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1.
Indian J Microbiol ; 64(2): 492-499, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-39010997

RESUMO

The production of coconut tree seedlings is an important step in the production process, as it substantially affects the productive performance of the adult plant, and the way of obtaining seedlings directly reflects the added costs. To minimize costs, the introduction of biostimulants can be considered a viable and sustainable technology. This study aimed to evaluate the effects of applying Bacillus cereus in promoting growth and reducing the costs of producing Brazilgreen dwarf coconut seedlings. The study has two stages, the first was an experiment carried out in a commercial nursery in the state of Pará-Brazil. The design was completely randomized, with two treatments: control with water (100% mineral fertilization) and B. cereus inoculation (50% mineral fertilization), with 10 replicates each. Biometric parameters and the quality of seedlings were evaluated. In the second stage, the production of stimulated seedlings was compared to that of commercial seedlings, and the effective operating cost (COE) and the total operating cost (TOC) were determined. Biostimulation with B. cereus promotes the growth of coconut tree seedlings, increases seedling quality, and reduces nursery time. In addition, the cost of production is reduced by 10%. Thus, microbial technology is a positive strategy for the production of Brazilian green dwarf coconut seedlings. Using B. cereus can guarantee obtaining seedlings with high performance and at a lower cost. These results may favor obtaining adult plants with high productivity. Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-023-01163-9.

2.
Sci Rep ; 14(1): 10240, 2024 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-38702364

RESUMO

This work presents the experimental assessment of a 20 mL batch reactor's efficacy in converting plastic and oil residues into biofuels. The reactor, designed for ease of use, is heated using a metallic system. The experiments explore plastic solubilization at various temperatures and residence times, employing a mixture of distilled water and ethylene glycol as the solvent. Initial findings reveal that plastic solubilization requires a temperature of 350 °C with an ethylene glycol mole fraction of 0.35, whereas 250 °C suffices with a mole fraction of 0.58. Additionally, the study includes a process simulation of a plant utilizing a double fluidized bed gasifier and an economic evaluation of the interesterification/pyrolysis plant. Simulation results support project feasibility, estimating a total investment cost of approximately $12.99 million and annual operating expenses of around $17.98 million, with a projected payback period of about 5 years.

3.
Braz J Infect Dis ; 28(2): 103744, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38670167

RESUMO

This is a cost analysis study based on hospital admissions, conducted from the perspective of the Brazilian Unified Health System (SUS), carried out in a cohort of patients hospitalized at the University Hospital of Brasília (UHB) due to Severe Acute Respiratory Infections (SARI) caused by COVID-19, from April 1, 2020, to March 31, 2022. An approach based on macro-costing was used, considering the costs per patient identified in the Hospital Admission Authorizations (HAA). Were identified 1,015 HAA from 622 patients. The total cost of hospitalizations was R$ 2,875,867.18 for 2020 and 2021. Of this total, 86.41 % referred to hospital services and 13.59 % to professional services. The highest median cost per patient identified was for May 2020 (R$ 19,677.81 IQR [3,334.81-33,041.43]), while the lowest was in January 2021 (R$ 1,698.50 IQR [1,602.70-2,224.11]). The high cost of treating patients with COVID-19 resulted in a high economic burden of SARI due to COVID-19 for UHB and, consequently, for SUS.


Assuntos
COVID-19 , Hospitalização , Humanos , COVID-19/economia , COVID-19/epidemiologia , Brasil/epidemiologia , Hospitalização/economia , Hospitalização/estatística & dados numéricos , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , SARS-CoV-2 , Idoso , Custos Hospitalares/estatística & dados numéricos , Admissão do Paciente/economia , Admissão do Paciente/estatística & dados numéricos
4.
Environ Sci Pollut Res Int ; 31(15): 22319-22338, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38430439

