RESUMO
The association between the polymorphism of SLC17A1 gene and hyperuricemia in Uyghur population in Xinjiang region was explored by Chi-square test.A total of 1 024 patients with hyperuricemia and 1 033 healthy volunteers were included.The genotype frequencies of CC,CT,and Tr in hyperuricemia and healthy controls were 24.9％,53.14％,21.96％ and 29.7％,47.52％,22.77％,respectively.There was statistical difference in SLC17A1 rs9467596 genotype frequencies between hyperuricemia cases and controls (x2 =7.492,P =0.024).CT genotype could increase the risk of hyperuricemia compared with CC genotype (OR =1.334,95％ CI 1.082-1.644).No statistical significance among the genotypes was found in age,body mass index,blood pressure,blood glucose,triglyceride,total cholesterol,High-density lipoprotein-cholesterol,low-density lipoprotein-Cholesterd,blood urea nitrogen,and Creatinine.The polymorphism of rs9467596 in SLC17A1 may be a genetic marker to assess risk of hyperuricemia among Xinjiang Uyghur population.
