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1.
Cogn Emot ; : 1-11, 2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-39046729

RESUMO

Even though some recent research revealed individuals with HSA typically display enhanced processing in the early stages of emotional information processing due to hypervigilance and vulnerability to negative stimuli, it is still unclear whether social anxiety affects the time course underlying processing bias for emotional stimuli. Therefore, the present study aimed to explore the early stage of processing social threat stimuli in high social anxiety (HSA) individuals by recording RTs and EEG data in the emotional Stroop task. Behavioral data showed that the HSA group responded to the threat words faster than neutral words (i.e. negative bias), but no emotional effects in the low social anxiety (LSA) group. Although the P1 component did not show any early effects, ERP data exhibited an enhanced N170 for HSA than for LSA groups. Threat words elicited larger N170 than neutral words in the LSA group only; this emotion effect was not evident in the HSA group. These findings indicated that social anxiety modulates early processing for social threat words. This study revealed the neural mechanisms underlying early emotional processing in individuals with social anxiety, providing insights for the evaluation and intervention of social anxiety.

2.
Lang Speech ; : 238309241260062, 2024 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-39049674

RESUMO

Mandarin tone 3 sandhi refers to the phenomenon whereby a tone 3 syllable changes to a tone 2 when followed by another tone 3. This phonological process creates a deviation between the tonal forms realized at morphemic (/tone3-tone3/) and word ([tone2-tone3]) levels, posing questions in terms of how disyllabic tone 3 sandhi words are represented and accessed. The current study conducted three cross-modal lexical decision priming experiments to investigate this issue. Experiment 1 manipulated the frequencies of the initial morpheme and whole word, showing that the higher initial-character frequency against the whole word gives stronger activation to the underlying representation and the lower frequency of the initial character leads to stronger activation of the surface tone. Experiments 2 and 3 operationalized the relative frequency of the initial tone 3 morpheme's realization as a sandhi tone, finding that the competition between the two tonal realizations also influences how T3 sandhi words are accessed. Specifically, the more frequently the T3 morpheme surfaces as a T2 allomorph, the less activated the underlying representation becomes in the mental lexicon. Our results indicate a complex interplay between morpheme, word, and the associated tonal representations in the mental lexicon and that these factors co-determine the lexical access of tone 3 sandhi.

3.
Orthop Traumatol Surg Res ; : 103954, 2024 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-39038515

RESUMO

INTRODUCTION: The Atasoy flap is considered simple and reliable for covering distal digital defects in adults. Various studies in children have shown more contrasting results, particularly in terms of aesthetics and function. The aim of this study is to evaluate the long-term results of this flap specifically in children, in order to determine its limitations and indications. HYPOTHESIS: The Atasoy flap is reliable and reproducible for coverage of distal digital substance loss up to zone 2 in children. MATERIALS AND METHODS: Fifty-six children who benefited from an Atasoy flap operated on between January 2017 and January 2020 were included. Lesion area, operative technique, postoperative complications (infection, healing difficulties, necrosis), and ultimately nail appearance, cold intolerance or finger pain, finger eviction, extension defect, and final parental satisfaction were analyzed. RESULTS: Forty-nine children were evaluated with a mean follow-up of 18 months (min = 3 months, max = 38 months, SD = 11.3 months). Eighteen children had a hook nail, resulting in 6 of them having their finger excluded. The majority of hook nails were found in zone III and in proximal zone II lesions (12 cases). Eighty-nine percent of children with distal suture fixation to the nail bed (8 children) had this complication. Cold intolerance was present in 9 children. There were no cases of extension failure or early post-operative complications. Final parent satisfaction was 9.1/10 (min = 5, max = 10, SD = 1.3). CONCLUSION: The Atasoy flap in children appears reliable for covering loss of distal digital substance. The main complication is the occurrence of hook nails. Compliance with its indications (transverse substance loss not exceeding the proximal third of zone II) and a precise surgical technique (distal needle fixation without suturing to the nail bed, deep flap lift, non-closure of the donor site) help limit this risk. LEVEL OF EVIDENCE: IV; retrospective study.

