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1.
Food Funct ; 6(11): 3585-92, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26328874

RESUMO

Depression is one of the prevalent and serious mental disorders and the number of depressed patients has been on the rise globally during the recent decades. Sea buckthorn seed oil from traditional Chinese medicine (TCM) is edible and has been widely used for treatment of different diseases for a long time. However, there are few published reports on the antidepressant effect of sea buckthorn seed oil. With the objective of finding potential biomarkers of the therapeutic response of sea buckthorn seed oil in chronic unpredictable mild stress (CUMS) rats, urine metabolomics based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate analysis was applied. In this study, we discovered a higher level of pimelic acid as well as palmitic acid and a lower level of suberic acid, citrate, phthalic acid, cinnamic acid and Sumiki's acid in urine of rats exposed to CUMS procedures after sea buckthorn seed oil was administered. These changes of metabolites are involved in energy metabolism, fatty acid metabolism and other metabolic pathways as well as in the synthesis of neurotransmitters and it is helpful to facilitate the efficacy evaluation and mechanism elucidating the effect of sea buckthorn seed oil for depression management.


Assuntos
Antidepressivos/farmacologia , Depressão/tratamento farmacológico , Medicamentos de Ervas Chinesas/farmacologia , Hippophae/química , Metabolômica/métodos , Óleos de Plantas/farmacologia , Sementes/química , Animais , Biomarcadores/urina , Ácidos Carboxílicos/urina , Depressão/urina , Cromatografia Gasosa-Espectrometria de Massas , Masculino , Análise Multivariada , Ácidos Pimélicos/urina , Ratos , Ratos Sprague-Dawley
2.
J Inherit Metab Dis ; 15(2): 220-3, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1527989

RESUMO

Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial beta-oxidation and disorders of peroxisomal beta-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.


Assuntos
Caprilatos , Ácidos Dicarboxílicos/análise , Ácidos Pimélicos/análise , Morte Súbita do Lactente , Adipatos/análise , Adipatos/urina , Ácidos Decanoicos/análise , Ácidos Decanoicos/urina , Ácidos Dicarboxílicos/urina , Reações Falso-Positivas , Humanos , Lactente , Ácidos Pimélicos/urina , Plásticos , Manejo de Espécimes/instrumentação , Fatores de Tempo , Corpo Vítreo/química
3.
JPEN J Parenter Enteral Nutr ; 13(3): 299-305, 1989.
Artigo em Inglês | MEDLINE | ID: mdl-2503641

RESUMO

Azelaic acid (Az), a straight saturated chain nine carbon dicarboxylic acid, was administered in saline form to six healthy male volunteers by iv route. Serum levels of Az and urinary amounts of both azelaic and pimelic (C7) acids were measured by an improved gas liquid chromatographic method. Stoichiometric analysis of Az metabolism was compared with that of glucose and palmitic acid. The respiratory quotient (RQ) as well as the ATP/CO2 ratio of Az were quite similar to that of palmitic acid. Therefore, Az oxidation is associated with a low cost of ATP synthesis in terms of carbon dioxide production. At the infusion rate used (7.5 g/hr) more than 50% of the administered dose was excreted in the urine. However, the remaining portion was cleared from the plasma in 200 min suggesting an uptake by body tissues which was also confirmed by indirect calorimetric analysis.


Assuntos
Ácidos Dicarboxílicos/administração & dosagem , Metabolismo Energético/efeitos dos fármacos , Nutrição Parenteral Total , Trifosfato de Adenosina/biossíntese , Adulto , Ácidos Dicarboxílicos/sangue , Ácidos Dicarboxílicos/urina , Alimentos Formulados , Humanos , Infusões Intravenosas , Masculino , Nutrição Parenteral Total/métodos , Ácidos Pimélicos/sangue , Ácidos Pimélicos/urina
4.
Clin Chim Acta ; 156(1): 85-90, 1986 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-3698320

RESUMO

A selected ion monitoring assay for thiodiglycollic acid in urine is described. Urine samples are analysed by combined gas chromatography-mass spectrometry as their dibutyl esters using pimelic acid as an internal standard. Rapid analysis was achieved by the simplification of sample preparation. The assay has proved to be reliable, with a detection limit of less than 0.5 mumol/l. The excretion of large amounts of thiodiglycollic acid in premature babies urine has been confirmed, with the greatest excretion occurring from those neonates born with a gestational age of 30 wk or less.


Assuntos
Recém-Nascido Prematuro , Tioglicolatos/urina , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Recém-Nascido , Ácidos Pimélicos/urina
5.
Pediatr Res ; 18(11): 1185-91, 1984 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-6514446

RESUMO

3-Methyladipic, 4-methylpimelic, 4-methylsuberic, pimelic, and azeleic acids were identified by gas chromatography-mass spectrometry in the amniotic fluid of fetuses with propionic acidemia. These compounds were virtually undetectable in normal amniotic fluid. Concentrations much higher than those of the amniotic fluid were found in the urine of neonatal infants with propionic acidemia and methylmalonic acidemia. It appears that the accumulation of these compounds is a consequence of the accumulation of propionyl-CoA. Evidence was obtained for the presence of other methyl-branched chain dicarboxylic acids. 4-Methylpimelic acid and 4-methylsuberic acid have not previously been identified in human physiological fluids.


Assuntos
Líquido Amniótico/metabolismo , Ácidos Dicarboxílicos/metabolismo , Malonatos/sangue , Ácido Metilmalônico/sangue , Ácidos Pimélicos/metabolismo , Propionatos/sangue , Cromatografia Gasosa , Ácidos Dicarboxílicos/urina , Feminino , Humanos , Espectrometria de Massas , Erros Inatos do Metabolismo/sangue , Ácidos Pimélicos/urina , Gravidez
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