Botulinum toxin type A is a potential therapeutic drug for chronic orofacial pain.

BACKGROUND: Botulinum toxin type A (BTX-A), produced by the gram-positive anaerobic bacterium Clostridium botulinum, acts by cleaving synaptosome-associated protein-25 (SNAP-25), an essential component of the presynaptic neuronal membrane that is necessary for fusion with the membrane proteins of neurotransmitter-containing vesicles. Recent studies have highlighted the efficacy of BTX-A in treating chronic pain conditions, including lower back pain, chronic neck pain, neuropathic pain, and trigeminal neuralgia, particularly when patients are unresponsive to traditional painkillers. This review focuses on the analgesic effects of BTX-A in various chronic pain conditions, with a particular emphasis on the orofacial region. HIGHLIGHT: This review focuses on the mechanisms by which BTX-A induces analgesia in patients with inflammatory and temporomandibular joint pain. This review also highlights the fact that BTX-A can effectively manage neuropathic pain and trigeminal neuralgia, which are difficult-to-treat chronic pain conditions. Herein, we present a comprehensive assessment of the central analgesic effects of BTX-A and a discussion of its various applications in clinical dental practice. CONCLUSION: BTX-A is an approved treatment option for various chronic pain conditions. Although there is evidence of axonal transport of BTX-A from peripheral to central endings in motor neurons, the precise mechanism underlying its pain-modulating effects remains unclear. This review discusses the evidence supporting the effectiveness of BTX-A in controlling chronic pain conditions in the orofacial region. BTX-A is a promising therapeutic agent for treating pain conditions that do not respond to conventional analgesics.

Conceptualising TMD symptom burden in youths: Symptom duration, frequency, intensity and interference.

OBJECTIVE: This study aimed to conceptualise Temporomandibular disorder (TMD) symptom burden and severity and explored their interrelationships with somatic symptoms and psychological distress. METHODS: Participants were recruited from a local polytechnic. The quintessential five TMD symptoms (5Ts) of the Diagnostic Criteria for TMDs (DC/TMD) were appraised and extended to evaluate the duration, frequency, intensity and interference of discrete TMD symptoms. Global TMD severity (GS) was computed by totaling the points for all TMD symptoms and dimensions. TMD (TS) and somatic symptom (SS) burden were assessed based on the Somatic Symptoms Scale-8, while psychological distress was measured with the Depression, Anxiety and Stress Scales-21. Statistical analyses were performed using Kruskal-Wallis/Dunn tests and Spearman's correlation (α = .05). RESULT: Of the 366 eligible participants (mean age 19.1 ± 2.3 years), 51.4% were 5Ts-negative and 48.6% were 5Ts-positive. Among the 5Ts-positive individuals, 25.3%/64.0% were 'bothered a little' whereas 4.5%/10.7% were 'bothered a lot' by TMD pain/headache. Correspondingly, 32.6%/12.4%/5.1% were 'bothered a little' while 2.8%/2.8%/1.1% were 'bothered a lot' by TMJ sounds/closed/open locking. TS burden was moderate-to-strongly correlated to aggregate symptom duration, frequency, intensity, interference, GS and SS burden (rs = .50-.88). While TS burden and GS were weakly associated with psychological distress (rs = .18-.36), SS burden was moderately related to depression, anxiety and stress (rs = .47-.53). CONCLUSIONS: TS burden can serve as a proxy for global TMD severity and may be more meaningful than the mere presence of TMD symptoms in clinical and research settings.

The epidemiological profile of temporomandibular joint disorders in the Tunisian population: A cross-sectional study.

Objective: This study aimed to explore the prevalence, signs, and symptoms of different types of TMD (Temporomandibular joint disorders) disorders in Tunisian patients. Methods: A retrospective cross-sectional study was conducted using the clinical records of patients from the Department of Functional Exploration, Pain, and Orofacial Dysfunction of the Dental Clinic of Monastir. Results: TMD is associated with a female predominance, with a peak prevalence among those aged between 20 and 40 years. Pain and a limited range of motion were significantly more prevalent in women (p = 0.019 and p = 0.012, respectively). Clicking sounds were the most frequent joint noises (38.2 %). Crepitus was more prevalent among older adults (33 %). Of the different types of TMD, disk displacement with reduction was the most prevalent (n = 216, 39 %). Sleep bruxism was more prevalent than awake bruxism (20.7 % VS 9.5 %). Due to the heterogeneous TMD signs and symptoms, patients tend to seek medical attention from various specialties (e.g. neurology and otolaryngology). Conclusion: The prevalence of different types of TMD, and the different signs and symptoms varied depending on sociodemographic characteristics, such as sex, age and lifestyle. Diagnosis is challenging and TMD may be confused with other orofacial pain conditions.

Does lifestyle modification (physical exercise and listening to music) improve symptoms in patients with a temporomandibular disorder? A randomized clinical trial.

Introduction: The aim of the study was to compare pain relief in temporomandibular disorder (TMD) patients with or without lifestyle modification. Materials and Methods: This randomized clinical trial was performed on patients with TMD, who did not regularly exercise or listen to music. The participants were allocated into two groups. In the treatment group, the participants were instructed to exercise five times or more per week (30 minutes per session) and listen to the music of their choice five times or more per week (15 minutes per session) for 12 weeks. In the control group, the participants had their usual lifestyle without any modifications. The participants were examined for clicking and crepitus in the joint and maximum mouth opening before and after the intervention. The pain severity was also documented based on a visual analog scale. Results: Thirty five patients were studied in each group. Twelve weeks after the intervention, the mean pain severity was 2.70 ± 0.73 in the treatment group and 4.63 ± 0.77 in the control group. The results of data analysis demonstrated a significant difference between the two groups regarding the mean pain severity at 12 weeks after the intervention (P <.001). Conclusions: Lifestyle modification through physical exercise and listening to music may reduce pain in TMD patients.

Prevalence of temporomandibular joint dysfunction among the indigenous population of India.

