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1.
Eur J Med Chem ; 221: 113522, 2021 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33984804

RESUMO

Statins play an important role in the treatment of hyperlipidemia, but drug resistance and adverse effects greatly limits their application. To discover new lipid-lowering drugs, three different series of tetrahydroprotoberberine derivatives (THPBs) were designed and synthesized. These compounds were first tested for their effects on viability of HepG2 cells and 21 compounds with the percent of cell viability over 90% were further screened to evaluate their ability to reduce total cholesterol (TC) and triglyceride (TG) levels. Among these derivatives, two compounds displayed significant down-regulation both intracellular of TC and TG content, especially compound 49 exhibited the greatest efficacy. Mechanistically, compound 49 promoted proteasomal degradation of SREBPs. Importantly, compound 49 displayed superior bioavailability (F = 65.1%) and obvious efficacy in the treatment of high fat diet induced obesity in vivo. Therefore, compound 49 is a promising candidate to develop new treatment of hyperlipidemia.


Assuntos
Antineoplásicos/farmacologia , Alcaloides de Berberina/farmacologia , Desenho de Fármacos , Hiperlipidemias/tratamento farmacológico , Proteína de Ligação a Elemento Regulador de Esterol 1/antagonistas & inibidores , Proteína de Ligação a Elemento Regulador de Esterol 2/antagonistas & inibidores , Antineoplásicos/síntese química , Antineoplásicos/química , Alcaloides de Berberina/síntese química , Alcaloides de Berberina/química , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Células Hep G2 , Humanos , Hiperlipidemias/metabolismo , Hiperlipidemias/patologia , Estrutura Molecular , Proteína de Ligação a Elemento Regulador de Esterol 1/genética , Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo , Proteína de Ligação a Elemento Regulador de Esterol 2/genética , Proteína de Ligação a Elemento Regulador de Esterol 2/metabolismo , Relação Estrutura-Atividade
2.
Eur J Med Chem ; 215: 113289, 2021 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-33611188

RESUMO

The total synthesis of berberine and selected analogues. And their evaluation as amyloid ß (Aß) aggregation inhibitors is described. The key step in the synthesis, the assembly of the berberine framework, was accomplished using an intermolecular Heck reaction. Berberine analog 17 incorporating a tertiary amine moiety showed good anti Aß aggregation activity, water solubility, and almost no toxicity to nerve cells.


Assuntos
Peptídeos beta-Amiloides/antagonistas & inibidores , Alcaloides de Berberina/farmacologia , Fragmentos de Peptídeos/antagonistas & inibidores , Multimerização Proteica/efeitos dos fármacos , Animais , Alcaloides de Berberina/síntese química , Simulação de Acoplamento Molecular , Células PC12 , Ratos
3.
Neurochem Int ; 139: 104807, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32711021

RESUMO

The biosynthesis of berberine alkaloids is thought to begin with the demethylation of berberine followed by methylation reactions to generate other type berberine alkaloids. This seemingly expeditious way to access berberine alkaloids has been stagnated for over half a century due to certain vexing synthetic problems, such as low isolated yield, complex operations and toxic reagents. We further investigated this bioinspired semi-synthesis strategy and significantly improved the synthetic efficacy, by providing a practical synthetic process for demethyleneberberine (DMB), columbamine and palmatine. Furthermore, we found that DMB (IC50, 9.06 µM) inhibited the activity of monoamine oxidase B (MAO-B), an enzyme that deaminates dopamine and is particularly involved in the pathology of Parkinson's disease. Besides, columbamine was able to decrease MAO-B activity by approximately 40%. These findings provide perquisites for further in vivo investigation to confirm the therapeutic potentiality of berberine alkaloids, DMB in particular.


Assuntos
Alcaloides de Berberina/síntese química , Berberina/análogos & derivados , Inibidores da Monoaminoxidase/síntese química , Monoaminoxidase/metabolismo , Extratos Vegetais/síntese química , Berberina/síntese química , Berberina/farmacologia , Alcaloides de Berberina/farmacologia , Sítios de Ligação/fisiologia , Relação Dose-Resposta a Droga , Humanos , Inibidores da Monoaminoxidase/farmacologia , Extratos Vegetais/farmacologia
4.
Angew Chem Int Ed Engl ; 59(40): 17556-17564, 2020 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-32476195

RESUMO

We describe enantioselective syntheses of strychnos and chelidonium alkaloids. In the first case, indole acetic acid esters were established as excellent partner nucleophiles for enantioselective cooperative isothiourea/Pd catalyzed α-alkylation. This provides products containing indole-bearing stereocenters in high yield and with excellent levels of enantioinduction in a manner that is notably independent of the N-substituent. This led to concise syntheses of (-)-akuammicine and (-)-strychnine. In the second case, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselective cooperative isothiourea/Ir catalyzed α-alkylation was overcome by appropriate substituent choice, leading to enantioselective syntheses of (+)-chelidonine, (+)-norchelidonine, and (+)-chelamine.


