How to protect long-term care facilities from pandemic-like events? - A systematic review on the effectiveness of non-pharmacological measures to prevent viral respiratory infections.

BACKGROUND: The SARS-CoV-2 pandemic underscored the need for pandemic preparedness, with respiratory-transmitted viruses considered as a substantial risk. In pandemics, long-term care facilities (LTCFs) are a high-risk setting with severe outbreaks and burden of disease. Non-pharmacological interventions (NPIs) constitute the primary defence mechanism when pharmacological interventions are not available. However, evidence on the effectiveness of NPIs implemented in LTCFs remains unclear. METHODS: We conducted a systematic review assessing the effectiveness of NPIs implemented in LTCFs to protect residents and staff from viral respiratory pathogens with pandemic potential. We searched Medline, Embase, CINAHL, and two COVID-19 registries in 09/2022. Screening and data extraction was conducted independently by two experienced researchers. We included randomized controlled trials and non-randomized observational studies of intervention effects. Quality appraisal was conducted using ROBINS-I and RoB2. Primary outcomes encompassed number of outbreaks, infections, hospitalizations, and deaths. We synthesized findings narratively, focusing on the direction of effect. Certainty of evidence (CoE) was assessed using GRADE. RESULTS: We analysed 13 observational studies and three (cluster) randomized controlled trials. All studies were conducted in high-income countries, all but three focused on SARS-CoV-2 with the rest focusing on influenza or upper-respiratory tract infections. The evidence indicates that a combination of different measures and hand hygiene interventions can be effective in protecting residents and staff from infection-related outcomes (moderate CoE). Self-confinement of staff with residents, compartmentalization of staff in the LTCF, and the routine testing of residents and/or staff in LTCFs, among others, may be effective (low CoE). Other measures, such as restricting shared spaces, serving meals in room, cohorting infected and non-infected residents may be effective (very low CoE). An evidence gap map highlights the lack of evidence on important interventions, encompassing visiting restrictions, pre-entry testing, and air filtration systems. CONCLUSIONS: Although CoE of interventions was low or very low for most outcomes, the implementation of NPIs identified as potentially effective in this review often constitutes the sole viable option, particularly prior to the availability of vaccinations. Our evidence-gap map underscores the imperative for further research on several interventions. These gaps need to be addressed to prepare LTCFs for future pandemics. TRIAL REGISTRATION: CRD42022344149.

Reconsidering screening thresholds in health assessments for obstructive sleep apnea using operational and safety incident data.

The rail industry in Australia screens workers for probable obstructive sleep apnea (OSA) due to known safety risks. However, existing criteria to trigger screening only identify a small proportion of workers with OSA. The current study sought to examine the relationship between OSA risk and rail incidents in real-world data from Australian train drivers, and conducted a proof of concept analysis to determine whether more conservative screening criteria are justified. Health assessment (2016-2018) and subsequent rail incident data (2016-2020) were collected from two passenger rail service providers. Predictors included OSA status (confirmed no OSA with a sleep study, controlled OSA, unknown OSA [no recorded sleep assessment data] and confirmed OSA with no indication of treatment); OSA risk according to the current Standard, and OSA risk according to more conservative clinical markers (BMI threshold and cardiometabolic burden). Coded rail safety incidents involving the train driver were included. Data were analysed using zero-inflated negative binomial models to account for over-dispersion with high 0 counts, and rail safety incidents are reported using Incidence Risk Ratios (IRRs). A total of 751 train drivers, typically middle-aged, overweight to obese and mostly men, were included in analyses. There were 43 (5.7%) drivers with confirmed OSA, 62 (8.2%) with controlled OSA, 13 (1.7%) with confirmed no OSA and 633 (84.4%) drivers with unknown OSA. Of the 633 train drivers with unknown OSA status, 21 (3.3%) met 'at risk' criteria for OSA according to the Standard, and incidents were 61% greater (IRR: 1.61, 95% Confidence Interval (CI) 1.02-2.56) in the years following their health assessment compared to drivers who did not meet 'at risk' criteria. A more conservative OSA risk status using lower BMI threshold and cardiometabolic burden identified an additional 30 'at risk' train drivers who had 46% greater incidents compared to drivers who did not meet risk criteria (IRR (95% CI) 1.46 (1.00-2.13)). Our more conservative OSA risk criteria identified more workers, with greater prospective incidents. These findings suggest that existing validated tools could be considered in future iterations of the Standard in order to more sensitively screen for OSA.

