Primary intestinal type mucinous adenocarcinoma of the ovary diagnosed during pregnancy - Maternal and neonatal treatment and outcomes: A case report.

The incidence of ovarian cancer during pregnancy is low. Most adnexal tumors removed during pregnancy are benign, with ovarian carcinomas found in approximately 1: 10,000-1: 50,000 pregnancies. Literature on this disease is scarce and consists mostly of retrospective studies and case reports. We report the case of a pregnant patient who presented with a primary intestinal-type mucinous adenocarcinoma of the ovary and underwent unilateral salpingo-oophorectomy, with no additional surgical or chemotherapy treatment after the histological diagnosis, despite an infiltrative stromal invasion pattern. To the best of our knowledge, no such case has been previously reported. Conservative treatment in this case of early ovarian carcinoma is possible during pregnancy and should be performed in the Department of Gynecological Oncology and Obstetrics of a tertiary referral hospital. Given the possibility of disease recurrence, such patients require strict clinical oncological surveillance, specialized prenatal care, and assistance from a multidisciplinary team to improve the maternal and perinatal outcomes.

Carcinoma mucinoso de mama: una estirpe histológica rara de pronóstico favorable / Mucinous Carcinoma of the Breast: A Rare Histological Type with a Favorable Prognosis

Resumen El carcinoma mucinoso es una estirpe poco frecuente de cáncer de mama, la cual representa menos del 4% de todos los cánceres primarios. Suele presentarse en pacientes postmenopáusicas, alrededor de la séptima década de la vida. Clínicamente se caracteriza por manifestarse como un nódulo palpable, rara vez acompañado de otra sintomatología. Las herramientas de imagen, como la mastografía y el ultrasonido, son fundamentales para su diagnóstico; sin embargo, en algunas situaciones se puede subestimar el diagnóstico dado a las características similares que comparte con otras lesiones benignas. El diagnóstico definitivo se realiza por medio de histopatología. Debido a la rareza de estos tumores, no existe un consenso sobre el tratamiento más adecuado. Muchos autores concuerdan que la intervención quirúrgica continúa siendo la piedra angular, ya que tiene un impacto positivo en la supervivencia y baja incidencia de recurrencias. Esta se puede acompañar posteriormente de terapias endocrinas adyuvantes. Afortunadamente, el pronóstico de este tipo de tumores suele ser favorable, incluso la supervivencia supera el 90% a los 5 años.

Abstract Mucinous carcinoma is a rare type of breast cancer, which represents less than 4% of all primary cancers. It usually occurs in postmenopausal patients, around the seventh decade of life. Clinically, it is characterized by the presence of a palpable nodule, rarely accompanied by other symptoms. Imaging tools, such as mammogram and ultrasound, are essential for its diagnosis, however, in some situations the diagnosis can be underestimated due to the similar characteristics that it shares with other benign lesions. Definitive diagnosis is made by histopathology. Regarding treatment, there is no consensus on the most appropriate, due to the low incidence of these tumors. Many authors agree that surgical intervention continues to be the best option, showing a positive impact on survival and low recurrences. This can be accompanied later by adjuvant endocrine therapies. Fortunately, the prognosis of this type of tumor is usually favorable, even survival exceeds 90% at 5 years.

Role of magnetic resonance imaging in the differentiation of mucinous ovarian carcinoma and mucinous borderline ovarian tumors

SUMMARY OBJECTIVE: This study was carried out to investigate the differentiation of mucinous borderline ovarian tumor from mucinous ovarian carcinoma using magnetic resonance imaging. METHODS: We evaluated 77 women patients who underwent abdominal magnetic resonance imaging due to pelvic mass. magnetic resonance imaging was reviewed by an experienced radiologist. A total of 70 women patients were included in the study. The magnetic resonance imaging features were retrospectively evaluated and compared between the two pathologies. RESULTS: There was no difference between the two groups in terms of maximum tumor size. Age at diagnosis was 56.29±11.92 in the mucinous ovarian carcinoma group and 44.74±13.60 in the mucinous borderline ovarian tumor group (p<0.05). A significant difference was found between the two groups, and it was observed that mucinous borderline ovarian tumors appeared in the younger age group compared to mucinous ovarian carcinomas. Presence of ascites, peritoneal dissemination, lymphadenopathy, and mural nodules was found significantly more frequently in mucinous ovarian carcinomas than in mucinous borderline ovarian tumors. Honeycomb appearance was found more frequently in mucinous borderline ovarian tumor patients than in mucinous ovarian carcinoma patients. CONCLUSION: magnetic resonance imaging findings of these two pathologies overlapped considerably. Compared with mucinous borderline ovarian tumors, mucinous ovarian carcinomas frequently had mural nodules larger than 5 mm, larger tumor size, peritoneal dissemination, and abnormal ascites.

Pure mucinous breast carcinoma in a 25-year-old female, a case report.