Assuntos
Alcaloides/química , Chelidonium/química , Strychnos/química , Alcaloides/síntese química , Alquilação , Benzofenantridinas/síntese química , Benzofenantridinas/química , Alcaloides de Berberina/síntese química , Alcaloides de Berberina/química , Catálise , Chelidonium/metabolismo , Humanos , Indóis/síntese química , Indóis/química , Irídio/química , Paládio/química , Sirtuína 1/antagonistas & inibidores , Sirtuína 1/metabolismo , Estereoisomerismo , Estricnina/síntese química , Estricnina/química , Strychnos/metabolismo , Tioureia/química
5.
Chem Commun (Camb) ; 56(61): 8569-8590, 2020 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-32537619

RESUMO

Catalytic processes in protecting-group-free syntheses of natural products are fast emerging towards achieving the goal of efficiency and economy in total synthesis. Present day sustainable development in synthesis of natural products does not permit the luxury of using stoichiometric reagents and protecting groups. Catalysis and step-economy can contribute significantly toward economy and efficiency of synthesis. This feature article details the ingenious efforts by many researchers in the last couple of years toward concise total syntheses, based on catalytic steps and protecting-group-free-strategies. These would again serve as guidelines in future development of reagents and catalysts aimed at achieving higher efficiency and chemoselectivity to the point that catalysis and protecting-group-free synthesis will be an accepted common practice.


Assuntos
Produtos Biológicos/química , Metais/química , Alquilação , Alcaloides de Berberina/síntese química , Alcaloides de Berberina/química , Produtos Biológicos/síntese química , Caproatos/síntese química , Caproatos/química , Catálise , Diterpenos/síntese química , Diterpenos/química , Imidazolidinas/síntese química , Imidazolidinas/química , Oxirredução , Quinonas/síntese química , Quinonas/química , Estereoisomerismo
6.
Molecules ; 24(11)2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31159274

RESUMO

Tetrahydropyran (THP) rings are common in several natural products, therefore, various strategies are being developed to synthesize these rings. The present work described the study of a one-pot synthesis of 2,4,6-trisubstituted tetrahydropyran compounds promoted by the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] through a Barbier-Prins reaction between allyl bromide and aldehydes. The use of [BMIM][PF6] gave Prins products from several aldehydes in good yields and reaction times. We also found that the anion, PF6-, accelerates the Barbier reaction when used alone, and the excess SnBr2 from the reaction conditions of the Barbier reaction leads to the formation of the THP rings, thus acting as a catalyst for Prins cyclization. Additionally, we demonstrate that ionic liquid can be recovered and reused five times in the preparation of 4-bromo-tetrahydro-2,6-diphenyl-2H-pyran without significant yield loss.


Assuntos
Alcaloides de Berberina/síntese química , Imidazóis/química , Líquidos Iônicos/química , Catálise , Técnicas de Química Sintética , Estrutura Molecular
7.
Molecules ; 23(6)2018 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-29895786

RESUMO

In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.


Assuntos
Alcaloides de Berberina/síntese química , Berberina/análogos & derivados , DNA/metabolismo , Berberina/química , Alcaloides de Berberina/química , Alcaloides de Berberina/farmacologia , DNA/química , Quadruplex G , Ligantes , Modelos Moleculares , Estrutura Molecular
8.
Bioorg Med Chem ; 26(9): 2586-2598, 2018 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-29680749

