How does community health feature in Global Financing Facility planning documents to support reproductive, maternal, newborn, child and adolescent health and nutrition (RMNAH-N)? insights from six francophone West African countries.

BACKGROUND: Community health is key for improving Reproductive, Maternal, Newborn, Child, and Adolescent Health and Nutrition (RMNCAH-N). However, how community health supports integrated RMNCAH-N service delivery in francophone West Africa is under-researched. OBJECTIVE: We examined how six francophone West African countries (Burkina Faso, Côte d'Ivoire, Guinea, Mali, Niger, and Senegal) support community health through the Global Financing Facility for Women, Children and Adolescents (GFF). METHODS: We conducted a content analysis on Investment Cases and Project Appraisal Documents from selected countries, and set out the scope of the analysis and the key search terms. We applied an iterative hybrid inductive-deductive approach to identify themes for data coding and extraction. The extracted data were compared within and across countries and further grouped into meaningful categories. RESULTS: In country documents, there is a commitment to community health, with significant attention paid to various cadres of community health workers (CHWs) who undertake a range of preventive, promotive and curative roles across RMNCAH-N spectrum. While CHWs renumeration is mentioned, it varies considerably. Most community health indicators focus on CHWs' deliverables, with few related to governance and civil registration. Challenges in implementing community health include poor leadership and governance and resource shortages resulting in low CHWs performance and service utilization. While some countries invest significantly in training CHWs, structural reforms and broader community engagement are lacking. CONCLUSIONS: There is an opportunity to better prioritize and streamline community health interventions, including integrating them into health system planning and budgeting, to fully harness their potential to improve RMNCAH-N.

Main findings: Although community health is a key component of the Investment Cases and the Project Appraisal Documents of most of the six francophone West African countries studied, the level of investment varies considerably between countries, and mostly skewed to community health workers, with very little left over for broader community engagement and oversight processes.Added knowledge: The study describes community health actors, community health interventions and monitoring within a global health initiative, how they fit into the wider health system, the challenges and weaknesses they face and the measures taken to mitigate them, and how they are budgeted.Global health impact for policy and action: There is a need to adopt a holistic community health systems approach, rather than one focused mainly on CHWs, to fully harness community health's potential to improve reproductive, maternal, newborn, child, and adolescent health and nutrition.

Genetic profile of progressive myoclonic epilepsy in Mali reveals novel findings.

Background and objectives: Progressive myoclonic epilepsy (PME) is a group of neurological disorders characterized by recurrent myoclonic seizures with progressive neurological deterioration. We investigated the genetics of three unrelated patients with PME from Mali, a country in sub-Saharan Africa highly underrepresented in genetic and genomic research. Methods: Participants were carefully examined and phenotyped. DNA was obtained for genetic analysis including whole exome sequencing (WES). In silico prediction tools and ACMG criteria were used to assess the deleteriousness of putative candidate variants. Results: Pedigree analysis suggests autosomal recessive inheritance patterns for one family and sporadic forms of PME for the two other cases. WES identified novel homozygous missense variants in all the three patients, one each for NHLRC1, EPM2A, and NEU1. The sequence variants segregated with PME in each family and in silico studies including protein 3D structures, CADD scores and ACMG criteria suggested that they were damaging. Discussion: PME is a group of clinically heterogeneous neurological disorders. Most reported cases in the literature are from European background with only a few cases described in North Africa. We report here novel pathogenic variants in three different genes causing PME phenotypes in three unrelated Malian patients, suggesting that genetic studies of underrepresented populations may expand the genetic epidemiology of PME. These findings also emphasize the need for inclusive genetic research to ensure a more targeted diagnostic and therapeutic approaches for diverse patient populations.

Digital Interventions for Managing Medication and Health Care Service Delivery in West Africa: Systematic Review.