4.
Orthop Traumatol Surg Res ; : 103955, 2024 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-39038514

RESUMO

INTRODUCTION: Bilateral prosthetic hip or knee replacement in one surgical session is a procedure that has been widely validated in the literature, whereas hip and knee replacement in one surgical session remains poorly documented. This study reports on the results of these procedures by analyzing early post-operative complications in a retrospective multicenter study. MATERIAL AND METHODS: Between 2009 and 2023, 51 patients underwent hip and knee replacement surgery in a single surgical session at 4 French centers. They were 24 men and 27 women, with a mean age of 68.8 years (36 - 87); 7 patients were ASA 1, 30 were ASA 2 and 14 ASA 3. Prosthetic hip replacement was always performed first, associated 33 times with the ipsi-lateral knee and 18 times with the contralateral knee. All early complications, within the first 90 days post-operatively, were recorded: death, phlebitis, pulmonary embolism, myocardial infarction, surgical site infection (SSI), knee stiffness treated by mobilization under general anesthesia, urinary tract infection, acute urine retention or any other adverse event related to care. Transfusion rates were also reported. RESULTS: The rate of early complications was 9.8% (5/51). No deaths, no phlebitis, no pulmonary embolism and no SSI were observed. Complications included one myocardial infarction, one urinary tract infection, one superficial infection, one haematoma treated by surgical evacuation and one recurrent instability requiring revision surgery (hip arthroplasty). The transfusion rate was 17.6% (9/51). The complication rate of ASA 3 patients was higher than that of ASA 1 and 2 patients, while there was no difference related to age or BMI. DISCUSSION: Our results confirm the feasibility of single-stage hip and knee replacement, with a low complication rate in ASA 1 and 2 patients. This study adds to the few published works on the subject and reports comparable results. The small sample size and the heterogeneity of patients and centers limit the scope of the results, these limitations being relative to the volume expected for a rare procedure. CONCLUSION: Single-session hip and knee arthroplasty should be reserved for patients selected according to comorbidities: ASA score, age and body mass index. ASA 3 patients have a higher risk of complications. LEVEL OF EVIDENCE: IV; retrospective.

5.
J Pediatr Psychol ; 2024 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-39028981

RESUMO

OBJECTIVE: Racially minoritized youth with T1D are made vulnerable to disproportionately adverse health outcomes compared to White peers due to enduring systems of oppression. Thus, understanding modifiable psychosocial factors associated with diabetes-related outcomes in racially minoritized youth may help to buffer deleterious effects of racism. One factor meriting exploration is racial-ethnic identity. There is currently limited research on measures fit to assess ethnic identity in youth with chronic illnesses. This study's purpose is to examine the factor structure, reliability, and validity of the revised Multigroup Ethnic Identity Measure (MEIM-R) in a racially- and income-diverse sample of youth with T1D across sociodemographic and illness-related proxies for one's positionality in oppressive systems. METHOD: As part of a larger study examining resilience, 142 youth with T1D ages 12-18 (Mage = 14.66, SDage = 1.62, 55.6% Black/African-American, 44.4% White) completed the MEIM-R and various psychosocial measures. HbA1c levels and illness duration were extracted from medical records and caregivers reported income information. Confirmatory factor analyses compared the structural validity of competing MEIM-R models, and uniform and non-uniform differential item functioning (DIF) was explored across sociodemographic and illness-related factors. RESULTS: While a bifactor structure was supported, the MEIM-R was found to exhibit DIF by race and gender on multiple MEIM-R items and did not demonstrate linear bivariate relations with other psychosocial factors. CONCLUSIONS: Since different MEIM-R item response patterns were observed across racial/ethnic and gender groups, caution is warranted in using this measure in racially and gender diverse youth with T1D.