RESUMO

In this study, quaternary palmatine is used as a lead compound to design and synthesize derivatives to evaluate bioactivities, with twenty-seven compounds of four series being obtained. Antibacterial activity was examined by determining the minimal inhibitory concentration (MIC) values on Staphylococcus aureus, Escherichia coli, and Candida albicans, three series of derivatives being found to exhibit activity in vitro with significant structure-activity relationship (SAR). Elongating the carbon chain led to the antibacterial activity increased, with quaternary 13-hexanoylpalmatine chloride, quaternary 13-(ω-ethoxycarbonyl)heptylpalmatine chloride, and 8-oxo-13-(N-n-nonyl)aminomethyldihydropalmatine, all of which possess the longest aliphatic carbon chain in the corresponding series of derivatives, showing the MIC values of 62.5, 7.81, and 15.63 µg/ml against S. aureus, respectively. The property of anti-ulcerative colitis (anti-UC) was assessed at the levels of both in vitro and in vivo, with X-box-binding protein 1 (XBP1) being targeted in vitro. Seven compounds were found not only to be hypocytotoxic toward intestinal epithelial cells, but also to exhibit activity of activating the transcription of XBP1 in vitro. Five compounds were found to possess significant dose-effect relationship with EC50 values at a level of 10-7 µM in vitro. 8-Oxo-13-formyldihydropalmatine as an intermediate was found to display significant curative effect on UC in vivo based on the biomarkers of body weight change, colon length change, and calculated values of disease activity index and colon macroscopic damage index of the experimental animals, as well as the examination into the pathological changes of the colon tissue of the modeled animals.


Assuntos
Antibacterianos/farmacologia , Antiulcerosos/farmacologia , Alcaloides de Berberina/farmacologia , Animais , Antibacterianos/síntese química , Antibacterianos/química , Antibacterianos/uso terapêutico , Antiulcerosos/síntese química , Antiulcerosos/química , Antiulcerosos/uso terapêutico , Alcaloides de Berberina/síntese química , Alcaloides de Berberina/química , Alcaloides de Berberina/uso terapêutico , Peso Corporal/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Colite Ulcerativa/tratamento farmacológico , Colo/metabolismo , Escherichia coli/efeitos dos fármacos , Levofloxacino/farmacologia , Camundongos Endogâmicos C57BL , Testes de Sensibilidade Microbiana , Estrutura Molecular , Contração Muscular/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Relação Estrutura-Atividade , Sulfassalazina/farmacologia , Proteína 1 de Ligação a X-Box/metabolismo
9.
Chemistry ; 23(50): 12149-12152, 2017 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-28603842

RESUMO

Herein, we report a Cp*CoIII -catalyzed C-H activation approach as the key step to create highly valuable isoquinolones and pyridones as building blocks that can readily be applied in the total syntheses of a variety of aromathecin, protoberberine, and tylophora alkaloids. This particular C-H activation/annulation reaction was achieved with several terminal as well as internal alkyne coupling partners delivering a broad scope with excellent functional group tolerance. The synthetic applicability of this protocol reported herein was demonstrated in the total syntheses of two Topo-I-Inhibitors and two 8-oxyprotoberberine cores that can be further elaborated into the tetrahydroprotoberberine and the protoberberine alkaloid core. Moreover these building blocks were also transformed to six different tylophora alkaloids in expedient fashion.


Assuntos
Alcaloides/síntese química , Alcaloides de Berberina/síntese química , Cobalto/química , Compostos Heterocíclicos de 4 ou mais Anéis/síntese química , Alcaloides/química , Alcaloides de Berberina/química , Carbono/química , Catálise , Compostos Heterocíclicos de 4 ou mais Anéis/química , Hidrogênio/química , Piridonas/química , Quinolonas/química , Tylophora/química , Tylophora/metabolismo
10.
Bioorg Med Chem Lett ; 27(6): 1437-1440, 2017 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-28214075

RESUMO

Cocaine addiction remains a serious challenge for clinical and medical research because there is no effective pharmacological treatment. l-THP, a natural product isolated from Corydalis yanhusuo W.T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites l-ICP, l-CD, and l-CP had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chemical synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors. The synthesis of these bioactive metabolites will allow further in vivo study of their potential in treating cocaine addiction.


