Increased pulsatility index of uterine artery Doppler between 26 and 28 weeks of gestation and adverse perinatal outcomes.

OBJECTIVE: To compare adverse perinatal outcomes in pregnant women with or without normalization of the mean pulsatility index (PI) uterine artery Doppler between 24 and 28 weeks of gestation. METHODS: Retrospective cohort which pregnant women were divided into three groups: normal uterine artery Doppler between 20-24 and 26-28 weeks (controls), abnormal uterine artery Doppler between 20-24 and normal between 26-28 weeks (anUtA), and abnormal uterine artery Doppler between 20-24 and 26-28 weeks (aaUtA). To compare adverse perinatal results between the groups Chi-square test was used. Binary logistic regression was used to assess the ability of uterine artery Doppler to predict birthweight < 10th and composite perinatal outcomes. RESULTS: Birthweight was significantly lower in the aaUtA compared to anUtA (2687 vs 3248 grams, p = 0.0479). A significant negative correlation was observed between the mean PI uterine artery Doppler during the 3rd trimester and birthweight (r = -0.13, R2 = 0.035, p = .0192). The prevalence of composite perinatal outcomes was significantly higher in aaUtA compared to anUtA (25.9 vs 0%, p = .013). Mean PI uterine artery Doppler during the 3rd trimester was significant predictor for birthweight < 10th (OR: 2.74, CI 95% = 1.03-7.3), but the protodiastolic notch and the association between mean PI uterine artery Doppler and protodiastolic notch were not. CONCLUSION: Maintenance of altered uterine artery Doppler during the 3rd trimester was associated with higher prevalence of composite perinatal outcomes and lower birthweight compared to its late normalization. Although modest, uterine artery Doppler in the 3rd trimester proved to be predictor of birthweight < 10th.

Abdomen agudo por torsión de masa anexial en tercer trimestre del embarazo, reporte de un caso y revisión de la literatura / Adnexal mass torsion as a cause of acute abdomen in the third trimester of pregnancy. Case report and review of the literature

Resumen INTRODUCCIÓN: Las masas anexiales en el embarazo son hallazgos fortuitos durante la gestación. Suelen diagnosticarse con la ecografía del primer trimestre. Su incidencia y curso clínico varían dependiendo de las semanas de embarazo. La complicación más común es la torsión con abdomen agudo. La incidencia de torsión va de 0.2 a 15%, con aumento durante el embarazo con masas de mayor tamaño. Son poco frecuentes durante el tercer trimestre del embarazo. Los cistoadenomas mucinosos son parte de los tumores epiteliales benignos más frecuentes del ovario; se consideran precursores de carcinomas mucinosos. CASO CLÍNICO: Paciente de 34 años, con antecedentes obstétricos de cuatro embarazos: dos partos y dos abortos, con 31 semanas de embarazo al ingreso al Hospital Universitario de la Samaritana de Colombia, justificado por un cuadro clínico de 18 horas de evolución consistente en: dolor abdominal intenso, tipo punzada, de predominio en la fosa iliaca y el flanco derechos. En la laparotomía se encontró un tumor ovárico con torsión, que se resecó. El estudio anatomopatológico reportó "tumor mucinoso de tipo endocervical con severos cambios por infarto". La evolución materno perinatal fue satisfactoria. CONCLUSIONES: El diagnóstico de torsión de masa anexial como causa de abdomen agudo en el tercer trimestre del embarazo es complejo pues requiere historia clínica, imágenes y estudios paraclínicos. El pronóstico materno-perinatal es bueno cuándo el tratamiento médico-quirúrgico es oportuno. Se requiere determinar el tipo de masa con estudios anatomopatológicos para continuar el tratamiento integral. El tumor mucinoso de ovario, tipo endocervical en masas torcidas de ovario, es raro.