6.
Sci Rep ; 14(1): 17080, 2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-39048599

RESUMO

Affect recognition in a real-world, less constrained environment is the principal prerequisite of the industrial-level usefulness of this technology. Monitoring the psychological profile using smart, wearable electroencephalogram (EEG) sensors during daily activities without external stimuli, such as memory-induced emotions, is a challenging research gap in emotion recognition. This paper proposed a deep learning framework for improved memory-induced emotion recognition leveraging a combination of 1D-CNN and LSTM as feature extractors integrated with an Extreme Learning Machine (ELM) classifier. The proposed deep learning architecture, combined with the EEG preprocessing, such as the removal of the average baseline signal from each sample and extraction of EEG rhythms (delta, theta, alpha, beta, and gamma), aims to capture repetitive and continuous patterns for memory-induced emotion recognition, underexplored with deep learning techniques. This work has analyzed EEG signals using a wearable, ultra-mobile sports cap while recalling autobiographical emotional memories evoked by affect-denoting words, with self-annotation on the scale of valence and arousal. With extensive experimentation using the same dataset, the proposed framework empirically outperforms existing techniques for the emerging area of memory-induced emotion recognition with an accuracy of 65.6%. The EEG rhythms analysis, such as delta, theta, alpha, beta, and gamma, achieved 65.5%, 52.1%, 65.1%, 64.6%, and 65.0% accuracies for classification with four quadrants of valence and arousal. These results underscore the significant advancement achieved by our proposed method for the real-world environment of memory-induced emotion recognition.


Assuntos
Aprendizado Profundo , Eletroencefalografia , Emoções , Rememoração Mental , Humanos , Eletroencefalografia/métodos , Emoções/fisiologia , Rememoração Mental/fisiologia , Masculino , Feminino , Adulto , Adulto Jovem
7.
Soc Cogn Affect Neurosci ; 19(1)2024 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-38903026

RESUMO

Although emotion words such as "anger," "disgust," "happiness," or "pride" are often thought of as mere labels, increasing evidence points to language as being important for emotion perception and experience. Emotion words may be particularly important for facilitating access to the emotion concepts. Indeed, deficits in semantic processing or impaired access to emotion words interfere with emotion perception. Yet, it is unclear what these behavioral findings mean for affective neuroscience. Thus, we examined the brain areas that support processing of emotion words using representational similarity analysis of functional magnetic resonance imaging data (N = 25). In the task, participants saw 10 emotion words (e.g. "anger," "happiness") while in the scanner. Participants rated each word based on its valence on a continuous scale ranging from 0 (Pleasant/Good) to 1 (Unpleasant/Bad) scale to ensure they were processing the words. Our results revealed that a diverse range of brain areas including prefrontal, midline cortical, and sensorimotor regions contained information about emotion words. Notably, our results overlapped with many regions implicated in decoding emotion experience by prior studies. Our results raise questions about what processes are being supported by these regions during emotion experience.


Assuntos
Mapeamento Encefálico , Encéfalo , Emoções , Imageamento por Ressonância Magnética , Humanos , Emoções/fisiologia , Imageamento por Ressonância Magnética/métodos , Encéfalo/fisiologia , Encéfalo/diagnóstico por imagem , Feminino , Masculino , Adulto Jovem , Mapeamento Encefálico/métodos , Adulto , Semântica , Processamento de Imagem Assistida por Computador/métodos , Estimulação Luminosa/métodos
8.
J Biomed Inform ; 156: 104667, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38848885

RESUMO

OBJECTIVES: Candidemia is the most frequent invasive fungal disease and the fourth most frequent bloodstream infection in hospitalized patients. Its optimal management is crucial for improving patients' survival. The quality of candidemia management can be assessed with the EQUAL Candida Score. The objective of this work is to support its automatic calculation by extracting central venous catheter-related information from Italian text in clinical notes of electronic medical records. MATERIALS AND METHODS: The sample includes 4,787 clinical notes of 108 patients hospitalized between January 2018 to December 2020 in the Intensive Care Units of the IRCCS San Martino Polyclinic Hospital in Genoa (Italy). The devised pipeline exploits natural language processing (NLP) to produce numerical representations of clinical notes used as input of machine learning (ML) algorithms to identify CVC presence and removal. It compares the performances of (i) rule-based method, (ii) count-based method together with a ML algorithm, and (iii) a transformers-based model. RESULTS: Results, obtained with three different approaches, were evaluated in terms of weighted F1 Score. The random forest classifier showed the higher performance in both tasks reaching 82.35%. CONCLUSION: The present work constitutes a first step towards the automatic calculation of the EQUAL Candida Score from unstructured daily collected data by combining ML and NLP methods. The automatic calculation of the EQUAL Candida Score could provide crucial real-time feedback on the quality of candidemia management, aimed at further improving patients' health.


