Performance Assessment of Universal Machine Learning Interatomic Potentials: Challenges and Directions for Materials' Surfaces.

Machine learning interatomic potentials (MLIPs) are one of the main techniques in the materials science toolbox, able to bridge ab initio accuracy with the computational efficiency of classical force fields. This allows simulations ranging from atoms, molecules, and biosystems, to solid and bulk materials, surfaces, nanomaterials, and their interfaces and complex interactions. A recent class of advanced MLIPs, which use equivariant representations and deep graph neural networks, is known as universal models. These models are proposed as foundation models suitable for any system, covering most elements from the periodic table. Current universal MLIPs (UIPs) have been trained with the largest consistent data set available nowadays. However, these are composed mostly of bulk materials' DFT calculations. In this article, we assess the universality of all openly available UIPs, namely MACE, CHGNet, and M3GNet, in a representative task of generalization: calculation of surface energies. We find that the out-of-the-box foundation models have significant shortcomings in this task, with errors correlated to the total energy of surface simulations, having an out-of-domain distance from the training data set. Our results show that while UIPs are an efficient starting point for fine-tuning specialized models, we envision the potential of increasing the coverage of the materials space toward universal training data sets for MLIPs.

Accuracy and time efficiency of conventional and digital outlining of extensions of denture foundation on preliminary casts.

PURPOSE: The purpose of this diagnostic study was to assess the accuracy and time efficiency of a digital method to draw the denture foundation extension outline on preliminary casts compared with the conventional technique. MATERIALS AND METHODS: A total of 28 preliminary edentulous casts with no anatomical landmarks were digitized using a laboratory scanner. The outlining of the entire basal seat of the denture was performed on preliminary casts and digitized. Casts with no extension outline were digitized and outlines were drawn using software (DWOS, Straumann). The accuracy of the extension outlined between both techniques was evaluated in the software (GOM Inspect; GOM GmbH) by file superimposition. Specificity and sensitivity tests were applied to measure accuracy. The paired t-test (95% CI) was used to compare the mean total area and the working time. RESULTS: The accuracy ranged from 0.57 to 0.92. The buccal and labial frenulum showed a lower value in the maxilla (0.57); while the area between the retromolar pad and buccal frenulum (0.64) showed a lower score in the mandible. The maxillary denture foundation and the working time for both arches were significantly longer for the digital method (P < .001). CONCLUSION: The denture foundation extension outline exhibited a sufficiently excellent accuracy for the digital method, except for the maxillary anterior region. However, the digital method required a longer working time.

Multi-biomarker approach reveals the effects of heavy metal bioaccumulation in the foundation species Prosopis laevigata (Fabaceae).

Mining is a major economic activity in many developing countries. However, it disturbs the environment, producing enormous quantities of waste, known as mine tailings, which can have deleterious environmental impact, due to their high heavy metals (HM) content. Often, foundation species that establish on mine tailings are good candidates to study the effects of HM bioaccumulation at different levels of biological organization. Prosopis laevigata is considered a HM hyperaccumulator which presents attributes of a foundation species (FS) and establishes naturally on mine tailings. We evaluated the bioaccumulation of Cu, Pb, and Zn in P. laevigata foliar tissue, the leaf micro- and macro-morphological characters, DNA damage, and population genetic effects. In total, 80 P. laevigata individuals (20/site) belonging to four populations: The individuals from both sites (exposed and reference) bioaccumulated HMs (Pb > Cu > Zn). However, in the exposed individuals, Pb and Cu bioaccumulation was significantly higher. Also, a significant effect of macro- and micro-morphological characters was registered, showing significantly lower values in individuals from the exposed sites. In addition, we found significant differences in genotoxic damage in P. laevigata individuals, between the exposed and reference sites. In contrast, for the micro-morphological characters, none of the analyzed metals had any influence. P. laevigata did not show significant differences in the genetic structure and diversity between exposed and reference populations. However, four haplotypes and four private alleles were found in the exposed populations. Since P. laevigata is a species that establishes naturally in polluted sites and bioaccumulates HM in its foliar tissues, the resulting genetic, individual and population effects have not been severe enough to show detrimental effects; hence, P. laevigata can be a useful tool in phytoremediation strategies for soils polluted with Pb and Cu, maintaining its important ecological functions.

