Extrusion of pilosebaceous units into blisters of patients affected by a new variant of endemic pemphigus in El Bagre, Colombia, South America.

BACKGROUND: A new variant of endemic pemphigus foliaceus is present in El Bagre, Colombia, and surrounding municipalities (El Bagre-EPF) that affects the skin and in some presentations affects other organs with autoantibodies directed against cell junctions. METHODS: We studied 200 El Bagre-EPF patient perilesional skin biopsies, as well as 200 skin biopsies from normal controls in the endemic area. RESULTS: We observed blister extrusions of sebaceous glands or entire pilosebaceous units via the isthmus in 23% of the patients and not in the controls. CONCLUSIONS: The extrusion of hair follicular unit contents is consistent with our previous pathologic findings of autoreactivity to these units, and their observed clinical decrease in patients affected by El Bagre-EPF.

Morphological and morphometric characterization of the preputial ostium, internal preputial leaflet, and free part of the penises of Aberdeen Angus and Nellore bulls / [Caracterização morfológica e morfométrica do óstio prepucial, do folheto prepucial interno e da parte livre do pênis de touros Aberdeen Angus e Nelore]

The morphological characteristics of the external genitalia of the bull may contribute to the etiopathogenesis of preputial diseases that trigger the impotence coeundi and losses in farms. The goal of this study was to establish morphometric parameters of the preputial ostium, the internal preputial leaflet (IPL), the free part and glans of the penis; describe the histological characteristics of the IPL; perform a count of the preputial sebaceous glands and compare these variables between 24-month-old Aberdeen Angus and Nellore bulls. At the slaughterhouse, 20 preputial pieces were collected from each breed. A device composed of base, rod, ring, and funnel was designed to hold each suspended and distended part. The IPL, the free part of the penis and the glans were measured. The ostium diameter was measured, and the radius, perimeter, and area of the preputial ostium were calculated. Samples were collected from the dorsal and ventral regions and from the cranial, medial, and caudal portions of the IPL. By electronic and optical microscopy, IPL characterization and sebaceous gland counts were performed. Analysis of variance was performed using the F test at 5%. It was concluded that Nellore bulls have a more extensive IPL and free part of the penis and more preputial sebaceous glands than Aberdeen Angus bulls. In both breeds, there are more glands in the ventral region of the ostium.

As características morfológicas da genitália externa do touro podem contribuir para a etiopatogenia de enfermidades prepuciais que desencadeiam a impotência coeundi e prejuízos nos criatórios. O objetivo deste estudo foi estabelecer parâmetros morfométricos do óstio prepucial, do folheto prepucial interno (FPI), da parte livre e da glande do pênis; descrever as características histológicas do FPI; realizar contagem de glândulas sebáceas prepuciais; e comparar essas variáveis entre touros Aberdeen Angus e Nelore, com 24 meses de idade. No abatedouro, colheram-se 20 peças prepuciais de cada raça. Elaborou-se um dispositivo composto por base, haste, anel e funil para sustentar cada peça suspensa e distendida. Realizou-se medição do FPI, da parte livre do pênis e da glande. Aferiu-se diâmetro do óstio, e calculou-se o raio, o perímetro e a área do óstio prepucial. Colheram-se amostras nas regiões dorsal e ventral e das porções cranial, medial e caudal do FPI. Por microscopia eletrônica e óptica, fez-se a caracterização do FPI e a contagem de glândulas sebáceas. Realizou-se análise de variância pelo teste F a 5%. Concluiu-se que touros Nelore possuem o FPI e a parte livre do pênis mais extensos e mais glândulas sebáceas prepuciais que touros Aberdeen Angus. Nas duas raças, há mais glândulas na região ventral do óstio.

Case for diagnosis. Verrucous plaque on the pubic region

Abstract Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Screening for neoplasms in these patients and their families is mandatory.

Case for diagnosis. Verrucous plaque on the pubic region.

Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Screening for neoplasms in these patients and their families is mandatory.

Sebaceoma on the scalp simulating a malignant pigmented neoplasia.

The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology.

Sebaceoma on the scalp simulating a malignant pigmented neoplasia

Abstract The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology.

Molecular Interactions of Different Steroids Contributing to Sebum Production. Review.