BACKGROUND: As a result of the recent advancements in technology, the incorporation of digital interventions into the health care system has gained a lot of attention and adoption globally. However, these interventions have not been fully adopted, thereby limiting their impact on health care delivery in West Africa. OBJECTIVE: This review primarily aims at evaluating the current digital interventions for medication and health care delivery in West Africa. Its secondary aim is to assess the impacts of digital interventions in managing medication and health care service delivery with the intent of providing vital recommendations that would contribute to an excellent adoption of digital intervention tools in the health care space in West Africa. METHODS: In line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), a comprehensive search through various databases yielded 529 results. After a rigorous screening, 29 articles that provided information on 3 broad digital health intervention tools were found eligible for this review. RESULTS: Out of 29 studies, 16 (55%) studies examined phone-based interventions, 9 (31%) studies focused on tele- and e-based interventions, and 4 (14%) studies evaluated digital interventions. These interventions were used for diverse purposes, some of which are monitoring adverse drug reactions, general health, sexual and reproductive health, and training of health care practitioners. The phone-based intervention appears to be the most known and impactful of all the interventions, followed by tele- and e-based, while digital interventions were scarcely used. CONCLUSIONS: Digital interventions have had a considerable level of impact on medication and health care delivery across West Africa. However, the overall impact is limited. Therefore, strategies must be developed to address the challenges limiting the use of digital intervention tools so that these tools can be fully incorporated into the health care space in West Africa.

A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT).

The SARS-CoV-2 pandemic ignited global efforts to rapidly develop testing, therapeutics, and vaccines. However, the rewards of these efforts were slow to reach many low- to middle-income countries (LMIC) across the African continent and globally. Therefore, two bead-based multiplexed serological assays were developed to determine SARS-CoV-2 exposure across four counties in Liberia. This study was conducted during the summer of 2021 on 189 samples collected throughout Grand Bassa, Bong, Margibi, and Montserrado counties. Our multiplexed immunoassay (MIA) detected elevated exposure to SARS-CoV-2 and multiple variant antigens. Additionally, we detected evidence of exposure to Dengue virus serotype 2, Chikungunya virus, and the seasonal coronavirus NL63. Our multiplexed inhibition test (MINT) was developed from the MIA to observe antibody-mediated inhibition of SARS-CoV-2 spike protein binding to its cognate cellular receptor ACE-2. We detected inhibitory antibodies in the tested Liberian samples, which were collectively consistent with a convalescent serological profile. These complementary assays serve to supplement existing serological testing needs and may enhance the technical capacity of scientifically underrepresented regions globally.

The main forest species encountered in southern and central Benin, West Africa.

Background: The south of Benin, a country in West Africa, is still home to remnants of dense forests that benefit from a particularly rainy sub-equatorial climate, with annual rainfall of up to 1,200 mm. These forest ecosystems are an integral part of the West African forest block, which stretches from Liberia to Togo. However, despite their richness and ecological importance, these forests are unfortunately subject to strong human pressures, particularly from slash-and-burn agriculture, intensive logging and the growing urbanisation of coastal areas. Preserving these forests is crucial, however, as they are home to remarkable plant and animal biodiversity, with many endemic species. What's more, these forests play an essential role in regulating the local climate, protecting soil and water resources, as well as providing local populations with a vital source of energy wood, non-timber forest products and support for their traditional agricultural practices. Faced with these conservation challenges, identifying and characterising the main tree species found in the forests of southern and central Benin, forest species and their ecology is an essential prerequisite for implementing sustainable management and restoration strategies for these threatened forest ecosystems in southern Benin. This work aims to identify and draw attention to the different forest species, specially tree forest species present in southern and central Benin. New information: The dataset provides information on forest species found in southern and central Benin, West Africa. This dataset is extremely useful for forestry research, as it focuses mainly on the various forest species of major importance. It can be used as a basis for characterising individuals or populations of species, based on their abundance in relation to anthropogenic pressure and changes in environmental conditions.These species are characteristic of forests and, above all, are of particular interest both to populations and to managers of protected areas. Field collections were initiated in 2007 as part of natural forest inventory work. The data collected have been completed by various field works that followed this work on forest species in southern Benin. The latest version of the dataset is publicly and freely accessible on the GBIF website at the address https://www.gbif.org/dataset/aff3a10a-a86b-4eff-98e4-d63f92fd6f7e.It should be noted that the fact that the collection and monitoring were carried out in southern Benin, a region known for its great diversity of species, over a period of 10 years making these data particularly relevant information to study the effects of climate change and human pressure on ecosystems in this area.

