Assuntos
Anetodermia/metabolismo , Basófilos/metabolismo , Macrófagos/enzimologia , Metaloproteinase 9 da Matriz/metabolismo , Anetodermia/patologia , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Criança , Humanos , Macrófagos/metabolismo , Masculino , Fator de Necrose Tumoral alfa/metabolismoRESUMO
Elastophagocytosis is the engulfment of the elastic fibres by the histiocytes, multinucleated giant cells, or both. The cutaneous lesions showing elastophagocytosis are annular elastolytic giant cell granuloma, actinic keratoses, persistent insect-bite reactions, elastosis perforans serpiginosa, foreign body granuloma. Occasionally, it may occur in infectious diseases like leprosy, granulomatous syphilis, North-American blastomycosis, bacterial folliculitis, and cutaneous leishmaniasis. We report a case of lepromatous leprosy with necrotic erythema nodosum leprosum with secondary anetoderma. Histopathology from the atrophic macule of anetoderma revealed periappendageal, perineural infiltration, elastophagocytosis and reduction in elastic fibres.
Assuntos
Tecido Elástico/metabolismo , Hanseníase Virchowiana/diagnóstico , Fagocitose , Anetodermia/diagnóstico , Anetodermia/etiologia , Anetodermia/metabolismo , Anetodermia/patologia , Tecido Elástico/patologia , Eritema Nodoso/diagnóstico , Eritema Nodoso/etiologia , Eritema Nodoso/metabolismo , Eritema Nodoso/patologia , Histiócitos/fisiologia , Humanos , Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/metabolismo , Hanseníase Virchowiana/patologia , Masculino , Pessoa de Meia-IdadeRESUMO
Anetoderma is a rare condition, consisting of well-circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45-year-old man with a 25-year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histological examination found an infiltrate composed of neoplastic cells with lymphoplasmocytoid morphology. The cells were positive for CD20, CD38 and CD138, and there was a monoclonal kappa light chain gene rearrangement of plasma cells. A diagnosis of cutaneous marginal-zone B-cell lymphoma was made. The pathogenesis of anetoderma remains unknown, but it is possible that cytokines or other soluble factors produced by the infiltrating lymphocytes have a role in this process.