Identifying DNase I hypersensitive sites using multi-features fusion and F-score features selection via Chou's 5-steps rule.

DNase I hypersensitive sites (DHSs) are regarded as those regions of chromatin that are sensitive to cleavage by the DNase I enzyme. Identification of DNase I hypersensitive sites will provide useful insights for discovering DNA's functional elements from the non-coding sequences in the biomedical research. Because of the significance for DNase I hypersensitive sites, it is indispensable to develop an accurate, fast, robust, and high-throughput automated computational model. In this paper, we develop a model named iDHSs-MFF by combining multiple fusion features and F-score features selection approach. The multiple fusion features include three auto-correlation descriptors based on the dinucleotide property matrix and the trinucleotide property matrix (TPM), Pseudo-DPM and Pseudo-TPM. Evaluation by the jackknife cross-validation indicates that the selected features by F-score are effective in the identification of DNase I hypersensitive sites. Experimental results on two benchmark datasets demonstrate that the proposed model outperforms some highly related models. Systematic application of this computational approach will greatly facilitate the analysis of transcriptional regulatory elements. The datasets and Matlab source codes are freely available at: https://github.com/shengli0201/Datasets.

Multi-Features Fusion for Fault Diagnosis of Pedal Robot Using Time-Speed Signals.

In order to realize automation of the pollutant emission tests of vehicles, a pedal robot is designed instead of a human-driven vehicle. Sometimes, the actual time-speed curve of the vehicle will deviate from the upper or lower limit of the worldwide light-duty test cycle (WLTC) target curve, which will cause a fault. In this paper, a new fault diagnosis method is proposed and applied to the pedal robot. Since principal component analysis (PCA), t-distributed stochastic neighbor embedding (t-SNE), and Autoencoder cannot extract feature information adequately when they are used alone, three types of feature components extracted by PCA, t-SNE, and Autoencoder are fused to form a nine-dimensional feature set. Then, the feature set is reduced into three-dimensional space via Treelet Transform. Finally, the fault samples are classified by Gaussian process classifier. Compared with the methods using only one algorithm to extract features, the proposed method has the minimum standard deviation, 0.0078, and almost the maximum accuracy, 98.17%. The accuracy of the proposed method is only 0.24% lower than that without Treelet Transform, but the processing time is 6.73% less than that without Treelet Transform. These indicate that the multi-features fusion model and Treelet Transform method is quite effective. Therefore, the proposed method is quite helpful for fault diagnosis of the pedal robot.

[Control of intelligent car based on electroencephalogram and neurofeedback].

To improve the performance of brain-controlled intelligent car based on motor imagery (MI), a method based on neurofeedback (NF) with electroencephalogram (EEG) for controlling intelligent car is proposed. A mental strategy of MI in which the energy column diagram of EEG features related to the mental activity is presented to subjects with visual feedback in real time to train them to quickly master the skills of MI and regulate their EEG activity, and combination of multi-features fusion of MI and multi-classifiers decision were used to control the intelligent car online. The average, maximum and minimum accuracy of identifying instructions achieved by the trained group (trained by the designed feedback system before the experiment) were 85.71%, 90.47% and 76.19%, respectively and the corresponding accuracy achieved by the control group (untrained) were 73.32%, 80.95% and 66.67%, respectively. For the trained group, the average, longest and shortest time consuming were 92 s, 101 s, and 85 s, respectively, while for the control group the corresponding time were 115.7 s, 120 s, and 110 s, respectively. According to the results described above, it is expected that this study may provide a new idea for the follow-up development of brain-controlled intelligent robot by the neurofeedback with EEG related to MI.

Control of intelligent car based on electroencephalogram and neurofeedback / 生物医学工程学杂志

To improve the performance of brain-controlled intelligent car based on motor imagery (MI), a method based on neurofeedback (NF) with electroencephalogram (EEG) for controlling intelligent car is proposed. A mental strategy of MI in which the energy column diagram of EEG features related to the mental activity is presented to subjects with visual feedback in real time to train them to quickly master the skills of MI and regulate their EEG activity, and combination of multi-features fusion of MI and multi-classifiers decision were used to control the intelligent car online. The average, maximum and minimum accuracy of identifying instructions achieved by the trained group (trained by the designed feedback system before the experiment) were 85.71%, 90.47% and 76.19%, respectively and the corresponding accuracy achieved by the control group (untrained) were 73.32%, 80.95% and 66.67%, respectively. For the trained group, the average, longest and shortest time consuming were 92 s, 101 s, and 85 s, respectively, while for the control group the corresponding time were 115.7 s, 120 s, and 110 s, respectively. According to the results described above, it is expected that this study may provide a new idea for the follow-up development of brain-controlled intelligent robot by the neurofeedback with EEG related to MI.