Genetic investigation of population structure in Atlantic chub mackerel, Scomber colias Gmelin, 1789 along the West African coast.

Sustainable management of transboundary fish stocks hinges on accurate delineation of population structure. Genetic analysis offers a powerful tool to identify potential subpopulations within a seemingly homogenous stock, facilitating the development of effective, coordinated management strategies across international borders. Along the West African coast, the Atlantic chub mackerel (Scomber colias) is a commercially important and ecologically significant species, yet little is known about its genetic population structure and connectivity. Currently, the stock is managed as a single unit in West African waters despite new research suggesting morphological and adaptive differences. Here, eight microsatellite loci were genotyped on 1,169 individuals distributed across 33 sampling sites from Morocco (27.39°N) to Namibia (22.21°S). Bayesian clustering analysis depicts one homogeneous population across the studied area with null overall differentiation (F ST = 0.0001ns), which suggests panmixia and aligns with the migratory potential of this species. This finding has significant implications for the effective conservation and management of S. colias within a wide scope of its distribution across West African waters from the South of Morocco to the North-Centre of Namibia and underscores the need for increased regional cooperation in fisheries management and conservation.

Coronavirus awareness, prevention, and household hardship survey data for the CHAMPS HDSS network: Data collected between August and September of 2022 from the Bamako HDSS, Mali.

Data were gathered through a collaborative initiative to investigate impacts of the COVID-19 pandemic and related lockdowns on child and maternal health, economic hardships, and access to care for children and pregnant women by the Child Health and Mortality Prevention Surveillance (CHAMPS) Network. The data were gathered in Bamako, the capital city of Mali (population ∼2.9 million) between August and September of 2022 through a Health and Demographic Surveillance System (HDSS). Data collectors used a survey instrument specifically designed to measure household awareness, knowledge, and prevalence of COVID-19, as well as hardships that households experienced since the onset of the pandemic in March of 2020. The data are from two neighborhoods of Bamako, Banconi and Djicoroni; the Health and Demographic Surveillance System (HDSS) operating in these neighborhoods tracks the health of approximately 235,000 inhabitants. The data were collected using a stratified random sample of 454 households.

On the partial impact of uncertainties on the nexus between macroeconomic fundamentals in West Africa.

We investigate the degree of interconnectedness between stock returns and exchange rate returns, and the influence of some selected global uncertainty indices on such a relationship within a time-frequency domain in West Africa through the bi and partial wavelet approaches. The analysis was based on monthly observations from February 2013 to June 2023. The results highlight a negative correlation between stock return and exchange rates. The partial wavelet analysis evidence a significant effect of the global economic policy uncertainty, the implied oil market volatility, and the United States volatility index in driving the co-movements observed in the currency and stock markets. We also find a significant impact of the stock market on the currency market, underscoring the need for robust stock market policies. It is recommended that policymakers prioritize strategies aimed at boosting stock market stability and depth which can positively affect the currency markets. The significant influence of global uncertainties or shocks should not be disregarded in the formulation of policies regarding exchange rates and stock return integration at various investment horizons.

Trends in Dermatological Diagnoses During Covid-19 Pandemic in Nigeria: A Retrospective Study.

INTRODUCTION: Coronavirus disease (COVID-19) quickly became a pandemic causing a global concern affecting public health directly and indirectly. Dermatology outpatient services were not an exception to the impact of COVID-19, especially in Sub-Saharan Africa. To the best of our knowledge, no similar study has been done in this region, and identifying patterns of dermatological diseases would help prepare adequately for future crises. OBJECTIVE: This study examined the changes in diagnostic patterns at the dermatology clinic before the COVID-19 pandemic and during the pandemic. METHODS: This retrospective study was conducted on dermatology outpatients seen at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. Diagnoses were compared during the pandemic (March to August 2020) with the corresponding period of the previous year. RESULTS: A total of 534 patients with 559 diagnoses were included. The average weekly dermatology clinic visits remained unchanged during the pandemic, although there was a 25.8% reduction in dermatology outpatients. The most common reasons for visiting the outpatient clinic during the COVID-19 pandemic were acne vulgaris, scabies, atopic dermatitis, dermatophytosis, and pityriasis versicolor. While the percentage of scabies significantly decreased during the pandemic; the percentage of allergic contact dermatitis, prurigo nodularis, candidiasis, hemangioma, and lupus erythematosus increased respectively. CONCLUSION: Although the COVID-19 pandemic had a negligible impact on the average weekly number of skin clinic visits, it caused a change in diagnostic patterns. Understanding the pattern of skin diagnoses may help hospitals better prepare for future pandemics.