Assuntos
Alcaloides de Berberina/síntese química , Receptores Dopaminérgicos/metabolismo , Animais , Alcaloides de Berberina/metabolismo , Sítios de Ligação , Humanos , Ensaio Radioligante
11.
J Med Chem ; 59(20): 9489-9502, 2016 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-27709945

RESUMO

A novel series of tetrahydroprotoberberine derivatives (THPBs) were designed, synthesized, and evaluated as selective α1A-adrenergic receptors (AR) antagonists for the treatment of benign prostatic hyperplasia. On the basis of the pharmacophore model of the marketed drug silodosin, THPBs were modified by introducing an indole segment into their core scaffolds. In calcium assays, 7 out of 32 compounds displayed excellent antagonistic activities against α1A-ARs, with IC50 less than 250 nM. Among them, compound (S)-27 had the most potent biological activity; its IC50 toward α1A-AR was 12.8 ± 2.2 nM, which is 781 and 20 times more selective than that toward α1B- and α1D-AR, respectively. In the functional assay using isolated rat tissues, compound (S)-27 inhibited norepinephrine-induced urethra smooth muscle contraction potently (IC50 = 0.5 ± 0.3 nM), without inhibiting the aortic contraction (IC50 > 1000 nM), displaying a better tissue selectivity than the marketed drug silodosin. Additional results of preliminary safety studies (acute toxicity and hERG inhibition) and pharmacokinetics studies indicated the potential druggability for compound (S)-27 which is a promising lead for the development of selective α1A-AR antagonists for the treatment of BPH.


Assuntos
Antagonistas de Receptores Adrenérgicos alfa 1/síntese química , Antagonistas de Receptores Adrenérgicos alfa 1/farmacologia , Alcaloides de Berberina/química , Alcaloides de Berberina/farmacologia , Desenho de Fármacos , Receptores Adrenérgicos alfa 1/metabolismo , Antagonistas de Receptores Adrenérgicos alfa 1/administração & dosagem , Antagonistas de Receptores Adrenérgicos alfa 1/química , Animais , Alcaloides de Berberina/administração & dosagem , Alcaloides de Berberina/síntese química , Relação Dose-Resposta a Droga , Canais de Potássio Éter-A-Go-Go/antagonistas & inibidores , Canais de Potássio Éter-A-Go-Go/metabolismo , Células HEK293 , Humanos , Masculino , Camundongos , Camundongos Endogâmicos , Estrutura Molecular , Ratos , Ratos Sprague-Dawley , Relação Estrutura-Atividade , Células Tumorais Cultivadas
12.
Chemistry ; 22(21): 7084-9, 2016 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-26990887

RESUMO

A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A(3) reaction, Pd-catalyzed reductive carbocyclization, and PtO2 -catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.


Assuntos
Alcaloides/síntese química , Benzazepinas/síntese química , Alcaloides de Berberina/síntese química , Alcaloides/química , Benzazepinas/química , Alcaloides de Berberina/química , Catálise , Ciclização , Hidrogenação , Modelos Moleculares , Oxirredução , Óxidos/química , Paládio/química , Platina/química , Estereoisomerismo
13.
Chemistry ; 22(5): 1800-4, 2016 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-26689172

RESUMO

A one-pot reaction of substituted benzaldehydes with alkyne-amines by a Rh-catalyzed C-H activation and annulation to afford various natural and unnatural protoberberine alkaloids is reported. This reaction provides a convenient route for the generation of a compound library of protoberberine salts, which recently have attracted great attention because of their diverse biological activities. In addition, pyridinium salt derivatives can also be formed in good yields from α,ß-unsaturated aldehydes and amino-alkynes. This reaction proceeds with excellent regioselectivity and good functional group compatibility under mild reaction conditions by using O2 as the oxidant.


Assuntos
Alcaloides/química , Alcaloides de Berberina/síntese química , Oxidantes/química , Aldeídos/química , Alcinos/química , Benzaldeídos/química , Alcaloides de Berberina/química , Catálise , Ligação de Hidrogênio , Estrutura Molecular
14.
Chin J Nat Med ; 14(10): 783-788, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28236408

RESUMO

The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.


Assuntos
Alcaloides de Berberina/síntese química , Alcaloides de Berberina/metabolismo , Gliocladium/metabolismo , Glicosídeos/síntese química , Glicosídeos/metabolismo , Alcaloides de Berberina/química , Biotransformação , Catálise , Glicosídeos/química , Glicosilação , Estrutura Molecular
15.
Angew Chem Int Ed Engl ; 54(47): 14187-9, 2015 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-26474300

RESUMO

The first total synthesis of the dimeric berberine alkaloid ilicifoline (ilicifoline B) is reported. Its carbon skeleton is constructed from ferulic acid, veratrole, and methanol. The synthesis reported herein employs starting materials solely derived from wood. The natural product is thus constructed entirely from renewable resources. The same strategy is applied to a formal total synthesis of morphinan alkaloids. The use of wood-derived building blocks (xylochemicals) instead of the conventional petrochemicals represents a sustainable alternative to classical synthetic approaches.