RESUMO

Advanced oxidation processes (AOPs) are wastewater treatment technologies that stand out for their ability to degrade Contaminants of Emerging Concern (CECs). The literature has extensively investigated these removal processes for different aqueous matrices. Once technically mature, some of these systems have become accredited to be applied on a large scale, and therefore, their systemic performances in the environmental and cost spheres have also become essential requirements. This study proposed corroborating this trend, analyzing the available literature on the subject to verify how experts in the AOP area investigated this integration during 2015-2023. For this purpose, a sample of publications was treated by applying the Systematic Review (SR) methodology. This resulted in an extract of 83 studies that adopted life-cycle logic to estimate environmental impacts and process costs or evaluated them as complementary to the technical dimension of each treatment technology. This analysis found that both dimensions can be used for selecting or sizing AOPs at the design scale. However, the appropriate choice of the impact categories for the environmental assessment and establishing a methodology for cost analysis can make the approach still more effective. In addition, a staggering number of processes would broaden the reality and applicability of the estimates, and adopting multicriteria analysis methodologies could address essential aspects of decision-making processes during the design of the arrangements. By meeting the original purposes, the study broadened the requirements for designing AOPs and disseminating their use in mitigating the discharge of CECs.


Assuntos
Bibliometria , Oxirredução , Águas Residuárias/química , Purificação da Água/métodos , Eliminação de Resíduos Líquidos/métodos
5.
Environ Sci Pollut Res Int ; 31(12): 18171-18187, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36823466

RESUMO

Renewable cooling via absorption chillers being supplied by various green heat technologies such as solar collectors has been widely studied in the literature, but it is still challenging to get positive economic outcomes from such systems due to the large expenses of solar thermal systems. This study offers the use of a new generation of solar collectors, so-called eccentric reflective solar collectors, for driving single-effect absorption chillers and thereby reducing the levelized cost of cooling. This article develops the most optimal design of this system (based on several different scenarios) using multi-objective optimization techniques and employs them for a case study in Brazil to assess its proficiency compared to conventional solar-driven cooling methods. For making the benchmarking analyses fair, the conventional system is also rigorously optimized in terms of design and operation features. The results show that the eccentric solar collector would enhance the cost-effectiveness by 29%. In addition, using optimally sized storage units would be necessary to get acceptable economic performance from the system, no matter which collector type is used. For the case study, at the optimal sizing and operating conditions, the levelized cost of cooling will be 124 USD/MWh and an emission level of 18.97 kgCO2/MWh.


Assuntos
Energia Solar , Luz Solar , Temperatura Baixa , Temperatura Alta , Transição de Fase
6.
Braz. j. infect. dis ; Braz. j. infect. dis;28(2): 103744, 2024. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1564143

RESUMO

ABSTRACT This is a cost analysis study based on hospital admissions, conducted from the perspective of the Brazilian Unified Health System (SUS), carried out in a cohort of patients hospitalized at the University Hospital of Brasília (UHB) due to Severe Acute Respiratory Infections (SARI) caused by COVID-19, from April 1, 2020, to March 31, 2022. An approach based on macro-costingwas used,considering thecosts perpatient identified in the Hospital Admission Authorizations (HAA). Were identified 1,015 HAA from 622 patients. The total cost of hospitalizations was R$ 2,875,867.18 for 2020 and 2021. Of this total, 86.41 % referred to hospital services and 13.59 % to professional services. The highest median cost per patient identified was for May 2020 (R$ 19,677.81 IQR [3,334.81-33,041.43]), while the lowest was in January 2021 (R$ 1,698.50 IQR [1,602.70-2,224.11]). The high cost of treating patients with COVID-19 resulted in a high economic burden of SARI due to COVID-19 for UHB and, consequently, for SUS.

