RESUMO
Se realizó un estudio descriptivo y transversal de 199 pacientes diagnosticados con cáncer de pulmón, atendidos en el Servicio de Neumología del Hospital General Docente Dr Juan Bruno Zayas Alfonso de Santiago de Cuba, de enero del 2014 a diciembre del 2017, con vistas a determinar la asociación de los marcadores tumorales con el proceso neoplásico. En la serie predominaron el sexo masculino y las edades de 50 a 69 años, así como los estadios IIIB y IV de la enfermedad. De igual modo resultó más frecuente la localización en el pulmón derecho y el tipo histológico cáncer de pulmón células no pequeñas, del cual fue más representativo el adenocarcinoma. Por su parte, el CYFRA 21.1 y el CA 72.4 fueron los dos marcadores asociados con los procesos tumorales pulmonares y fueron ratificados como tal.
A descriptive and cross-sectional study of 199 patients diagnosed with lung cancer, assisted in the Pneumology Service of Dr Juan Bruno Zayas Alfonso Teaching General Hospital was carried out in Santiago de Cuba, from January, 2014 to December, 2017, aimed at determining the association of tumoral markers with the neoplastic process. In the series there was a prevalence of the male sex and patients aged 50 to 69, as well as the IIIB and IV stages of the disease. In a same way it was more frequent the localization in the right lung and the histologic type non small cells lung cancer, from which adenocarcinoma was more representative. On the other hand, CYFRA 21.1 and CA 72.4 were the two markers associated with lung tumoral processes and were confirmed as such.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais , Neoplasias Pulmonares/epidemiologia , Epidemiologia Descritiva , Estudos Transversais , Carcinoma Pulmonar de Células não PequenasRESUMO
Objective To study the expression of WWOX, ErbB2 and Ki67 protein in non-small cell lung cancer(NSCLC) and the relationships with cell proliferation. Methods WWOX and ErbB2 protein expressions were evaluated by immunohistochemistry in 81 NSCLC patients (50 squamous cell carcinomas,31 adenocarcinomas and 20 adjacent normal lung tissues) and the correlations with histopathologic cell proliferation were analyzed. Results WWOX expression was absent/reduced in 72.8% of NSCLC, while it was normal in 80.0% of adjacent normal lung tissues. WWOX expression was strongly associated with tumor histology, histologic grade and lymph node metastasis ( X2 = 5.44, P = 0.019 ; X2 = 4.740, P = 0.029, X2 = 4.51, P = 0.034 ), reduced WWOX expression was higher in squamous cell carcinomas and in poorly differentiated tumors. The overexpression of ErbB2 was associated with TNM stage and lymph node metastasis ( X2 = 6.90, P = 0.009 ; X2= 5.68, P=0.017). WWOX expression was negatively related to the overexpression of ErbB2 (r=-0.239, P <0.05 ). WWOX expression intensity was nega-tively related to the high index of cell proliferation (r=-0.252, P<0.05 ). Conclusion The loss of WWOX ex-pression plays different roles in tumorigenesis of NSCLC and is related to high aggressiveness of tumors. The loss of WWOX expression and the overexpression of ErbB2 can estimate the prognosis of NSCLC.