Abstract BACKGROUND: Adnexal masses of pregnancy are incidental findings during pregnancy. They are usually diagnosed with first trimester ultrasound. Their incidence and clinical course vary depending on the weeks of pregnancy. The most common complication is torsion with acute abdomen. The incidence of torsion ranges from 0.2 to 15%, with an increase during pregnancy with larger masses. They are rare during the third trimester of pregnancy. Mucinous cystoadenomas are among the most frequent benign epithelial tumors of the ovary; they are considered precursors of mucinous carcinomas. CLINICAL CASE: 34-year-old female patient, with obstetric history of four pregnancies: two deliveries and two miscarriages, 31 weeks pregnant on admission to the Hospital Universitario de la Samaritana of Colombia, justified by a clinical picture of 18 hours of evolution consisting of: intense abdominal pain, stabbing type, predominantly in the right iliac fossa and flank. At laparotomy the torsion was found and resected. The anatomopathological study reported "mucinous tumor of endocervical type with severe infarction changes". Maternal perinatal evolution was satisfactory. CONCLUSIONS: The diagnosis of adnexal mass torsion as a cause of acute abdomen in the third trimester of pregnancy is complex as it requires clinical history, imaging and paraclinical studies. The maternal-perinatal prognosis is good when medical-surgical treatment is timely. It is necessary to determine the type of mass with anatomopathological studies to continue the integral treatment. Mucinous ovarian tumor, endocervical type in twisted ovarian masses, is rare.

Phase Entropy Analysis of Electrohysterographic Data at the Third Trimester of Human Pregnancy and Active Parturition.

Phase Entropy (PhEn) was recently introduced for evaluating the nonlinear features of physiological time series. PhEn has been demonstrated to be a robust approach in comparison to other entropy-based methods to achieve this goal. In this context, the present study aimed to analyze the nonlinear features of raw electrohysterogram (EHG) time series collected from women at the third trimester of pregnancy (TT) and later during term active parturition (P) by PhEn. We collected 10-min longitudinal transabdominal recordings of 24 low-risk pregnant women at TT (from 35 to 38 weeks of pregnancy) and P (>39 weeks of pregnancy). We computed the second-order difference plots (SODPs) for the TT and P stages, and we evaluated the PhEn by modifying the k value, a coarse-graining parameter. Our results pointed out that PhEn in TT is characterized by a higher likelihood of manifesting nonlinear dynamics compared to the P condition. However, both conditions maintain percentages of nonlinear series higher than 66%. We conclude that the nonlinear features appear to be retained for both stages of pregnancy despite the uterine and cervical reorganization process that occurs in the transition from the third trimester to parturition.

¿Qué hay en común entre el hígado graso agudo del embarazo y la preeclampsia? Subdiagnóstico clínico de alta mortalidad / What is in Common Between Acute Fatty Liver of Pregnancy and Preeclampsia? Highly Mortal Clinical Sub-Diagnosis / O que tem em comum o fígado gorduroso agudo da gestação e a pré-eclâmpsia? Subdiagnóstico clínico de alta mortalidade

Resumen: El hígado graso agudo del embarazo es una de las alteraciones hepáticas con mayor mortalidad (cerca del 18%) presentes en la gestación, aunque es una patología poco frecuente: 1 de cada 7000 a 16.000 embarazos presenta muchas complicaciones y requiere un manejo inmediato para evitar la muerte de la gestante o del feto; sin embargo esta patología se puede enmascarar con la preeclampsia, que es otra patología hepática de mayor frecuencia, lo cual retrasa el manejo y aumenta el número de complicaciones. El objetivo de este artículo es realizar una búsqueda bibliográfica acerca del hígado graso agudo del embarazo e identificar los factores similares entre esta patología y la preeclampsia severa para lograr hacer un diagnóstico y manejo oportunos. Para ello se realizó una búsqueda sistemática en las bases de datos, PubMed, Science Direct, Medline, Embase, en junio de 2017; además, se seleccionaron artículos originales, reportes de casos y artículos de revisión, publicados en los últimos diez años.