7.
Prev Vet Med ; 218: 105992, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37598460

RESUMO

From 2001, due to the launching of the National Program for the Control and Eradication of Brucellosis and Tuberculosis, Brazil began a series of studies aimed at the epidemiological characterization of bovine brucellosis in its federative units. In the state of Mato Grosso, studies conducted in 2003 and 2014 showed a reduction in the prevalence of infected herds from 41.2 % to 24 % and in the prevalence of seropositive animals from 10.2 % to 5.1 %. These results stemmed from the efficient heifer vaccination program with S19 implemented by the state. From this scenario, the present study quantified and compared the benefits and costs of bovine brucellosis control in the state through a financial analysis. When considering private and public costs, the Net Present Value (NPV) was estimated at US$ 37.5 million, the Internal Rate of Return (IRR) was calculated at 31 %, and the Benefit-Cost Ratio (BCR) was 2.3. When considering only the private costs, the NPV was US$ 51.3 million, the IRR was 46 % and the BCR was 3.43, indicating that the cattle producer in Mato Grosso had a return of US$ 3.43 for each US$ 1.00 invested. Therefore, the bovine brucellosis control actions carried out in the state of Mato Grosso between 2003 and 2014 were highly advantageous from the economic point of view. The most rational way to continue decreasing bovine brucellosis prevalences at low cost in the state is to maintain the heifer vaccination program, using the RB51 vaccine in addition to S19.


Assuntos
Brucelose Bovina , Brucelose , Doenças dos Bovinos , Animais , Bovinos , Feminino , Análise Custo-Benefício , Brasil/epidemiologia , Brucelose Bovina/epidemiologia , Brucelose Bovina/prevenção & controle , Estudos Retrospectivos , Brucelose/veterinária
8.
J. bras. econ. saúde (Impr.) ; 15(2): 129-145, Agosto/2023.
Artigo em Inglês, Português | LILACS, ECOS | ID: biblio-1518987

RESUMO

Objetivo: Comparar o implante transcateter de valva aórtica (TAVI) ao tratamento conservador em pacientes inoperáveis ou à cirurgia de troca valvar (SAVR) em pacientes com risco cirúrgico alto ou intermediário conforme a Society of Thoracic Surgeons (STS), por meio de uma revisão sistemática de avaliações econômicas completas. Avaliar a variabilidade de modelos econômicos, parâmetros, pressupostos e sua influência nos resultados finais. Métodos: Foi realizada uma busca da literatura nas bases Medline, EMBASE, Cochrane Library, Web of Science, SciELO e International HTA Base e busca manual. Foram incluídas análises econômicas completas baseadas em modelos econômicos publicadas entre 2011 e 2022, em português, inglês e espanhol. A qualidade dos estudos foi avaliada usando o instrumento QHES (Quality of Health Economic Studies). Resultados: Foram incluídos 36 estudos, majoritariamente análises de custo-utilidade (64%), da Europa (41%), utilizando dados de eficácia dos estudos PARTNER. O modelo de Markov (61%) foi predominante. O custo da prótese do TAVI foi um parâmetro de impacto na análise de sensibilidade nos três grupos. Os estudos alcançaram uma boa qualidade no instrumento QHES. Conclusão: O TAVI tendeu a ser custo-efetivo em relação aos comparadores. Os modelos não foram homogêneos nos parâmetros, horizontes temporais e taxa de desconto, podendo impactar a custo-efetividade do TAVI e dificultar a comparação dos resultados entre diferentes países e perspectivas.


ABSTRACT Objective: To compare transcatheter aortic valve implantation (TAVI) to conservative treatment in inoperable patients or to valve replacement surgery (SAVR) in patients at high or intermediate surgical risk according to the Society of Thoracic Surgeons (STS), through a systematic review of comprehensive economic evaluations. Evaluate the variability of economic models, parameters, assumptions and their influence on final results. Methods: A literature search was performed in Medline, EMBASE, Cochrane Library, Web of Science, SciELO and International HTA Base and manual search. Complete economic analyzes based on economic models published between 2011 and 2022 in Portuguese, English and Spanish were included. The quality of the studies was evaluated using the QHES (Quality of Health Economic Studies) instrument. Results: Thirty-six studies were included, mostly cost-utility analyses (64%), from Europe (41%), and using efficacy data from the PARTNER studies. The Markov model (61%) was predominant. The cost of the TAVI prosthesis was the most important parameter in the sensitivity analysis in the three groups. The studies achieved a good quality in QHES instrument. Conclusion: TAVI tended to be cost-effective relative to comparators. The models were not homogeneous in parameters, time horizons and discount rate, which may have an impact on the cost-effectiveness of TAVI, making it difficult to compare the results between different countries and perspectives.