Assuntos
Algoritmos , Candidemia , Estado Terminal , Registros Eletrônicos de Saúde , Unidades de Terapia Intensiva , Processamento de Linguagem Natural , Humanos , Aprendizado de Máquina , Itália , Cateteres Venosos Centrais/microbiologia , Candida/isolamento & purificação , Feminino , Masculino , Idoso , Pessoa de Meia-Idade
9.
Heliyon ; 10(11): e31591, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38882268

RESUMO

In this study, we aimed to identify how Information Technology professionals make sense of digital transformation, in order to compare this perception with the scientific literature on the topic. To conduct the research, we adopted the Social Representation Theory. Thus, via an online tool, we applied the words evocation technique as well as an ancillary questionnaire comprising open and closed questions. The expressions collected were then semantically treated and categorized, being then analyzed vis-à-vis their frequency of evocation, relevance, connectedness, and cooccurrence. Then, we performed similarity and content analyses for the open answers received. In doing so, we detected dissonance between scientific production on the concept of digital transformation and the perception of Information Technology professionals on this construct, concluding that such professionals have a technocentric view of digital transformation, based mainly on its technological aspects, which can prevent digital transformation initiatives from fully achieving the desired objectives.

10.
Cogn Emot ; : 1-9, 2024 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-38888553

RESUMO

Recent studies suggest that instrumental hypnosis is a useful experimental tool to investigate emotional and language processing effects. However, the capacity of hypnotic suggestions to intervene during the response inhibition of emotional words remains elusive. This study investigated whether hypnotic suggestion can improve the inhibition of prepotent negative word responses in an emotional Hayling sentence completion task. High-suggestible participants performed a computerised emotional Hayling task. They were first asked to select the appropriate words ending highly predictable sentences among two propositions (initiation part), and then to select the filler words that did not end the sentences correctly (inhibition part). Half of the expected final words had a negative emotional valence, while the other half was neutral. The task was performed in a control condition (without suggestion) and with a hypnotic suggestion to decrease emotional reactivity. The results revealed that hypnotic suggestion (compared to the control condition) hastened response times on negative final words in the inhibition part, showing that hypnotic suggestion can enhance cognitive control over prepotent negative word responses in a sentence completion task. We suggest that this modulation stems from a reduction in the emotional relevance of the final words caused by the hypnotic suggestion.

11.
Front Psychol ; 15: 1366903, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38863664

RESUMO

Intonation words play a very important role in early childhood language development and serve as a crucial entry point for studying children's language acquisition. Utilizing a natural conversation corpus, this paper thoroughly examines the intentional communication scenes of five Mandarin-speaking children before the age of 1;05 (17 months). We found that children produced a limited yet high-frequency set of intonation words such as " [a], [æ], [ε], [ən], [ə], eng [əŋ], [o], and [i]." These intonation words do not express the children's emotional attitudes toward propositions or events; rather, they are utilized within the frameworks of imperative, declarative, and interrogative intents. The children employ non-verbal, multimodal means such as pointing, gesturing, and facial expressions to actively convey or receive commands, provide or receive information, and inquire or respond. The data suggests that the function of intonation words is essentially equivalent to holophrases, indicating the initial stage of syntactic acquisition, which is a milestone in early syntactic development. Based on the cross-linguistic universality of intonation word acquisition and its inherited relationship with pre-linguistic intentional vocalizations, this paper proposes that children's syntax is initiated by the prosodic features of intonation. The paper also contends that intonation words, as the initial form of human vocal language in individual development, naturally extend from early babbling, emotional vocalizations, or sound expressions for changing intentions. They do not originate from spontaneous gesturing, which seems to have no necessary evolutionary relationship with the body postures that chimpanzees use to change intentions, as suggested by existing research. Human vocal language and non-verbal multimodal means are two parallel and non-contradictory forms of communication, with no apparent evidence of the former inheriting from the latter.

12.
J Appl Behav Anal ; 57(3): 574-583, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38819033

RESUMO

This study evaluated how speech disfluencies affect perceived speaker effectiveness. Speeches with filler sounds and filler words at different rates of disfluencies (i.e., 0, 2, 5, and 12 per minute) were created and evaluated by a crowdsourcing service for survey-based research for the speaker's public speaking performance. Increased disfluencies, particularly filler sounds, significantly affected perceptions across most categories, notably at higher rates of filler sounds (i.e., 12 per minute). A low, but nonzero, rate of disfluencies (5 per minute) did not adversely affect perceived effectiveness. These findings suggest that although reducing filler sounds is crucial for optimizing perceived speaking effectiveness, a rate of five or fewer disfluencies per minute may be acceptable.