Abstract: Acute fatty liver of pregnancy (AFLP) is one of the liver disorders with the highest mortality rate (about 18%) during pregnancy, although it is rare: 1 in 7,000 to 16,000 pregnancies has many complications and requires immediate treatment to avoid the death of the pregnant woman or the fetus. However, this pathology can be masked by preeclampsia, which is another more frequent liver disease. This delays treatment and increases the number of complications. The aim of this article is to conduct a bibliographic search about AFLP and identify similar factors between this pathology and severe preeclampsia to make a diagnosis and provide treatment in a timely manner. For this, a systematic search was carried out in databases (PubMed, Science Direct, Medline, Embase) in June 2017. In addition, original articles, case reports, and review articles published in the last ten years were selected.

Resumo: O fígado gorduroso agudo da gestação é uma das alterações hepáticas com mais mortalidade (cerca de 18 %) presentes na gravidez, embora seja uma patologia pouco frequente: 1 de cada 7.000 a 16.000 gestações apresenta muitas complicações e requer uma ação imediata para evitar a morte da gestante ou do feto. Contudo, essa patologia pode ser camuflada com a pré-eclâmpsia, que é outra patologia hepática de maior frequência, o que atrasa seu tratamento e aumenta o número de complicações. Nesse sentido, o objetivo deste estudo é realizar uma busca bibliográfica sobre o fígado gorduroso agudo da gestação e identificar os fatores semelhantes entre ele e a pré-eclâmpsia grave para poder fazer um diagnóstico e tratamento oportunos. Para isso, foi realizada uma busca sistemática nas bases de dados, PubMed, Science Direct, Medline, Embase, em junho de 2017, das quais foram selecionados artigos originais, relatos de caso e artigos de revisão, publicados nos últimos dez anos.

Hemorragia de la Segunda Mitad del Embarazo en el Hospital Provincial General Docente Riobamba, Chimborazo, Ecuador 2017 - 2018 / Antepartum hemorrhage in the Hospital Provincial General Docente Riobamba, Chimborazo, Ecuador 2017 - 2018

Introducción: la hemorragia obstétrica es la segunda causa más frecuente de mortalidad materna en el Ecuador, a pesar de ello, es un tema que se ha estudiado poco a nivel provincial y nacional. Objetivo: determinar la ocurrencia e identificar los factores de riesgo, manifestaciones clínicas y comorbilidades más frecuentes de la hemorragia de la segunda mital del embarazo. Métodos: estudio descriptivo, transversal, donde se analizaron las historias clínicas de las pacientes obstétricas con hemorragia de la segunda mitad del embarazo atendidas en el Hospital Provincial General Docente Riobamba (HPGDR) entre junio 2017 y junio 2018. Resultados: de un total de 3 460 pacientes obstétricas atendidas, 0.49% (n = 17) cumplieron los criterios de hemorragia en la segunda mital del embarazo, las cuales tuvieron una edad media de 29 años (desviación estándar = 7), una edad gestacional media de 36 semanas (desviación estándar = 5) y en su mayoría fueron multíparas. El desprendimiento de placenta normoinserta fue la principal patología causante de la hemorragia y el dolor abdominal el principal síntoma manifestado, en la mayoría no se observó otras comorbilidades obstétricas. Conclusión: se observó una baja ocurrencia de hemorragia de la segunda mitad del embarazo en el HGDR entre junio 2017 y junio 2018, siendo la causa más frecuente el desprendimiento de placenta normoinserta y el principal mitivo de consulta dolor abdominal.

Introduction: obstetric hemorrhage is the second most frequent cause of maternal mortality in Ecuador. Nevertheless, the topic has been little studied at a local and national level. Objective: to determine the ocurrence and identify the most frequent risk factors, clinical manifestations and comorbilities in antepartum hemorrhage. Methods: it is a descriptive, cross-sectional study, in which clinical histories of obstetric patients with hemorrhage of the second half of pregnancy were analyzed in the Hospital Provincial General Docente Riobamba (HGPDR) between June 2017 and June 2018. Results: from 3 460 obstetric patients attended, 0.49% (n = 17) met antepartum hemorrhage criteria. Women were in average 29 years old (standard deviation = 7), had an average gestational age of 36 weeks (standard deviation = 5) and were multiparous. Detachment of normoinserta placenta was the main cause of bleeding, abdominal pain was the most frequent symptom reported and in the majority of cases no obstetric comorbilities were observed. Conclusions: it was observed a low ocurrence of hemorrhage of the second half of pregnancy in the HGDR between June 2017 and June 2018. The mots common cause of the patology was detachment of normoinserta placenta and the most frequent complain reported was abdominal pain.