Considerable progress has been made in learning about the physiology and biochemistry of the sebaceous glands and several of the diseases that affect this component of the skin. Of these diseases, acne has particular importance. It is associated with adolescence, and because of the hormonal changes that take place in this stage, when it is severe it can cause depression. Moreover, in a considerable proportion of acne sufferers both adolescent and adult, it can produce tumors and deformation of the sebaceous glands. This seriously affects the sufferers to the point where it may limit their professional activities because they do not want to be seen in public. Several important issues from classic studies on the sebaceous gland will be reviewed in this document to report the state of the art of current treatments for the pathology of these glands. The sebaceous gland is an intracrine organ, capable of synthesizing and metabolizing different steroidal hormones. The role of each of the enzymes involved in these processes of the skin will be analyzed. The presence of different hormone receptors in the scientific literature will be also reviewed, due to the role of the sebaceous gland in lipogenesis at different ages. We also describe the mechanism of action of androgens and progestins in relation to coregulators recruited for lipogenesis in this gland. We propose several new steroidal compounds based on their mechanism of action to block lipogenesis in the sebaceous glands. These molecules offer potential for new treatment options for skin diseases.

Sebaceous cyst in the oral cavity.

Sebaceous glands are reported to be normally located in the oral region in the vermilion of the upper lip and on the buccal mucosa. They are small yellowish bodies located immediately beneath the mucosa, and although numerous pathologies of these tissues have been described, very few clinical reports have been made. Pathologies such as ectopic location, hyperplasia, adenomas, carcinomas, and cysts have been described. If an excretory duct suffers a dilatation which does not regress of its own accord, it may originate a cyst. The purpose of this clinical report is to describe a free sebaceous cyst located in the upper lip.

Carcinoma de glándulas sebáceas limitado a conjuntiva bulbar / Sebaceous gland carcinoma restricted to bulb conjunctiva

El carcinoma de glándulas sebáceas es un tumor infrecuente que puede desarrollarse a partir de cualquier glándula sebácea en la piel. El 75 por ciento de las veces es de origen ocular y afecta principalmente las glándulas de Zeiss, Meibomio y de la carúncula. Se caracteriza por un comportamiento agresivo, con alta probabilidad de invasión a piel, conjuntiva y córnea. Sin embargo, el compromiso de la conjuntiva como localización primaria es raro. Se presenta un caso con diagnóstico de carcinoma sebáceo de patrón nodular primario de la conjuntiva bulbar, atendido en el Hospital Universitario de Santander durante los años 2014-2016. El propósito del presente estudio es dar a conocer el caso de una patología infrecuente con pocos casos reportados en la literatura, enfatizar su importancia dentro de los diagnósticos diferenciales de masas en la conjuntiva y del estudio histopatológico como método para obtener un diagnóstico definitivo y realizar un abordaje temprano(AU)

Sebaceous gland carcinoma is an uncommon tumor that may derive from any sebaceous gland of the skin. In 75 percent of cases is ocular and mainly affects the Zeiss, Melbonium and caruncle glands. It is characterized for its aggressiveness, high probability of passing into the skin, the conjunctiva and the cornea. However, the involvement of the conjunctiva as a primary location is rare. This is a case diagnosed with sebaceous carcinoma of primary nodullary pattern of the bulb conjunctiva, which was seen at the university hospital of Santander from 2014 to 2016. The objective of the study was to show the case of an infrequent pathology with very few cases reported up to now in literature, to make emphasis on its importance within the differential diagnoses of masses present in the conjunctiva and of the histopathological study as a method to obtain a final diagnosis and to make an early intervention(AU)

Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne.

Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. Propionibacterium acnes is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the NFκ B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Two treatments were performed over six months: 15% azelaic acid gel (AA) bid (n = 18) and oral contraceptive (COC) drospirenone 3 mg/ethinylestradiol .02 mg (n = 20). Biopsies were taken at baseline (control, lesion, perilesional) and at the conclusion (lesion and perilesional) of the study to evaluate TLR-2 expression by immunohistochemistry. Lesion count and blind photographic evaluation were used for efficacy. The groups were homogeneous: 70% of lesions were located in the submandibular area, 95% of participants had inflammatory lesions; of these, 50% had persistent and 50% had late-onset acne. The mean ages were 33.7 ± 5.5 and 33.1 ± 5.3 years (COC and AA group, respectively). A moderate clinical improvement was observed in both groups. No difference in TLR-2 expression in the lesion or perilesional areas was observed; however, reduced TLR-2 expression was seen in the control group. A significant reduction in expression was observed after both treatments, with no difference between the groups. This finding suggests an anti-inflammatory effect of COCs and AA in adult female acne, via modulation of the TLR-2 receptor.