INTRODUCTION: La maladie à coronavirus (COVID-19) est rapidement devenue une pandémie suscitant une préoccupation mondiale, affectant directement et indirectement la santé publique. Les services ambulatoires de dermatologie n'ont pas échappé à l'impact du COVID-19, en particulier en Afrique subsaharienne. À notre connaissance, aucune étude similaire n'a été réalisée dans cette région, et l'identification des tendances des maladies dermatologiques permettrait de se préparer adéquatement pour les crises futures. OBJECTIF: Cette étude a examiné les changements dans les tendances diagnostiques à la clinique de dermatologie avant et pendant la pandémie de COVID-19. MÉTHODES: Cette étude rétrospective a été menée sur des patients ambulatoires de dermatologie vus à l'hôpital universitaire d'enseignement Nnamdi Azikiwe, Nnewi, au Nigeria. Les diagnostics ont été comparés pendant la pandémie (mars à août 2020) avec la période correspondante de l'année précédente. RÉSULTATS: Un total de 534 patients avec 559 diagnostics ont été inclus. Le nombre moyen de consultations hebdomadaires à la clinique de dermatologie est resté inchangé pendant la pandémie, bien qu'il y ait eu une réduction de 25,8 % des patients ambulatoires de dermatologie. Les raisons les plus courantes de consulter la clinique ambulatoire pendant la pandémie de COVID-19 étaient l'acné vulgaire, la gale, la dermatite atopique, la dermatophytose et le pityriasis versicolor. Alors que le pourcentage de gale a diminué de manière significative pendant la pandémie, le pourcentage de dermatite de contact allergique, de prurigo nodulaire, de candidose, d'hémangiome et de lupus érythémateux a augmenté respectivement. CONCLUSION: Bien que la pandémie de COVID-19 ait eu un impact négligeable sur le nombre moyen hebdomadaire de consultations à la clinique de dermatologie, elle a entraîné un changement dans les tendances diagnostiques. Comprendre les tendances des diagnostics de peau peut aider les hôpitaux à mieux se préparer pour les futures pandémies. MOTS CLÉS: COVID-19, patients ambulatoires de dermatologie, diagnostics dermatologiques, Afrique de l'Ouest, Nigeria, tendances.

Effectiveness of lifestyle interventions for glycaemic control among adults with type 2 diabetes in West Africa: a systematic review and meta-analysis protocol.

BACKGROUND: Lifestyle interventions are key to the control of diabetes and the prevention of complications, especially when used with pharmacological interventions. This protocol aims to review the effectiveness of lifestyle interventions in relation to nutrition and physical activity within the West African region. This systematic review and meta-analysis seeks to understand which interventions for lifestyle modification are implemented for the control of diabetes in West Africa at the individual and community level, what evidence is available on their effectiveness in improving glycaemic control and why these interventions were effective. METHODS: We will review randomised control trials and quasi-experimental designs on interventions relating to physical activity and nutrition in West Africa. Language will be restricted to English and French as these are the most widely spoken languages in the region. No other filters will be applied. Searching will involve four electronic databases - PubMed, Scopus, Africa Journals Online and Cairn.info using natural-language phrases plus reference/citation checking. Two reviewers will independently screen results according to titles and abstracts against the inclusion and exclusion criteria to identify eligible studies. Upon full-text review, all selected studies will be assessed using Cochrane's Collaboration tool for assessing the risk of bias of a study and the ROBINS-I tool before data extraction. Evidence will be synthesised narratively and statistically where appropriate. We will conduct a meta-analysis when the interventions and contexts are similar enough for pooling and compare the treatment effects of the interventions in rural to urban settings and short term to long term wherever possible. DISCUSSION: We anticipate finding a number of studies missed by previous reviews and providing evidence of the effectiveness of different nutrition and physical activity interventions within the context of West Africa. This knowledge will support practitioners and policymakers in the design of interventions that are fit for context and purpose within the West African region. SYSTEMATIC REVIEW REGISTRATION: This systematic review has been registered in the International Prospective Register for Systematic Reviews - PROSPERO, with registration number CRD42023435116. All amendments to this protocol during the process of the review will be explained accordingly.

