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1.
J Neurovirol ; 27(3): 507-509, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33876411

RESUMO

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents respiratory symptoms as the most common clinical manifestations. Similar to some other viral infections, it can cause severe neurological damages. Here, we describe a 40-year-old man case who initially was admitted to a major hospital with presenting 7 days with weak flu-like symptoms (cough) and fever then presented neurology signs for 3 days. Physical examination and brain magnetic resonance imaging (MRI) showed cerebral vasculopathy. Molecular testing was performed on nasopharyngeal swab by real-time reverse transcription polymerase chain reaction (RT-PCR) which was positive for SARS-CoV-2. The patient received supportive cares and was treated with routine antiplatelet therapy. He was improved and discharged 10 days after admission with no symptoms. Our findings report a 40-year-old man with flu-like symptoms that indicate cerebral vasculopathy that was discharged with no symptoms. Therefore, physicians should be monitor patients with worsening or progressive central nervous system results. The pathobiology of this virus is still incompletely known; therefore, extensive studies are needed to reveal the effect of COVID-19 on the nervous system.


Assuntos
Arterite/virologia , Encefalopatias/virologia , COVID-19/complicações , Adulto , Humanos , Irã (Geográfico) , Masculino , SARS-CoV-2
2.
J Infect Dis ; 223(7): 1284-1294, 2021 04 08.
Artigo em Inglês | MEDLINE | ID: mdl-32809013

RESUMO

BACKGROUND: Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV induces amyloid formation that may aggravate vasculitis. Thus, we determined if VZV central nervous system infection produces amyloid. METHODS: Aß peptides, amylin, and amyloid were measured in cerebrospinal fluid (CSF) from 16 VZV vasculopathy subjects and 36 stroke controls. To determine if infection induced amyloid deposition, mock- and VZV-infected quiescent primary human perineurial cells (qHPNCs), present in vasculature, were analyzed for intracellular amyloidogenic transcripts/proteins and amyloid. Supernatants were assayed for amyloidogenic peptides and ability to induce amyloid formation. To determine amylin's function during infection, amylin was knocked down with small interfering RNA and viral complementary DNA (cDNA) was quantitated. RESULTS: Compared to controls, VZV vasculopathy CSF had increased amyloid that positively correlated with amylin and anti-VZV antibody levels; Aß40 was reduced and Aß42 unchanged. Intracellular amylin, Aß42, and amyloid were seen only in VZV-infected qHPNCs. VZV-infected supernatant formed amyloid fibrils following addition of amyloidogenic peptides. Amylin knockdown decreased viral cDNA. CONCLUSIONS: VZV infection increased levels of amyloidogenic peptides and amyloid in CSF and qHPNCs, indicating that VZV-induced amyloid deposition may contribute to persistent arterial inflammation in VZV vasculopathy. In addition, we identified a novel proviral function of amylin.


Assuntos
Peptídeos beta-Amiloides , Amiloide , Arterite , Herpes Zoster , Polipeptídeo Amiloide das Ilhotas Pancreáticas , Fragmentos de Peptídeos , Amiloide/líquido cefalorraquidiano , Peptídeos beta-Amiloides/líquido cefalorraquidiano , Arterite/líquido cefalorraquidiano , Arterite/diagnóstico , Arterite/virologia , DNA Complementar , DNA Viral , Herpes Zoster/líquido cefalorraquidiano , Herpes Zoster/diagnóstico , Herpesvirus Humano 3 , Humanos , Polipeptídeo Amiloide das Ilhotas Pancreáticas/líquido cefalorraquidiano , Fragmentos de Peptídeos/líquido cefalorraquidiano , Acidente Vascular Cerebral
3.
Vet Rec ; 187(12): e113, 2020 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-33288633

RESUMO

In early 2019, four stallions in the south of England tested positive for equine viral arteritis following routine prebreeding screening. Here, a team from Defra and the APHA describe the epidemiological investigation that was carried out to determine the origin of infection and the potential for its transmission across the country.


Assuntos
Arterite/veterinária , Doenças dos Cavalos/epidemiologia , Doenças dos Cavalos/virologia , Animais , Arterite/epidemiologia , Arterite/prevenção & controle , Arterite/virologia , Surtos de Doenças , Equartevirus , Doenças dos Cavalos/prevenção & controle , Cavalos , Masculino , Reino Unido/epidemiologia
4.
Vet Rec ; 184(26): 791-793, 2019 06 29.
Artigo em Inglês | MEDLINE | ID: mdl-31249119

RESUMO

Following the recent confirmation of cases of equine viral arteritis in stallions in south-west England, James Crabtree of Equine Reproductive Services (UK) discusses the disease and its potential routes of spread into and around the UK.


