Manejo hospitalario con terapia topica no convencional de pacientes quemados. Turbo (Antioquia). Junio 1987-Julio 1988 / Hospital management with nonconventional topic therapy in burned patients. Turbo (Antioquia) June 1987-July 1988

Se realizo un estudio prospectivo y descriptivo en terapia topica de quemaduras en el Hospital San Jose de Turbo, Antioquia. Se evaluaron los resultados en 24 pacientes hospitalizados por quemaduras de variada extension y profundidad, con la aplicacion de un topico no convencional (pomada pulgarin o SUNDERI m.r.) compuesto por refampicina, quinina e indometacina. Se encontro una extension promedio de 20.4%. Se clasificaron grado II profundo el 37.5% de los casos. La mortalidad en el estudio fue del 4.1% (1 paciente). El promedio de dias -estancia fue de 21 dias. Se obtuvo un 100% de cicatrizacion optima en el 70.8% de los casos y el promedio fue de 92.7% de cicatrizacion adecuada, es decir: sin retraccion, irregularidad o fibrosis. Se concluye que la sustancia es util en el manejo topico del paciente quemado, principalmente donde no hay recursos especializados de salud; y que se necesitan futuros estudios para determinar su utilidad en el manejo integral de las quemaduras

Patient acceptance of prefilled disposable vaginal applicator.

Patient acceptance of a new, compact, prefilled disposable vaginal applicator was tested in an open study in which 2% butoconazole cream was used for the treatment of vulvovaginal candidiasis. Twenty nonpregnant patients with clinical signs and symptoms of candidiasis and microscopic identification of Candida in wet smear were treated for 3 days and then asked to rate the convenience of and their acceptance of the prefilled vaginal applicator. No adverse events were reported. All of the patients readily accepted the idea of a prefilled applicator and judged the shape and surface of the test applicator to be comfortable and the applicator to be easily inserted. Patients judged this applicator to be the most convenient and least messy when compared with other commercially available, reusable, or prefilled disposable applicators.

Pharmacokinetics of transdermal drug delivery.

The pharmacokinetics of drug delivery from transdermal controlled-release devices consisting of (a) a membrane plus a reservoir or (b) a monolithic slab are examined. For the period when the devices act as if the drug reservoir were infinite, simple relationships for the steady-state slope and time lag are derived and studied. An analysis of the time region when depletion of the finite dose is obtained is used to estimate the useful device lifetime. Applications to patch design are discussed.

Bilateral primary carcinoma of the ureter: topical intraureteral thiotepa.

We report a rare case of bilateral simultaneous ureteral carcinoma. Management included instillation of thiotepa into the remaining ureter via a subcutaneous conduit after reoperation for recurrence.

Method of preparation and application of small quantities of semi-solid topicals.

Quantifying with accuracy small amounts of semi-solid viscus materials is critical in some situations. A sample dish and loading device for a micropipette is described which permits efficient and accurate loading and dispensing of microliter quantities. This is especially valuable for dealing with small quantities of radiolabelled viscus materials.

Systems approach to vaginal delivery of drugs I: development of in situ vaginal drug absorption procedure.

In the framework of the development of drug delivery systems for locally administered contraceptive drugs, a reliable method that can afford quantitative evaluation of drug absorption behavior was explored using the rabit doe. A system was constructed based upon perfusing the drug solution in the vaginal tract. For this purpose, a "rib-cage" type cell was constructed and surgically implanted in the rabbit prior to an experiment. The primary purpose of the present paper is to evaluate the method, including the surgical operation and the perfusion system. The absorption experiments were carried out using n-butanol-1minus 14C as the model solute to survey the reproducibility of the absorption behavior. Experiments were conducted with a number of rabbits on several successive days to determine the day-to-day and animal-to-animal variations. The drug disappearance in the reservoir followed first-order kinetics from which the apparent permeability coefficient was calculated. The results indicated that a set of experiments may be carried out on a single animal and that the method generally affords rather high precision.