Os arquivos da Fiocruz: fontes para a pesquisa sobre a ciência e a saúde na ditadura militar (1964-1985) / The Fiocruz archives: sources for research on science and health during the military dictatorship (1964-1985)

Resumo Analisa a relação entre o processo de redemocratização política do país a partir da década de 1980 e a questão da identificação, preservação e acesso aos arquivos dos órgãos de informação e segurança que durante a ditadura militar (1964-1985) atuaram no combate aos adversários do regime autoritário. Aborda a ação da ditadura sob as instituições universitárias e científicas, de forma a destacar a importância do arquivo institucional da Fundação Oswaldo Cruz, assim como os arquivos pessoais mantidos pelos cientistas e doados à Casa de Oswaldo Cruz. Apresenta os arquivos e coleções organizados e disponíveis à consulta pública, que podem servir como fontes de pesquisa para os estudos históricos sobre a ciência e a saúde na ditadura.

Abstract The scope of this paper is to analyze the relationship between the country's political redemocratization process from the 1980s onwards and the issue of identification, preservation and access to the archives of information and security bodies that worked to combat the opponents of the authoritarian regime during the military dictatorship (1964-1985). It addresses the dictatorship's action on university and scientific institutions, to highlight the importance of the archive of the Oswaldo Cruz Foundation, as well as the personal files maintained by scientists and donated to Casa de Oswaldo Cruz. It features archives and collections organized and available for public consultation, which can serve as research sources for historical studies on science and health during the dictatorship.

On the reproductive strategies post-colony foundation: major termite pest species with distinct ecological habits differ in their oviposition dynamics.

Termite colony foundation precedes the incipient stage, when the first oviposition cycle takes place, followed by months of reproductive inactivity. The royal couple is supposed to cease oviposition during this period, investing energy to care for the first brood. When a suitable number of alloparents differentiate, egg-laying resumes. Here we followed oviposition dynamics, embryo development and queen/king body changes in laboratory colonies of the major pest species Coptotermes gestroi (Rhinotermitidae) and Cryptotermes brevis (Kalotermitidae) during 9 months. We show that they differ in these oviposition dynamics, as C. gestroi queens displayed an uninterrupted oviposition whereas C. brevis laid a cohort of eggs and ceased oviposition during a 3-month period (lag phase). C. gestroi oviposition dynamic was remarkable and suggests that occurrence of progeny was not a limiting factor, thus queens and kings were able to concomitantly invest energy in reproduction and parental care. These findings contrast those reported for rhinotermitids from temperate areas, and we discuss the likely reasons for such a condition, including endogenous rhythms, avoidance of a high mortality rate of the first progeny and adaptation to the weather conditions of the Neotropical region. Oviposition dynamic in C. brevis resembled those of several termite species, in which the royal couple cease reproduction to care for the first brood. Rearing conditions did not influence oviposition dynamics (egg-laying cycle followed by a lag phase), thus our results on the oviposition of C. gestroi and C. brevis correspond to different reproductive strategies post-foundation adopted by these pest species.

La solidaridad fundamento ético de la medicina en Cuba

Los terremotos de Turquía y Siria tuvieron lugar el 6 de febrero del 2023. El primer sismo ocurrió a 34 km al oeste de la Ciudad de Gaziantep a las 04:17 am hora local, con una magnitud de Mw 7.8 y una intensidad Mercalli máxima de XI. Hubo daños generalizados y decenas de miles de muertos. Al menos 52 000 personas murieron, 118, 626 resultaron heridos sin complicaciones de muerte y 2, 4 millones fueron desplazadas. La ayuda nacional e internacional no se hizo esperar. En este trabajo mostramos, de forma gráfica, como un grupo de la brigada médica Henry Reeve de Cuba, especialmente el equipo quirúrgico, brinda su apoyo solidario en las áreas afectadas por el sismo específicamente en el Hospital de Kahramanmarash.

The earthquakes in Turkey and Syria occurred on February 6, 2023. The first earthquake occurred 34 km west of Gaziantep City at 04:17 am local time, with a magnitude of Mw 7.8 and a maximum Mercalli intensity of XI. There was widespread damage and tens of thousands of deaths. At least 52,000 people died, 118,626 were injured without fatal complications, and 2.4 million were displaced. National and international aid did not wait. In this work we show, graphically, how a group of the Henry Reeve medical brigade of Cuba, especially the surgical team, offers its solidarity support in the areas affected by the earthquake, specifically in the Kahramanmarash Hospital.

