Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential.

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

Hemorrhagic fever viruses: pathogenesis, therapeutics, and emerging and re-emerging potential

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

Dengue clásico y hemorrágico: sospecha diagnostica de una enfermedad reemergente / Hemorragic and clasical Dengue: suspect diagnosis of a reemerging disease

El dengue, conocido popularmente como” fiebre quebrantahuesos” es la más importante enfermedad viral humana transmitida por vectores artrópodos del genero Aedes, principalmente A. aegypti, se ha extendido en regiones tropi­cales y subtropicales alrededor del mundo representando una amenaza para millones de personas por lo que se la con­sidera como una de las principales enfermedades virales reemergentes a escala mundial. El dengue presenta un amplio espectro de manifestaciones clínicas que van desde los casos inaparentes hasta las formas aparentes de Dengue clásico (DC) y las formas graves y a veces fatales de Dengue Hemorrágico (DH) /Síndrome de Choque por Dengue ( SCD) En virtud a que el dengue puede confundirse con múltiples enfermedades , numerosos casos de infección pueden ser sub­diagnosticados o mal diagnosticados, la sospecha diagnostica es fundamental para un diagnostico precoz y un plan te­rapéutico temprano que puede modificar el curso de la enfermedad.

Dengue is the most important re­emerging infectious diseases called “bone­breaker” transmitted to humans through the bites of infective female Aedes mosquitoes. It is extended in tropical and sub­tropical regions around the world; million people are now at risk from dengue and it is considered the most important re­emerging infectious diseases, clinical fe­atures are very variable from due to multiple alterations induced by the virus in the organism (DF/DHF). Diagnosis of dengue virus infection it must be difficult if we do not suspect it, rapid clinical and serologic diagnosis is an important steep to management and prevention skills.