Assuntos
Arterite/veterinária , Doenças dos Cavalos/virologia , Vigilância de Evento Sentinela/veterinária , Animais , Arterite/epidemiologia , Arterite/virologia , Doenças dos Cavalos/epidemiologia , Cavalos , Masculino , Saúde Reprodutiva , Reino Unido/epidemiologia
5.
J Nucl Cardiol ; 26(4): 1258-1265, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-29417417

RESUMO

BACKGROUND: HIV infection is associated with the risk of development of atherosclerosis at a younger age. We compared arterial inflammation in HIV-infected and HIV-uninfected patients with otherwise low-risk factors for cardiovascular disease (CVD) using FDG PET/CT. METHODS: 242 patients aged 18-40 years with low-risk factors for CVD consisting of 121 HIV-infected patients and 121 HIV-uninfected age- and gender-matched controls were studied, mean age = 34.95 ± 5.46 years. We calculated and compared the target-to-background ratio of FDG uptake in ascending aorta of HIV-infected and non-infected patients. RESULTS: Median CD4 count and viral load were 375.5 cells/mm3 (range 2-1094) and 6391.00 copies/mL (range 24-1,348,622), respectively. There was slightly higher but significant overlap in the TBR between HIV-infected group compared with control (1.22, 0.87-2.02 vs. 1.12, 0.38-1.40, P < 0.001). TBR was neither affected by CD4 count levels nor the presence or absence of detectable viremia. We also found no significant difference in TBR between male and female patients with HIV infection. We found a weak positive correlation between TBR and CD4 count, TBR and duration of HIV infection, and a very weak negative correlation between TBR and viral load. There was no significant difference in TBR between patients on HAART and those not yet commenced on therapy. CONCLUSION: Marginally higher TBR with a significant overlap exist in HIV-infected patients compared with control. Arterial F-18 FDG uptake is not affected by the CD 4 count, viral load, gender, or duration of HIV infection.


Assuntos
Aorta , Arterite/diagnóstico por imagem , Arterite/virologia , Infecções por HIV/complicações , Infecções por HIV/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Adolescente , Adulto , Estudos Transversais , Feminino , Fluordesoxiglucose F18 , Humanos , Masculino , Compostos Radiofarmacêuticos , Adulto Jovem
6.
J Infect Dis ; 218(suppl_2): S107-S112, 2018 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-30247600

RESUMO

Varicella zoster virus (VZV) is a ubiquitous, exclusively human alphaherpesvirus that produces varicella then becomes latent in ganglionic neurons. In elderly and immunocompromised individuals, VZV reactivates and typically produces herpes zoster. Studies of patients with VZV vasculopathy have identified key clinical, imaging, and laboratory features to assist in diagnosis and treatment. Complementary studies have further expanded the spectrum of VZV vasculopathy to include the extracranial circulation and identified mechanisms contributing to its pathogenesis. Given our increasing aging population and recognition that VZV reactivation manifesting as zoster is a risk factor for stroke and myocardial infarction, recognition of VZV as a potential cause of vascular disease with or without associated zoster rash is essential to decrease associated morbidity and mortality because VZV vasculopathy can be treated with antiviral therapy.


Assuntos
Arterite/virologia , Herpes Zoster/patologia , Herpesvirus Humano 3 , Acidente Vascular Cerebral/etiologia , Antivirais/uso terapêutico , Doenças da Aorta/virologia , Herpes Zoster/complicações , Herpes Zoster/tratamento farmacológico , Humanos , Fatores de Risco , Acidente Vascular Cerebral/virologia
7.
Exp Mol Pathol ; 100(1): 114-5, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26688577

RESUMO

Varicella Zoster Virus (VZV) antigen has been reported to be present in the majority of temporal artery biopsies with implications for antiviral treatment in patients with giant cell arteritis. Using immunohistochemistry with VZV antibodies we found reactivity present in diverse myocyte types (smooth, skeletal and cardiac), diverse arteries (including temporal, coronary, and vertebral) and diverse clinical settings. This phenomenon is likely due to shared epitopes between VZV proteins and muscle elements and not due to actual VZV infection. We conclude that VZV immunohistochemistry should be used with caution for screening of VZV infection in the setting of temporal artery biopsies.