INTRODUCTION: Mucinous carcinoma is a variant of invasive breast carcinomas representing 2% of them. These tumors frequently develop in postmenopausal females; it is a rare histological variant in young patients. CASE PRESENTATION: A 25-year-old female refers a slow growth mass of 2 years of evolution. Excisional biopsy reveals a pure mucinous carcinoma with positive hormone receptors and negative HER2. She was treated with hormone therapy and surgical resection. DISCUSSION: Mucinous carcinoma is a rare variant reported in young patients. Many series report that is frequently found in postmenopausal patients. We present a case of a pure mucinous carcinoma in a 25-year-old female with the importance of being a low-frequency malignancy in young patients. CONCLUSION: Due to its benign course, it is important to know that this lesion can also present in young patients. The importance underlies in the multidisciplinary management at the right time in a proper way.

Hallazgos clínico-patológicos del cáncer mucinoso de la mama / Pathological and clinical findings of mucinous carcinoma of the breast

Resumen OBJETIVO: Determinar la frecuencia y los hallazgos clínico-patológicos del carcinoma mucinoso de la mama. MATERIALES Y MÉTODOS: Estudio retrospectivo, observacional, descriptivo y transversal consistente en el análisis de los expedientes clínicos de pacientes atendidas en el Hospital de Ginecología Luis Castelazo Ayala entre el 1 de enero de 2009 y el 31 de diciembre 2016 con muestras quirúrgicas referidas por el servicio de Anatomía patológica con diagnóstico de carcinoma mucinoso de la mama. Criterios de inclusión: casos de carcinoma mucinoso de la mama. Criterios de exclusión: ausencia de registro de biopsia o de reporte histológico, carcinoma de la mama asociado con otro tipo histológico distinto. RESULTADOS: Se encontraron 64 casos de carcinoma mucinoso invasor de la mama. Promedio de edad: 61.9 años (límites 32 y 95). Diez pacientes se ubicaron en el grupo de 66 a 70 años y 8 en el de 41 a 45 años. Se registraron 49 casos de carcinoma mucinoso puro y 15 de carcinoma mixto, de éstos 9 correspondieron al tipo histológico ductal, 1 al tipo lobulillar, 3 al ductolobulillar y 2 de otra variante histológica. CONCLUSIONES: El carcinoma mucinoso es una variante rara del carcinoma invasivo del conducto mamario que aparece en mujeres de edad avanzada. El diagnóstico y el tratamiento oportuno son posibles mediante mamografía y confirmación histopatológica.

Abstract OBJECTIVE: To determine the frequency and clinicopathological findings of Mucinous carcinoma of the breast. MATERIALS AND METHODS: Retrospective, observational, descriptive and transversal study. Analyzed the clinical records of patients whose surgical samples were referred to the pathology Department of the Hospital of Gynecology Luis Castelazo Ayala with the diagnosis of Mucinous carcinoma of the breast, during the 01 of January 2009 to the December 31, 2016. Inclusion criteria all cases of Mucinous carcinoma of the breast and the exclusion of those who did not have record of biopsy or absence of histological report, carcinoma of the breast associated with another different histological type. RESULTS: 64 cases with invasive Mucinous carcinoma of the breast between 2009 and 2016 were reported. The average age was 61.9 years (32 to 95 limits). We identified 10/64 patients aged 66 to 70 years and 8/64 in the 41 to 45 years. There were 49/64 Mucinous carcinoma of pure and 15/64 mixed carcinoma, of which 9/15 corresponded to the histological type of ductal, Lobular type 1/15, 3/15 ductolobulillar and other histological Variant 2/15. CONCLUSIONS: Mucinous carcinoma is a rare variant of the invasive carcinoma of the breast duct that occurs in older women. It is possible to have a diagnosis and treatment using mammography and histopathological confirmation.

Mucinous carcinoma of the breast: a case report and review of the literature. / Carcinoma mucinoso de la mama: reporte de caso y revisión de la literatura.

Mucinous carcinoma of the breast is a rare histological type, which represents between 1 and 4% of breast cancers. Treatment does not differ from other histological types, and it occurs more frequently in older adult women. Prognosis is good. We report the case of a 72-year-old patient with a 1-year disease course characterized by the appearance of a slow-growing tumor in the left upper quadrant of the left breast, in which the core biopsy showed mucinous breast carcinoma of a low nuclear grade. The patient underwent quadrantectomy plus a sentinel node biopsy, which confirmed the initial diagnosis.

El carcinoma mucinoso de la mama es un tipo histológico raro, que representa entre el 1 y el 4% de los cánceres de mama. Su tratamiento no difiere de los demás tipos histológicos. Se presenta con mayor frecuencia en mujeres adultas mayores y se distingue por un buen pronóstico. En este artículo, se reporta el caso de una paciente de 72 años, con tiempo de enfermedad de un año, caracterizado por la aparición de una tumoración de crecimiento lento y progresivo en el cuadrante superior externo de la mama izquierda, a la cual se realizó biopsia core. La biopsia arrojó un resultado de carcinoma mucinoso de mama, con grado nuclear bajo. La paciente fue sometida a cuadrantectomía más biopsia de ganglio centinela, lo cual confirmó el diagnóstico inicial.

CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

Mucinous carcinoma of the breast: iconographic essay with histopathological correlation / Carcinoma mucinoso da mama: ensaio iconográfico com correlação histopatológica

The present essay is aimed at describing the most characteristic imaging findings of mucinous carcinoma of the breast, with emphasis on the patterns related to better prognosis. The authors selected cases of mucinous carcinoma of the breast whose images were available, highlighting the imaging findings suggestive of this subtype of breast cancer, either at mammography, ultrasonography or magnetic resonance imaging.

O objetivo deste artigo é descrever os aspectos de imagem mais característicos do carcinoma mucinoso de mama, destacando-se os padrões relacionados a melhor prognóstico. Foram selecionados casos de carcinoma mucinoso de mama enfatizando as características de imagem que sugiram esse subtipo de neoplasia mamária, seja na mamografia, ultrassonografia ou ressonância magnética.

Carcinoma mucinoso ecrino primario de la piel: reporte de un caso clínico patológico y revisión de la literatura / Primary mucinous eccrine carcinoma of skin: a case report and literature review

El carcinoma mucinoso ecrino primario de la piel es infrecuente, existen cerca de 100 casos publicados en la literatura. Fue descrito por primera vez por Lennox y colaboradores el año 1952. Presentamos un caso de carcinoma mucinoso ecrino primario de la piel, en un hombre de 82 años de edad, quien consultó por una masa cutánea retroauricular de 10 años de evolución, sin evidencias de enfermedad sistémica ni recurrencia local al año del control postoperatorio

The primary mucinous eccrine carcinoma of skin is infrequent, nearby 100 cases are published in the literature. It was described by the first time by Lennox and cols. at 1952. We present a case of primarily mucinous eccrine carcinoma of the skin, in an 82 year old man, who consulted for a retroauricular cutaneous mass of 10 years of evolution, without evidences of systemic disease or local recurrence at the year of the after surgery.

Carcinoma mucinoso invasor da mama e seus diagnósticos diferenciais em biópsia por agulha grossa: revisão da literatura / Mucinous invasive carcinoma of the breast and its differential diagnosis by core biopsy: review of the literature

A biópsia por agulha grossa (BAG), ou core biopsy, é uma técnica utilizada para retirar pequenos cilindros de tecido mamário. Além de lesões palpáveis, o desenvolvimento de técnicas radiológicas acuradas de localização de lesões mamárias difundiu o uso da BAG como primeira abordagem histológica de lesões não palpáveis. O diagnóstico diferencial do carcinoma mucinoso com lesões mucinosas benignas por BAG pode ser desafiador, principalmente se a lesão apresentar extravasamento de mucina. A acurácia do diagnóstico nesses casos é de extrema relevância para determinar o tipo de procedimento a ser realizado e o tratamento a ser seguido. Este estudo traz revisão e atualização da literatura sobre carcinoma mucinoso invasor da mama e seus diagnósticos diferenciais, com ênfase nos desafios para diagnóstico por intermédio da BAG. Entre os diagnósticos diferenciais estão alterações fibrocísticas com mucina luminal, lesões mucinosas papilares e mucocele-símile (que variam desde as benignas até aquelas associadas a hiperplasia ductal atípica e carcinoma ductal in situ). Alterações mucinosas também podem ser encontradas em uma variedade de lesões, como fibroadenoma e tumor phyllodes, adenoma pleomórfico e mucinose nodular. Conclui-se que a BAG é uma técnica confiável para diagnóstico de carcinoma mucinoso da mama e seus diagnósticos diferenciais, porém, em casos de dúvida ou de escassez de material, é prudente realizar biópsia excisional para melhor esclarecimento do diagnóstico.

The needle core biopsy is a technique applied to remove small cylinders of breast tissue. The development of accurate radiological techniques for location of breast lesions has spread the use of core biopsy as the first histological approach to non-palpable lesions. The differential diagnosis of mucinous carcinoma and benign mucinous lesions by core biopsy may be challenging, mainly when the lesion shows mucin extravasation. The accuracy of diagnosis in these cases is extremely important to determine the type of procedure to be performed, as well as the treatment choice. This study shows a review and an update of the literature as to invasive mucinous carcinoma of the breast and its differential diagnosis, with emphasis on the challenges of diagnosis by core biopsy. Among the differential diagnoses are fibrocystic changes with luminal mucin, mucinous papillary lesions, mucocele-like lesions that range from benign to those associated with atypical ductal hyperplasia and ductal carcinoma in situ. Mucinous changes may also be found in a variety of lesions such as fibroadenoma, phyllodes tumor, pleomorphic adenoma and nodular mucinosis. In conclusion, core biopsy is a reliable technique for the diagnosis of mucinous carcinoma of the breast and its differential diagnosis, however, in doubtful cases or when the sample is scarce, it is advisable to perform an excisional biopsy to clarify the diagnosis.