Demodicosis: revisión de la literatura / Demodicosis: review of the literature

La demodicosis es una patología cutánea crónica caracterizada por lesiones eritemato-maculares pruriginosas, cuyo agente causal son ácaros foliculares del género Demodex. Presenta un abanico amplio y polimorfo de manifestaciones clínicas, donde la sospecha clínica se presentará frente a una erupción facial crónica persistente o recurrente, resistente a terapia convencional y de distribución asimétrica. El diagnóstico definitivo es difícil, y requiere un cuadro clínico compatible y la presencia de alta densidad de Demodex. El siguiente documento hace una revisión de conceptos con respecto a la patogenia, clínica, diagnóstico y tratamiento de esta entidad.

Demodicosis is a chronic skin condition characterized by itchy erythematous macular lesions whose causal agents are gender follicular Demodex mites. This entity presents a wide and polymorphous range of clinical manifestations, in which clinical suspicion appears in case of persistent or recurrent chronic facial rash, resistant to conventional therapy and with an asymmetric distribution. The definitive diagnosis is hard to reach, and requires a compatible clinical picture and a high density of Demodex. The following document is a review of concepts regarding pathogenesis, symptoms, diagnosis and treatment of this disease.

Carcinoma sebáceo de párpado. Reporte de un caso / Sebaceous carcinoma of the eyelid. Case report

Objetivo: Reportar el caso de una paciente con carcinoma sebáceo de párpado y revisar la literatura. Diseño del estudio: Reporte de caso. Métodos: Se reporta un caso de una paciente con diagnóstico de carcinoma sebáceo de párpado que fue remitida a la Clínica de Oftalmología San Diego Medellín-Colombia, a la consulta de Oncología ocular en el año 2015. Se realizó una revisión detallada de la historia clínica, se tomaron fotos a color previa firma de consentimiento informado por parte de la paciente y se realizó biopsia e inmunohistoquímica respectiva. Se cuenta con la aprobación el comité de ética médica de la Universidad Pontificia Bolivariana. Resultados: Reporte de carcinoma sebáceo de párpado. Mujer de 66 años a la que se le hizo diagnóstico de carcinoma sebáceo de párpado luego de resección y se confirmó con el estudio anatomopatológico y de inmunohistoquímica. Se realizaron estudios de extensión en busca de metástasis a distancia. Conclusión: El carcinoma sebáceo de párpado es una entidad poco frecuente en la práctica clínica oftalmológica siendo estas lesiones fácilmente confundidas con lesiones benignas como chalazión y blefaroconjuntivitis por la poca familiaridad del especialista con la enfermedad. Es necesario tener un alto índice de sospecha y saber que existe para tratar esta entidad de manera oportuna evitando intervenciones no indicadas en este tipo de lesión.

Objective: To report the case of a patient with sebaceous carcinoma of the eyelid and literature review. Study Design: Case report. Methodology: A case of a patient diagnosed with sebaceous carcinoma of the eyelid which was referred to the oncology service to Clinic of Ophthalmology San Diego Medellin-Colombia in 2015. A detailed review of the medical history and photography documentation was done. Results: Sebaceous carcinoma of the eyelid was reported. A woman of 66 years old who has had diagnosis of eyelid sebaceous carcinoma after resection and confirmed with histopathologic and immunohistochemical study. Extension studies were conducted in order to rule out metastases. Conclusion: The sebaceous carcinoma of the eyelid is a rare entity in the ophthalmological setting and could be easily confused with benign lesions such as blepharitis and chalazion for those ophthalmologists unfamiliar with this condition. A high index of suspicion of this entity is recommended in a timely manner to avoid interventions that are not indicated in this type of lesion.

