A Clinical Study of Pediatric Myelodysplastic Syndrome: Application of International Prognostic Scoring System and the Review of the Korean Literature / 대한암학회지

PURPOSE: Myelodysplastic syndrome (MDS) in children needs to be elucidated in terms of clinical characteristics, natural history, the most effective treatment and prognostic factors, as the disease is very rare and its definition and classification has not reached a consensus by many physician. This study was aimed to describe the characteristics and the disease courses of Korean children with MDS, and to analyze the usefulness of prognostic scoring systems in the prediction of transformation to acute myelogenous leukemia (AML) and overall survival among subgroups. MATERIALS AND METHODS: Fourteen children with MDS seen at Chonnam University Hospital and additional 59 patients identified by the review of Korean literature were evaluated to define clinical characteristics and disease courses. Kaplan-Meier (K-M) probability of leukemic transformation and overall survival were plotted. FAB subtypes, subgroups by Boumemouth Scoring System (BSS), and International Prognostic Scoring System (IPSS) risk groups were compared to predict transformation to AML and overall survival. RESULTS: The median age of 14 patients was 36.5 months. The sex ratio was 3.7:1 (M: F). The frequency of FAB subtypes in Korea was similar to that of other countries except for higher proportion of RA (37%). K-M 3-yr probability of AML transformation and survival for Korean patients were 54.7%, and 49.8%, respectively. Although FAB system, BMS and IPSS were all capable of discriminating subgroups in the prediction of AML transformation and survival, they did not reach the significant level possibly due to small number of patients assigned to each subgroup. CONCLUSION: The clinical characteristics of Korean children with MDS were not different from those of other countries. This study showed the high rate of AML transformation and poor survival in children with MDS.

Comparison between old and new clinical staging of primany liver cancer / 中国癌症杂志

Purpose:To compare old and new clinical staging of primary liver cancre. Methods:317 cases of primary liver cancer(PLC) patients,hospita lized and dead,were investigated retrospectively for overall median survival and survival after various therapies,according to various stages,and therapies and comparison among groups and test of median survival were carried out. Results:Survival in patients with new stage Ⅱa+Ⅱb or old Ⅱw ere significantly longer than newⅢa+Ⅲb or oldⅢ, but no significant differenc es were observed between new stageⅡa+Ⅱb and oldⅡ , or new stage Ⅲa+Ⅲb and oldⅢ. Median survival by new staging , decreased in peoper order from stageⅡ a ,Ⅱb , Ⅲa to Ⅲb respectively, significant different was found only between s tage Ⅲa and Ⅲb but not betweenⅡa andⅡb . Survival decreased respectively fr om interventional treatment ,systemic chemotherapy and palliative therapy;the in terventional treatment group did much better than the palliative group but no si milar differences were observed in the other groups. Conclusions:New clinical staging of PLC did not show significan t superiorly over the old one as judged by median survival.It can be questioned whether basing on largest diameter is less than 5/10 cm or more than 10 cm to di stinguish Ⅱa and Ⅱb is valid.Interventional treatment should be applied as soo n as possible to prolong survival whether it be the new or old clinical staging.

The Effect of Plasma ?-EP on Hemorrhagic Shock in Rats during Acute Hypoxia / 第三军医大学学报

40 rats were divided into 2 groups. At sea level and simulated high altitude of 4000m respectively, nalozone and saline are injected to observe the effect of nalozone on LVSP, LVDP, dp/dtmax, HR and survival time in hemorrhaged rats.blood plasma ?-EP is measured before and after bleeding to study the relation between ?-EP and hemorrhagic shock.Results: the circulatory parameters on hemorrhagic shock change more significantly at high altitude than at sea level; naloxone make these parameters recover and the survival time prolong both at sea level and high altitude; blood plasma ?-EP increases after bleeding, especially at high altitude-Suggestions; at high altitude hemorrbagic shock may be induced easilier.and symptomy is severer, development occurs rapider, and mortality higher is higher; change of ?-EP is related to the patholgical process of hemorhagic shock and the effect of ?-EP on cardiac contractility may be one of causes affecting bemorrbagic shock; naloxone has a role to antagonize hemorrhage shock at high altitude;