Microplastic dynamics and risk projections in West African coastal areas: Developing a vulnerability index, adverse ecological pathways, and mitigation framework using remote-sensed oceanographic profiles.

Microplastic pollution presents a serious risk to marine ecosystems worldwide, with West Africa being especially susceptible. This study sought to identify the key factors driving microplastic dynamics in the region. Using NASA's Giovanni system, we analyzed environmental data from 2019 to 2024. Results showed uniform offshore air temperatures due to turbulence (25.22-45.62 K) with significant variations nearshore. Salinity levels remained largely stable (4 PSU) but slightly decreased in southern Nigeria. Surface wind speeds rose from 4.206-5.026 m/s in Nigeria to over 5.848 m/s off Mauritania, while eastward stress hotspots were prominent in Nigeria and from Sierra Leone to Senegal. Photosynthetically available radiation (PAR) beam values peaked off Mauritania and dipped from Nigeria to Sierra Leone, with the inverse pattern observed for diffuse PAR. Hotspots of high absorption, particulate backscattering, elevated aerosol optical depth, and remote sensing reflectance all pointed to substantial particulate matter concentrations. The Microplastic Vulnerability Index (MVI) identifies the coastal stretch from Nigeria to Guinea-Bissau as highly vulnerable to microplastic accumulation due to conditions that favor buildup. In contrast, moderate vulnerability was observed from Guinea-Bissau to Senegal and in Mauritania, where conditions were less extreme, such as higher offshore temperatures that could promote widespread microplastic suspension and cooler nearshore temperatures that favor sedimentation. Increased turbulence and temperatures in coastal areas of Senegal and Mauritania may enhance microplastic transport and impact marine life. In Nigeria, stable coastal conditions-characterized by consistent temperatures, low turbulence, and uniform salinity-may lead to increased persistence and accumulation of microplastics in sensitive habitats like mangroves and coral reefs. These findings highlight the need for region-specific management strategies to address microplastic pollution and effectively protect marine ecosystems.

Assessing greywater characteristics in the sahel region and perception of the local population on its reuse in agriculture.

Research on greywater reuse in water stressed areas is in full swing. However, the perception of greywater reuse is one of the least researched areas in West Africa, particularly in Sahelian countries. This study aimed to fills a significant gap in the existing literature, which has largely ignored the specific socio-demographic contexts of developing countries in the Sahelian regions. The study involved in-depth interviews with 240 rural households and the collection of 40 greywater samples in four locations for laboratory analysis. The survey focused on greywater management and household perceptions of greywater reuse in agriculture. The analyses focused on determining the physico-chemical and microbiological parameters of greywater collected from households. The results showed that over 80 % of households discharged greywater into the natural environment without prior treatment. The majority of respondents were aware that poor greywater management poses a health risk. The results also showed an association between locality, gender, education level and perceptions of poor grey water management. Respondents were willing to accept the reuse of greywater in agriculture, to consume irrigated vegetables and to install a greywater treatment system. The quality analysis showed that the greywater was not in compliance with the legal discharge limits. This study highlights that in order to promote sustainable greywater management practices within households, it is important to design effective greywater treatment systems that meet the needs of the target population. Awareness campaigns, education and training programmes on wastewater management could also be established.

Prevalence of hepatitis and HIV infection among 18-months old children in Guinea-Bissau before vaccination.

