Fertility preservation in nonepithelial ovarian malignancy / 中国实用妇科与产科杂志

Non-epithelial ovarian malignant tumors account for about 10% of ovarian tumors,and mostly develops in young women.Although surgery and radiotherapy and chemotherapy can make patients get the chances of survival,but often lead to different degrees of damage to reproductive function,causing physical and psychological suffering.While improving the survival rate of patients with malignant ovarian tumors,it is an important research issue to protect the reproductive function of patients as much as possible in the treatment of malignant ovarian tumors.The fertilitysparing treatment has a good effect on non-epithelial ovarian malignant tumors,especially malignant ovarian germ tumors.In this article,we discuss the surgical treatment of fertility protection,the implementation of postoperative adjuvant treatment and the application of assisted reproductive technology in non-epithelial ovarian malignant tumors.

Application of Real World Fufang Kushen Injection in Treatment of Ovarian Malignant Tumor Based on Electronic Medical Data of Hospital Information System / 中国中医药信息杂志

Objective To analyze the population characteristics, diagnostic characteristics and drug characteristics of patients with ovarian malignant tumor in the real world; To provide references for the clinical rational use of Fufang Kushen Injection.Methods Based on the electronic medical data warehouse of hospital information system of 39 hospitals from nationwide,the use of Fufang Kushen Injection in the treatment and diagnosis of electronic health data in patients with ovarian malignant tumor from August 2003 to December 2014 were extracted. Analysis of frequency and rate were based on the description of the demographic information, diagnosis information, records information such as the characteristics of prescription drugs. Result Data of 22 hospitals, including 1510 cases of patients with ovarian malignant tumor. The average age of patients was (54.93±12.75) years old, and obstetrics and gynecology department and oncology department had the most hospitalized patients, and outpatient admission is the most common hospitalized way. The single dose was (14.53±4.24)mL, and the course of treatment was (6.62±5.49)d.In the treatment of ovarian malignant tumors, combined western medicines were mainly anti-tumor chemotherapy drugs, immunomodulators, hepatoprotective agents, H1 receptor antagonists and electrolyte balance regulator, while combined TCM were clearing heat and antidote medicine, tonifying yang qi medicine, tonifying qi medicine, regulating qi medicine, and hemostatic medicine. The total effective rate was 47.85%. Conclusion Population characteristics of Fufang Kushen Injection in the treatment of ovarian malignant tumors are clear;and the real world clinical dosage, course of treatment with instructions related to define the scope of the basic varieties. Clinical combination has a wide range of drugs.

To explore the clinical of ovarian malignant tumor with increased count of platelet / 国际检验医学杂志

Objective To explore the clinical significance of platelet count increasing in patients with ovarian malignant tumor . Methods 80 cases of ovarian malignant tumor patients ,80 patients with ovarian benign tumor and 80 cases of healthy women were enrolled in the study as group A ,B ,C respectively .The group A was divided into FIGOⅠ group(n=30) ,and FIGOⅡ and above group(n=50) .Platelet count was detected by using fully automatic blood cell analyzer and the serum CA125 concentrations were also measured for all the groups .Results The platelet count and CA125 concentrations in group A were higher than group B and group C(P< 0 .05) .The positive rate of platelet increasing and serum CA125 were also higher than group B and group C(P<0 .05) .There were significant differences between FIGOⅠ group and FIGOⅡ and above group in platelet count and CA125 concen‐trations .Conclusion Ovarian malignant tumor complicated with increased platelet count is common in patients of advanced stage . The increased platelet count could indicate the malignant degree of ovarian malignant tumor .

DETECTION AND CLINICAL SIGNIFICANCE OF MICRORNA IN OVARIAN CANCER / 现代医院

Objective To study the expressions of miR-10a, miR-93 and miR-200a in malignant ovarian tumor tissues and their clinical significances.Methods Real-time quantitative PCR was used to detect the expression of 40 cases of normal ovarian tissue, 40 cases of benign ovarian cyst and 40 cases of miR-10a, miR-93 and miR-200a in malignant ovarian tumor tissues.Analysis of variance and t-Test were respectively applied to compare the expression of miR in different tissues and analyze the correlation between miR and clinicopathological characteristics of malignant ovarian tumor .Kaplan-Meier Log-rank test and Cox proportional hazards regression model were adopted in prognosis.Results The expression lev-els of miR-10a in ovarian cancer tissues were significantly higher than that in benign ovarian tumor tissues and normal ovari-an tissues (p0.05).The expression quantity of miR-10a in malignant ovarian tumor tissues with greater omen-tum metastasis, lymph node metastasis and distant organ metastasis was significantly higher than that without metastasis ( p<0.05).The median survival time of patients with higher expression of miR -10a was lower than that of patients with low ex-pression of miR-10a (p=0.01).Multi-factor Cox model analysis showed that the expression quantity of miR -10a was an independent factor affecting survival prognosis in patients(p=0.002).Conclusion Our data suggest that miR-10a is asso-ciated with ovarian cancer metastasis, which is the main factor affecting prognosis in ovarian cancer.It might serve as a bio-marker for judging the prognosis in ovarian cancer.

Tumor necrosis factor-related apoptosis-inducing ligand and its receptors help fight ovarian malignant tumor / 医学研究生学报

Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) is a recently identified cytokine of apoptosis that selectively induces the apoptosis of various tumor cells but not normal cells.The members of this family known to date are TRAIL and its five related receptors.TRAIL and its receptors are expressed in ovarian malignant tumor cells and can induce their apoptosis.Many chemotherapeutic agents can enhance TRAIL-induced apoptosis of malignant tumor cells,so TRAIL-induced cytotoxicity holds a powerful promise in the fight against ovarian malignant tumor.

Preserving fertility treatment for 40 patients with ovarian malignant tumors / 中国癌症杂志

Purpose: To discuss the feasibility and effect of reserving fertility treatments for young patients with ovarian malignant tumors. Methods: Retrospective analysis of clinical data of 40 patients receiving conservative treatments. Results: Among the 40 cases, there were 25 cases of malignant ovarian germ cell tumors, 13 cases of epithelium carcinomas, 2 cases of sexual cord mesenchymal tumors. 34 patients have survived till now, among which there are 20 cases of malignant ovarian germ cell tumors, 12 cases of epithelium carcinomas, 2 cases of sexual cord mesenchymal tumors. 8 patients relapsed after the first operation, six of which had hysterectomy as second operation. Among the 32 surving patients who have preserved their uterus, 31 patients have normal menstruations. 11 patients married and 6 patients had successful pregnancies. Conclusions: We should try our best to preserve the fertility of young patients with ovarian malignant tumors.