Biological and phytochemical investigation of plants XV. Pteryxia terebinthina var. terebinthina (Umbelliferae).

Aqueous extracts of Pteryxia terebinthina var. terebinthina were shown to possess antiarrhythmic activity. A novel furanocoumarin, pterybinthinone, the known coumarins pteryxin and umbelliferone, and sucrose were isolated from this plant. Attempts to re-isolate a structurally undefined, defibrillatory substance by means of a published protocol were unsuccessful.

Analgesic activity of substituted benzylidinohydrazines.

Sixteen substitued benzylidinohydrazines were evaluated for morphine-like analgesic activity by mouse tail-pinch test while aconitine-induced writhing test in mice was used to determine their ability to possess aspirin-like analgesia. All benzylidinohydrazines exhibited analgesic activity where protection against tail-pinch and aconitine-induced writhing response ranged from 16.7-83.3% and 16.7-66.7%, respectively.