Assuntos
Estenose da Valva Aórtica , Análise Custo-Benefício , Análise de Custo-Efetividade , Revisão Sistemática
9.
Environ Sci Pollut Res Int ; 30(27): 70213-70228, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37145363

RESUMO

The removal of organic matter from Pisco production wastewater was evaluated using coagulation/flocculation, filtration as a pre-treatment, and solar photo-Fenton, with the use of two types of photoreactors: compound parabolic collectors (CPC) and flat plate (FP), with and without utilizing the ozonation process. The overall removal efficiency for chemical oxygen demand (COD) was 63% and 15% using FP and CPC, respectively. Also, for the overall removal efficiency of polyphenols, a percentage of 73% and 43% were obtained using FP and CPC, respectively. When ozone was used in the solar photoreactors, the resulting trends were similar. COD and polyphenol removal, using an FP photoreactor in the solar photo-Fenton/O3 process, resulted in values of 98.8% and 86.2% after the process. COD and polyphenol removal, using solar photo-Fenton/O3 process in a CPC, resulted in values of 49.5% and 72.4%, respectively. The economic indicators of annual worth and economic treatment capacity established that FP reactors represent lower costs than CPCs. These results were corroborated by the economic analyses of the evolution of costs versus COD removed as well as by the cash flow diagrams projected for 5, 10, and 15 years.


Assuntos
Eliminação de Resíduos Líquidos , Poluentes Químicos da Água , Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/análise , Peróxido de Hidrogênio/química , Ferro/química , Oxirredução , Polifenóis/análise
10.
Trop Anim Health Prod ; 55(3): 225, 2023 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-37225948

RESUMO

Bovine brucellosis, mainly caused by Brucella abortus, is a worldwide distribution anthropozoonosis that causes great economic losses. In 2001, Brazil launched the National Program for the Control and Eradication of Brucellosis and Tuberculosis (PNCEBT). Contemporaneously, a great effort to characterize the epidemiology of the disease in Brazilian states was started. In the state of Rondônia, a first epidemiological study was carried out in 2004, revealing a prevalence of 35.2% of infected herds and 6.22% of seropositive females. In 2014, after a successful heifer vaccination program with strain 19 (S19), a second study detected a reduction in the prevalence of infected herds to 12.3% and of seropositive females to 1.9%. The present study aimed to quantify and compare the costs and benefits related to the control of bovine brucellosis in the state through an accounting analysis. Vaccinating heifers and performing serological tests to move animals were computed as private costs. The expenditures of the state official veterinary service for brucellosis control were considered public cost. The considered benefits of lowering prevalence were decreased cow replacement, decreased abortions, decreased perinatal and cow mortality, and increased milk production. Considering private and public costs, the net present value (NPV) was estimated at US$ 18.3 million, the internal rate of return (IRR) was calculated at 23%, and the benefit-cost ratio (BCR) was 1.7. When considering only the private costs, the NPV was US$34.9 million, the IRR was 49%, and the BCR was 3.0, meaning that the bovine producer had a return of 3 for each unit of currency invested. The results showed that the bovine brucellosis control measures implemented in the state of Rondônia, which had as its main strategy the vaccination of heifers with S19, produced highly advantageous economic results. The state should continue with its vaccination program, stimulating the use of the RB51 vaccine in addition to S19, to achieve further reductions in prevalence at low cost.