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil.Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining...(AU)

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...(AU)

Caracterización clinicopatológica de los tumores malignos palpebrales / Clinical and pathological characterization of palpebral malignant tumors

OBJETIVOS: describir las características clinicopatológicas de los tumores malignos palpebrales. MÉTODOS: estudio descriptivo y retrospectivo de pacientes con diagnóstico histopatológico de carcinoma basocelular, epidermoide y adenocarcinoma de glándulas sebáceas, atendidos en el Servicio de Oculoplastia del Instituto Cubano de Oftalmología, de enero de 2005 a diciembre de 2010. Se incluyó un total de 109 pacientes; se analizó la edad, el sexo, el color de la piel, las formas clínicas, la localización anatómica, el grado de diferenciación celular y la frecuencia anual. RESULTADOS: el grupo de edad entre 60 y 79 años constituyó el 50,5 % de los casos. El sexo masculino constituyó el 47,7 % y el femenino el 52,3 %. El carcinoma basocelular se presentó en el 68,8 % de los pacientes, el carcinoma epidermoide en el 19,3 % y el adenocarcinoma de glándulas sebáceas en el 11,9 %. La piel blanca mostró el 88 % de los casos; el carcinoma basocelular nodular estuvo presente en el 53,3 % y la noduloulcerativa en 33,3 %. En el párpado inferior se presentó el carcinoma basocelular en el 69,3 % y el epidermoide en el 66,7 %. El 44,1 % de los diagnósticos histopatológicos fueron moderadamente diferenciados. Mostró 21 casos de carcinoma basocelular en el 2009; 7 de carcinoma epidermoide en el 2007 e igual número de casos de adenocarcinoma de glándulas sebáceas en el 2010. CONCLUSIONES: más de la mitad de los pacientes que presentan tumores malignos palpebrales son adultos mayores, femeninos y blancos. Se evidencia la totalidad de las formas clínicas de presentación; predomina en el párpado inferior el carcinoma basocelular y el epidermoide. La mayoría de los casos muestra grado de diferenciación celular moderado y la frecuencia anual tiene disímil comportamiento.

OBJECTIVES: to describe the clinicopathological features of malignant eyelid. METHOD: a descriptive, retrospective study of patients with histopathologic diagnosis of basal cell carcinoma, squamous cell and adenocarcinoma of sebaceous glands, assisted in the service of oculoplasty the Cuban Institute of Ophthalmology January 2005 to December 2010. It was included 109 patients; we analyzed age, sex, skin color, clinical symptoms, anatomic location, degree of cell differentiation and annual basis. RESULTS: 60 to 79 years occurred in 50,5 %. It was 47,7 % were male and female 52,3 %. The basal cell carcinoma was present in 68,8 %, squamous cell carcinoma in 19,3 % and adenocarcinoma of sebaceous glands in (11,9 %. White skin was 88 %. Nodular basal cell carcinoma in 53,3 %, the nodule-ulcerative in 33,3 %. In the lower eyelid basal cell carcinoma showed a 69,3 % and 66,7 % epidermoid. The 44,1 % of the histopathological diagnoses were moderately differentiated. Showed 21 cases of basal cell carcinoma in 2009, 7 squamous cell carcinoma in 2007 and an equal number of cases of adenocarcinoma of sebaceous glands in 2010. CONCLUSIONS: over half of the patients were elderly, female and white, showed all the clinical forms predominated in the lower eyelid basal cell carcinoma and squamous cell, most of the cases showed degree of cell differentiation moderate annual rate showed dissimilar behavior in the period under study with more cases in 2009.

Tegument study of Saanen goats and their crossbred Boer / Estudo do tegumento de cabras da raça Saanen e seus mestiços com Boer

The study aimed to evaluate Saanen goats and their crossbred Boer through the structures of tegument: sweat ducts, sebaceous glands, hair follicles and epidermal thickness as their thermoregulatory characteristics. Samples of tegument of genetic groups Saanen and Saanen x Boer were collected of the cervical, thoracic and gluteal regions for the preparation of histological slides. Thus the following measurements were obtained: epidermal thickness (m); hair follicles per area (2,281,700 m2); area (m2), perimeter (m) and quantity per area (2,281,700 m2) of the sweat ducts and sebaceous glands. The experimental design was completely randomized in 2x3 factorial (two genetic groups and three regions of tegument collection). Crossbred animal had greater number of hair follicles, which promotes greater protection factor to solar radiation,    and the gluteal region responsible by largest number of follicles.

O trabalho teve como objetivo avaliar exemplares da raça caprina Saanen e seus mestiços com Boer através das estruturas do tegumento: ductos sudoríparos, glândulas sebáceas, folículos pilosos e espessura da epiderme quanto as suas características termorregulatórias. Foram coletadas amostras do tegumento dos grupos genéticos Saanen e Saanen x Boer, das regiões cervical, torácica e glútea, para a confecção das lâminas histológicas. Assim, obtiveram-se as seguintes medidas: espessura da epiderme (m); folículos pilosos por área (2.281.700 m2); área (m2), perímetro (m) e quantidade por área (2.281.700 m2) dos ductos sudoríparos e das glândulas sebáceas. O delineamento experimental foi inteiramente casualizado em esquema fatorial 2x3 (dois grupos genéticos e três regiões de coleta do tegumento). Os animais cruzados apresentaram maior número de folículos pilosos, o que promove maior fator de proteção à radiação solar, sendo a região glútea responsável pela maior quantidade de folículos.