'Eradication was a dirty word': Anti-gambiae campaign, between cooperation and rivalry (1938-1940).

This article analyzes the efforts of the International Health Division of the Rockefeller Foundation (IHDRF) in its project initiative that resulted in the extermination of the African mosquito Anopheles gambiae from Brazil in 1940. This species, which originated in Dakar, Senegal, was identified in the Brazilian city of Natal in 1930, where insufficient local emergency sanitation actions enabled it to spread into the interior of the Brazilian northeast, causing an unprecedented malaria epidemic in the Americas in 1938, after years of silent spread. We will analyse the formation of Brazil's Malaria Service of the Northeast (MSNE), discussing its political and scientific controversies and how the transition from the idea of extermination to the idea of eradication was consolidated in the political process of creating this successful sanitation campaign. In addition, we will discuss how the integration and transnational development of medical entomology at the time was a fundamental factor in the cooperation and challenges among scientists involved in this campaign. The international cooperation of scientists, albeit oriented towards the project of eradication of this mosquito, organised different research agendas and gained new insights into the global dissemination of mosquito-borne diseases.

Foundation species canopies affect understory beta diversity differently depending on species mobility.

Beta diversity measures the spatial variation in species composition. Because it influences several community attributes, studies are increasingly investigating its drivers. Spatial environmental heterogeneity is a major determinant of beta diversity, but canopy-forming foundation species can locally modify environmental properties. We used intertidal communities dominated by the canopy-forming alga Mazzaella laminarioides as a model system to examine how a foundation species affects spatial environmental heterogeneity and the resulting beta diversity. Since canopies were found to reduce the spatial variation of temperature and desiccation during low tides, we hypothesized that canopies would decrease understory beta diversity, which we tested through a field experiment that contrasted canopy removal with presence treatments over 32 months. The beta diversity of sessile species was always lower under canopies, but canopies never affected the beta diversity of mobile species. The observed responses for sessile species may result from their abundance being more dependent on spatial abiotic variation than for mobile species, which can occur in stressful areas while temporarily foraging or in transit to other areas. These responses may likely apply to other systems exhibiting canopy-forming foundation species hosting sessile and mobile species assemblages.

Os limites do financiamento de bolsistas da Fundação Rockefeller: Maria Palmira Macedo Tito de Morais e a enfermagem internacional, 1936-1966 / Limits of the Rockefeller Foundation fellowship funding: Maria Palmira Macedo Tito de Morais and international nursing, 1936-1966

Resumo Este artigo analisa a formação internacional de Maria Palmira Macedo Tito de Morais, como bolsista da Fundação Rockefeller no campo da enfermagem, durante o Estado Novo português. Compreende-se de que forma os contextos locais influenciaram as ações da agência filantrópica internacional, o que culminou em disputas com a Organização Mundial da Saúde pela presença da enfermeira portuguesa em seus quadros. São utilizados como fonte dois dossiês sobre Maria Tito de Morais e seus dois cartões de bolsista, coletados no Rockefeller Archive Center, um relatório da Direção Geral de Saúde de Portugal e o periódico A Tribuna, consultado na Hemeroteca Digital brasileira. Conclui-se que as estratégias utilizadas pela Fundação Rockefeller, ao financiar a formação de Maria Tito de Morais com o intuito de cooptá-la para seu staff, não garantiram o controle sobre sua trajetória profissional.

Abstract The article analyses Maria Palmira Macedo Tito de Morais' international nursing education as a Rockefeller Foundation fellow, during the Portuguese Estado Novo. It studies the local contexts influence on the international philanthropic agency's actions, culminating in disputes with World Health Organization over the Portuguese nurse as staff. The sources are two dossiers on Maria Tito de Morais and her two fellowship cards collected at the Rockefeller Archive Center, a report of the Directorate-General of Health of Portugal and the journal A Tribuna, consulted at the Brazilian Digital Library. In conclusion, the Rockefeller Foundation's strategies, when funding Maria Tito de Morais' education aiming to hire her did not guarantee control over her professional trajectory.