Mandatory immunizations for health students in Lyon (France), overview and evaluation / Obligations d'immunisation des étudiants en santé de Lyon, état des lieux et évaluation

OBJECTIVES: To establish an overview of vaccination amongst health students in Lyon 1 University and to evaluate the implementation of a new verification system of immunization obligations with an electronic vaccination card (EVC) from the “MesVaccins.net” website. METHODS: A questionnaire was sent by the Lyon 1 University Student Health Service (SHS) to the first-year health studies students over the age of 18 in Lyon in 2020-2021 who shared their EVC; exploitation of these EVCs’ data. RESULTS: Amongst all students, 67.4% transmitted their information to the SHS. They reported organizational difficulties in updating (33.3%) and certifying their EVC with a healthcare professional (55.9%). Global satisfaction of the students was 78.0%. This study highlighted many differences between Lyon Est and Lyon Sud campuses, especially about general knowledge of the SHS, visibility of the promotion campaign, rate of students who transmitted their information to the SHS and rate of up-to-date students. Regarding mandatory immunization, 83.4% of the students were up-to-date with diphtheria-tetanus-poliomyelitis, 56.8% with hepatitis B, and 64.7% had done a tuberculin intradermal test; 43.4% of the students were simultaneously up-to-date with these three immunizations. CONCLUSION: The rate of up-to-date students is insufficient. This study stresses the necessity of an early campaign of immunizations promotion, with better access to healthcare professionals able to certify EVCs.

Objectifs: Établir un état des lieux de la vaccination des étudiants en santé de l'université Lyon 1 et évaluer la mise en place d'un nouveau dispositif de vérification des obligations d'immunisation à l'aide du carnet de vaccination électronique (CVE) MesVaccins.net. Méthodes: Questionnaire envoyé par le Service de santé universitaire (SSU) de Lyon 1 aux étudiants majeurs en première année de santé en 2020-2021 ayant partagé leur CVE ; exploitation des données de ces CVE. Résultats: Les étudiants étaient 67,4 % à avoir transmis leurs informations au SSU. Ils ont rapporté des difficultés organisationnelles pour se mettre à jour (33,3 %) et pour faire valider leur CVE par un professionnel de santé (55,9 %). La satisfaction globale des étudiants vis-à-vis de ce dispositif était de 78,0 %. Cette étude a mis en avant plusieurs différences entre les campus de Lyon Est et Lyon Sud, notamment sur la connaissance du SSU, la visibilité de la campagne, le pourcentage d'étudiants qui ont transmis leurs informations et le pourcentage d'étudiants à jour. Concernant les immunisations obligatoires, 83,4 % des étudiants étaient à jour du vaccin diphtérie-tétanos-poliomyélite, 56,8 % de l'hépatite B et 64,7 % avaient pratiqué une intradermoréaction ; 43,4 % des étudiants étaient à jour simultanément de ces trois immunisations. Conclusion: Le pourcentage d'étudiants à jour est insuffisant. Cette étude souligne la nécessité d'une campagne précoce de promotion des immunisations avec un meilleur accès des étudiants à des professionnels de santé validant les CVE.

Differences in the risk profiles of drunk and drug drivers: Evidence from a mandatory roadside survey.