Assuntos
Fala , Humanos , Masculino , Feminino , Percepção da Fala , Adulto , Fonética , Adulto Jovem
13.
Cogn Emot ; : 1-18, 2024 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-38738622

RESUMO

The brain processes underlying the distinction between emotion-label words (e.g. happy, sad) and emotion-laden words (e.g. successful, failed) remain inconclusive in bilingualism research. The present study aims to directly compare the processing of these two types of emotion words in both the first language (L1) and second language (L2) by recording event-related potentials (ERP) from late Chinese-English bilinguals during a lexical decision task. The results revealed that in the early word processing stages, the N170 emotion effect emerged only for L1 negative emotion-laden words and L2 negative emotion-label words. In addition, larger early posterior negativity (EPN) was elicited by emotion-laden words than emotion-label words in both L1 and L2. In the later processing stages, the N400 emotion effect was evident for L1 emotion words, excluding positive emotion-laden words, while it was absent in L2. Notably, L1 emotion words elicited enhanced N400 and attenuated late positive complex (LPC) compared to those in L2. Taken together, these findings confirmed the engagement of emotion, and highlighted the modulation of emotion word type and valence on word processing in both early and late processing stages. Different neural mechanisms between L1 and L2 in processing written emotion words were elucidated.

14.
Work ; 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38728196

RESUMO

BACKGROUND: Handgrip strength (HGS) is a reliable assessment of hand function. Interpretation of HGS is commonly done using normative data. Normative HGS data HGS considers the influence of age and gender without adjustment for anthropometric measurements or functional factors known to influence HGS. OBJECTIVE: To determine the potential relationship of select anthropometric measurements (height, weight, hand length and width, forearm length and circumference) and functional factors (hand dominance, work and lifestyle category) to HGS. METHODS: This study included a sample of 119 males and 96 female workers from North Queensland. HGS and six anthropometric measurements were obtained using calibrated instruments and reliable measurement protocols. Age and gender along with three functional factors were documented by self-report. RESULTS: Right and left mean HGS was greater for individuals who performed heavy/very heavy work (58.1±10.1 kg and 54.1±10.9 kg respectively) compared to light (38.5±12.3 kg and 35.5±11.8 kg) or medium work (44.1±10.8 kg and 40.0±12.9 kg). Mean HGS was greater for individuals who performed heavy/very heavy activity (right 48.5±13.6 kg and left 44.5±13.7 kg) compared to light activity (right 36.3±11.2 kg and left 33.9±11.3 kg) within their lifestyle. HGS positively correlated with gender (p = 0.0001), work (p = 0.001) and anthropometric measurements of forearm circumference (p = 0.001), hand length (p = 0.006) and hand width (p = 0.052). CONCLUSIONS: Easy to measure anthropometric measurements of forearm circumference, hand length and width are the strongest predictors of HGS in addition to an individual's physical activity at work and in their lifestyle. Consideration of these factors could lead to improved evaluation of HGS scores.

15.
J Psycholinguist Res ; 53(4): 49, 2024 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-38782761

RESUMO

Previous studies on L2 (i.e., second language) Chinese compound processing have focused on the relative efficiency of two routes: holistic processing versus combinatorial processing. However, it is still unclear whether Chinese compounds are processed with multilevel representations among L2 learners due to the hierarchical structure of the characters. Therefore, taking a multivariate approach, the present study evaluated the relative influence and importance of different grain sizes of lexical information in an L2 Chinese two-character compound decision task. Results of supervised component generalized linear regression models with random forests analysis revealed that the orthographic, phonological and semantic information all contributed to L2 compound processing, but the L2 learners used more orthographic processing strategies and fewer phonological processing strategies compared to the native speakers. Specifically, the orthographic information was activated at the whole-word, the character and the radical levels in orthographic processing, and the phonological information at the whole-word, the syllable, and the phoneme levels all exerted contributions in phonological processing. Furthermore, the semantic information of the whole words and the constituents was accessed in semantic processing. These findings together suggest that the L2 learners are able to use cues at all levels simultaneously to process Chinese compound words, supporting a multi-route model with a hierarchical morphological structure in such processing.