Assuntos
Anticorpos/imunologia , Arterite/virologia , Epitopos/imunologia , Herpesvirus Humano 3/isolamento & purificação , Idoso , Antivirais/uso terapêutico , Criança , Reações Cruzadas , Reações Falso-Positivas , Feminino , Humanos , Imuno-Histoquímica/métodos , Masculino , Pessoa de Meia-Idade
8.
Am J Dermatopathol ; 37(9): 691-8, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26291418

RESUMO

Epstein-Barr virus (EBV) infection can rarely present as painful genital ulcers, mostly in young female adolescents. Typically diagnosed by clinical findings, EBV vulvar ulceration (EBVVU) is rarely biopsied. Herein, the authors report the histopathology in 8 biopsies from 7 EBVVU patients, all serologically confirmed for acute (4/7) or reactivated-chronic (3/7) EBV infection. The 7 women all presented with 1 or more painful, punched-out vulvar ulcers. Only patients with acute EBV infection showed other clinical findings: fever and/or atypical lymphocytosis affected 75% (3/4); lymphadenopathy in 50%; and malaise/fatigue, dysuria and/or hepatomegaly in 25%. All reactivated-chronic EBVVU had a solitary ulcer, and 2 had history of a similar episode of vulvar ulceration (aphthosis). Histopathologically, lymphocytic arteritis was identified in 88% (7/8); a submucosal scar was found in the eighth specimen. Other histopathologies included venulitis (62%), endarteritis obliterans (38%), thrombosis (25%), neutrophilic sebaceous adenitis (25%), and mucosal lymphoid hyperplasia (12%). Dense angiocentric CD3 CD4 T-cell lymphocyte-predominant infiltrates were found, regionally or diffusely. In 2 specimens, neutrophils compromised half of the infiltrate. Minor components of CD8, CD20, and CD30 lymphocytes, CD123 plasmacytoid monocytes, CD68 macrophages, and plasma cells were present. Small-vessel endothelium and smooth muscle adjacent to the ulcers faintly expressed cytoplasmic EBV latent membrane protein-1 (LMP1). In situ hybridization for early EBV mRNA (EBER) identified rare solitary or scattered clustered positive lymphocytes in 38%. Polymerase chain reaction for EBV DNA was positive in one EBER positive biopsy. EBV infection has been documented in muscular vessel vasculitis. Based on the aforementioned, EBVVU appears to be the consequence of localized lymphocytic arteritis.


Assuntos
Arterite/virologia , Infecções por Vírus Epstein-Barr/complicações , Úlcera/virologia , Doenças da Vulva/patologia , Doenças da Vulva/virologia , Adolescente , Adulto , Criança , Feminino , Herpesvirus Humano 4 , Humanos , Imuno-Histoquímica , Hibridização In Situ , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Úlcera/patologia , Adulto Jovem
9.
J Cutan Pathol ; 42(6): 416-9, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25726843

RESUMO

We report the first case of macular arteritis in a 33-year-old Black, African female with concurrent human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Of particular interest in macular arteritis is the striking discordance between the clinical presentation and the histopathological findings, a fact that both dermatologists and dermatopathologists should be aware. Histopathologically, the case showed typical findings of macular arteritis with a perivascular, predominantly lymphocytic, infiltrate and intraluminal thrombosis. Both HIV and HBV have been reported as viral inducers of cutaneous polyarteritis nodosa (PAN). Their association with macular arteritis in this case supports existing evidence that macular arteritis and cutaneous PAN represent a single-disease spectrum of vasculitides, with macular arteritis representing the chronic, lymphocytic and indolent stage, and cutaneous PAN the neutrophilic, acute stage with a risk for systemic progression. Lymphocytic thrombophilic arteritis (LTA), a third, uncommon disease would be in between macular arteritis and cutaneous PAN on a spectrum. Features of this case and other published cases provide strong evidence that there is a single, mild-to-severe disease spectrum of macular arteritis-LTA-cutaneous PAN.


Assuntos
Arterite/virologia , Infecções por HIV/patologia , Hepatite B/patologia , Poliarterite Nodosa/virologia , Dermatopatias Vasculares/virologia , Adulto , Arterite/patologia , Progressão da Doença , Feminino , Infecções por HIV/virologia , Hepatite B/virologia , Humanos , Hiperpigmentação/patologia , Hiperpigmentação/virologia , Linfócitos/patologia , Poliarterite Nodosa/patologia , Dermatopatias Vasculares/patologia , Vasculite/patologia
10.
Vet Clin North Am Equine Pract ; 30(3): 543-60, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25441113

RESUMO

Equine arteritis virus (EAV), the causative agent of equine viral arteritis (EVA), is a respiratory and reproductive disease that occurs throughout the world. EAV infection is highly species-specific and exclusively limited to members of the family Equidae, which includes horses, donkeys, mules, and zebras. EVA is an economically important disease and outbreaks could cause significant losses to the equine industry. The primary objective of this article is to summarize current understanding of EVA, specifically the disease, pathogenesis, epidemiology, host immune response, vaccination and treatment strategies, prevention and control measures, and future directions.