Assuntos
Brucelose Bovina , Brucelose , Doenças dos Bovinos , Gravidez , Animais , Bovinos , Feminino , Brasil/epidemiologia , Brucelose Bovina/epidemiologia , Brucelose Bovina/prevenção & controle , Brucella abortus , Brucelose/epidemiologia , Brucelose/prevenção & controle , Brucelose/veterinária , Vacinação/veterinária
11.
Rev. Ciênc. Agrovet. (Online) ; 22(2): 186-193, mai. 2023. graf, tab
Artigo em Inglês | VETINDEX | ID: biblio-1444973

RESUMO

Nitrogen(N) is the most required nutrient in the cultivation of corn (Zea maysL.), also representing a significantshare in the production costs. The objective was to evaluate the efficiency for one experimental year of different sourcesof nitrogen fertilizers applied in topdressing on the corn grain yield and their respective fertilization costs. The experiment was carried out under field conditions and without irrigation under no-tillage system, in a Red Oxissol. For sowing, 280 kg ha-1of NPK fertilizer 12-30-20 was used for all treatments. In addition to the control treatment (NPK), four nitrogen formulations wereapplied in topdressing: Urea, Super N, Nitromag, and Sulfammo, both formulations applied 50% in the V3/V4 and 50% V7/V8 stages, in four replicates.Grain yield was determined at the physiological maturation. The type of nitrogen fertilizer did not influence corn grain yield, an average of 9016 kg ha-1. The largest profits were achieved with the application of Super N, Urea and Nitromag. Nitrogen fertilizers with slow and controlled N release does not promote an increase in corn grain yield in relation to Urea. The use of Super N in topdressing has the highest profitability in corn cultivation.(AU)


O nitrogênio (N) é o nutriente mais requerido no cultivo do milho (Zea maysL.), ainda representa significativa participação no custo de produção. O objetivo foi avaliar a eficiência em um ano experimental de diferentes fontes de fertilizantes nitrogenados aplicados em cobertura na produtividade de grãos demilho e os seus respectivos custos da adubação. O experimento foi realizado em condições de campo e sem irrigação sob sistema plantio direto, em Latossolovermelho. Na semeadura foi utilizado 280 kgha-1de adubo NPK 12-30-20 para todos os tratamentos. Além do tratamento testemunha (NPK), quatro formulações nitrogenadas foram aplicadas em cobertura: Ureia, Super N, Nitromag, e Sulfammo, ambas as formulaçõesaplicadas 50% no estádioV3/V4 e 50% V7/V8,em quatro repetições. Na maturação fisiológica foi determinada a produtividade de grãos.O tipo de fertilizante nitrogenado não influenciou na produtividade de grãos de milho, média de 9016 kg ha-1. Os maiores lucros foram com a aplicação de Super N, Ureia e Nitromag. O uso em cobertura de fertilizantes nitrogenados de lenta e controlada liberação de N não promovem aumento na produtividade de grãos de milho em relação a Ureia. O uso de Super N em cobertura apresenta a maior lucratividadeno cultivo do milho.(AU)


Assuntos
Zea mays/fisiologia , Fertilizantes/análise , Análise Custo-Benefício/métodos , Nitrogênio/química
12.
Heliyon ; 9(3): e14137, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36942228

RESUMO

This research analyzes the impact of a hybrid off-grid renewable energy system consisting of wind turbines, solar photovoltaic, hydrokinetic turbines and battery-backed to provide a group of novel airplane-shaped buildings, generates development in nearby towns that sit on a city vantage point from Cuenca in Ecuador. This is an innovative proposal that, in addition to using renewable energy in the complex of buildings, generates development in nearby towns. Three sources of renewable energy under energy control, load cycle and load monitoring are used to determine new patterns in the behavior of the sources with respect to the demand for electricity. Above all, it reduces carbon. With the support of HOMER Pro, the generation sources are optimized to cover the electrical demand patterns of the group of buildings in the form of airplanes. The results show that the systems that include solar panels, wind and hydrokinetic generators have a higher cost but there is more guarantee by maintaining their charge levels in the batteries above 40%. The proposed methodology and design can be widely adapted to places with similar characteristics worldwide, creating a novel solution for this type of buildings powered by renewable energy. The annual energy required by the set of buildings is 234.86 MW h/year. When projecting the renewable energy system for 25 years, an NPC of $37,600 and a COE of $0.386/kWh are achieved.

