The sum of kidney donor profile index and estimated post-transplant survival scale and their correlation with egfr decline in deceased donor kidney recipients

Background: The impact of donor quality on post-kidney transplant survival may vary by candidate condition. Objective: Analyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR). Methods: This was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital. Results: We analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively. Conclusions: The sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.

The Sum of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scale and Their Correlation with eGFR Decline in Deceased Donor Kidney Recipients.

BACKGROUND: The impact of donor quality on post-kidney transplant survival may vary by candidate condition. OBJECTIVE: Analyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR). METHODS: This was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital. RESULTS: We analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively. CONCLUSIONS: The sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.

Using body donor demographics to assist the implementation of donation programs in Brazil.

The use of human material in anatomy education depends upon the generosity of body donors. However, little is known regarding the demographics of body donors in Brazil, where voluntary body donation is a relatively rare phenomenon. Hence, the aim of the present study was to elucidate the demographic profile of applicants to the Body Donation Program (BDP) at the Federal University of Health Sciences of Porto Alegre in Brazil, as well as to assess whether the observed characteristics of body donors are unique to that sample, or if they merely reflect the characteristics of the regional population. Information derived from the specific forms filled out by donors between January 2008 and June 2016 at the time of registration were collected. Data from 416 forms were analyzed. Based on this study, the typical applicant in Brazil is typically a white female (67.4%), over 60 years of age (60.3%), unmarried or single (70.6%), affiliated with a religious group (89.1%), of middle class background (40.4%), who has completed high school and/or holds a university degree (93.8%). The motivation of donors was, in most cases, an altruistic gesture, represented by the desire to help society and science. Elucidating these demographic characteristics of potential donors may help identify the target public to which information regarding body donation campaigns could be directed. Anat Sci Educ 10: 475-486. © 2017 American Association of Anatomists.

Living donor kidney transplantation: the donor profile in Trinidad and Tobago / Trasplante renal de donantes vivos: perfil del donante en Trinidad y Tobago

OBJECTIVE: The National Organ Transplant Unit (NOTU) of Trinidad and Tobago, first implemented in January 2006, was mandated to facilitate renal and corneal transplantation. Since then, 60 transplants have been performed utilizing living kidney donors. The aim of this study is to ascertain the typical donor profile and to highlight the safety involved with live kidney donation. SUBJECTS AND METHODS: This descriptive study utilized the medical records of 60 consecutive live kidney donors between the period January 2006 and May 2010. Donor information was recorded on Microsoft Excel spreadsheets and analysed using the Statistical Package for Social Sciences 12.0. RESULTS: Among the 60 donors, males and females were in equal proportions with a mean age of 35.0 (± 10.7) years; a mean body mass index (BMI) of 25.8 (± 4.2) kg/m2 and 48.3% were of East Indian decent. The majority of donors were related to the recipient (71.7%). At donation, the mean creatinine was 84.9 (± 17.7) µmol/L, average urine creatinine clearance, 1.83 (± 0.53) mL/s and mean 24 hour urine protein, 141.8 (± 78.6) mg. There was a significant association between the BMI at donation and proteinuria one year after donation (p = 0.043). The average hospital stay was 5.0 (± 0.95) days with minimal postoperative complications. CONCLUSION: The typical live kidney donor in Trinidad and Tobago is a 35-year old, slightly overweight male or female who is usually of East Indian decent, donating a kidney to a relative. Living kidney donation in this Transplant Unit is safe with minimal short-term complications.

OBJETIVO: La Unidad Nacional de Trasplantes de Órganos (UNTO) de Trinidad y Tobago, implementada por primera vez en enero de 2006, fue instituida con el propósito de facilitar los trasplantes de rinón y córnea. Desde entonces se han realizado 60 trasplantes utilizando donantes vivos de rinón. El objetivo de este estudio es determinar el perfil del donante típico y destacar la seguridad que conlleva la donación renal de vivo. SUJETOS Y MÉTODOS: Este estudio descriptivo utilizó historias clínicas de 60 donantes vivos de rinón consecutivos, entre el período de enero de 2006 a mayo de 2010. La información del donante fue registrada en hojas de cálculo de Microsoft Excel y analizada usando el programa estadístico para las ciencias sociales SPSS 12.0. RESULTADOS: Entre los 60 donantes, hubo igual proporción de hombres y mujeres con edad promedio de 35.0 (± 10.7) anos, un índice de masa corporal (IMC) promedio de 25.8 (± 4.2) kg/m2, y un 48.3% eran de descendencia indo-oriental. La mayor parte de los donantes eran parientes del receptor (71.7%). En el momento de la donación, la creatinina promedio fue 84.9 (± 17.7) µmol/L, el promedio de aclaramiento de creatinina en orinafue 1.83 (± 0.53) mL/s, y el promedio de proteína en orina de 24 horas, 141.8 (± 78.6) mg. Hubo una asociación significativa entre el IMC en la donación y la proteinuria un ano después de la donación (p = 0.043). El promedio de estadía en el hospital fue 5.0 (± 0.95) días con complicacionespostoperatorias mínimas. CONCLUSIÓN: El típico donante vivo de rinón en Trinidad y Tobago es un hombre o mujer de 35 anos de edad, ligeramente pasado de peso, generalmente de descendencia indo-oriental, que dona el rinón a un pariente. La donación renal de vivo en esta Unidad de Trasplante es segura, con complicaciones mínimas a corto plazo.