Purpose: Primary dental care facilities and awareness about temporomandibular disorders are lacking among the indigenous population of Kerala. The aim of the study was to determine the prevalence of temporomandibular joint dysfunction (TMD) disorders among the indigenous populations of Kerala. Methodology: This cross-sectional study included adults aged 18 years and above, visiting primary health care centre in the tribal hamlet in the town of Kalpetta, Wayanad District, Kerala, India, for reasons other than dental. Axis I and II of Research Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) was used to screen for TMD. A local language validated screening questionnaire was used. The clinical examination was carried out as per the DC/TMD by a calibrated examiner. The data was processed using SPSS and the frequencies and proportions for signs and symptoms of TMD were estimated. Results: Among 198 adults screened, 23 (11.6 %) had TMD. Among these 60 % of the adults were aged 31-65 years and predominantly females (86.9 %). 39 % of these patients were dentulous. All affected adults experienced TMD related pain for more than 3 months with 90 % of them experiencing moderate-to-severe pain. Myofascial pain was the most prevalent type. Other findings included moderate anxiety levels in 34.8 % and abnormal oral behaviour and high physical symptoms in 40 % TMD patients. Conclusion: TMD disorders were prevalent among the indigenous population and remained undiagnosed. The study highlights the need for screening and the availability of basic dental care for the indigenous populations.

Perspective on Temporomandibular Joint Disorder: Foramen Tympanicum Defect.

BACKGROUND: Foramen tympanicum (FT) is a defect located anterior-inferior to the external acoustic meatus. We evaluated its prevalence, location, size, and relationship with temporomandibular joint (TMJ) disorders. METHODS: Cone beam computed tomography was performed for 200 patients who presented to the Karamanoglu Mehmetbey University Ahmet Kelesoglu Faculty of Dentistry Hospital. The location and size of the FT in the axial and sagittal planes were evaluated. Descriptive statistics were used to compare the study parameters among age and sex groups. Patients with FT were reevaluated by two maxillofacial surgeons at the study centre. RESULTS: In total, 200 images from 400 joints were examined. Unilateral and bilateral FT (19 [9.5%] and 8 [4%], respectively) was detected in 35 (17.5%) images from 27 (13.5%) patients. Examinations were performed for TMJ disorders in 24 patients. Participants with bilateral defects had the highest rates of presence of sounds and ear pain on the left and right sides (p < .05). CONCLUSION: Foramen tympanicum can lead to TMJ disorders and spread of tumours or infections from the external auditory canal to the infratemporal fossa. The increased prevalence of such disorders in patients with bilateral FT suggests an association between them.

Pain Patterns of the Temporomandibular Joint Dysfunction and Implications of Stress-Related Behaviors: A Pilot Study / Patrones de Dolor de la Disfunción de la Articulación Temporomandibular e Implicaciones de los Comportamientos Relacionados con el Estrés: Un Estudio Piloto

SUMMARY: Temporomandibular joint dysfunction interferes with the quality of life and activities of daily living among patients. The symptoms of temporomandibular dysfunction, including pain and clicking and popping sounds, are worsened during stressful events, and patients report increased pain around the temporomandibular joint. Stress-related behaviors, such as teeth clenching and teeth grinding, are commonly reported as increasing during stress. The prevalence of temporomandibular dysfunction and stress-related behaviors is reported differently in the literature. Stress in higher education is common. The purpose of this pilot study was to investigate the prevalence of temporomandibular joint dysfunction and stress-related behaviors among staff members at a local University. The study also sought to explore pain patterns described by people experiencing temporomandibular joint dysfunction and the relationship between stress-related behaviors and pain symptoms experienced. Further, the impact of stress on symptoms experienced by people with temporomandibular dysfunction was investigated in this pilot study.

La disfunción de la articulación temporomandibular interfiere con la calidad de vida y las actividades de la vida diaria entre los pacientes. Los síntomas de la disfunción temporomandibular, incluidos el dolor y los chasquidos, empeoran durante los eventos estresantes, y los pacientes informan un aumento del dolor alrededor de la articulación temporomandibular. Los comportamientos relacionados con el estrés, como apretar y rechinar los dientes, suelen aumentar durante el estrés. La prevalencia de la disfunción temporomandibular y los comportamientos relacionados con el estrés se informa de manera diferente en la literatura. El estrés en la educación superior es común. El propósito de este estudio piloto fue investigar la prevalencia de la disfunción de la articulación temporomandibular y los comportamientos relacionados con el estrés entre los miembros del personal de una universidad local. El objetivo del estudio además fue explorar los patrones de dolor descritos por personas que experimentan disfunción de la articulación temporomandibular y la relación entre los comportamientos relacionados con el estrés y los síntomas de dolor experimentados. Además, en este estudio piloto se investigó el impacto del estrés en los síntomas que experimentan las personas con disfunción temporomandibular.

Is low back pain a risk/prognostic factor for the development and/or progression of temporomandibular disorders? A systematic review with meta-analysis.

OBJECTIVES: To evaluate the association between low back pain (LBP) and painful temporomandibular disorders (TMDs). METHODS: Systematic review of observational studies. Searches were conducted using OVID MEDLINE, CINHAL, Web of Science and PUBMED databases up to 21 October 2022. Qualitative and quantitative analyses were performed. Risk of bias (RoB) was assessed using the Quality in Prognosis Studies tool (QUIPS). RESULTS: Eight studies were included in the present review with meta-analysis. The first onset of TMDs was more likely in patients with previous chronic LBP (hazard ratio (HR) 1.53 [95% confidence interval (CI): 1.28; 1.83, p < .00001]). In addition, patients with chronic LBP had 3.25 times the odds (OR) [95% CI: 1.94; 5.43, p < .00001] of having chronic TMDs than those who did not have chronic LBP. In addition, the higher the exposure to chronic LBP, the higher the risk of developing a first onset of TMDs. CONCLUSIONS: Chronic LBP can be considered a risk/contributing factor for painful TMDs. Although there is a high certainty in the evidence linking chronic LBP with the risk of a first onset of TMDs, there are insufficient studies to draw definitive conclusions. Furthermore, while an association between chronic LBP and chronic TMDs and a dose-effect was observed between these two conditions, a limited number of studies and evidence exist to support these findings. Future studies are needed to increase the body of evidence.