13.
J Agric Food Chem ; 71(13): 5275-5282, 2023 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-36961295

RESUMO

The increasing demand pressures the vegetable oil industry to develop novel refining methods. Degumming with type C phospholipases (PLCs) is a green technology and provides extra oil. However, natural PLCs are not active under the harsh conditions used in oil refining plants, requiring additional unit operations. These upfront capital expenditures and the associated operational costs hinder the adoption of this method. Here, we present a process based on ChPLC, a synthetic PLC obtained by consensus sequence design, possessing superior thermal stability and catalytic properties. Using ChPLC, crude soybean oil degumming was completed at 80 °C in 30 min, the temperature and residence time imposed by the design of existing oil refining plants. Remarkably, an extra yield of oil of 2% was obtained using 60% of the dose recommended for PLCs marketed today, saving upfront investments and reducing the operational cost of degumming. A techno-economic analysis indicates that, for medium size plants, ChPLC reduces the overall cost of soybean oil enzymatic degumming by 58%. The process presented here facilitates the implementation of enzymatic technologies to oil producers, regardless of their processing capacity, bringing potential annual benefits in the billion-dollar range for the global economy.


Assuntos
Óleos de Plantas , Óleo de Soja , Fosfolipases Tipo C , Temperatura
14.
Molecules ; 28(3)2023 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-36770944

RESUMO

Biorefinery feasibility is highly influenced by the early design of the best feedstock transformation pathway to obtain value-added products. Pretreatment has been identified as the critical stage in biorefinery design since proper pretreatment influences subsequent reaction, separation, and purification processes. However, many pretreatment analyses have focused on preserving and valorizing six-carbon sugars for future use in bioconversion processes, leaving aside fractions such as hemicellulose and lignin. To date, there has been no pretreatment systematization for the removal of lignocellulosic fractions. This work defines pretreatment efficacy through operational, economic, environmental, and social indicators. Thus, using the data reported in the literature, as well as the results of the simulation schemes, a multi-criteria weighting of the best-performing schemes for the isolation or removal of cellulose, hemicellulose, and lignin was carried out. As a main result, it was concluded that dilute acid is the most effective for cellulose isolation and hemicellulose removal for producing platform products based on six- and five-carbon sugars, respectively. Additionally, the kraft process is the best methodology for lignin removal and its future use in biorefineries. The results of this work help to elucidate a methodological systematization of the pretreatment efficacy in the design of biorefineries as an early feasibility stage considering sustainability aspects.


Assuntos
Celulose , Lignina , Lignina/metabolismo , Biomassa , Celulose/metabolismo , Açúcares , Hidrólise
15.
J Pediatr ; 256: 11-17.e2, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-36470464

RESUMO

OBJECTIVE: To evaluate the cost-effectiveness of tympanostomy tube placementvs nonsurgical medical management, with the option of tympanostomy tube placement in the event of treatment failure, in children with recurrent acute otitis media (AOM). STUDY DESIGN: A Markov decision model compared management strategies in children ages 6-35 months, using patient-level data from a recently completed, multicenter, randomized clinical trial of tympanostomy tube placement vs medical management. The model ran over a 2-year time horizon using a societal perspective. Probabilities, including risk of AOM symptoms, were derived from prospectively collected patient diaries. Costs and quality-of-life measures were derived from the literature. We performed one-way and probabilistic sensitivity analyses, and secondary analyses in predetermined low- and high-risk subgroups. The primary outcome was incremental cost per quality-adjusted life-year gained. RESULTS: Tympanostomy tubes cost $989 more per child than medical management. Children managed with tympanostomy tubes gained 0.69 more quality-adjusted life-days than children managed medically, corresponding to $520 855 per quality-adjusted life-year gained. Results were sensitive to the costs of oral antibiotics, missed work, special childcare, the societal cost of antibiotic resistance, and the quality of life associated with AOM. In probabilistic sensitivity analyses, medical management was favored in 66% of model iterations at a willingness-to-pay threshold of $100 000/quality-adjusted life-year. Medical management was preferred in secondary analyses of low- and high-risk subgroups. CONCLUSIONS: For young children with recurrent AOM, the additional cost associated with tympanostomy tube placement outweighs the small improvement in quality of life. Medical management for these children is an economically reasonable strategy. TRIAL REGISTRATION: ClinicalTrials.gov number, NCT02567825.