Transient decrease in sound tolerance levels following hearing deprivation in normal-hearing subjects.

Objective: To determine the circadian influence on sound sensitivity produced by temporal hearing deprivation in healthy normal human subjects. Design: Participants underwent bilateral earplugging before completion of anthropometry, the author's developed questionnaire, the Hamilton Anxiety and Depression Inventory, pure tone audiometry (PTA), stapedial reflex thresholds (SRT), distortion products otoacoustic emissions input/output (DPOAE-I/O), and uncomfortable loudness levels (ULLs). Afterward, the participants were randomly divided into group A, starting at 8:00 a.m. and finishing at 8:00 p.m., and group B, starting at 4:00 p.m. and ending at 4:00 a.m. Serum cortisol levels and audiological test results were obtained at the beginning and end of the session and 24-h free urinary cortisol levels were measured. Study sample: Thirty healthy volunteers. Results: PTA was 2.68 and 3.33 dB HL in groups A and B, respectively, with no statistical difference between them. ULLs were significantly lower in group A compared to group B, with an average of 8.1 dB SPL in group A and 3.3 dB SPL in group B (p < 0.0001). A SRT shift was observed in group A, with no difference in group B, and a night shift in DPOAE-I/O in group B. Conclusions: Reduced loudness tolerance is demonstrated during daytime hearing deprivation in contrast to nighttime; this may be due to increased central gain in the awake cortex.

COVID-19 and zoonoses in Brazil: Environmental scan of one health preparedness and response.

The emergence of the COVID-19 pandemic reinforced the central role of the One Health (OH) approach, as a multisectoral and multidisciplinary perspective, to tackle health threats at the human-animal-environment interface. This study assessed Brazilian preparedness and response to COVID-19 and zoonoses with a focus on the OH approach and equity dimensions. We conducted an environmental scan using a protocol developed as part of a multi-country study. The article selection process resulted in 45 documents: 79 files and 112 references on OH; 41 files and 81 references on equity. The OH and equity aspects are poorly represented in the official documents regarding the COVID-19 response, either at the federal and state levels. Brazil has a governance infrastructure that allows for the response to infectious diseases, including zoonoses, as well as the fight against antimicrobial resistance through the OH approach. However, the response to the pandemic did not fully utilize the resources of the Brazilian state, due to the lack of central coordination and articulation among the sectors involved. Brazil is considered an area of high risk for emergence of zoonoses mainly due to climate change, large-scale deforestation and urbanization, high wildlife biodiversity, wide dry frontier, and poor control of wild animals' traffic. Therefore, encouraging existing mechanisms for collaboration across sectors and disciplines, with the inclusion of vulnerable populations, is required for making a multisectoral OH approach successful in the country.

Unsupervised Damage Detection for Offshore Jacket Wind Turbine Foundations Based on an Autoencoder Neural Network.

Structural health monitoring for offshore wind turbine foundations is paramount to the further development of offshore fixed wind farms. At present time there are a limited number of foundation designs, the jacket type being the preferred one in large water depths. In this work, a jacket-type foundation damage diagnosis strategy is stated. Normally, most or all the available data are of regular operation, thus methods that focus on the data leading to failures end up using only a small subset of the available data. Furthermore, when there is no historical precedent of a type of fault, those methods cannot be used. In addition, offshore wind turbines work under a wide variety of environmental conditions and regions of operation involving unknown input excitation given by the wind and waves. Taking into account the aforementioned difficulties, the stated strategy in this work is based on an autoencoder neural network model and its contribution is two-fold: (i) the proposed strategy is based only on healthy data, and (ii) it works under different operating and environmental conditions based only on the output vibration data gathered by accelerometer sensors. The proposed strategy has been tested through experimental laboratory tests on a scaled model.

