Assuntos
Intoxicação por Mercúrio , Mercúrio/fisiologia , Mercúrio/toxicidade , Absorção , Acrodinia/induzido quimicamente , Administração por Inalação , Animais , Biotransformação , Encéfalo/metabolismo , Carbono/metabolismo , Sistema Digestório/efeitos dos fármacos , Sistema Digestório/metabolismo , Desenvolvimento Embrionário e Fetal/efeitos dos fármacos , Poluentes Ambientais/sangue , Poluentes Ambientais/toxicidade , Poluentes Ambientais/urina , Fezes , Feminino , Cabelo/efeitos dos fármacos , Cabelo/metabolismo , Humanos , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Lactação , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Mercúrio/análise , Síndrome Nefrótica/induzido quimicamente , Placenta/efeitos dos fármacos , Placenta/metabolismo , Gravidez , Insuficiência Renal/induzido quimicamente , Selênio/química , Selênio/metabolismo , Pele/efeitos dos fármacos , Pele/metabolismo , Enxofre/química , Enxofre/metabolismo , Distribuição TecidualAssuntos
Acrodinia/induzido quimicamente , Amálgama Dentário/efeitos adversos , Intoxicação por Mercúrio/etiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Troca Materno-Fetal/efeitos dos fármacos , Troca Materno-Fetal/fisiologia , Mercúrio/farmacocinética , Gravidez , Efeitos Tardios da Exposição Pré-NatalRESUMO
1. A survey on the literature concerning the toxicity of amalgam is presented. 2. Opinions from various sources are discussed. It is found that there are no conclusive experimental results of clinical importance. Existing results on adults cannot be applied to children, who are more sensitive to amalgam. 3. Research into the toxicity of amalgam in children has begun. Results are expected later in 1992.
Assuntos
Amálgama Dentário/efeitos adversos , Intoxicação por Mercúrio/etiologia , Acrodinia/induzido quimicamente , Criança , Humanos , Concentração Máxima Permitida , Fatores de RiscoAssuntos
Acrodinia/induzido quimicamente , Poluentes Atmosféricos/intoxicação , Hipertireoidismo/induzido quimicamente , Intoxicação por Mercúrio/complicações , Acrodinia/diagnóstico , Acrodinia/tratamento farmacológico , Adolescente , Humanos , Hipertireoidismo/diagnóstico , Hipertireoidismo/tratamento farmacológico , Masculino , Intoxicação por Mercúrio/diagnóstico , Intoxicação por Mercúrio/tratamento farmacológico , VolatilizaçãoRESUMO
Two sisters and their brother who had been exposed to mercury vapours from a broken fever thermometer were treated for acrodynia. Their urinary Hg concentrations, as well as the relatively few data that can be found in previous publications, show that the brain of children below the age of 5 years is much more sensitive to chronic mercury intoxication than the cerebrum of adults. Hg concentrations of well below 50 micrograms/l in the urine can be associated with severe symptoms. One of our patients had a mercury concentration of 6.3 micrograms/l. In adults with occupational exposure, urinary mercury concentrations of up to 200 micrograms/l are tolerated and permitted. Acrodynia possibly is not always diagnosed when it is occurring. Normal values for urinary Hg excretion in children under basal conditions and after administration of a chelating agent should be established.
Assuntos
Acrodinia/induzido quimicamente , Intoxicação por Mercúrio/diagnóstico , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Mercúrio/farmacocinética , Fatores de Risco , TermômetrosRESUMO
A case of acrodynia in an eight-and-a-half-year-old girl is presented whose symptoms--profuse perspiration, swelling, desquamation, pain, itching of the extremities, pinkish color of the nose and cheeks and hypertension--responded sharply to nifedipine therapy.
Assuntos
Acrodinia/tratamento farmacológico , Intoxicação por Mercúrio/complicações , Nifedipino/uso terapêutico , Acrodinia/induzido quimicamente , Acrodinia/patologia , Criança , Feminino , HumanosRESUMO
A 14-month-old girl who presented with multiple systemic complaints was found to have gingivitis, peeling of her palms and soles, and a peculiar acral eruption. A diagnosis of acrodynia, or pink disease, was confirmed by elevated levels of mercury in the urine. The many cutaneous manifestations of this once common disease are discussed.
Assuntos
Acrodinia/patologia , Intoxicação por Mercúrio/patologia , Dermatopatias/induzido quimicamente , Acrodinia/induzido quimicamente , Feminino , Humanos , Lactente , Intoxicação por Mercúrio/complicações , Hipotonia Muscular/induzido quimicamente , Sialorreia/induzido quimicamente , Dermatopatias/patologia , Sudorese/efeitos dos fármacosRESUMO
Medical attention was sought for a 23-month-old toddler because of anorexia, weight loss, irritability, profuse sweating, peeling and redness of his fingers and toes, and a miliarial rash. The diagnosis was mercury poisoning, and an investigation of his environment disclosed that he had been exposed to mercury from broken fluorescent light bulbs. Acrodynia resulting from fluorescent bulbs has not been previously reported.
Assuntos
Acrodinia/induzido quimicamente , Iluminação , Intoxicação por Mercúrio/etiologia , Exposição Ambiental , Utensílios Domésticos , Humanos , Lactente , MasculinoRESUMO
Pink disease has virtually disappeared since teething powders were withdrawn. We describe a case in a boy who was exposed to metallic mercury vapour. We discuss the potential health hazard of spilled elemental mercury in the house and the difficulties of removing it from the environment.