Assuntos
Otite Média , Qualidade de Vida , Criança , Humanos , Lactente , Pré-Escolar , Análise Custo-Benefício , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/cirurgia , Otite Média/terapia , Otite Média/diagnóstico , Antibacterianos/uso terapêutico , Ventilação da Orelha Média
16.
SN Bus Econ ; 3(1): 3, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36531601

RESUMO

Alternative data are now widely used in economic analyses worldwide but still infrequent in studies on the Brazilian economy. This research demonstrates how alternative data extracted from Google Trends and Google Mobility contribute to innovative economic analysis. First, it demonstrates that the search for the future on the internet is correlated (R = 0.62) with the average household income in Brazilian states. The three Brazilian states with the most people looking for the future on the internet have an average household income 1.6 times higher than people from states that do not have this behavior. The search for the future represents 10.9% of the economic development potential of the states, while the proportion of people with university degrees, scientific publications, and researchers represents another 60.4%. The reduction in mobility in retail/recreation locations averaged 34.28% in Brazil, Ecuador, Paraguay, and Uruguay. This group of countries had COVID-19 infection and death rates 1.25 and 1.74 times higher than in countries that reduced their mobility in retail/recreation locations by 45.03%. The impact of reduced mobility in retail/recreation locations on the unemployment rate, gross domestic product degrowth, and inflation in countries such as Brazil was 1.1, 2.2, and 2.6 times lower than in countries that reduced mobility more of people. The research contributions are associated with identifying new indicators extracted from alternative data and their application to carry out innovative economic analyses.

17.
Braz. J. Pharm. Sci. (Online) ; 59: e23264, 2023. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1520318

RESUMO

Abstract In Brazil, insulin analogs stand out as one of the most demanded medications by judicial means. However, the guarantee of judicial access does not guarantee rational use. In context, pharmacotherapeutic follow-up (PF) is shown to be clinical effective strategy for patients with diabetes. To evaluate direct medical costs one year after performing PF in patients with type 1 diabetes mellitus using insulin analogs ordered by court in Public Health System (Sistema Único de Saúde - SUS). This is a partial economic analysis, nested within a quasi-experimental study. Patients with T1DM who receive insulin analogs by judicialization in a medium-sized Brazilian city participated. The PF was conducted following the method adapted from the Pharmacotherapy workup (PW). Data were collected considering the period of one year before the start of the intervention and one year after the start of the intervention. Direct medical costs were evaluated and the difference in costs was calculated. 28 patients participated in the intervention. After PF, direct costs were -$3,696.78. Sensitivity analysis showed that there is a 33.4 % chance for PF to present cost savings when compared to baseline. The PF has the potential to reduce direct medical costs from the perspective of the SUS.