Constructing the brief diagnostic criteria for temporomandibular disorders (bDC/TMD) for field testing.

BACKGROUND: Despite advances in temporomandibular disorders' (TMDs) diagnosis, the diagnostic process continues to be problematic in non-specialist settings. OBJECTIVE: To complete a Delphi process to shorten the Diagnostic Criteria for TMD (DC/TMD) to a brief DC/TMD (bDC/TMD) for expedient clinical diagnosis and initial management. METHODS: An international Delphi panel was created with 23 clinicians representing major specialities, general dentistry and related fields. The process comprised a full day workshop, seven virtual meetings, six rounds of electronic discussion and finally an open consultation at a virtual international symposium. RESULTS: Within the physical axis (Axis 1), the self-report Symptom Questionnaire of the DC/TMD did not require shortening from 14 items for the bDC/TMD. The compulsory use of the TMD pain screener was removed reducing the total number of Axis 1 items by 18%. The DC/TMD Axis 1 10-section examination protocol (25 movements, up to 12 sets of bilateral palpations) was reduced to four sections in the bDC/TMD protocol involving three movements and three sets of palpations. Axis I then resulted in two groups of diagnoses: painful TMD (inclusive of secondary headache), and common joint-related TMD with functional implications. The psychosocial axis (Axis 2) was shortened to an ultra-brief 11 item assessment. CONCLUSION: The bDC/TMD represents a substantially reduced and likely expedited method to establish (grouping) diagnoses in TMDs. This may provide greater utility for settings requiring less granular diagnoses for the implementation of initial treatment, for example non-specialist general dental practice.

Therapies used for the management of myofascial temporomandibular disorders: bibliometric analysis / Terapias utilizadas para o manejo da disfunção temporomandibular de origem miofascial: análise bibliométrica

ABSTRACT BACKGROUND AND OBJECTIVES: Temporomandibular disorder (TMD) is the term used to describe a set of painful and functional conditions that can affect the temporomandibular joint (TMJ), the masticatory muscles and/or their associated structures. For myofascial TMD, conservative therapies, including drugs, physical therapy, occlusal splint and pain self-management show the best benefits to the patient. The objective of this study was to carry out, through a bibliometric analysis, a review of the existing knowledge regarding the treatments used in myofascial TMD. CONTENTS: The search was conducted in the Web of Science (WOS) and SCOPUS databases in July and updated in December 2023, through the MeSh descriptors "Temporomandibular Joint Dysfunction Syndrome" and "Therapeutics". Moreover, bibliometric mapping was performed using the VOSviewer software. For the analysis, data on the terms of the title and abstract, type of document, number of citations, name of journals, most cited article and year of publication were included. Besides these, the country of the corresponding author, type of treatment, type of study and the results were included in the analysis. Of the 760 articles identified, 63 were selected to compose this review. Of these, most were original articles, clinical trials and were published in 2012. The most frequent treatments were: occlusal splint, laser, manual therapy, botulinum toxin and dry needling. Of the 15 countries analyzed, Brazil was the country with the highest number of publications. CONCLUSION: There was an increase in articles published on the topic, with Brazil being the country with the highest number of publications. Finally, the most used treatments were occlusal splint and laser.

RESUMO JUSTIFICATIVA E OBJETIVOS: Disfunção temporomandibular (DTM) é um termo utilizado para descrever um conjunto de condições dolorosas e funcionais que podem afetar a articulação temporomandibular (ATM), os músculos mastigatórios e/ou suas estruturas associadas. Para DTM miofascial, terapias conservadoras, incluindo fármacos (analgésicos e/ou anti-inflamatórios), fisioterapia, placa oclusal e autogestão da dor apresentam os melhores benefícios para o paciente. O objetivo deste estudo foi abordar, através de uma análise bibliométrica, o conhecimento existente sobre os tratamentos utilizados na DTM de origem miofascial. CONTEÚDO: A busca foi realizada na base de dados Web of Science (WOS) e SCOPUS, em julho e atualização em dezembro de 2023, por meio dos descritores do MeSh "Temporomandibular Joint Dysfunction Syndrome" e "Therapeutics". Além disso, um mapeamento bibliométrico foi realizado no software VOSviewer. Para análise, foram incluídos dados sobre os termos do título e do resumo, tipo de documento, número de citações, nome dos periódicos, artigo mais citado e ano de publicação e, além destes, o país do autor correspondente, tipo de tratamento, tipo de estudo e resultados. Dos 760 artigos identificados, 63 foram selecionados para compor esta revisão. Destes, a maioria era artigos originais, ensaios clínicos e foram publicados em 2012. Os tratamentos mais frequentes foram: placa oclusal, laser, terapia manual, toxina botulínica e agulhamento a seco. Dos 15 países analisados, o Brasil foi o país com maior número de publicações. CONCLUSÃO: Houve um aumento de artigos sobre a temática publicados, sendo o Brasil o país com mais publicações e os tratamentos mais utilizados foram placa oclusal e laser.