BACKGROUND: The study assesses the prevalence rates of alcohol- and drug-involved driving in Catalonia (Spain). METHOD: Drivers were randomly selected for roadside testing using a stratified random sampling procedure representative of all vehicles circulating on non-urban roads. Mandatory alcohol and drug tests were performed during autumn 2017. A sample of 6860 drivers were tested for alcohol use, of these 671 were also tested for drugs. Standard procedures were employed by traffic officers to detect alcohol and drug use. Alcohol breath tests were performed with breathalyser devices and on-site drug screening systems were used to test for drugs. RESULTS: The prevalence of alcohol use above the legal limit and drug use were 1.2 % (95 % CI: 0.9-1.5 %) and 8.3 % (95 % CI: 5.8-11.2 %), respectively. The most frequent drugs detected were THC (5.6 %, 95 % CI: 3.7-8.0 %), cocaine (3.5 %, 95 % CI: 2.0-5.5 %) and amphetamines (1.6 %, 95 % CI: 0.6-3.4 %). Alcohol use was detected more frequently on conventional roads, at weekends and during night-time hours. Drug use was detected more frequently in young males during daytime hours. CONCLUSIONS: Driver risk profiles associated with alcohol use and drug use differ. Positive alcohol use is not a predictor of drug use when controlling for all other factors.

Health Insurance Is Associated with Decreased Odds for Undiagnosed Prediabetes and Type 2 Diabetes in American Adults.

Over a third of adults in the United States have prediabetes, and many of those with prediabetes will progress to type 2 diabetes within 3-5 years. Health insurance status may factor into a proper diagnosis of prediabetes and diabetes. This study sought to determine the associations between health insurance and undiagnosed prediabetes and diabetes in a national sample of American adults. Publicly available data from 13,029 adults aged 18-64 years from the 2005-2016 waves of the National Health and Nutrition Examination Survey were analyzed. Health insurance type (Medicaid, Private, Other, None) was self-reported. Prediabetes and diabetes status were assessed with measures of self-report, glycohemoglobin, fasting plasma glucose, and two-hour glucose. Covariate-adjusted logistic models were used for the analyses. Overall, 5976 (45.8%) participants had undiagnosed prediabetes, while 897 (6.8%) had undiagnosed diabetes. Having health insurance was associated with decreased odds ratios for undiagnosed prediabetes: 0.87 (95% confidence interval (CI: 0.79, 0.95)) for private insurance, 0.84 (CI: 0.73, 0.95) for other insurance, and 0.78 (CI: 0.67, 0.90) for Medicaid. Moreover, having private health insurance was associated with 0.82 (CI: 0.67, 0.99) decreased odds for undiagnosed diabetes. Health insurance coverage and screening opportunities for uninsured individuals may reduce prediabetes and diabetes misclassifications.

Caracterización del comportamiento clínico y de laboratorio de pacientes con sospecha de dengue / Characterization of clinical and laboratory behavior of patients with suspected dengue

RESUMEN Fundamento: el dengue es una enfermedad infecciosa muy extendida en varias regiones del planeta. Objetivo: caracterizar el comportamiento de algunos parámetros clínicos y de laboratorio de pacientes con sospecha de dengue. Métodos: se realizó un estudio analítico longitudinal prospectivo en el Hospital Clínico Quirúrgico Docente Amalia Simoni desde de junio de 2016 a junio de 2017. El universo estuvo compuesto por 151 pacientes de los cuales se seleccionó una muestra de forma probabilística aleatoria simple compuesta por 90 pacientes. Los datos se recogieron en un formulario y se procesaron en una base de datos creada con SPSS v23. Resultados: los resultados agrupados en forma de tablas, mostraron predominio de los pacientes del sexo masculino, los síntomas iniciales más frecuentes estuvieron dados por fiebre asociada a cefalea y artralgia. Conclusiones: entre los síntomas iniciales encontrados predominaron los pacientes que no presentaron signos de alarma de dengue, la aparición de estos signos se asoció de forma significativa a leucocitosis, hematocrito elevado y trombocitopenia.