Tegument study of Saanen goats and their crossbred Boer / Estudo do tegumento de cabras da raça Saanen e seus mestiços com Boer

The study aimed to evaluate Saanen goats and their crossbred Boer through the structures of tegument: sweat ducts, sebaceous glands, hair follicles and epidermal thickness as their thermoregulatory characteristics. Samples of tegument of genetic groups Saanen and Saanen x Boer were collected of the cervical, thoracic and gluteal regions for the preparation of histological slides. Thus the following measurements were obtained: epidermal thickness (m); hair follicles per area (2,281,700 m2); area (m2), perimeter (m) and quantity per area (2,281,700 m2) of the sweat ducts and sebaceous glands. The experimental design was completely randomized in 2x3 factorial (two genetic groups and three regions of tegument collection). Crossbred animal had greater number of hair follicles, which promotes greater protection factor to solar radiation,    and the gluteal region responsible by largest number of follicles.(AU)

O trabalho teve como objetivo avaliar exemplares da raça caprina Saanen e seus mestiços com Boer através das estruturas do tegumento: ductos sudoríparos, glândulas sebáceas, folículos pilosos e espessura da epiderme quanto as suas características termorregulatórias. Foram coletadas amostras do tegumento dos grupos genéticos Saanen e Saanen x Boer, das regiões cervical, torácica e glútea, para a confecção das lâminas histológicas. Assim, obtiveram-se as seguintes medidas: espessura da epiderme (m); folículos pilosos por área (2.281.700 m2); área (m2), perímetro (m) e quantidade por área (2.281.700 m2) dos ductos sudoríparos e das glândulas sebáceas. O delineamento experimental foi inteiramente casualizado em esquema fatorial 2x3 (dois grupos genéticos e três regiões de coleta do tegumento). Os animais cruzados apresentaram maior número de folículos pilosos, o que promove maior fator de proteção à radiação solar, sendo a região glútea responsável pela maior quantidade de folículos.(AU)

Inguinal ulcerated sebaceous carcinoma: an unusual presentation / Carcinoma sebaceo inguinal ulcerado: apresentacao incomum

Sebaceous carcinoma is a rare and aggressive skin tumor. It can be located in any area of the body, the most commonly involved area being the periorbital region. It does not entail a typical clinical presentation, which explains the often late diagnosis. The aim of this report is to outline the rarity of the disease and its atypical clinical description, since to this day, inguinal ulcers with clinical manifestation have not been reported. We present and discuss a case of sebaceous carcinoma with an unusual clinical presentation, in an elderly male patient. The precise approach to genital ulcers, as shown in this case, is a diagnostic challenge that requires a great deal of effort on the part of the clinician.

O carcinoma sebáceo é um tumor cutâneo raro e agressivo. Pode localizar-se em qualquer área do corpo sendo a região periorbital a mais comumente envolvida. Ele não tem uma apresentação clínica típica, o que explica o diagnóstico frequentemente tardio. O objetivo deste relato é apresentar a raridade da doença e uma descrição clínica atípica, uma vez que, até a presente data, não foi relatada úlcera inguinal como manifestação clínica. Apresentamos e discutimos um caso de carcinoma sebáceo, com uma apresentação clínica incomum em um paciente idoso do sexo masculino. A abordagem de úlceras genitais, como mostrado no presente caso, é um desafio diagnóstico que requer uma grande quantidade de esforço por parte do clínico.

Achado incidental de glândula sebácea em colo uterino: provavelmente um processo metaplásico / An incidental finding of sebaceous glands in the uterine cervix: a probable metaplastic process

As glândulas sebáceas ectópicas são achados muito infrequentes no trato genital feminino. Descrevemos um caso que ocorreu em paciente de 42 anos de idade, submetida à histerectomia total, devido à leiomiomatose e ao prolapso uterino.

The ectopic sebaceous glands have been extremely rare findings in female genital system. We describe the case of 42 years-old patient with total hysterectomy due to leiomyomatosis and uterine prolapsed.