OBJECTIVES: This study reports on the prevalence of hepatitis B virus (HBV) in children in Guinea-Bissau before the hepatitis B vaccine was introduced. METHODS: Cross-sectional study. From 2005 to 2008, 187 children aged 18 months were enrolled in a vaccine trial and had blood samples taken to test for HBV (HbsAg, anti-HBs and anti-HBc), hepatitis C virus (HCV) and HIV. RESULTS: HBsAg prevalence was 11.2% and prevalence of any HBV serological marker was 16.0%. No children were positive for HCV. One was positive for HIV-1. CONCLUSIONS: The prevalence of HBsAg was high compared to other sub-Saharan African countries pre-immunisation, underscoring the importance of broad and sustained HBV vaccination. This study indicates that the majority of HBV transmission is horizontal during childhood in Guinea-Bissau.

In Silico Screening of Phytocompounds from West African Traditional Medicine and Molecular Docking Targeting Dengue Virus Protein NS2B/NS3.

Traditional medicine offers a wide range of application for in silico study techniques. This drug research and development strategy is embryonic in the West African context, particularly in Burkina Faso, which is increasingly faced with emerging diseases such as dengue fever. Circulation of the 4 serotypes of this virus has been documented in the country. This study aims to evaluate the therapeutic potential of phytocompounds contained in the West African pharmacopoeia against dengue virus NS2B/NS3 protein, using computational methods integrating several software packages and databases. Based on a literature review, we identified 191 molecules from 30 plants known for their antiviral effects. Five met the inclusion criteria for molecular docking: patulin from calotropis procera, resiniferonol from Euphorbia poissonii, Securinol A from Flueggea virosa, Shikimic acid and Methyl gallate from Terminalia macroptera. The best binding scores were observed between resiniferonol and the serotypes 1, 2 and 4 NS2B/NS3 protease, with binding energies of -7.4 Kcal/mol, -6.8 Kcal/mol and -7.3 Kcal/mol respectively; while the NS2B/NS3 protease of serotype 3 had the best affinity for securinol A (-7 Kcal/mol). This study points the way to further research in computer aided drug design field and calls for multidisciplinary collaboration to promote West African medicinal plants against health challenges.

Erratum: Livestock feed resources used as alternatives during feed shortages and their impact on the environment and ruminant performance in West Africa: a systematic review.

[This corrects the article DOI: 10.3389/fvets.2024.1352235.].

Climate change and health in the Sahel: a systematic review.

The Sahel region is projected to be highly impacted by the more frequent hazards associated with climate change, including increased temperature, drought and flooding. This systematic review examined the evidence for climate change-related health consequences in the Sahel. The databases used were Medline (PubMed), Embase (Ovid), Web of Science (Clarivate) and CABI Global Health. Hand searches were also conducted, which included directly engaging Sahelian researchers and hand-searching in the African Journals Online database. Of the 4153 studies found, 893 were identified as duplicates and the remaining 3260 studies were screened (title and abstract only) and then assessed for eligibility. A total of 81 studies were included in the systematic review. Most studies focused on vector-borne diseases, food security, nutrition and heat-related stress. Findings suggest that mosquito distribution will shift under different climate scenarios, but this relationship will not be linear with temperature, as there are other variables to consider. Food insecurity, stunting (chronic malnutrition) and heat-related mortality are likely to increase if no action is taken owing to the projected impact of climate change on environmental factors and agriculture. Seventy-one per cent of manuscripts (n = 58) had first authors from institutions in North America or Europe, of which 39.7% (n = 23) included co-authors from African institutions.

Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG.

The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudoviruses (PSV) was developed and envelope coreceptor usage, neutralization sensitivity and cross-clade reactivity were characterized. These PSV were neutralized by some antibodies targeting major neutralizing determinants, but potentially important differences were observed in specific sensitivities (eg. to sCD4, MPER and V2/V3 monoclonal antibodies), as well as in properties such as variable loop lengths, number of potential N-linked glycans and charge, demonstrating distinct antigenic characteristics of CRF02_AG and subtype G. There was preferential neutralization of the matched CRF/subtype when PSV from subtype G or CRF02_AG were tested using pooled plasma. These novel Nigerian PSV will be useful to study HIV-1 CRF- or subtype-specific humoral immune responses for subtype G and CRF02_AG.

