A Study on the Correlation between Change in the Geometrical Dimension of a Free-Falling Molten Glass Gob and Its Viscosity.

To produce flawless glass containers, continuous monitoring of the glass gob is required. It is essential to ensure production of molten glass gobs with the right shape, temperature, viscosity and weight. At present, manual monitoring is common practice in the glass container industry, which heavily depends on previous experience, operator knowledge and trial and error. This results in inconsistent measurements and consequently loss of production. In this article, a multi-camera based setup is used as a non-invasive real-time monitoring system. We have shown that under certain conditions, such as keeping the glass composition constant, it is possible to do in-line measurement of viscosity using sensor fusion to correlate the rate of geometrical change in the gob and its temperature. The correlation models presented in this article show that there is a strong correlation, i.e., 0.65, between our measurements and the projected viscosity.

Introducing the Alba® Primary Packaging Platform. Part 2: Inorganic Extractables Evaluation.

Sensitivity of drugs to one or more elements of the primary packaging is a serious concern for the pharmaceutical industry. Biologics in particular are highly sensitive, leading to a higher risk of incompatibility and stability test failure as worst-case scenario.This potential incompatibility-and the consequent formulation instability due to the interactions between the drug and the primary container surface-may have multiple causes: the intrinsic nature of the container surface, leachables coming from the materials used, substances coming from the production process, or silicone oil droplets or other particles.The Alba primary packaging platform was designed to have the same interface between the drug and the glass container surface on the different primary packaging containers in order to minimize the emergence of instabilities at later stages of formulation development. Alba containers are internally treated with an innovative cross-linked coating based on silicone oil lubricant, and the additional rubber components have been selected to minimize the possible differences between the container typologies.This paper shows in great detail the reduction of the inorganic extractables released and the comparability of the performances of the different containers obtained using Alba technology.The improvement has been demonstrated by stressing the containers with different extract solutions; Alba-coated containers show a strong reduction of inorganic extractables and of corrosion degree compared to spray-on siliconized and bulk products. The containers included in the Alba platform present comparable results, and this represents a strong advantage during the drug formulation development by facilitating the transition from one container to another.LAY ABSTRACT: The sensitivity of drugs to one or more elements of the primary packaging is a serious concern for the pharmaceutical industry. Biologics in particular are highly sensitive, leading to a higher risk of incompatibility and stability test failure worst-case scenario.This potential incompatibility-and the consequent formulation instability due to the interactions between the drug and the primary container surface-may have multiple causes: the intrinsic nature of the container surface, leachables coming from the materials used, substances coming from the production process, or silicone oil droplets or other particles.The Alba primary packaging platform was designed to minimize these problems associated with the interaction between the drug and its primary packaging. This paper shows in great detail and with robust data the inorganic extractables release reduction and the delamination risk mitigation obtained using the Alba technology.

Investigation on validity period of glassware containing sterilized oral small instruments after disinfection unsealing / 重庆医学

Objective To study the validity period of glassware containing sterilized oral instruments after disinfection unsea‐ling .Methods Fifteen stomatology consulting rooms were selected on the normal working day by using the convenience sampling method .2 sterilized glass containers (filled with sterilized instruments) were selected in each room .The samples were collected at 4 ,8 ,24 ,48 ,72 ,96 ,120 ,144 ,168 h during the use process after unsealing the containers and the growth situation of bacteria was carefully observed .Results Thirty glasswares had no bacterial growth at 4 ,8 ,24 ,48 h during the use process after unsealing ,only 3 bacteria grew in the sampling culture at 72 h ,the differences had no statistical significance compared with at 4 ,8 ,24 ,48 h (P>0 .05);10 bacteria grew in the sampling culture at 96 h ,the differences had statistical significance compared with at 4 ,8 ,24 ,48 h (P<0 .05) .The validity period of glassware containing sterilized oral instruments after disinfection unsealing was 48 h .Conclusion The validity period of glassware containing sterilized oral instruments is 48 h after disinfection unsealing ,the extension of validity period can decrease the sterilization times ,reduce the equipment wastage and prolong the equipment service life .