La resignificación participativa de la fundamentación pedagógica como escenario vital para la construcción del Proyecto Educativo Institucional / Participatory Reunification of Pedagogical Foundation as a Vital Scenario for the Construction of the Institutional Educational Project (PEI)

Resumen La Escuela Normal Superior Pbro. José Gómez Isaza (Antioquia - Colombia) realizó una investigación acción participativa propendiendo por resignificar de la fundamentación pedagógica de su Proyecto Educativo Institucional (PEI). Situación suscitada por la necesidad de formar otro tipo de maestros, con un perfil acorde a las demandas del contexto y las diversas poblaciones con las que se desenvuelven. Después de haber desplegado una ruta metodológica pensada por los actores/investigadores, fue necesaria una nueva fundamentación pedagógica, subyaciendo así una propuesta pedagógica crítico-dialógica que repensó desde categorías potencializadoras elementos básicos del currículo: formación, didáctica, investigación, relaciones pedagógicas y evaluación. Con esta propuesta se entretejió sistémicamente un nuevo PEI.

Abstract Priest José Gómez Isaza Normal High School, Antioquia, Colombia led a participatory action research striving for the redefinition of the pedagogical foundation of its Institutional Educational Project (PEI). This situation sprang from the need to form other types of teachers, according to a profile based on the demands of the context and the various populations with which they develop. After having deployed a methodological route which was designed by the actors/researchers, a new pedagogical foundation was necessary. Thus, underpinning a critical-dialogical pedagogical proposal, which reconsidered from potentializing categories, basic elements of the curriculum: training, didactics, research, pedagogical relations, and evaluation. With this proposal, a new PEI was systematically interwoven.

Community-wide consequences of nonconsumptive predator effects on a foundation species.

Predators can exert nonconsumptive effects (NCEs) on prey, which often take place through prey behavioural adjustments to minimise predation risk. As NCEs are widespread in nature, interest is growing to determine whether NCEs on a prey species can indirectly influence several other species simultaneously, thus leading to changes in community structure. In this study, we investigate whether a predator can exert NCEs on a foundation species and indirectly affect community structure. Through laboratory experiments, we first tested whether the predatory marine snail Acanthina monodon exerts negative NCEs on larviphagy (consumption of pelagic larvae) and phytoplankton filtration rates of the mussel Perumytilus purpuratus, an intertidal foundation species. These hypotheses stem from the notion that mussels may decrease feeding activities in the presence of predator cues to limit detection by predators. Afterwards, a field experiment tested whether the presence of A. monodon near mussel beds leads to higher colonisation rates of invertebrates that reproduce through pelagic larvae (expected under a lower larviphagy in P. purpuratus) and to a lower algal biomass on P. purpuratus shells (expected under a lower metabolite excretion in the mussels), thereby changing the community structure of the species typically found in P. purpuratus beds. The laboratory experiments revealed that waterborne cues from A. monodon limit the larviphagy and filtration rates of P. purpuratus. In turn, the field experiment showed that A. monodon cues led to greater abundances of barnacles and bivalves and a lower algal biomass in P. purpuratus beds, thus altering community structure. Overall, this study shows that a predator can indirectly affect community structure through NCEs on an invertebrate foundation species. As invertebrate foundation species are ubiquitous worldwide, understanding predator NCEs on these organisms could help to better understand community regulation in systems structured by such species.

Validación de la calculadora de la Fundación de Medicina Fetal para tamiz de preeclampsia adaptada a población mexicana / Validation of the Fetal Medicine Foundation calculator for pre-eclampsia screening test adapted to a Mexican population

Resumen OBJETIVO: Validar el rendimiento de la calculadora de la Fundación de Medicina Fetal 4.0 adaptada a población mexicana. MATERIALES Y MÉTODOS: Estudio de cohorte efectuado en embarazos con feto único, según el modelo de riesgos en competencia para preeclampsia en un centro de medicina fetal de la Ciudad de México. El riesgo a priori se calculó de acuerdo con la historia clínica. La presión arterial media, el índice de pulsatilidad medio de la arteria uterina y la proteína plasmática A asociada al embarazo se midieron a las 11 a 14 semanas de gestación con metodología estandarizada. El valor de cada marcador se transformó en múltiplos de la mediana adaptados a la población local. Se aplicaron la distribución normal multivariante y el teorema de Bayes para obtener las probabilidades posprueba individuales, que se utilizaron como clasificadores para el área bajo la curva de característica receptor-operador. RESULTADOS: La incidencia de preeclampsia fue del 5.0% (54/1078). El área bajo la curva de característica receptor-operador fue de 0.784 (0.712; 0.856) para preeclampsia a menos de 37 semanas y de 0.807 (0.762; 0.852) para preeclampsia global. CONCLUSIONES: La calculadora FMF 4.0 adaptada a población mexicana resultó válida. Si bien tuvo menor rendimiento al esperado para preeclampsia a menos de 37 semanas, el rendimiento para preeclampsia global fue satisfactorio. Se justifica desarrollar la calculadora local.