Características miofuncionais orofaciais em adultos com disfunção temporomandibular crônica / Orofacial myofunctional characteristics in adults with chronic temporomandibular disorder

Objetivo: avaliar a condição miofuncional orofacial de indivíduos com disfunção temporomandibular, caracterizar o padrão de mastigação e investigar a relação entre a condição miofuncional orofacial e o desempenho nas funções de mastigação e deglutição. Materiais e métodos: foram analisados prontuários de participantes de um projeto de extensão interdisciplinar de odontologia e fonoaudiologia. A idade mínima para compor a amostra foi 18 anos. Os participantes haviam realizado exame odontológico e avaliação fonoaudiológica, com o protocolo de Avaliação Miofuncional Orofacial com Escores. Os resultados foram apresentados por distribuição absoluta,relativa e medidas de tendência central.Foram aplicados o teste t-student para amostras independentes e correlação de Pearson para avaliar associação. O nível de significância adotado foi 5%. As análises foram realizadas no IBM SPSS Statistics 21. Resultados: Dezessete prontuários integraram a amostra. A média de idade dos participantes foi 41,2 anos (±12,2),76,5% eram do sexo feminino. A média do escore total (AMIOFE) indicou condição miofuncional normal (92,5±5,14), porém da mastigação (7,94±1,60) e deglutição (13,1±1,17) revelam prejuízos funcionais. Não houve diferença significativa entre homens e mulheres no escore total (p=0,687), tampouco nas diferentes categorias avaliadas. Discussão:Os escores totais encontrados neste estudo, na mastigação e deglutição, estão de acordo com outras pesquisas realizadas e revelam alteração na função. Conclusão: as alterações funcionais orofaciais encontradas nos indivíduos com disfunção temporomandibular crônica deste estudo estão relacionadas com a condição miofuncional orofacial de uma maneira geral, e devem ser consideradas na elaboração de planos de tratamento, com o objetivo de proporcionar maior estabilidade aos resultados.

Aim: to evaluate the orofacial myofunctional condition of individuals with temporomandibular disorders, to characterize the mastication pattern and to investigate the relationship between the orofacial myofunctional condition and performance in mastication and swallowing functions. Materials and methods: medical records of participants in an interdisciplinary extension project in dentistry and speech therapy were analyzed. The minimum age to compose the sample was 18 years old. The participants had undergone a dental examination and speech-language pathology assessment, using the Orofacial Myofunctional Evaluation Protocol With Score protocol. Results were presented by absolute and relative distribution and measures of central tendency. Student's t-test for independent samples and Pearson's correlation were applied to assess association. The significance level adopted was 5%. Analyzes were performed using IBM SPSS Statistics 21. Results: seventeen medical records were part of the sample. The participants' mean age was 41.2 years (±12.2), 76.5% were female. The mean total score (OMES) indicated normal myofunctional condition (92.5±5.14), but mastication (7.94±1.60) and swallowing (13.1±1.17) revealed functional impairments. There was no significant difference between men and women in the total score (p=0.687), nor in the different categories evaluated. Discussion: The total scores found in this study, in mastication and swallowing, are in agreement with other studies carried out and reveal changes in function. Conclusion: functional variations found in subjects with chronic temporomandibular joint dysfunction in this study are related to general myofunctional orofacial disorder, and must be taken into consideration in treatment plans, with the aim of granting stability to the results.

Impacto das medidas de distanciamento social relacionadas à covid-19 em pacientes com disfunção temporomandibular / Impact of social distancing related to COVID-19 in patients with temporomandibular disorder

Aim: To evaluate the impact of the social distancing imposed by COVID-19 in the socioeconomic, familiar and health scope of the participants, as well as the relation of the gravity of the sign and symptoms of Temporomandibular disorder. Materials and methods: Two questionnaires were applied, one by telephone interview and the other virtual. The first asked about signs and symptoms of temporomandibular disorder and the second about behavior during the pandemic. Results: The sample was composed by 15 patients, mostly women who lived in Porto Alegre. 64,3% of the subjects declared there was a decrease in household income during this period. Concerning to difficulties found to access health service, make an appointment, and get health care, were the most cited, each pointed to 61,5% of the sample. The presence of anxiety and depression feelings were cited 64,3%. There was an increase in alcohol consumption during the pandemic as a decrease in the frequency of physical activity. Discussion: Several studies that were conducted during and after the pandemic, corroborate the findings that the social distancing cause negative repercussions in the mental health, socioeconomics situations and in the daily habits in the population from all over the world. Conclusion: With this study we could observed and analyzed how the patients who suffered with TMD faced the challenges proposed by the social distancing, due to COVID-19. We can conclude that the pandemic causes several negatives effects in most of the group.

Objetivo: Avaliar os impactos das medidas de distanciamento social impostas pelaCOVID-19 nas esferas socioeconômicas, familiar e de saúde dos participantes, bem como a relação com a gravidade dos sinais e sintomas de disfunção temporomandibular. Materiais e Métodos: Foram aplicados dois questionários sendo um por entrevista telefônica e outro virtual. O primeiro perguntava sobre sinais e sintomas da disfunção temporomandibular e o segundo sobre comportamento durante a pandemia. Resultados: A amostra foi composta por 15 pacientes, em sua maioria do sexo feminino e que residia na cidade de Porto Alegre. Desses, 64,3% dos entrevistados declararam que houve diminuição na renda familiar durante este período. Com relação às dificuldades encontradas para acesso aos serviços de saúde, a marcação de consultas e conseguir atendimento de saúde, foram as mais citadas, cada uma das dificuldades apontada por 61,5%. A presença de sentimentos de ansiedade e depressão foi citada por 64,3%. Houve aumento na ingestão de bebidas alcoólicas durante a pandemia, bem como diminuição da frequência de atividade física. Discussão: Diversos estudos realizados durante e após a pandemia, corroboram os achados de que o isolamento social causou repercussões negativas na saúde mental, nas situações socioeconômicas e nos hábitos diários da população em todo o mundo. Conclusão: Com este estudo conseguimos observar e analisar como os pacientes que sofrem com a disfunção temporomandibular enfrentaram os desafios propostos pelo isolamento social, decorrente da covid-19. Podemos concluir que a pandemia e o isolamento social causaram impactos negativos em grande parte do grupo em questão.