Surveillance of Antimicrobial Resistance in the ECOWAS Region: Setting the Scene for Critical Interventions Needed.

Antimicrobial resistance poses a significant challenge to public health globally, leading to increased morbidity and mortality. AMR surveillance involves the systematic collection, analysis, and interpretation of data on the occurrence and distribution of AMR in humans, animals, and the environment for action. The West African Health Organization, part of the Economic Community of West African States (ECOWAS), is committed to addressing AMR in the region. This paper examines the status of AMR surveillance in ECOWAS countries using available WHO data from the TrACSS survey and GLASS enrollments. The analysis reveals that while progress has been made, significant challenges remain. Twelve of the fifteen ECOWAS countries are enrolled in GLASS, and ten have developed national action plans (NAPs) for AMR. However, there is a need to ensure all countries fully implement their NAPs, continue reporting to GLASS, and use the data for evidence-based actions and decision making. Surveillance systems for AMR and antimicrobial consumption/use vary across countries with some demonstrating limited capacity. All countries, except Cabo Verde, reported having a reference laboratory for AMR testing. Strengthening laboratory capabilities, data management and use, and multisectoral coordination are crucial for effective AMR surveillance and response. Based on the findings and the regional context, it is essential to prioritize capacity building, data utilization, and the adoption of standardized guidelines for AMR surveillance. Collaboration among ECOWAS countries, the WAHO, and international partners is essential to address AMR comprehensively. Ensuring a consistent supply of essential antimicrobial medications and reagents is vital.

Cellular immune response to SARS-CoV-2 and clinical presentation in individuals exposed to endemic malaria.

Ghana and other parts of West Africa have experienced lower COVID-19 mortality rates than other regions. This phenomenon has been hypothesized to be associated with previous exposure to infections such as malaria. This study investigated the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influence of previous malaria exposure. Blood samples were collected from individuals with asymptomatic or symptomatic COVID-19 (n = 217). A variety of assays were used to characterize the SARS-CoV-2-specific immune response, and malaria exposure was quantified using Plasmodium falciparum ELISA. The study found evidence of attenuated immune responses to COVID-19 among asymptomatic individuals, with elevated proportions of non-classical monocytes and greater memory B cell activation. Symptomatic patients displayed higher P. falciparum-specific T cell recall immune responses, whereas asymptomatic individuals demonstrated elevated P. falciparum antibody levels. Summarily, this study suggests that P. falciparum exposure-associated immune modulation may contribute to reduced severity of SARS-CoV-2 infection among people living in malaria-endemic regions.

Livestock feed resources used as alternatives during feed shortages and their impact on the environment and ruminant performance in West Africa: a systematic review.

Ruminant feed is a major problem for the livestock sector in West African developing countries causing animal nutritional diseases, reducing ruminant production, and creating a massive ecological crisis through greenhouse gas emissions. Alternative feeds, which include agro-industrial by-products, fodder trees, crop residues, insects, fodder legumes, algae, and pulses, constitute enormous feed resources for livestock in Africa. This study was conducted in accordance with the methodological recommendations of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We conducted a literature search using Google Scholar, Web of Science, and Scopus to identify documents related to alternative ruminant feeds using the following keywords: alternative feeds, ruminant products, environmental impacts, and West Africa. Those that met the inclusion criteria were included, resulting in 44 articles published between 2013 and 2023. These studies included 45 alternative feeds divided into six groups, including agro-industrial by-products (48.89%), followed by fodder trees (17.78%), crop residues (13.33%), insects (8.89%), fodder legumes (6.67%) and seaweeds (4.44%). Our results revealed that alternative feed resources and their effects on ruminant's performances and environment are poorly known in West Africa, which limits their inclusion in rations and sometimes leads to their misuse. Future research should focus on these aspects in order to make efficient use of these resources to improve ruminant milk and meat production.