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2.
J Eur Acad Dermatol Venereol ; 24(2): 178-85, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19796089

RESUMO

BACKGROUND: Some adnexal tumours have many controversies about their histogenesis. OBJECTIVES: To evaluate the eccrine and/or apocrine differentiation phenotype in cases of cylindroma and clear cell hidradenoma with CD15 and p63 antibodies. METHODOLOGY: Slides and blocks of six cases of cylindroma and seven cases of nodular hidradenoma (clear cells) were analyzed by the technique of immunohistochemistry with CD15 and p63 antibodies. RESULTS: In all cases of cylindroma we obtained negative results for CD15 antibody and positive for p63 antibody. In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells. In the two other cases, cystic lesions were present and occasional clear cells could be seen. The reaction with CD15 antibody was positive in granular and cytoplasmic pattern in six of seven cases, especially in cells with suggestive clear cytoplasm in lower proportion than this clear cells could be seen in haematoxylin and eosin. The positivity for p63 antibody, nuclear pattern, was observed in six of seven cases, in the major part of tumour cells. In only one case, the positivity was in 20% of cells. Limitation Samples are in small number because these are relatively rare tumours. CONCLUSIONS: The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma.


Assuntos
Acrospiroma/imunologia , Carcinoma Adenoide Cístico/imunologia , Imunofenotipagem , Acrospiroma/patologia , Carcinoma Adenoide Cístico/patologia , Diferenciação Celular , Humanos , Imuno-Histoquímica , Antígenos CD15/imunologia , Proteínas de Membrana/imunologia
3.
J Am Acad Dermatol ; 55(2 Suppl): S46-9, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16843124

RESUMO

Eccrine poromas are benign, adnexal tumors that most often occur as a solitary lesion on the palm or sole. The occurrence of multiple eccrine poromas is extremely rare. In this report, we describe the development of several eccrine poromas in an acral distribution in a 42-year-old man. Before the appearance of these tumors, the patient had received total body irradiation and allogeneic bone marrow transplantation for treatment of acute lymphocytic leukemia. As a complication of the bone marrow transplant, the patient developed chronic graft-versus-host disease, which was treated with immunosuppressive therapy. We discuss this patient and review the available literature regarding multiple eccrine poromas.


Assuntos
Acrospiroma/etiologia , Doença Enxerto-Hospedeiro/tratamento farmacológico , Imunossupressores/efeitos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/radioterapia , Neoplasias das Glândulas Sudoríparas/etiologia , Irradiação Corporal Total/efeitos adversos , Acrospiroma/imunologia , Acrospiroma/patologia , Adulto , Transplante de Medula Óssea/efeitos adversos , Doença Crônica , Terapia Combinada , Humanos , Masculino , Neoplasias Induzidas por Radiação/imunologia , Neoplasias Induzidas por Radiação/patologia , Neoplasias das Glândulas Sudoríparas/imunologia , Neoplasias das Glândulas Sudoríparas/patologia
4.
Br J Dermatol ; 149(5): 1059-63, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14632816

RESUMO

An 81-year-old woman came to our clinic (Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan) with multiple erythematous, indurated papules over the left side of her face. Two years earlier, the patient had a skin biopsy done at a similar anatomical area with the histopathological diagnosis of Bowen's disease. After reviewing surgical specimens and confirming no systemic involvement, clear cell eccrine porocarcinoma with extensive cutaneous metastasis has been diagnosed. In addition, the peripheral blood lymphocyte function of the patient was evaluated. The expression of interleukin-2 receptors on lymphocytes after stimulation is abnormal compared with the age-matched normal control and a patient with cutaneous squamous cell carcinoma. This clinical manifestation of eccrine porocarcinoma is exceptional, and lymphocyte dysfunction in this patient has probably contributed to extensive cutaneous metastasis.


Assuntos
Acrospiroma/patologia , Neoplasias Cutâneas/secundário , Neoplasias das Glândulas Sudoríparas/patologia , Acrospiroma/imunologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Linfócitos/imunologia , Receptores de Interleucina-2/sangue , Neoplasias Cutâneas/imunologia , Neoplasias Cutâneas/patologia , Neoplasias das Glândulas Sudoríparas/imunologia
5.
Dermatology ; 190(1): 72-6, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-7894103

RESUMO

A 73-year-old woman with a malignant hidroacanthoma simplex on her right lower limb is reported. The lesion was immunohistochemically studied. Carcino-embryonic antigen and epithelial membrane antigen were found in the luminal border of ductal structures within the aggregations of neoplastic cells. We review the literature on this subject.


Assuntos
Acrospiroma/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Acrospiroma/imunologia , Acrospiroma/ultraestrutura , Idoso , Feminino , Humanos , Imuno-Histoquímica , Perna (Membro) , Neoplasias das Glândulas Sudoríparas/imunologia , Neoplasias das Glândulas Sudoríparas/ultraestrutura
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