ABSTRACT Background: dengue is an infectious disease widespread in several regions of the planet. Objective: to characterize the behavior of some clinical and laboratory parameters of patients with suspected dengue. Methods: a prospective longitudinal analytical study was carried out at the Amalia Simoni Teaching Surgical Clinical Hospital in the period from June 2016 to June 2017. The universe consisted of 151 patients from which a sample of simple probabilistic form composed of 90 patients was selected randomly. The data was collected in a form and processed in a database created with SPSS v23. Results: the results grouped in the form of tables, showed predominance of male patients, the most frequent initial symptoms were due to fever associated with headache and arthralgia. Conclusions: among the most frequent initial symptoms, patients with no signs of dengue alarm predominated, the appearance of these signs was significantly associated with leukocytosis, elevated hematocrit and thrombocytopenia.

Review of Evidence for Using Chest X-Rays for Active Tuberculosis Screening in Long-Term Care in Canada.

Background: People living in long-term care facilities (LTCF) are at high risk to develop active tuberculosis primarily as a result of reactivation of a latent TB infection, or endemic transmission between residents. Current national guidelines in Canada are to use a posterior-anterior and lateral chest X-ray to screen for TB for those over 65 years old, upon admission to a LTCF. Objective: To assess the available evidence for cost benefits of universal chest X-ray screening for new LTCF residents. Methodology: We conducted a search for all articles published until September 2018, in PubMed and WorlCat databases, in English, using a combination of key words: chest X-ray, chest radiography or CXR, long-term care, elderly, screening, and tuberculosis. We also reviewed publicly available guidelines for screening new residents to LTCF from across Canada. We report on a qualitative synthesis of the evidence in the documents retrieved. Results: The final review yielded four cost-effectiveness studies (2 of 4 conducted in countries with low incidence), one systematic review, one recommendation/editorial, and one cohort study. We found that in a tuberculosis low-incidence country the CXR cost per identified case was $672,298 CAD. Enacting a more targeted screening program, perhaps one that tests only those who previously had TB, or other high-risk medical conditions may enhance the cost-effectiveness. Recommendations: We suggest reviewing the screening policy for active TB in people entering LTCF, which is based on a CXR. The results indicate that a targeted search for active TB in people with symptoms or other high-risk medical conditions may be more cost-effective.

Effect of a cognitive test at license renewal for older drivers on their crash risk in Japan.

OBJECTIVE: To evaluate the effect of adding a cognitive test to a license renewal procedure for drivers aged 75 years or older in reducing their motor vehicle collisions (MVCs). The test has been obligatory since June 2009. METHODS: Using monthly police-reported national data on MVCs from January 2005 through December 2016, we calculated the rates of MVCs per licensed driver-year by sex and age group (70-74, 75-79, 80-84 and 85 years or older) for each month together with the ratios of MVC rates of drivers in the three oldest age groups (which are subject to the test) to those of the 70-74 years group (not subject to the test) to control for extraneous factors affecting MVCs over the study period. Then, we conducted an interrupted time-series analysis by regressing the rate ratio stratified by sex and age group on the number of months from January 2005, June 2009 (when the cognitive test was introduced to a license renewal procedure) and June 2012 (when all drivers subject to the test have taken it at least once). RESULTS: The rates showed a longitudinal decrease in male and female drivers over the study period without any apparent effects of the introduction of the cognitive test while no significant decrease was observed in the rate ratios after the introduction of the cognitive test. CONCLUSIONS: There were no clear safety benefits of the cognitive test for drivers aged 75 years or older to reduce their MVCs.

The knowledge, perceptions and relationship behaviour of rugby and football players towards HIV infection at the University of Limpopo.