The prevalence of signs and symptoms of temporomandibular dysfunction in academics of a university center: association of emotional frameworks / A prevalência de sinais e sintomas de disfunção temporomandibular em acadêmicos de um centro universitário: associação de quadros emocionais

ABSTRACT BACKGROUND AND OBJECTIVES: Recent research has shown that undergraduate students are more susceptible to stressful situations due to the need to exercise various skills, and that this factor is a potential trigger for temporomandibular joint dysfunction (TMD) syndrome. In view of this, there is a need to highlight, through scientific studies, the fact that young students may be more vulnerable to the development of anxiety and stress, which is also associated with the incidence and/or development of bruxism and TMD. The present study's objective was to describe the intensity of symptoms of anxiety, depression and stress and to characterize the presence and severity of TMD symptoms in dentistry students. METHODS: The sample consisted of 118 students. All of them completed the Índice Anamnésico de Fonseca (Fonseca Anamnesis Index - IAF) questionnaire and the shortened version of the Depression, Anxiety and Stress Scale (DASS-21), which provide relevant information about the sample under investigation and allowed us to acquire epidemiological data about TMD symptoms, associated risk sources and repercussions on quality of life. The data was tabulated and categorized. Descriptive statistical analysis and linear association between the scales are presented. RESULTS: In response to the DASS-21, the three subscales showed that 51% of the individuals had some level of depression, 54% some degree of stress and 61% some level of anxiety. The presence of TMD symptoms was present in 67% of the sample. There was a linear association between the intensity of symptoms of the three subscales of the DASS-21 and the severity of symptoms according to the IAF. CONCLUSION: The information and results obtained in this study revealed a prevalence of signs of anxiety and TMD symptoms in dentistry students.

RESUMO JUSTIFICATIVA E OBJETIVOS: Pesquisas recentes alertam que acadêmicos do curso de graduação estão mais suscetíveis a situações de estresse devido à necessidade de exercer diversas habilidades, esse fator é um potencial desencadeador da síndrome da disfunção da articulação temporomandibular (DTM). Diante disso, surge a necessidade de evidenciar, mediante estudos científicos, o fato de que os estudantes jovens podem mostrar-se mais vulneráveis para o desenvolvimento de ansiedade e estresse, estando também associada a incidência e/ou desenvolvimento do bruxismo e da DTM. O objetivo deste estudo foi descrever a intensidade dos sintomas de ansiedade, depressão, estresse e caracterizar a presença e gravidade dos sintomas de DTM em acadêmicos de odontologia. MÉTODOS: A amostra foi de 118 acadêmicos. Todos preencheram o questionário e Índice Anamnésico de Fonseca (IAF) e a versão reduzida da Escala de Depressão, Ansiedade e Estresse (DASS-21), os quais fornecem informações relevantes sobre a amostra investigada e permitiu adquirir dados epidemiológicos acerca de sintomas de DTM, fontes de risco associadas e repercussão sobre a qualidade de vida. Os dados foram tabulados e categorizados. Apresenta-se a análise estatística descritiva e associação linear entre as escalas. RESULTADOS: Em resposta ao DASS-21, as três subescalas demonstraram que 51% dos indivíduos apresentam algum nível de depressão; 54% algum grau de estresse e 61% algum nível de ansiedade. A presença de sintomas de DTM está presente em 67% da amostra. Houve uma associação linear entre a intensidade dos sintomas das três subescalas da DASS-21 com a gravidade dos sintomas pelo IAF. CONCLUSÃO: As informações e resultados obtidos no presente estudo revelaram prevalência de sinais de ansiedade e sintomas de DTM em acadêmicos do curso de Odontologia.

Bruxismo y su asociación con la disfunción temporomandibular en niños. Revisión de literatura / Bruxism and its association with temporomandibular disorders in children. Literature review

Resumen Introducción: El bruxismo está definido como una actividad oral motora que consiste en el apretamiento o rechinamiento involuntario (rítmico o espasmódico no funcional) de los dientes, con una prevalencia de 5,9% a 49,6% en niños. Lo que podría contribuir a problemas clínicos asociados con la articulación temporomandibular. La asociación entre la disfunción temporomandibular (DTM) y el bruxismo en niños aún no está totalmente establecida. Objetivo: El objetivo de esta revisión de literatura es recopilar información actualizada de estudios que hayan abordado la asociación entre el bruxismo y la disfunción temporomandibular en niños de 3 a 12 años. Metodología: Se realizó una búsqueda en las bases de datos de Scopus, Pubmed y Scielo usando los descriptores "Niño", "Niños", "Preescolar", "Bruxismo", "Bruxismo del sueño", "Disfunción Temporomandibular"; y, "Síndrome de la Disfunción de Articulación Temporomandibular". Fueron incluidos artículos publicados en los últimos 15 años en idiomas español, inglés y portugués. Fueron incluidos estudios transversales, de cohorte, casos controles y ensayos clínicos aleatorizados. Resultados: Se evaluaron 242 artículos, de los cuales solo 11 fueron incluidos de acuerdo a los criterios de inclusión. Entre los estudios incluidos, dos de ellos no encontraron asociación entre DTM y bruxismo, tres encontraron una tendencia o probable asociación y seis encontraron una asociación positiva. Conclusiones: Existen estudios que relatan asociación entre el bruxismo y las disfunciones temporomandibulares en niños de 3 a 12 años, relacionando la presencia de signos y síntomas de la DTM con el bruxismo, pudiendo ser este último, un factor de riesgo para la presencia de DTM.

ABSTRACT Introduction: Bruxism is defined as an oral motor activity that consists of involuntary clenching or grinding (non-functional rhythmic or spasmodic) of the teeth, with a prevalence rate ranging from 5.9% to 49.6% in children, which could contribute to clinical problems associated with the temporomandibular joint. The association between bruxism in children and temporomandibular dysfunction (TMD) is not yet fully established. Objective: The objective of this literature review is to collect up-to-date information on studies that have addressed the association between bruxism and temporomandibular dysfunction in children ranging 3 - 12 years of age. Methods: A search was performed in the Scopus, PubMed and SciELO databases using the descriptors "Child", "Children", "Child, Preschool", "Bruxism", "Sleep Bruxism", "Temporomandibular Dysfunction" and "Temporomandibular Joint Dysfunction Syndrome." Articles published in the last 15 years in the Spanish, English and Portuguese languages were included. Results: A total of seventy-two articles were assessed. Only 11 articles were included according to the inclusion criteria. Among the included studies, two of them found no association between TMD and bruxism, three found a trend or probable association, and six found a positive association. Conclusion: There are studies that report an association between bruxism and temporomandibular dysfunctions in children ranging 3 - 12 years old, relating the presence of signs and symptoms of TMD with bruxism.