Asociación entre la ansiedad materna y el parto pretérmino en Lima, Perú / Association between maternal anxiety and preterm delivery in Lima, Peru

Introducción: el parto pretérmino se define como el parto antes de las 37 semanas. Se han establecido diversos factores desencadenantes, entre los cuales se encuentra la ansiedad. En Perú se han realizado pocos estudios en relación con el tema. Objetivo: determinar la asociación entre la ansiedad materna durante el tercer trimestre de embarazo y el desarrollo de parto pretérmino. Métodos: estudio de tipo cohorte prospectiva realizado en un hospital público de Lima-Perú, que incluyó a 247 gestantes (enero de 2014 a enero de 2015). Se evaluó a gestantes entre las semanas 28 y 35 de embarazo, durante la visita prenatal. Los datos perinatales se obtuvieron del libro de partos y de la historia clínica materna. El instrumento utilizado para medir la ansiedad fue la encuesta State Trait Anxiety Inventori (STAI). El análisis de datos se realizó mediante STATA versión 11.1. Resultados: la mediana de edad de las participantes fue 27, 68,1 por ciento fueron convivientes y 58 por ciento tuvieron secundaria completa. Se encontró una incidencia de parto pretérmino de 11,6 por ciento. En el análisis multivariado ajustado, se encontró un riesgo relativo de 1,23 (IC 95 por ciento: 0,57-2,65) para ansiedad de estado y un riesgo relativo de 0,97 (IC 95 por ciento: 0,45-2,06) para ansiedad de rasgo. En el análisis bivariado se encontró una asociación significativa con preeclampsia. Conclusión: Se recomienda realizar más estudios longitudinales para establecer mejor la asociación ansiedad materna - parto pretérmino(AU)

Introduction: preterm delivery is defined as delivery before 37 weeks of gestational age. Several triggering factors have been established, anxiety being one of them. Few studies on the subject have been conducted in Peru. Objective: determine the association between maternal anxiety during the third trimester of pregnancy and preterm delivery. Methods: a prospective cohort study was conducted at a public hospital in Lima, Peru, from January 2014 to January 2015. The study sample consisted of 247 pregnant women of 28-35 weeks of pregnancy. Evaluation was performed during prenatal visits. Perinatal data were obtained from the labor and delivery registry and the patients' medical records. The tool used to measure anxiety was the survey State Trait Anxiety Inventory (STAI). Data were analyzed with STATA version 11,1. Results: mean age of participants was 27 years; 68,1 percent cohabitated with their partners, and 58 percent had completed high school. Preterm delivery had an incidence of 11,6 percent. Adjusted multivariate analysis revealed a relative risk of 1,23 (95 percent CI 0,57-2,65) for state anxiety and ,.97 (95 percent CI 0,45-2,06) for trait anxiety. Bivariate analysis found a significant association with preeclampsia. Conclusion: anxiety during the third trimester of pregnancy was found to be a risk factor for preterm delivery. It is recommended to perform other longitudinal studies to more clearly determine the association between maternal anxiety and preterm delivery(AU)

Assessment of ultrasound and Doppler parameters in the third trimester of pregnancy as predictors of adverse perinatal outcome in unselected pregnancies.