Assuntos
Multilinguismo , Psicolinguística , Semântica , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , China , Idioma , Fonética , Leitura
16.
J Psycholinguist Res ; 53(3): 46, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38744739

RESUMO

Wh-words have been analysed as existential quantifiers (Chierchia in Logic in grammar: polarity, free choice, and intervention. Oxford University Press, Oxford, 2013; Fox, in Sauerland U, Stateva P (eds) Presupposition and implicature in compositional semantics (Palgrave studies in pragmatics, language and cognition). Palgrave MacMillan, Houndmills, pp 71-120, 2007; Liao in Alternative and exhaustification: non-interrogative uses of Chinese wh-words. Harvard University, 2010) or universal quantifiers (Nishigauchi, in: Theoretical and applied linguistics at Kobe Shoin 2, Kobe Shoin Institute for Linguistic Sciences, 1999). These two accounts have distinct predictions on how children initially interpret wh-words. The universal account predicts that children should initially interpret wh-words as universal quantifiers, whereas the existential account anticipates that children should start out with the existential interpretation. To adjudicate between the two accounts, the present study was designed to explore pre-schoolers' semantic knowledge of wh-quantification. Specifically, it investigated the interpretation of the wh-word shenme 'what' with 4-and 5-year-old Mandarin-speaking children and a control group of adults. Using a Truth Value Judgment Task (Crain and Thornton in Investigations in universal grammar: a guide to experiments on the acquisition of syntax and semantics. MIT Press, Cambridge, 1998), Experiment 1 evaluated whether children interpret the wh-word shenme 'what' as closer in meaning to the polarity sensitive item renhe 'any' or the universal quantifier suoyou 'all' in the antecedent of ruguo 'if' conditionals. Using a Question-Answer Task, Experiments 2 & 3 respectively investigated whether children interpret shenme 'what' as closer in meaning to renhe 'any' or suoyou 'all' in two types of questions: yes-no questions with the particle ma and A-not-A questions. It was found that both children and adults interpret shenme 'what' as closer in meaning to renhe 'any' than suoyou 'all'. The findings suggest that Mandarin-speaking pre-schoolers already have adult-like semantic knowledge of wh-quantification: wh-words are existential quantifiers rather than universal quantifiers. Due to the paucity of primary linguistic input, children's early mastery of the non-interrogative wh-words appear to support the biolinguistic approach to language acquisition (Chomsky in Aspects of the theory of syntax. MIT Press, Cambridge, 1965; Pinker in Language learnability and language development. Harvard University Press, Cambridge, 1984; Crain et al. in Language acquisition from a biolinguistic perspective. Neurosci Biobehav Rev, 2016. https://doi.org/10.1016/j.neubiorev.2016.09.004 ).


Assuntos
Semântica , Humanos , Masculino , Feminino , Pré-Escolar , Adulto , Psicolinguística , Idioma , Adulto Jovem , China
17.
Brain Res ; 1838: 148993, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-38729334

RESUMO

Previous studies, using the Continuous Flash Suppression (CFS) paradigm, observed that (Western) university students are better able to detect otherwise invisible pictures of objects when they are presented with the corresponding spoken word shortly before the picture appears. Here we attempted to replicate this effect with non-Western university students in Goa (India). A second aim was to explore the performance of (non-Western) meditators practicing Sudarshan Kriya Yoga in Goa in the same task. Some previous literature suggests that meditators may excel in some tasks that tap visual attention, for example by exercising better endogenous and exogenous control of visual awareness than non-meditators. The present study replicated the finding that congruent spoken cue words lead to significantly higher detection sensitivity than incongruent cue words in non-Western university students. Our exploratory meditator group also showed this detection effect but both frequentist and Bayesian analyses suggest that the practice of meditation did not modulate it. Overall, our results provide further support for the notion that spoken words can activate low-level category-specific visual features that boost the basic capacity to detect the presence of a visual stimulus that has those features. Further research is required to conclusively test whether meditation can modulate visual detection abilities in CFS and similar tasks.