Assuntos
Alcaloides de Berberina/síntese química , Produtos Biológicos/síntese química , Madeira/química , Alcaloides de Berberina/química , Produtos Biológicos/química , Estrutura Molecular
16.
Chemistry ; 21(37): 12908-13, 2015 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-26220197

RESUMO

Cyclic amines such as pyrrolidine undergo redox-annulations with 2-formylaryl malonates. Concurrent oxidative amine α-CH bond functionalization and reductive N-alkylation render this transformation redox-neutral. This redox-Mannich process provides regioisomers of classic Reinhoudt reaction products as an entry to the tetrahydroprotoberberine core, enabling the synthesis of (±)-thalictricavine and its epimer. An unusually mild amine-promoted dealkoxycarbonylation was discovered in the course of these studies.


Assuntos
Aminas/química , Alcaloides de Berberina/síntese química , Pirrolidinas/química , Alcaloides de Berberina/química , Catálise , Ciclização , Estrutura Molecular , Oxirredução
17.
Org Biomol Chem ; 13(12): 3732-41, 2015 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-25687222

RESUMO

An efficient and mild protocol for the direct construction of aryl- and alkyl-substituted isoquinolines has been realized through silver nitrate catalyzed aromatic annulation of o-(1-alkynyl)arylaldehydes and ketones with ammonium acetate. The salient feature of this methodology is that this annulation could be effected at room temperature leading to a wide range of isoquinoline derivatives in good to excellent yields. Additionally, this approach has been employed to the synthesis of biologically important isoquinoline alkaloids such as berberine and palmatine.


Assuntos
Acetatos/química , Aldeídos/química , Alcaloides de Berberina/química , Berberina/química , Isoquinolinas/química , Cetonas/química , Prata/química , Temperatura , Berberina/síntese química , Alcaloides de Berberina/síntese química , Catálise
18.
J Org Chem ; 80(3): 2010-6, 2015 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-25584789

RESUMO

A facile one-pot synthesis of protoberberines from readily accessible 1,2,3,4-tetrahydroisoquinoline-1-carbonitriles and 1,2-bis(bromomethyl)arenes is described. The reaction cascade comprises four consecutive transformations, all of which can be effected under a single set of conditions. Ten protoberberines, including the alkaloids pseudopalmatine and pseudoepiberberine, were prepared in yields up to 86% according to this strategy. No chromatographic purification of the products is required, and the route is devoid of any protecting group manipulations.


Assuntos
Alcaloides/química , Alcaloides/síntese química , Compostos de Amônio/química , Alcaloides de Berberina/química , Alcaloides de Berberina/síntese química , Nitrilas/química , Tetra-Hidroisoquinolinas/química , Estrutura Molecular
19.
Angew Chem Int Ed Engl ; 53(52): 14555-8, 2014 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-25348493

RESUMO

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50 % is a large improvement over the single, previous synthesis. By design, this modular route allows the rapid synthesis of other members of the protoberberine family (e.g., pseudocoptisine and palmatine) by substitution of the readily available aryl bromide and ketone coupling partners. Moreover, by combining enolate arylation with in situ functionalization, substituents can be rapidly and regioselectively introduced at the alkaloid C13 position, as demonstrated by the total synthesis of dehydrocorydaline. The avoidance of electrophilic aromatic substitution reactions to make the isoquinoline allows direct access to analogues possessing more varied electronic properties, such as the fluorine-containing derivative synthesized here.


Assuntos
Alcaloides de Berberina/química , Paládio/química , Alcaloides de Berberina/síntese química , Produtos Biológicos/síntese química , Produtos Biológicos/química , Catálise , Isoquinolinas/química , Estereoisomerismo
20.
Zhongguo Zhong Yao Za Zhi ; 39(4): 699-703, 2014 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-25204150

RESUMO

For the establishment of chemical library of protoberberines provided for the bio-activity screening, the target compounds were synthesized by thermal degradation and nucleophilic substitution reactions with the bio-active alkaloid, palmatine (1), as the raw material, and their structures were identified and conformed by 1H-NMR and MS spectra. Among them, 13 compounds were new.


Assuntos
Alcaloides de Berberina/química , Medicamentos de Ervas Chinesas/química , Alcaloides de Berberina/síntese química , Medicamentos de Ervas Chinesas/síntese química , Estrutura Molecular
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