Assuntos
Humanos , Masculino , Feminino , Pacientes/classificação , Diabetes Mellitus Tipo 1/patologia , Judicialização da Saúde , Insulina/análogos & derivados , Assistência Farmacêutica/classificação , Redução de Custos/classificação , Custos e Análise de Custo/estatística & dados numéricos , Tratamento Farmacológico , Ensaios Clínicos Controlados não Aleatórios como Assunto/instrumentação , Métodos
18.
Data Brief ; 45: 108681, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36426061

RESUMO

This data article is associated with the research article "Sustainable production of ethyl levulinate by levulinic acid esterification obtained from Colombian rice straw". This paper shows the methodology to calculate the Life Cycle Inventory (LCI) of the foreground system to perform the Life Cycle Assessment (LCA) of the ethyl levulinate (EL) production from Colombian rice straw (RS). This process encompasses two main stages: (i) RS production (involving cultivation and harvesting) and (ii) EL production (involving acid hydrolysis, levulinic acid (LA) purification, and El production). On one hand, foreground data related to paddy rice cultivation was gathered from the literature review. Besides, emissions of the cultivation stage were calculated using the IPCC (Intergovernmental Panel on Climate Change) methodology. The SQCB (Sustainable Quick Check for Biofuels) methodology was used to calculate NH3, NOx, N2O and NO3 emissions, whereas the SALCA (Swiss Agricultural Life Cycle Assessment) model was used to calculate phosphorous emissions to water. The Turc method was employed to calculate the irrigation requirements based on the rainfall and agrological features of rice culture. On the other hand, foreground data related to RS conversion to EL within a biorefinery scheme was obtained from simulation using Aspen Plus v.12. Lastly, background data associated with raw materials, catalysts, and utilities were gathered from Ecoinvent database. All the inventories are meaningful to carry out future environmental assessments involving sustainable production processes using RS as raw material or biorefinery processes using dilute acid hydrolysis.

19.
Artigo em Inglês | MEDLINE | ID: mdl-35876049

RESUMO

This work explores the techno-economic aspects of landfill leachate treatment by an integrated scheme composed of microfiltration (MF), nanofiltration (NF), and zeolite application for carbon and nitrogen removal. In bench-scale experiments, MF and NF were investigated, and zeolite batch tests were carried out to determine optimum conditions. A preliminary economic analysis is presented for a 200 m3 d-1 full-scale treatment facility based on the data obtained from experimental tests and literature surveys. The maximum removals of 92%, 94%, and 79% for chemical oxygen demand (COD), absorbance at 254 nm, and ammonium nitrogen (NH4+-N) were achieved in bench experiments, respectively. It was possible to reach the local discharge standard for COD (200 mg L-1), but it was not possible to reach the Brazilian disposal requirement for NH4+-N (20 mg L-1). The total cost of the integrated MF + NF + zeolite system was estimated at 19.89 US$m-3. In this study, the costs of the zeolite application account for around 70% of the total costs of the integrated scheme. Membrane process integration was an adequate strategy for removing organic compounds at low operating costs; However, further NH4+-N depuration is needed to meet discharge requirements.


Assuntos
Poluentes Químicos da Água , Zeolitas , Análise da Demanda Biológica de Oxigênio , Carbono/análise , Nitrogênio/análise , Poluentes Químicos da Água/análise , Zeolitas/química
20.
Food Chem ; 383: 132446, 2022 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-35202925

RESUMO

This study aimed to verify if microwave hydrodiffusion and gravity (MHG) could efficiently extract anthocyanins from strawberries and raspberries with low environmental impact and costs. Our findings revealed that it was possible to extract 69 and 64% anthocyanins from the strawberries and raspberries in a single extraction step, respectively. When the co-product (product remaining after extracting in natura fruits) was hydrated with green solvents and subjected to re-extraction, it was possible to exhaustively extract the anthocyanins from both fruits. Using the Green Analytical Procedure Index (GAPI), the MHG proved to cause low environmental impact due to the solvents used, enabling the reuse of the co-product for food and pharmaceutical products application. Moreover, the MHG was economically viable, and the sample pretreated with distilled water was the most indicated re-extraction method. The MHG process proved to be exhaustive for strawberry and raspberry anthocyanins, thus demonstrating to be an excellent alternative for sustainable extraction.


Assuntos
Fragaria , Rubus , Antocianinas , Frutas , Micro-Ondas , Solventes
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