BACKGROUND:  Sport has the capability to unite a country. To achieve winning teams, athletes have to rely on each other and often have close physical contact. Disclosure of a positive human immunodeficiency virus (HIV) status may be problematic for athletes in contact sports as they may suffer discrimination and stigmatisation which may impact their relationship behaviours. This may impact frontline nursing and medical staff dealing with on-field 'blood' injuries. OBJECTIVES:  The purpose of this study was to determine if individuals who participate in football and rugby are aware of the risk of HIV infection in contact sports and their perceptions and reported behaviour towards HIV-positive athletes. METHOD:  A cross-sectional survey design with a qualitative element. Quantitative data were analysed using descriptive statistics, while thematic content analysis was used to analyse qualitative data.Non-proportional quota sampling was used for male rugby (n = 23) and football (30) players registered at the University of Limpopo (Turfloop campus). RESULTS:  The results supported previous research in that there are gaps in HIV knowledge. For instance, not knowing that anal sex may cause HIV infection and believing that saliva can transmit HIV and that blood transfusions are unsafe. CONCLUSION:  Problematic findings were that a portion of the sample believed that having sex with a virgin could cure HIV and the majority of the sample believed that being 'bewitched' could cause HIV and acquired immunodeficiency syndrome (AIDS).

Congenital syphilis in a philanthropic maternity of the state of Sergipe: still a challenge / Sífilis congênita em maternidade filantrópica do estado de Sergipe: ainda um desafio

Introduction: Syphilis is a bacterial disease whose main means of contamination are the transplacental and sexual pathways. Its high prevalence in pregnancy in Brazil makes it a national public health issue. Objective: To evaluate the positivity of the mandatory testing recommended by the Brazilian Ministry of Health (MoH) in children of VDRL-positive mothers, using data from a congenital syphilis clinic in a Philanthropic Maternity of Aracaju, Sergipe (SE). Methods: Observational, longitudinal and descriptive design, following the MoH' congenital syphilis elimination program protocol (2006). Live births of VDRL-positive mothers were included from January 2010 to December 2014. Data analysis was performed using SPSS v21.0. Results: A total of 428 newborns (NB) were evaluated; 395 long-bone r-rays were carried out, of which, 7.3% had radiological alterations. VDRL positivity was found in cerebrospinal fluid (2.7%) and in peripheral blood (70.3%). The ear testing was altered in 3.0% and the examination of the eye fundus altered in 2.5%. The chance of having bone changes was greater in those who were born weighing from 1 to 2.5 kg and in those who presented with syphilis symptoms. Cerebrospinal fluid positivity was higher in those who had bone changes, were symptomatic, and whose partners were not treated. Maternal treatment decreased the chance of bone changes in infants. Conclusion: The non-treponemal test, VDRL, in peripheral blood was the most significant in the identification of the vertical transmission, corresponding to 70.3% of the identified samples, suggesting that its use had a greater diagnostic sensitivity, being the long bones radiography, ear test, and eye fundus test complementary in screening children of VDRL-positive mothers. In addition, the outpatient follow-up was statistically significant (p<0.01) in reducing the patients' morbidity and mortality. This reinforces the importance of updating the guidelines for Congenital Syphilis management by the Ministry of Health, used in the institution at the time of the study, aiming to eradicate this disease that still persists despite almost seven decades of penicillin usage

