RESUMO
El carcinoma anaplásico de tiroides (CAT), representa la neoplasia de peor pronóstico de la glándula tiroides. Generalmente se caracteriza por un comportamiento localmente agresivo, cuya sintomatología clásica es disfonía, disfagia y disnea. La supervivencia media, sin tratamiento no rebasa los seis meses. En el Instituto Nacional de Cancerología (INCan) representa el 18 por ciento de los carcinomas tiroideos. La tomografía computada (TAC), es el estudio de elección para conocer la extensión de la lesión y planear el abordaje quirúrgico. La cirugía continúa siendo el tratamiento de primera elección; en casos cuya resección es incompleta o en tumores no extirpables, la radioterapia puede ser de utilidad. La quimioterapia no ha demostrado beneficio alguno en el manejo de estas neoplasias
Assuntos
Carcinoma/ultraestrutura , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/tratamento farmacológico , Neoplasias da Glândula Tireoide/radioterapia , Neoplasias da Glândula Tireoide/terapia , Anaplasia/ultraestrutura , Glândula Tireoide/patologiaRESUMO
Clinical, histological and histochemical features of anaplastic temporal ganglioglioma in a 30-year-old woman are described. Short clinical course (preoperative 2 years, postoperative 6 months), anaplastic features of glial astrocytic component with scarce GFAP and negative vimentin immunostaining indicate aggressive character of the tumor. Ganglionic component is confirmed by the strong Con A affinity and discrete FN and NSE immunostaining.
Assuntos
Anaplasia/patologia , Neoplasias Encefálicas/patologia , Ganglioglioma/patologia , Lobo Temporal/patologia , Adulto , Anaplasia/diagnóstico , Anaplasia/cirurgia , Anaplasia/ultraestrutura , Astrócitos/ultraestrutura , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/cirurgia , Neoplasias Encefálicas/ultraestrutura , Evolução Fatal , Feminino , Ganglioglioma/diagnóstico , Ganglioglioma/cirurgia , Ganglioglioma/ultraestrutura , Humanos , Neuroglia/ultraestrutura , Lobo Temporal/cirurgia , Lobo Temporal/ultraestrutura , Tomografia Computadorizada por Raios XRESUMO
Electron microscopic and cytological study of mammary carcinoma cells of different degrees of anaplasia was carried out using morphometric methods in 15 patients with infiltrating carcinoma of this localization and correlation of cytological and histological data. The results showed the quantitative ultrastructural characteristics of the infiltrating mammary carcinoma reflecting the level of development of granular reticulum and polyribosomal apparatus to differ significantly depending on the degree of the tumor anaplasia established by cytological and histological studies with a light microscope. The cytological signs showing the maximum correlation with the ultrastructural changes in cells were found to include the numbers of "naked" nuclei, sizes of the cells and nuclei, number of nucleoli in the cell. Combinations of these signs typical for mammary carcinoma of different degrees of anaplasia are described.