OBJECTIVES: The aim of the study was to investigate ultrasound and Doppler parameters in the third trimester of pregnancy as possible predictors of adverse perinatal outcome in unselected pregnancies. MATERIAL AND METHODS: We performed a retrospective cross-sectional study including unselected pregnant women be-tween 27 and 36 + 6 weeks of gestation. The following ultrasound and Doppler parameters were assessed: estimated fetal weight (EFW) [g], EFW percentile, placental maturity grade (Grannum classification), single vertical deepest pocket (SVDP) of amniotic fluid [cm], amniotic fluid index (AFI) [cm], mean uterine artery (UtA) pulsatility index (PI), umbilical artery (UA) PI, middle cerebral artery (MCA) PI, MCA peak systolic velocity (PSV) [cm/s], and cerebroplacental ratio (CPR). Adverse perinatal outcome was defined as Apgar score of < 7 at 1 min, birth weight of < 2500 g at delivery, and gestational age of < 37 weeks at delivery. The unpaired t test was used to compare the groups. RESULTS: AFI (p = 0.01), mean UtA PI (p = 0.04) and mean UA PI (p = 0.03) were significantly different with regard to the Apgar score at 1 min. EFW, EFW percentile, SVDP of amniotic fluid, AFI, mean UtA PI, UA PI, and MCA PI were significantly different (p < 0.001) in terms of birth weight. Placental maturity grade (p = 0.02), SVDP of the amniotic fluid (p < 0.001), AFI (p < 0.001), mean UtA PI (p < 0.001), UA PI (p = 0.001), and MCA PI (p < 0.001) were significantly different as far as gestational age at delivery is concerned. CONCLUSION: Ultrasound and Doppler parameters may predict adverse perinatal outcomes in unselected pregnancies in the third trimester of pregnancy.

[Anaesthetic management of patients in the third trimester of pregnancy undergoing urgent laparoscopic surgery. Experience in a general hospital]. / Cirugía laparoscópica de urgencia en el tercer trimestre de gestación y su manejo anestésico. Experiencia de un hospital general.

BACKGROUND: Laparoscopic surgery is well accepted as a safe technique when performed on a third trimester pregnant woman. OBJECTIVE: The aim is to describe the anaesthetic management of a group of patients undergoing this type of surgery. MATERIAL AND METHODS: An analysis was made of records of 6 patients in their third trimester of pregnancy and who underwent urgent laparoscopic surgery from 2011 to 2013. CLINICAL CASES: The study included 6 patients, with a diagnosis of acute cholecystitis in 4 of them. The other 2 patients had acute appendicitis, both of who presented threatened preterm labour. CONCLUSION: The most frequent indications for laparoscopic surgery during the last trimester of birth were found to be acute cholecystitis and acute appendicitis. Acute appendicitis is related to an elevated risk of presenting threatened preterm labour.

The impact of gestational diabetes and hypothyroidism on the third-trimester ultrasound parameters and in adverse perinatal outcomes: a retrospective cohort study.

OBJECTIVE: To assess the impact of gestational diabetes and hypothyroidism on the third-trimester ultrasound parameters and in adverse perinatal outcomes. METHODS: We performed a retrospective cohort study with 817 singleton pregnant women between 26w0d and 37w6d of gestation which were divided in four groups: 56 gestational diabetes mellitus (GDM), 63 hypothyroidism, 14 GDM + hypothyroidism, and 684 controls. The following ultrasound parameters were assessed: mean uterine artery pulsatility index (PI), umbilical artery PI, middle cerebral artery PI, single deepest pocket (SDP) and cerebroplacental ratio (CPR). Adverse perinatal outcomes were the following: low birth weight, macrosomia, and Agar score at 1st min <7. These four groups were compared using the Kruskall-Wallis and χ(2) tests. RESULTS: Pregnant women from GDM showed higher weight (p < 0.001), BMI (p < 0.001), SDP (p < 0.001) and newborns with higher birth weight (p = 0.008) and macrosomia (p = 0.02) than other groups. Comparing with control, hypothyroidism showed higher SDP (p < 0.05). CONCLUSION: Pregnant women with GDM showed higher risk of macrosomic newborns than other three groups. Both pregnant women with GDM and hypothyroidism showed higher SDP than normal pregnancies.