Introdução: A sífilis é uma doença bacteriana que tem como principais meios de contaminação a via transplacentária e a sexual. Sua alta prevalência na gestação no Brasil a torna um problema de saúde pública. Objetivo: Avaliar a positividade dos exames preconizados pelo Ministério da Saúde (MS) em filhos de mães Venereal Disease Research Laboratory (VDRL) positivo, mediante dados do ambulatório de sífilis congênita numa maternidade filantrópica de Aracaju (SE). Métodos: Design observacional, longitudinal e descritivo, seguindo o protocolo do programa de eliminação de sífilis congênita do MS de 2006. Foram incluídos nascidos vivos de mães VDRL positivo, no período de janeiro de 2010 a dezembro de 2014. Na análise de dados, utilizou-se o software SPSS® versão 21.0. Resultados: Foram avaliados 428 recém-nascidos (RN); 395 realizaram radiografia de ossos longos, dos quais 7,3% tinham alterações radiológicas. O VDRL foi positivo no liquor em 2,7% e no sangue periférico em 70,3% deles. O teste da orelhinha e o exame de fundo de olho foram alterados em 3,0 e 2,5%, respectivamente. A chance de ter alterações ósseas foi maior naqueles que nasceram com peso entre 1 e 2,5 kg e naqueles que apresentaram sintomas de sífilis. A positividade do liquor foi maior naqueles que tinham alterações ósseas, eram sintomáticos e cujos parceiros não foram tratados. O tratamento materno diminuiu a chance de alterações ósseas nos bebês. Conclusão: O teste não treponêmico, o VDRL, em sangue periférico foi o mais significativo na identificação da transmissão vertical, correspondendo a 70,3% das amostras identificadas, sugerindo-se que sua utilização teve maior sensibilidade diagnóstica, tendo a radiografia de ossos longos, o teste da orelhinha e o exame de fundo de olho um papel complementar no rastreio dos filhos de mães VDRL positivo. Além disso, o acompanhamento ambulatorial dos pacientes foi estatisticamente significativo (p<0,01) para redução de morbimortalidade dos pacientes avaliados. Isso reforça a importância da manutenção das guidelines para manejo de sífilis congênita do MS, utilizadas na instituição na época do estudo, objetivando erradicar essa doença que ainda persiste apesar de quase sete décadas do uso da penicilina

Therapeutic monoclonal antibodies and clinical laboratory tests: When, why, and what is expected?

BACKGROUND: We herein provide an overview of the clinical laboratory tests that should be performed before, during and after using therapeutic monoclonal antibodies (mAbs) and the clinical laboratory tests that may be affected by mAbs. METHODS: The labels of FDA-approved therapeutic mAbs were downloaded from DailyMed (the official website for drug labels) and were used as the sources of data for this review. RESULTS: It was found that most of the labels provided information relevant to the clinical laboratory tests, including the tests needed before mAbs treatment to check the patients' background status and to identify potentially sensitive patients, the tests needed during or after the treatment to evaluate the patients' response, and the mAbs that may lead to false positive or negative results for clinical laboratory tests. CONCLUSIONS: The present findings will be of interest to physicians, laboratory scientists, those involved in drug development and surveillance and individuals making health care policy.

Referentes teóricos sobre la retinopatía de la prematuridad y sus criterios de pesquisa / Theoretical framework on retinopathy of prematurity and research criteria

Fundamento: La retinopatía de la prematuridad es una microangiopatía vasoproliferativa que se desencadena en los niños pretérminos y con factores de riesgo para su desarrollo. Puede avanzar, de no ser detectada y tratada, hacia la discapacidad visual e incluso la ceguera, de ahí la importancia de su pesquisaje. Se realizó una revisión sistemática sobre este tema relativamente joven en la oftalmología, en la base de datos Medline, que involucrara la última década, por ser esta la etapa en que Cuba ha desarrollado el trabajo de pesquisaje y tratamiento de la enfermedad. Objetivo: Actualizar los conocimientos acerca de la retinopatía de la prematuridad y sus criterios de pesquisa. Desarrollo: En el mundo se han realizado estudios multicéntricos para su mejor comprensión y manejo; y se han unificado criterios para su clasificación, siendo los principales factores de riesgo a los que se asocia la baja edad gestacional al nacimiento, el bajo peso extremo, el empleo de ventilación y oxígeno, entre otros. Existen varios tratamientos para evitar la ceguera por retinopatía de la prematuridad, siendo el láser el más utilizado actualmente, combinándose en muchos casos con terapéuticas novedosas como la vitrectomía y los antiangiogénicos. En cuanto a los criterios de pesquisa no existe uniformidad en el mundo, pero Cuba cuenta con un Protocolo Nacional para su manejo, que garantiza su diagnóstico oportuno y un tratamiento inmediato. Conclusiones: La retinopatía de la prematuridad es una enfermedad oftalmológica que constituye prioridad en Cuba, existiendo en el país un protocolo nacional para su manejo y así evitar el daño visual que puede ocasionar.

