1.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-535002
RESUMO
The effects of superoxide dismutase (SOD) on mitochondrial function after hypoxic and reoxygenated perfusions in isolated rat hearts were observed. Significant decreases in respiration control ratio (RCR) and ADP/O ratio (P/O) as well as activities of succinic dehydrogenase (SDH) and cytochrome oxidase (CCO) were found alter 40 minutes' hypoxia and 20 minutes' reoxygenated perfusion. Adding SOD to the perfusion fluid during the reperfusion period could restore the decreased mitochondfial function, which was shown by increased RCR and P/O as well as activities of SDH and CCO.