Predictive model for temporomandibular disorder in adolescents: Decision tree.

BACKGROUND: Temporomandibular disorders (TMD) do not only occur in adults but also in adolescents, with negative impacts on their development. AIM: To propose a predictive model for TMD in adolescents using a decision tree (DT) analysis and to identify groups at high and low risk of developing TMD in the city of Recife, PE, Brazil. DESIGN: This cross-sectional study was conducted in Recife on 1342 schoolchildren of both sexes aged 10-17 years. The analyses were performed using Pearson's chi-squared test and Fisher's exact test, as well as the CHAID algorithm for the construction of the DT. The SPSS statistical program was used. RESULTS: The prevalence of TMD was 33.2%. Statistically significant associations were observed between TMD and sex, depression, self-reported orofacial pain, and orofacial pain on clinical examination. The DT consisted of self-reported orofacial pain, orofacial pain on physical examination, and depression, with an overall predictive power of 73.0%. CONCLUSION: The proposed tree has a good predictive capacity and permits to identify groups at high risk of developing TMD among adolescents, such as those with self-reported orofacial pain or orofacial pain on examination associated with depression.

Repouso eletromiográfico dos músculos mastigatórios de pacientes com disfunção temporomandibular antes e após intervenção fonoaudiológica com e sem bandagem elástica / Electromyographic rest of the masticatory muscles of patients with temporomandibular disorders before and after speech therapy with and without elastic bandage / Resto electromiográfico de los músculos masticatorios de pacientes con trastornos temporomandibulares antes y después de logopedia con y sin venda elástica

Objetivo: A pesquisa tem por objetivo verificar os limiares de repouso eletromiográfico dos músculos masseter e temporal em pacientes com disfunção temporomandibular (DTM) antes e após intervenção fonoaudiológica com e sem a utilização de bandagem elástica terapêutica. Métodos: A coleta contou com 14 participantes do sexo feminino, com idade entre 18 e 40 anos, com diagnóstico de DTM muscular ou mista. As pacientes foram divididas entre dois grupos classificados em: pacientes com bandagem associada à terapia tradicional (CB) e grupo de terapia tradicional (SB). As pacientes inicialmente foram avaliadas pelo exame de eletromiografia de superfície nas situações de contração voluntária máxima e repouso, e após quatro semanas de intervenção, foi realizada nova avaliação com os mesmos instrumentos. A análise dos dados ocorreu de forma quantitativa e qualitativa. Resultados:No grupo SB o músculo masseter direito apresentou aumento dos valores de repouso com significância, foi observado que o mesmo ocorreu para todos os músculos deste grupo, influenciando no equilíbrio da musculatura ipsilateral e contralateral, no entanto sem evidência estatística. O grupo CB não demonstrou valores estatísticos significativos, porém qualitativamente os valores de repouso muscular diminuíram e equilibraram-se de forma contralateral. Conclusão: Não foram observadas mudanças estatisticamente significantes nos limiares eletromiográficos durante repouso dos músculos masseter e temporal em ambos os grupos. Qualitativamente houve aumento dos valores eletromiográficos após terapia manual tradicional em todos os músculos do grupo SB. Com relação ao grupo CB, houve diminuição dos valores do repouso eletromiográfico após terapia, embora sem evidências estatísticas. (AU)

Purpose: Objective: The research aims to verify the electromyographic rest thresholds of the masseter and temporal muscles in patients with temporomandibular disorders (TMD) before and after speech therapy intervention with and without the use of therapeutic elastic bandage. Methods: The collection included 14 female participants, aged between 18 and 40 years, who had a diagnosis of muscular or mixed TMD. The patients were divided into two groups: with traditional therapy (CB) bandage and traditional therapy (SB) only group. The patients underwent initial evaluation, as well as surface electromyography in situations of maximum voluntary contraction and rest and at the end of the four weeks of intervention, a new evaluation was performed with the same instruments. Data analysis occurred quantitatively and qualitatively. Results: In the SB group, the right masseter muscle showed a significant increase in resting values. It was observed that the same occurred for all muscles in this group, influencing the balance of the ipsilateral and contralateral muscles, although without statistical evidence. The CB group did not show statistically significant values, but qualitatively the muscle rest values decreased and balanced in a contralateral way. Conclusion: No statistically significant changes were observed in the resting electromyographic thresholds of the masseter and temporalis muscles in both groups. Qualitatively, there was an increase in electromyographic values after traditional manual therapy in all muscles in the SB group. Regarding the CB group, there was a decrease in electromyographic resting values after therapy, although without statistical evidence. (AU)

Objetivo: La investigación tiene como objetivo verificar los umbrales electromiográficos de reposo de los músculos masetero y temporal en pacientes con trastornos temporomandibulares (TMD) antes y después de la terapia del habla con y sin el uso de venda elástica terapéutica. Métodos: La colección incluyó a 14 participantes mujeres, con edades entre 18 y 40 años, diagnosticadas con TTM muscular o mixta. Los pacientes fueron divididos en dos grupos clasificados en: pacientes con vendaje asociado a terapia tradicional (CB) y grupo de terapia tradicional (SB). Los pacientes fueron inicialmente evaluados mediante electromiografía de superficie en situaciones de máxima contracción voluntaria y reposo, luego de cuatro semanas de intervención se realizó una nueva evaluación con los mismos instrumentos. El análisis de datos se llevó a cabo cuantitativa y cualitativamente. Resultados: En el grupo SB, el músculo masetero derecho presentó un aumento significativo en los valores de reposo, se observó que lo mismo ocurrió para todos los músculos de este grupo, influyendo en el equilibrio de los músculos ipsilaterales y contralaterales, sin embargo, sin evidencia estadística. El grupo CB no mostró valores estadísticamente significativos, pero cualitativamente los valores de descanso muscular disminuyeron y se equilibraron contralateralmente. Conclusión: No se observaron cambios estadísticamente significativos en los umbrales electromiográficos en reposo de los músculos masetero y temporal en ambos grupos. Cualitativamente, hubo un aumento de los valores electromiográficos después de la terapia manual tradicional en todos los músculos del grupo SB. En cuanto al grupo CB, hubo una disminución de los valores electromiográficos de reposo después de la terapia, aunque sin evidencia estadística. (AU)

Advanced mandibular reconstruction with fibular free flap and alloplastic TMJ prosthesis with digital planning.

