RESUMO
INTRODUCTION: Chromosomal translocations at 2p23 cause overexpression of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase involved in signalling pathways that regulate cell proliferation. This translocation occurs in 5% of lung adenocarcinoma and has been demonstrated to be useful as a therapeutic target for crizotinib. sinonasal adenocarcinomas (SNAC) are histologically similar to lung adenocarcinomas; the aim of this study was to evaluate the presence of ALK alterations in SNAC. METHOD: Break-apart fluorescent in-situ hybridization was used to analyse the presence of ALK translocations in 96 tumour samples. In addition, ALK protein expression was studied by immunohistochemistry. RESULTS: The samples of SNAC did not show ALK translocation. Moreover, ALK protein expression was absent in all cases. CONCLUSIONS: These results suggest that ALK is not involved in SNAC.
Assuntos
Adenocarcinoma/genética , Cromossomos Humanos Par 2/ultraestrutura , Regulação Neoplásica da Expressão Gênica , Proteínas de Neoplasias/genética , Neoplasias Nasais/genética , Neoplasias dos Seios Paranasais/genética , Receptores Proteína Tirosina Quinases/genética , Translocação Genética , Adenocarcinoma/metabolismo , Adenocarcinoma/patologia , Idoso , Idoso de 80 Anos ou mais , Quinase do Linfoma Anaplásico , Cromossomos Humanos Par 2/genética , Crizotinibe , Feminino , Seguimentos , Humanos , Hibridização in Situ Fluorescente , Masculino , Pessoa de Meia-Idade , Proteínas de Neoplasias/biossíntese , Neoplasias Nasais/química , Neoplasias Nasais/metabolismo , Neoplasias Nasais/patologia , Neoplasias dos Seios Paranasais/metabolismo , Neoplasias dos Seios Paranasais/patologia , Pirazóis , Piridinas , Receptores Proteína Tirosina Quinases/biossínteseRESUMO
Los carcinomas de senos paranasales son entidades poco frecuentes y cuando se diagnostican, generalmente ya se encuentran en estados avanzados de la enfermedad, dado que el proceso neoplásico en las etapas iniciales crece invadiendo las cavidades paranasales, para luego en etapas avanzadas producir la deformación de las corticales. Dentro de las manifestaciones clínicas se pueden presentar epistaxis, obstrucción nasal, dolor en zona maxilar, dolor o movilidad dentaria. Se presentan dos casos clínicos que dentro de las primeras manifestaciones cursaron con dolor de la zona maxilar y movilidad anormal de un diente. Al momento de realizar el diagnóstico definitivo los procesos tumorales se encontraban muy avanzados, comprometiendo diversas estructuras como seno maxilar, etmoidal, esfenoidal, y piso de órbita, lo que obliga a realizar grandes resecciones de la zona maxilofacial. El rol del odontólogo en el diagnóstico de la enfermedad podría ser de gran importancia, al sospechar que un aumento de volumen del reborde, la movilidad dentaria anormal o un dolor de la zona maxilar no siempre corresponden a causas odontogénicas.
Paranasal sinus cancer are rare entities, but when diagnosed, often already in advanced stages of the disease, because the neoplastic process in the initial stages grows invading the paranasal sinuses and then in advanced stages, produces deformation of cortical bone. Among the clinical manifestations epistaxis, nasal obstruction, pain in maxillary area, pain or tooth mobility may occur. We present two clinical cases in which within the first manifestations are the maxillary pain and abnormal tooth mobility. When making the final diagnosis, tumor processes were well advanced, engaging various structures as maxillary sinus, ethmoid, sphenoid, and orbital floor, forcing large resections perform maxillofacial area. The role of the dentist in the diagnosis of the disease could be of great importance, suspecting that an increase maxillary volume, abnormal tooth mobility or pain of the maxillary not always correspond with odontogenic causes.
Assuntos
Humanos , Masculino , Adulto , Feminino , Idoso , Carcinoma/cirurgia , Carcinoma/diagnóstico , Neoplasias dos Seios Paranasais/cirurgia , Neoplasias dos Seios Paranasais/diagnósticoRESUMO
Se presentan 2 casos clínicos de pacientes jóvenes, tratados en la consulta de Otorrinolaringología del Hospital Clinicoquirúrgico Docente «Dr. Joaquín Castillo Duany" de Santiago de Cuba. Uno de los afectados presentaba obstrucción nasal, rinorrea y algia facial, desde hacía 7 meses; el otro, aumento de volumen en el globo ocular derecho. En ambos, los resultados de la biopsia corroboraron el diagnóstico de carcinoma epidermoide diferenciado nasosinusal.
Two case reports of young patients, who were treated in the Otolaryngology Department from "Dr. Joaquín Castillo Duany" Teaching Clinical Surgical Hospital in Santiago de Cuba are presented. One of the cases presented nasal obstruction, rhinorrea and facial pain, for 7 months; the other one presented an increase of volume in the right ocular globe. In both, the results of the biopsy confirmed the diagnosis of differentiated nasosinusal epidermoid carcinoma.
RESUMO
Se presentan 2 casos clínicos de pacientes jóvenes, tratados en la consulta de Otorrinolaringología del Hospital Clinicoquirúrgico Docente Dr Joaquín Castillo Duany de Santiago de Cuba. Uno de los afectados presentaba obstrucción nasal, rinorrea y algia facial, desde hacía 7 meses; el otro, aumento de volumen en el globo ocular derecho. En ambos, los resultados de la biopsia corroboraron el diagnóstico de carcinoma epidermoide diferenciado nasosinusal(AU)
Two case reports of young patients, who were treated in the Otolaryngology Department from Dr Joaquín Castillo Duany Teaching Clinical Surgical Hospital in Santiago de Cuba are presented. One of the cases presented nasal obstruction, rhinorrea and facial pain, for 7 months; the other one presented an increase of volume in the right ocular globe. In both, the results of the biopsy confirmed the diagnosis of differentiated nasosinusal epidermoid carcinoma(AU)
