia uniflora Mill

Introducción: Cassia uniflora Mill se emplea en el control aleloquímico de Parthenium hysterophorus; se ha reportado que presenta actividad larvicida frente a Aedes aegypti. Tradicionalmente se ha usado como antiespasmódico y para el tratamiento de erupciones cutáneas. Objetivo: realizar un tamizaje fitoquímico a los extractos etéreo, alcohólico y acuoso de la especie Cassia uniflora Mill para conocer los metabolitos secundarios que sean de interés biológico en la terapéutica. Métodos: se recolectaron partes aéreas y subterráneas de la planta, se lavaron, desinfectaron, secaron, pulverizaron y se sometieron a extracciones sucesivas con solventes de polaridad creciente. Los extractos se filtraron y se realizaron ensayos fitoquímicos de identificación. Resultados: el tamizaje fitoquímico, efectuado a los extractos etéreo, alcohólico y acuoso de las hojas, tallos, cáscaras de los frutos, semillas y raíces, demostró la existencia de varias familias de metabolitos secundarios de interés biológico y farmacológico, entre los que se destacan, por su significativa presencia, las quinonas y las coumarinas. Conclusiones: de acuerdo con la diversidad de metabolitos secundarios presentes en las partes evaluadas de C. uniflora, así como los efectos biológicos reportados para la especie, sería interesante realizar nuevos estudios que aporten evidencias sobre su eficacia y seguridad, como forma de avalar su empleo tradicional.

Introduction: Cassia uniflora Mill is used for the allelochemical control of Parthenium hysterophorus; and its larvicidal activity on Aedes aegypti has been reported. It has also been applied as antispasmodic agent and as treatment of cutaneous rash. Objective: to perform a phytochemical screening on alcoholic, ethereal and aqueous extracts from the Cassia uniflora Mill species to identify the secondary metabolites of biological interest in therapeutics. Methods: aerial and underground parts of the plant were harvested, washed, disinfected, dried, powdered and subjected to successive extractions with solvents of increasing polarity. The extracts were filtered to carry out phytochemical tests for identification. Results: the phytochemical screening of ethereal, alcoholic and aqueous extracts from leaves, stems, fruit peels, seeds and roots, confirmed the existence of several families of secondary metabolites of biological and pharmacological interest such as quinones and coumarins that stand out because of their significance presence. Conclusions: according to the diversity of secondary metabolites in the tested parts of Cassia uniflora Mill, as well as the biological effects reported for this species, it would be interesting to conduct new studies to find pieces of evidence on its effectiveness and safety, as a way of supporting traditional use of this plant.