Abstract OBJECTIVE: To validate the performance of the Fetal Medicine Foundation 4.0 calculator adapted to the Mexican population. MATERIALS AND METHODS: Cohort study performed in singleton pregnancies, according to the competing risk model for preeclampsia in a fetal medicine center in Mexico City. The a priori risk was calculated according to the clinical history. Mean arterial pressure, mean uterine artery pulsatility index and pregnancy-associated plasma protein A were measured at 11 to 14 weeks of gestation with standardized methodology. The value of each marker was transformed into multiples of the median adapted to the local population. Multivariate normal distribution and Bayes' theorem were applied to obtain individual posttest probabilities, which were used as classifiers for the area under the receiver-operator characteristic curve. RESULTS: The incidence of preeclampsia was 5.0% (54/1078). The area under the receiver-operator characteristic curve was 0.784 (0.712; 0.856) for preeclampsia at less than 37 weeks and 0.807 (0.762; 0.852) for global preeclampsia. CONCLUSIONS: The FMF 4.0 calculator adapted to Mexican population proved valid. Although it had lower performance than expected for preeclampsia at less than 37 weeks, the performance for global preeclampsia was satisfactory. The development of the local calculator is justified.

Desenvolvimento de pesquisas no Nordeste e a importância das Fundações de Amparo (2014-2016) / Research development in the Northeast and the importance of Amparo Foundations (2014-2016)

Resumo: A FAP é corresponsável pelo desenvolvimento científico, tecnológico e a inovação no país. Com o levantamento e análise de editais publicados no site das nove FAPs da região Nordeste, constatou-se o total de 316 editais entre 2014 e 2016. Observa-se, em sua maioria, apoio para eventos, publicações e programas de pós-graduação, além de pesquisas. O Serviço Social deve atentar para a importância dessa agência de fomento, na perspectiva da qualidade da formação e do exercício profissional.

Abstract: FAP is co-responsible for scientific, technological development and innovation in the country. The survey and analysis of notices published on the website of the nine FAPs in the Northeast Region, found 316 notices between the years 2014 to 2016. It was found that the funding is mostly used for events, publications and postgraduate programs, in addition to research. Social Work must pay attention to the importance of this funding agency, in view of the quality of training and professional practice.

The Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials in Mozambique, Pakistan, and India: an individual participant-level meta-analysis

To overcome the three delays in triage, transport and treatment that underlie adverse pregnancy outcomes, we aimed to reduce all-cause adverse outcomes with community-level interventions targeting women with pregnancy hypertension in three low-income countries. Methods: In this individual participant-level meta-analysis, we de-identified and pooled data from the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised controlled trials in Mozambique, Pakistan, and India, which were run in 2014-17. Consenting pregnant women, aged 12-49 years, were recruited in their homes. Clusters, defined by local administrative units, were randomly assigned (1:1) to intervention or control groups. The control groups continued local standard of care. The intervention comprised community engagement and existing community health worker-led mobile health-supported early detection, initial treatment, and hospital referral of women with hypertension. For this meta-analysis, as for the original studies, the primary outcome was a composite of maternal or perinatal outcome (either maternal, fetal, or neonatal death, or severe morbidity for the mother or baby), assessed by unmasked trial surveillance personnel. For this analysis, we included all consenting participants who were followed up with completed pregnancies at trial end. We analysed the outcome data with multilevel modelling and present data with the summary statistic of adjusted odds ratios (ORs) with 95% CIs (fixed effects for maternal age, parity, maternal education, and random effects for country and cluster). This meta-analysis is registered with PROSPERO, CRD42018102564. Findings: Overall, 44 clusters (69 330 pregnant women) were randomly assigned to intervention (22 clusters [36 008 pregnancies]) or control (22 clusters [33 322 pregnancies]) groups. 32 290 (89·7%) pregnancies in the intervention group and 29 698 (89·1%) in the control group were followed up successfully. Median maternal age of included women was 26 years (IQR 22-30). In the intervention clusters, 6990 group and 16 691 home-based community engagement sessions and 138 347 community health worker-led visits to 20 819 (57·8%) of 36 008 women (of whom 11 095 [53·3%] had a visit every 4 weeks) occurred. Blood pressure and dipstick proteinuria were assessed per protocol. Few women were eligible for methyldopa for severe hypertension (181 [1%] of 20 819) or intramuscular magnesium sulfate for pre-eclampsia (198 [1%]), of whom most accepted treatment (162 [89·5%] of 181 for severe hypertension and 133 [67·2%] of 198 for pre-eclampsia). 1255 (6%) were referred to a comprehensive emergency obstetric care facility, of whom 864 (82%) accepted the referral. The primary outcome was similar in the intervention (7871 [24%] of 32 290 pregnancies) and control clusters (6516 [22%] of 29 698; adjusted OR 1·17, 95% CI 0·90-1·51; p=0·24). No intervention-related serious adverse events occurred, and few adverse effects occurred after in-community...

