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1.
Pharmacol Ther ; 195: 21-38, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30347212

RESUMO

The need for better antifungal therapy is commonly accepted in view of the high mortality rates associated with systemic infections, the low number of available antifungal classes, their associated toxicity and the increasing number of infections caused by strains with natural or acquired resistance. The urgency to expand the range of therapeutic options for the treatment of fungal infections has led researchers in recent decades to seek alternative antifungal targets when compared to the conventional ones currently used. Although new potential targets are reported, translating the discoveries from bench to bedside is a long process and most of these drugs fail to reach the patients. In this review, we discuss the development of antifungal drugs focusing on the approach of drug repurposing and the search for novel drugs for classical targets, the most recently described gene targets for drug development, the possibilities of immunotherapy using antibodies, cytokines, therapeutic vaccines and antimicrobial peptides.


Assuntos
Antifúngicos/uso terapêutico , Micoses/terapia , Animais , Anticorpos Monoclonais/uso terapêutico , Produtos Biológicos/uso terapêutico , Desenvolvimento de Medicamentos , Humanos , Imunoterapia , Vacinas/uso terapêutico
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;49(11): e5644, 2016.
Artigo em Inglês | LILACS | ID: lil-797887

RESUMO

This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification of leader molecules and their optimization, the selection of a candidate substance for clinical development, and the use of animal models during the early studies of proof-of-concept (or principle). This report also discusses the relevance of validated and predictive animal models selection, as well as the correct use of animal tests concerning the experimental design, execution and interpretation, which affect the reproducibility, quality and reliability of non-clinical studies necessary to translate to and support clinical studies. Collectively, improving these aspects will certainly contribute to the robustness of both scientific publications and the translation of new substances to clinical development.


Assuntos
Animais , Simulação por Computador , Descoberta de Drogas , Avaliação Pré-Clínica de Medicamentos/métodos , Desenho Assistido por Computador , Modelos Animais , Reprodutibilidade dos Testes
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