Assuntos
Acrodinia/induzido quimicamente , Mercúrio/efeitos adversos , Descontaminação , Exposição Ambiental , Humanos , Lactente , MasculinoRESUMO
trans-Bis(salicylaldoximato)copper(II) (CuSAO2), the parent compound of a new group of antiproliferative copper(II) complexes, was studied in vivo. It had marked antitumor activity against Ehrlich ascites carcinoma in NMRI mice. Survival was considerably increased, and, in some cases, total cures were encountered. No activity against leukemia L1210 was found in female DBA/2J mice, although CuSAO2 is equally effective against L1210 and Ehrlich carcinoma cells in vitro. The side effects of CuSAO2 included weight loss, weakness, acrodynia, and blindness; all of these side effects were transient.
Assuntos
Antineoplásicos , Carcinoma de Ehrlich/tratamento farmacológico , Cobre/uso terapêutico , Leucemia L1210/tratamento farmacológico , Compostos Organometálicos/uso terapêutico , Acrodinia/induzido quimicamente , Animais , Cegueira/induzido quimicamente , Peso Corporal/efeitos dos fármacos , Carcinoma de Ehrlich/patologia , Cobre/efeitos adversos , Feminino , Leucemia L1210/patologia , Camundongos , Compostos Organometálicos/efeitos adversos , Fatores de TempoRESUMO
In a family exposed to metallic mercury vapour two patients had acrodynia, one had the nephrotic syndrome, and one person remained well. Recognition of the variable manifestations of the disease and prevention of further exposure were the most important aspects of management. Recovery appeared to be complete as blood mercury levels fell to normal. Urinary mercury levels were too variable to be reliable as indications of progress.
Assuntos
Acidentes Domésticos , Acrodinia/induzido quimicamente , Intoxicação por Mercúrio/complicações , Síndrome Nefrótica/induzido quimicamente , Adolescente , Adulto , Criança , Exposição Ambiental , Feminino , Humanos , Masculino , Mercúrio/análise , Mercúrio/sangue , Mercúrio/urina , Intoxicação por Mercúrio/tratamento farmacológico , Penicilamina/uso terapêutico , Fatores de TempoRESUMO
A 31 year-old inhabitant of French Guiana was prescribed mercuric iodide per os for two and a half months. Shortly before the end of the treatment he developed fasciculations in the trunk and particularly the lower limb muscles, distal painful paresthesias with vasomotor disorders, episodes of excessive perspiration and palmoplantar erythema, moderate fluctuating hypertension, progressive loss of weight and irritability with insomnia. Clinical and electrical signs of neuropathy were lacking. The clinical picture was that of Morvan's fibrillary chorea with acrodynia, the conditions of onset strongly suggesting a mercurial intoxication. Blood and particularly urine mercury levels were elevated. Administration of dimercaprol (BAL) considerably increased urinary excretion of mercury and there was progressive improvement and finally recovery after two months of BAL treatment. This case exemplifies the possible co-existence of fibrillary chorea and acrodynia. Whereas in many cases of fibrillary chorea a precise etiology cannot be determined, the affection can be induced by mercury as by gold administration. The fact that cases of fibrillary chorea due to mercury poisoning are rarely reported may be the result of individual patient hypersensitivity or particular metabolic absorption and excretion features of mercury. This case cannot be included within the continuous activity syndrome of muscle fibers described by Isaacs, since muscle contractures were absent and there was associated acrodynia. Moreover, there was no latent polyneuropathy, in spite of the intense fasciculations. It must be concluded, therefore, that in spite of its rarity fibrillary chorea should keep its semiologic autonomy.
Assuntos
Acrodinia/induzido quimicamente , Coreia/induzido quimicamente , Intoxicação por Mercúrio/complicações , Acrodinia/diagnóstico , Adulto , Coreia/diagnóstico , Humanos , Masculino , Mercúrio/metabolismo , Intoxicação por Mercúrio/diagnósticoAssuntos
Anormalidades Induzidas por Medicamentos , Talidomida/efeitos adversos , Acrodinia/induzido quimicamente , Infecções Bacterianas/tratamento farmacológico , Criança , Pré-Escolar , Cloranfenicol/efeitos adversos , Ectromelia/induzido quimicamente , Feminino , Humanos , Hipoglicemiantes/uso terapêutico , Lactente , Recém-Nascido , Masculino , Troca Materno-Fetal , Mercúrio/efeitos adversos , Gravidez , Raquitismo/tratamento farmacológico , Sepse/tratamento farmacológico , Vitamina D/uso terapêuticoRESUMO
Dichloroacetate is known to reduce plasma cholesterol and triglyceride in patients with Fredrickson Types IIb or IV hyperlipoproteinemia. We now report the effects of chronic, oral dichloroacetate administration (as the sodium salt) in two patients with severe homozygous familial hypercholesterolemia. Dichloroacetate markedly reduced serum total and low density lipoprotein cholesterol levels and lowered the low density lipoprotein to high density lipoprotein cholesterol ratio. One patient developed a polyneuropathy while receiving dichloroacetate which resolved following discontinuation of the drug. Because of its apparent toxicity, dichloroacetate cannot be recommended for chronic oral use. Investigation of the mechanism of its lipid-lowering effect, however, may provide insight into the pathogenesis and treatment of hypercholesterolemic disorders.