INTRODUCTION: Resection of the mandible and temporomandibular joint (TMJ) without formal reconstruction is a devastating condition that negatively affects all aspects of the patient's life. We have approached the reconstruction of mandibular defects that include the condyle with simultaneous reconstruction with a vascularized free fibular flap (FFF) using Surgical Design and Simulation (SDS) and alloplastic TMJ prosthesis. The objective of this study is to report the functional and quality of life (QOL) outcomes in a cohort of patients that had undergone our reconstructive protocol. METHODS: This was a prospective case series of adult patients that underwent mandibular reconstruction with FFF and alloplastic TMJ prosthesis at the our center. Pre-operative and post-operative maximum inter-incisal opening (MIO) measurements were collected, and patients completed a QOL questionnaire (EORTC QLQ-H&N35) during those perioperative visits. RESULTS: Six patients were included in the study. The median patient age was 53 years. Heat map analysis of the QOL questionnaire revealed that patients reported a positive clinically significant change in the domains of pain, teeth, mouth opening, dry mouth, sticky saliva, and senses (relative change of 2.0, 3.3, 3.3, 2.0, 2.0, and 1.0 respectively). There were no negative clinically significant changes. There was a median perioperative MIO increase of 15.0 mm, and this was statistically significant (p = 0.027). CONCLUSIONS: This study highlights the complexities involved in mandibular reconstruction with involvement of the TMJ. Based on our findings, patients can obtain an acceptable QOL and good function following simultaneous reconstruction with FFF employing SDS and an alloplastic TMJ prosthesis.

Correlation between the event of the COVID-19 pandemic and symptoms of anxiety, depression and temporomandibular disorder in university students: cross-sectional study / Correlação entre o evento da pandemia de COVID-19 e sintomas de ansiedade, depressão e de disfunção temporomandibular em estudantes universitários: estudo transversal

ABSTRACT BACKGROUND AND OBJECTIVES: The COVID-19 pandemic has been shown to be a probable aggravator of psychological responses such as anxiety and depression. This study aimed to assess the correlation between symptoms of anxiety and depression during the COVID-19 pandemic and the existence of symptoms associated with temporomandibular dysfunction (TMD) in a Brazilian university population. METHODS: This epidemiological, cross-sectional clinical study evaluated its variables of interest using the COVID-19 Fear Scale, Hospital Anxiety and Depression Scale (HADS-A and HADS-D), Diagnostic Criteria for Temporomandibular Dysfunction (DC/TMD) and Oral Behavior Checklist (OBC) questionnaires. RESULTS: A total of 373 participants (females = 273) with a mean age of 23.8±5.45 years were included in this study. In addition, 78.2% of participants with anxiety symptoms and 54.5% of participants with depression symptoms reported a high level of TMD-related parafunction (p<0.01). The presence of anxiety symptoms increased the odds of developing intense fear of COVID-19 by 14.9 times (p<0.001) and the odds of developing moderate fear of COVID-19 by 3.5 times (p<0.001). The presence of an intense fear of COVID-19 increased the chances of developing anxiety symptoms by 17.15 times (p<0.001), while the presence of a moderate fear increased these chances by 3.12 times (p<0.001). In addition, the presence of intense (p=0.01) or moderate (p=0.018) COVID-19 fears increased the odds of developing TMD-related pain symptoms by 2.47 and 1.84 times, respectively, in this population. CONCLUSION: The presence of painful TMD symptoms was possibly influenced by fear of COVID-19. This, in turn, was related to the presence of anxiety and depression symptoms reported by the target population of this study.

RESUMO JUSTIFICATIVA E OBJETIVOS: A pandemia de COVID-19 mostrou-se um provável agravante de respostas psicológicas como ansiedade e depressão. Este estudo teve como objetivo avaliar a correlação entre sintomas de ansiedade e depressão durante o período da pandemia de COVID-19 e a existência de sintomas associados à disfunção temporomandibular (DTM) em uma população universitária brasileira. MÉTODOS: Este estudo clínico epidemiológico e transversal avaliou as suas variáveis de interesse por meio dos questionários Escala de Medo do COVID-19, Escala Hospitalar de Ansiedade e Depressão (HADS-A e HADS-D), Critérios Diagnósticos para Disfunção Temporomandibular (DC/DTM) e Checklist de Comportamentos Orais (OBC). RESULTADOS: Ao todo, 373 participantes (sexo feminino = 273), com média de idade de 23,8±5,45 anos foram incluídos neste estudo. Ademais, 78,2% dos participantes com sintomas de ansiedade e 54,5% dos participantes com sintomas de depressão reportaram alto nível de parafunção relacionada à DTM (p<0,01). A presença de sintomas de ansiedade aumentou em 14,9 vezes as chances de desenvolvimento de um quadro de medo intenso do COVID-19 (p<0,001) e de um quadro de 3,5 vezes nas chances de desenvolvimento de medo moderado do COVID-19 (p<0,001). A presença de um medo intenso do COVID-19 aumentou em 17,15 vezes as chances de desenvolvimento de sintomas de ansiedade (p<0,001), enquanto a presença de um medo moderado aumentou essas chances em 3,12 vezes (p<0,001). Ademais, a presença de medos intensos (p=0,01) ou moderados (p=0,018) do COVID-19 aumentou 2,47 e 1,84 vezes, respectivamente, as chances de desenvolvimento de sintomatologias dolorosas relacionadas à DTM nessa população. CONCLUSÃO: A presença dos sintomas dolorosos da DTM foi possivelmente influenciada pelo medo do COVID-19. Isso, por sua vez, esteve relacionado à presença de sintomas de ansiedade e de depressão, reportados pela população-alvo deste estudo.