Comparison of the retention of conventional dentures after the use of common adhesive brands on poor denture foundations: an in vitro study / Comparación de la retención de dentaduras convencionales con el uso de marcas comerciales de adhesivos en procesos alveolares deficientes: un estudio in vitro

There is no information about the possible impact in denture retention after the use of common denture adhesives (DAs) when poor denture foundations (PDF) are present. Moreover, there is a lack of information about which current formulation provides greater retention and for how long. Twelve models from edentulous patients with different ridge shape and border height were used and complete dentures were manufactured. Four different formulation brands of DAs were tested after 10 minutes and three, six, nine, and 12 hours of DA application using a universal testing machine. The Fittydent® and Fixodent® adhesives had the highest retention at 12 hours. The PDF group increased on average its retention by 400 %. However, the group presented lower retention compared to the good denture foundation group. In conclusion, DAs significantly increased denture retention. The PDF group were the most benefited with the application of DAs. The Fixodent® paste had the highest retention.

No existe información acerca del posible impacto en la retención de dentaduras después del uso de adhesivos dentales comunes (DAs) cuando existen rebordes alveolares deficientes (PDF). Más aun, existe una falta de información acerca de cuál formula actual provee mayor retención y por cuanto tiempo. Doce modelos de pacientes edentulos con diferentes formas y alturas en sus rebordes alveolares fueron usados, y dentaduras completas les fueron realizadas. Cuatro diferentes fórmulas y marcas de DAs fueron evaluadas después de 10 minutos, tres, seis, nueve y 12 horas de que se aplicó el DA usando una maquina universal de pruebas. Los adhesivos Fittydent® y Fixodent® presentaron la retención más alta a las 12 horas. El grupo con PDF incrementó su retención hasta en un 400 %. Sin embargo, el grupo presentó menor retención cuando se comparó con el grupo que posee adecuados procesos alveolares. Los DAs incrementaron significativamente la retención de las dentaduras. El grupo PDF fue el más beneficiado con la aplicación de DAs. La pasta Fixodent® provee la más alta retención.

Assessment of the water quality of a subtropical lake using the NSF-WQI and a newly proposed ecosystem specific water quality index.

A Water Quality Index (WQI) is a formulation that enables the estimation of the overall quality of a water body based on significant parameters. One example of this is the well-known and widely accepted NSF-WQI, which is frequently used to assess chemical, physical, and microbiologic features of waterbodies in temperate latitudes. In this work, a well-structured method, completely based on multivariate statistical methods and historical data distributions, was used to develop an ecosystem specific water quality index (ES-WQI). Lake Cajititlán, a subtropical Mexican lake located in Tlajomulco de Zúñiga, was selected as a case of study because it is an endorheic shallow lake that shows signs of high levels of eutrophication due to anthropogenic contamination. As a result of the contamination, and its sensibility to changes in the water level, it undergoes important changes in its water features, such as turbidity and intense green color, and experiences massive events of fish mortality. The proposed ES-WQI describes the changes in water quality over the year well and correlates with the capability of the lake to support aquatic life, as the lowest estimated values coincide with the biggest events of massive fish mortality in the lake. Furthermore, the ES-WQI clearly differentiates between typical cyclic behaviors and actual deteriorating trends and is capable of tracking incremental changes all over the range of the possible concentration values of the water quality parameters.