Antiviral Activities of Eucalyptus Essential Oils: Their Effectiveness as Therapeutic Targets against Human Viruses.

Given the limited therapeutic management of infectious diseases caused by viruses, such as influenza and SARS-CoV-2, the medicinal use of essential oils obtained from Eucalyptus trees has emerged as an antiviral alternative, either as a complement to the treatment of symptoms caused by infection or to exert effects on possible pharmacological targets of viruses. This review gathers and discusses the main findings on the emerging role and effectiveness of Eucalyptus essential oil as an antiviral agent. Studies have shown that Eucalyptus essential oil and its major monoterpenes have enormous potential for preventing and treating infectious diseases caused by viruses. The main molecular mechanisms involved in the antiviral activity are direct inactivation, that is, by the direct binding of monoterpenes with free viruses, particularly with viral proteins involved in the entry and penetration of the host cell, thus avoiding viral infection. Furthermore, this review addresses the coadministration of essential oil and available vaccines to increase protection against different viruses, in addition to the use of essential oil as a complementary treatment of symptoms caused by viruses, where Eucalyptus essential oil exerts anti-inflammatory, mucolytic, and spasmolytic effects in the attenuation of inflammatory responses caused by viruses, in particular respiratory diseases.

Effect of process variables on heating profiles and extraction mechanisms during hydrodistillation of eucalyptus essential oil.

The effect of different process variables, such as solid/liquid ratio (1: 1, 1: 3, or 1: 5 g/ml) and stirring speeds (0, 200, or 400 rpm), was studied on the extraction mechanisms of eucalyptus essential oil obtained by hydrodistillation (HD). Different performance parameters such as obtained yield, energy requirements, and environmental impact were compared to those obtained by steam distillation (SD). Two different mathematical models were used to describe the process behavior. The obtained results indicate that the system with a solid/liquid ratio of 1:5 g/ml using a stirring speed of 400 rpm yielded maximum for HD (1.19% ± 0.01%). The environmental impact expressed as Ecopoints (EI99) ranged between 50.87 ± 13.18 and 78.17 ± 13.82 mPT/g essential oil (EO) for systems with steam injection, whereas for HD took values between 16.9 ± 0.3 and 19.24 ± 1.4 mPT/g EO at optimal operating conditions. The model parameters allowed us to identify that large amounts of steam at lower heating velocities induce a high accumulation of EO in the aqueous layer (vapor-liquid equilibrium at the interface), favoring the extraction process.