Prevalence of Temporomandibular Disorders in Orthognathic Surgery patients: A systematic review conducted according to PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.

BACKGROUND: Orthognathic surgery is done to treat a variety of dentofacial abnormalities, but a wide gap still remains on how it can result in temporomandibular joint dysfunction (TMD). The primary goal of this review was to assess the effects of various orthognathic surgical techniques on the emergence or exacerbation of TMJ dysfunction. METHODS: A comprehensive search was conducted across several databases using Boolean operators and MeSH keywords related to temporomandibular joint disorders (TMDs) and orthognathic surgical interventions, with no limitation on the year of publication. Two independent reviewers screened the identified studies based on predetermined inclusion and exclusion criteria, followed by a risk of bias assessment using a standardised tool. RESULTS: Five articles were considered for inclusion in this review. A greater number of females opted for surgical options than their male cohorts. Three studies were of prospective design, 1 of retrospective and 1 of observational type. Mobility on lateral excursion, tenderness on palpation, arthralgia and popping sounds were the TMD characteristics that showed significant differences. Overall, orthognathic surgical intervention did not show an increase in TMD signs and symptoms as compared to nonsurgical counterparts. CONCLUSION: Though orthognathic surgery reported greater cases of some TMD symptoms and signs as compared to the nonsurgical cohorts in four studies, the conclusive evidence is debatable. Further studies are recommended with a longer follow-up period and greater sample size to determine the impact of orthognathic surgery on TMJ.

Experimental pain thresholds and psychosocial features across menstrual cycle in myofascial orofacial pain compared to healthy individuals: cross-sectional study / Limiares de dor experimental e características psicossociais ao longo do ciclo menstrual na dor miofascial orofacial em comparação com indivíduos saudáveis: estudo transversal

ABSTRACT BACKGROUND AND OBJECTIVES: The hormonal impact on pain perception during the menstrual cycle is a major focus of study, and further elucidation in temporomandibular disorders (TMD) field is necessary. Thus, this cross-sectional study evaluated experimental pain thresholds, psychosocial features, and clinical pain report on TMD women across menstrual cycle versus healthy controls. METHODS: A total of 220 women's clinical files were screened, with 80 selected and divided into control group (healthy individuals, n=40) and TMD group (myofascial pain, n=40). Regarding the menstrual cycle phases, the files were divided into Pre-Luteal and Luteal. The Perceived Stress Scale (PSS), Pain Catastrophizing Scale (PCS), Mechanical Pain Threshold (MPT), Wind-up (WUR), Pressure Pain Threshold (PPT), Conditioned Pain Modulation (CPM) and Visual Analogue Scale (VAS) were analyzed at a 5% significance level, by Two-Way ANOVA test and post hoc Tukey test. RESULTS: PSS and PCS were significantly different between TMD and control group (p<0.001), regardless of menstrual cycle. Healthy individuals in the Luteal phase presented higher MPT values compared to the other phases (p<0.001). PPT showed significant difference across menstrual phases (p=0.022), but no differences in multiple comparisons. VAS values showed no difference between menstrual cycle phases (p=0.376). CONCLUSION: Finally, healthy individuals in the Luteal phase have higher MPT and PPT values on the orofacial region. Pain report in patients with TMD showed no difference throughout the menstrual cycle, showing that small alterations on experimental pain thresholds may not be clinically relevant. The presence of chronic pain seems to be more related to psychosocial features than hormonal fluctuations.

RESUMO JUSTIFICATIVA E OBJETIVOS: O impacto do ciclo menstrual na percepção da dor é um foco importante de estudo, sendo necessária uma maior elucidação na disfunção temporomandibular (DTM). Assim, este estudo transversal avaliou limiares de dor experimental, características psicossociais e relatos de dor em mulheres com DTM ao longo do ciclo menstrual, comparadas com controles saudáveis. MÉTODOS: 220 prontuários de mulheres foram analisados, sendo 80 selecionados para os grupos de controle (saudáveis, n=40) e DTM (dor miofascial, n=40). Nas fases do ciclo menstrual, as pacientes foram divididas nas categorias Pré-Luteal e Luteal. Os instrumentos Escala de Estresse Percebido (PSS), Escala de Pensamentos Catastróficos (PCS), Limiar de Dor Mecânica (MPT), Wind-up Ratio (WUR), Limiar de Dor à Pressão (PPT), Modulação Condicionada da Dor (CPM) e Escala analógica visual (EAV) foram analisados com nível de significância de 5%, pelos testes ANOVA de dois fatores e Tukey post hoc. RESULTADOS: As escalas PSS e PCS foram significativamente diferentes entre os grupos DTM e controle (p<0,001), independentemente do ciclo menstrual. Indivíduos saudáveis na fase luteal apresentaram MPT maior em comparação com outras fases (p,0,001). O PPT mostrou diferença significativa entre as fases menstruais (p=0,022), sem diferença nas comparações múltiplas. Os valores da EAV não apresentaram diferença entre as fases menstruais (p=376). CONCLUSÃO: Indivíduos saudáveis na fase luteal têm MPT e PPTl maior na região orofacial. Os relatos de dor em pacientes com DTM não mostraram diferença ao longo do ciclo menstrual, indicando que pequenas alterações nos limiares experimentais podem ser clinicamente relevantes. A presença de dor crônica parece estar mais relacionada com características psicossociais do que com flutuações hormonais.