Assuntos
Estudantes , Yoga , Humanos , Yoga/psicologia , Masculino , Feminino , Adulto Jovem , Adulto , Estudantes/psicologia , Percepção Visual/fisiologia , Atenção/fisiologia , Estimulação Luminosa/métodos , Percepção da Fala/fisiologia , Meditação/métodos , Meditação/psicologia , Sinais (Psicologia) , Adolescente
18.
Acta Biochim Biophys Sin (Shanghai) ; 56(6): 937-944, 2024 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-38761011

RESUMO

Bacteriophages have been used across various fields, and the utilization of CRISPR/Cas-based genome editing technology can accelerate the research and applications of bacteriophages. However, some bacteriophages can escape from the cleavage of Cas protein, such as Cas9, and decrease the efficiency of genome editing. This study focuses on the bacteriophage T7, which is widely utilized but whose mechanism of evading the cleavage of CRISPR/Cas9 has not been elucidated. First, we test the escape rates of T7 phage at different cleavage sites, ranging from 10 -2 to 10 -5. The sequencing results show that DNA point mutations and microhomology-mediated end joining (MMEJ) at the target sites are the main causes. Next, we indicate the existence of the hotspot DNA region of MMEJ and successfully reduce MMEJ events by designing targeted sites that bypass the hotspot DNA region. Moreover, we also knock out the ATP-dependent DNA ligase 1. 3 gene, which may be involved in the MMEJ event, and the frequency of MMEJ at 4. 3 is reduced from 83% to 18%. Finally, the genome editing efficiency in T7 Δ 1. 3 increases from 20% to 100%. This study reveals the mechanism of T7 phage evasion from the cleavage of CRISPR/Cas9 and demonstrates that the special design of editing sites or the deletion of key gene 1. 3 can reduce MMEJ events and enhance gene editing efficiency. These findings will contribute to advancing CRISPR/Cas-based tools for efficient genome editing in phages and provide a theoretical foundation for the broader application of phages.


Assuntos
Bacteriófago T7 , Sistemas CRISPR-Cas , Edição de Genes , Edição de Genes/métodos , Bacteriófago T7/genética , DNA Ligases/genética , DNA Ligases/metabolismo , Proteínas Virais/genética , Proteínas Virais/metabolismo , Genoma Viral
19.
Res Social Adm Pharm ; 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38714397

RESUMO

This bibliometric review analyzes the evolution of telepharmacy research, significantly amplified by the COVID-19 pandemic. By employing bibliometric analysis, the study aims to provide a comprehensive overview of the current state and emerging trends in telepharmacy. This approach helps in identifying key areas of growth, predominant themes, and potential gaps in the literature. Utilizing data from 330 papers (1981-2023) sourced from Scopus and analyzed with Bibliometrix™, this study applies both performance analysis and science mapping methods to examine the telepharmacy literature. The findings reveal a consistent growth in telepharmacy research, with an 8.07 % average annual growth rate. Performance analysis highlights key authors, influential works, and leading journals and countries in the field. Document co-citation analysis identifies four developmental phases of telepharmacy: emergence, take-off, expansion, and future trajectory by uncovering the intellectual structure of the field. Co-words analysis elucidates evolving conceptual structures and significant subfields over time. These findings serve to inform practitioners and researchers about the evolving landscape of telepharmacy, guiding future research and practice in this increasingly important field.

20.
Behav Res Methods ; 56(4): 3794-3813, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38724878

RESUMO

The use of taboo words represents one of the most common and arguably universal linguistic behaviors, fulfilling a wide range of psychological and social functions. However, in the scientific literature, taboo language is poorly characterized, and how it is realized in different languages and populations remains largely unexplored. Here we provide a database of taboo words, collected from different linguistic communities (Study 1, N = 1046), along with their speaker-centered semantic characterization (Study 2, N = 455 for each of six rating dimensions), covering 13 languages and 17 countries from all five permanently inhabited continents. Our results show that, in all languages, taboo words are mainly characterized by extremely low valence and high arousal, and very low written frequency. However, a significant amount of cross-country variability in words' tabooness and offensiveness proves the importance of community-specific sociocultural knowledge in the study of taboo language.


Assuntos
Idioma , Tabu , Humanos , Semântica , Comparação Transcultural
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