Background: The retinopathy of the prematurity is a vasoproliferative microangiopathy that is unchained in preterm children and with factors of risk for its development. It can advance, of not being detected and treated, toward the visual handicap and even the blindness, of there the importance of their inquire criteria. It was carried out a systematic revision on this relatively young topic in ophthalmology, in the database Medline that involved the last decade, to be this the stage in that Cuba has developed the inquire criteria work and treatment of the illness. Objective: To upgrade the knowledge about the retinopathy of the prematurity and its investigation approaches. Development: In the world there have been carried out multicentre studies for its best understanding and handling; and it have become unified approaches for its classification, being the main factors of risk to those that associates the low gestational age at birth, the extreme low weight, the ventilation and oxygen employment, among others. Several treatments exist to avoid the blindness for retinopathy of the prematurity, being the laser the more used at the moment, combining in many cases with therapeutic novel as the vitrectomy and the angiogenic. As for the investigation approaches uniformity doesn't exist in the world, but Cuba has a National Protocol for its handling that guarantees its opportune diagnosis and an immediate treatment. Conclusions: The retinopathy of the prematurity is an ophthalmologic illness that constitutes priority in Cuba, existing in the country a national protocol for its handling and this way to avoid the visual damage that can cause.

Adoption of Donor Screening Policy in a Tissue Bank at a Tertiary Hospital / 대한수혈학회지

BACKGROUND: Tissues for transplantation can save lives or restore essential functions. According to national policies and regulations, access to suitable transplantation, as well as the level of safety, quality, efficacy of donation, and transplantation of tissues, differ significantly between countries. We reviewed a few guidelines on tissue banking from the aspect of screening tests. In addition, four-year experience with screening panels for donated bones and donors at a tertiary hospital is introduced. METHODS: Seven national and international guidelines for screening tests for donors and donated tissues were reviewed. At our institution, screening tests for donation involve two steps. At retrieval, the first screening panel, including ABO/Rh typing, unexpected antibody screening, VDRL, HBsAg, anti-HBs, anti-HBc IgM, anti-HCV, anti-HIV, and microbiological cultures was performed. The second screening panel, including the same tests, except culture studies, was performed after 90 days. From 2008 to 2011, a total of 245 retrievals of bone tissue were performed and the screening panel results were analyzed. RESULTS: Mandatory screening serologic tests for living donors can differ according to local law or regulation and/or screening for endemic diseases. At our institution, among 245 donated bones for a period of four years, 61 bone tissues were discarded due to noncompliance for the second screening (n=32), contamination or no culture study results (n=9), abnormal serologic test results (n=8), and so on. CONCLUSION: Donor screening policies for tissue banking are various according to national laws or endemic disease status. Second screening tests with consideration of the window period should be adopted.

The analysis of playsical examination for 74 624 senior high school graduate students / 中华健康管理学杂志

Objective To investigate and analyze the constitution and health condition of senior high school graduate students,and to find methods to improve and promote teenagers' health.Methods Seventy-four thousand six hundred and twenty-four senior high school students graduated from the vear 2003 to 2007 were taken the health examination according to common university and college recruitment examination standard by special medical personnel.The whole data were statistically analyzed.Results The data showed that there were 30 cases of acute viral hepatitis,41 cases of infiltrative pulmonary tuberculosis,5 cases of congenital heart diseases,the rate of hepatitis B virus(HBV)infection was 9.0%(6959/74 624),nearsightedness 82.0%(61 082/74 624);and that the rate of purely qualification,unqualified quantity and specialty limit rate(contain Single disease accumulated) for registering was 14.0%,72 cases and 93.0%(69 593/74 624) respectively.Conclusion The constitution of senior high school graduate students was unsatisfactory.