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Nutrients ; 9(11)2017 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-29088099

RESUMO

Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study. The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine (p < 0.05). Verbal memory, assessed using the Wechsler memory scale-logical memory, was preserved in the ACS group. An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017). The suppression of CCL24 expression was greatest in people who were in their 70s (p < 0.01). There was a significant correlation between the preservation of verbal memory and suppression of CCL24 expression in the group that was in the 70s (Poisson correlation, r = 0.46, p < 0.05). These results suggest that ACS may preserve verbal episodic memory, probably owing to CCL24 suppression in the blood, especially in elderly participants.


Assuntos
Envelhecimento , Anserina/administração & dosagem , Carnosina/administração & dosagem , Quimiocina CCL24/sangue , Suplementos Nutricionais , Mediadores da Inflamação/sangue , Leucócitos Mononucleares/efeitos dos fármacos , Transtornos da Memória/prevenção & controle , Adulto , Fatores Etários , Idoso , Envelhecimento/sangue , Envelhecimento/imunologia , Envelhecimento/psicologia , Anserina/efeitos adversos , Biomarcadores/sangue , Carnosina/efeitos adversos , Quimiocina CCL24/genética , Cognição/efeitos dos fármacos , Suplementos Nutricionais/efeitos adversos , Método Duplo-Cego , Regulação para Baixo , Combinação de Medicamentos , Feminino , Humanos , Leucócitos Mononucleares/imunologia , Leucócitos Mononucleares/metabolismo , Masculino , Transtornos da Memória/sangue , Transtornos da Memória/diagnóstico , Transtornos da Memória/psicologia , Memória Episódica , Pessoa de Meia-Idade , Fatores de Tempo , Tóquio , Resultado do Tratamento
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