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2.
J Infect Dis ; 141(3): 289-92, 1980 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-7365279

RESUMO

Hepatitis B e antigen (HBeAg) was detected by agar gel diffusion in the serum of four Ugandan adults (three patients with tropical splenomegaly syndrome and one healthy adult) who did not have detectable hepatitis B surface antigen (HBsAg) by radioimmunoassay. Two of them had antibody to hepatitis B core antigen, and the other two had antibody to HBsAg. Detection of HBeAg by a relatively insensitive immunodiffusion test in the absence of HBsAg detectable by a sensitive radioimmunoassay suggested that production or removal of these two antigens may occur independently.


Assuntos
Crioglobulinas/análise , Antígenos da Hepatite B/classificação , Antígenos da Hepatite B/isolamento & purificação , Antígenos de Superfície da Hepatite B/análise , Adulto , Feminino , Antígenos de Superfície da Hepatite B/isolamento & purificação , Vírus da Hepatite B/isolamento & purificação , Humanos , Hiperesplenismo/imunologia , Hiperesplenismo/microbiologia , Masculino , Pessoa de Meia-Idade , Uganda
5.
S Afr Med J ; 54(26): 1092-5, 1978 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-371031

RESUMO

A woman who developed hepatitis B during the 3rd trimester of pregnancy gave birth to a preterm, small-for-gestational-age infant whose blood also contained hepatitis B antigen. The effects of viral hepatitis on the fetus are reviewed and an approach to the management of such pregnancies is formulated.


Assuntos
Hepatite A , Hepatite B , Doenças do Recém-Nascido , Complicações Infecciosas na Gravidez , Doença Aguda , Adulto , Complexo Antígeno-Anticorpo , Aleitamento Materno , Doença Crônica , Feminino , Sangue Fetal/análise , Hepatite A/prevenção & controle , Hepatite A/transmissão , Hepatite B/prevenção & controle , Hepatite B/transmissão , Antígenos da Hepatite B/análise , Antígenos da Hepatite B/classificação , Humanos , Imunidade Materno-Adquirida , Imunização , Recém-Nascido , Troca Materno-Fetal , Trabalho de Parto Prematuro , Gravidez , Terceiro Trimestre da Gravidez
6.
Am J Clin Pathol ; 70(1 Suppl): 159-69, 1978 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-99023

RESUMO

Experimental hepatitis B vaccines have recently been developed and are undergoing preliminary evaluation. These vaccines are unique in that they are prepared from viral antigen purified from the plasmas of human chronic carriers because hepatitis B virus has not been cultivated in vitro. They appear to be safe and antigenic, but care must be exercised in their evaluation because of the potential risks inherent in all vaccines.


Assuntos
Vírus da Hepatite B , Hepatite B/imunologia , Vacinas Virais/isolamento & purificação , Animais , Reações Antígeno-Anticorpo , Antígenos , Proteínas Sanguíneas , Análise Custo-Benefício , Técnicas de Cultura , Contaminação de Medicamentos , Hepatite B/epidemiologia , Hepatite B/microbiologia , Hepatite B/transmissão , Antígenos da Hepatite B/classificação , Antígenos do Núcleo do Vírus da Hepatite B/isolamento & purificação , Vírus da Hepatite B/imunologia , Herpesviridae/imunologia , Humanos , Fígado , Proteínas , Risco , Vacinas Virais/efeitos adversos
7.
Vox Sang ; 34(4): 231-8, 1978.
Artigo em Inglês | MEDLINE | ID: mdl-622829

RESUMO

Screening for e antigen and anti-e was performed in 517 HBs antigen chronic carriers, 329 blood donors and 188 hemodialyzed patients. e antigen was detected in 35 blood donors (10.6 percent): 88 percent had a high titre of HBsAg, and 80 percent had a distrubed liver function. No difference was noted regarding sex and age of the carrier. Anti-e was detected in 33.7 percent of the bood donors. A significant difference (p less than 0.01) was noted between males (29 percent) and females (46.6 percent). Anti-e was found more prevalent in young people between 21 and 34 than in older people (p less than 0.05). Anti-e was rarely found when the titre of HBsAg was low or high. 88 percent of the anti-e carriers had an intermediate titre from 1/1 to 1/32 by CEP. Both e Ag and anti-e were more prevalent in ad subtype than in ay subtype (p less than 0.02 for both). Inside the ad subtype, anti-e is less frequent in adr (6 percent) than in adw2 (42 percent) and in adw4 (57 percent); p less than 0.01. The difference between the prevalence of e Ag in adr (31 percent) and in adw2 (17 percent) is not significant but the healthy carriers with e antigen are more numerous in adr than in adw2 subtype. e antigen was detected in 53.7 percent of HBs Ag-hemodialyzed patients and anti-e in 3.7 percent of these patients. These results are neither correlated with the liver function nor with the state of chronic carrier (27 percent of e Ag in transient HBs Ag carrier).


Assuntos
Anticorpos Antivirais/análise , Anticorpos Anti-Hepatite B/análise , Antígenos da Hepatite B/análise , Hepatite B/imunologia , Adulto , Portador Sadio , Feminino , Antígenos da Hepatite B/classificação , Antígenos de Superfície da Hepatite B/análise , Humanos , Masculino , Pessoa de Meia-Idade , Diálise Renal
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