Assuntos
Arterite/veterinária , Infecções por Arterivirus/veterinária , Equartevirus/isolamento & purificação , Doenças dos Cavalos/virologia , Aborto Animal/virologia , Animais , Arterite/fisiopatologia , Arterite/virologia , Infecções por Arterivirus/fisiopatologia , Infecções por Arterivirus/virologia , Equidae , Feminino , Doenças dos Cavalos/fisiopatologia , Cavalos , Gravidez
11.
Dis Aquat Organ ; 94(3): 243-8, 2011 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-21790072

RESUMO

Viral hepatitis associated with adenoviral infection has been reported in California sea lions Zalophus californianus admitted to rehabilitation centers along the California coast since the 1970s. Canine adenovirus 1 (CAdV-1) causes viral hepatitis in dogs and infects a number of wildlife species. Attempts to isolate the virus from previous sea lion hepatitis cases were unsuccessful, but as the hepatitis had morphologic features resembling canine infectious hepatitis, and since the virus has a wide host range, it was thought that perhaps the etiologic agent was CAdV-1. Here, we identify a novel adenovirus in 2 stranded California sea lions and associate the infection with viral hepatitis and endothelial cell infection. Phylogenetic analysis confirmed the classification of the sea lion adenovirus in the Mastadenovirus genus with the most similarity to tree shrew adenovirus 1 (TSAdV-1, 77%). However, as the sea lion adenovirus appeared to be equally distant from the other Mastadenovirus species based on phylogenetic analysis, results indicate that it represents an independent lineage and species. Although sequences from this novel virus, otarine adenovirus 1 (OtAdV-1), show some similarity to CAdV-1 and 2, it is clearly distinct and likely the cause of the viral hepatitis in the stranded California sea lions.


Assuntos
Infecções por Adenoviridae/veterinária , Adenoviridae/classificação , Arterite/veterinária , Hepatite Viral Animal/virologia , Leões-Marinhos , Adenoviridae/genética , Infecções por Adenoviridae/epidemiologia , Infecções por Adenoviridae/virologia , Sequência de Aminoácidos , Animais , Arterite/virologia , California/epidemiologia , DNA Polimerase Dirigida por DNA/genética , DNA Polimerase Dirigida por DNA/metabolismo , Regulação Viral da Expressão Gênica/fisiologia , Hepatite Viral Animal/epidemiologia , Filogenia , Proteínas Virais/genética , Proteínas Virais/metabolismo
13.
Dev Med Child Neurol ; 48(2): 139-42, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16417671

RESUMO

We report a case of a 7-month-old male with primary intracranial haemorrhage 2 months after infection with varicella zoster virus (VZV). His initial clinical course was complicated by seizures and right hemiparesis; when last seen at 22 months the only positive finding was of left hand preference. Although the literature has recently established the association of arterial ischaemic stroke and VZV infection, primary intracranial haemorrhage has been reported only in one case. The child reported here had anterior interhemispheric haemorrhage due to a focal arteritis of the left anterior cerebral artery. The vascular abnormality was transient and had radiological features compatible with either a focal arteritis or vasospasm as a direct result of blood surrounding the vessels. We postulate that direct invasion of VZV caused extensive inflammation of the vessel wall and aggressive tissue penetration resulting in necrotizing angiitis and intracranial haemorrhage. We suggest that VZV infection should be considered a potential risk factor for intracranial haemorrhage in children.


Assuntos
Herpes Zoster/complicações , Herpesvirus Humano 3/patogenicidade , Hemorragias Intracranianas/etiologia , Artéria Cerebral Anterior/patologia , Arterite/etiologia , Arterite/virologia , Humanos , Lactente , Inflamação , Hemorragias Intracranianas/virologia , Masculino , Necrose , Fatores de Risco
14.
Am J Dermatopathol ; 27(5): 411-7, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16148411

RESUMO

Post herpes zoster (HZ) reactions have been associated with panoply of neoplastic, inflammatory, and fibro-inflammatory cutaneous disorders. Varicella zoster virus (VZV) DNA has not been identified in most of these reports. After an episode of HZ, a healthy, active 90-year-old female developed ulcerative nodules in the affected trigeminal V1 dermatome and the contra-lateral trigeminal region over a 1-year period. Excision and/or biopsy of all these lesions showed similar pathologic changes that consisted of herpetic folliculitis, adjacent dense mixed nodular lymphocytic infiltrates with germinal centers (cutaneous lymphoid hyperplasia (CLH)), and in the deeper excision specimens, an obliterative vasculitis of a vessel with smooth muscle in its wall. Immunophenotype analysis revealed a mixed, predominate T- and B-cell population without loss of pan-T cell antigens or aberrant expression by B cells of T-cell antigens. Polymerase chain reaction for herpetic DNA was positive for VZV DNA. Lymphocyte gene rearrangement analysis revealed 2 distinct, anatomically and chronologically, monoclonal B-cell populations and a monoclonal T-cell population in one nodule. Treatment with valacyclovir has lead to almost complete resolution of her cutaneous nodules after 6 months of therapy. In this case, it can be surmised that persistence of VZV infection and lack of effective cell-mediated immunity lead to development of both immunopathology (vasculitis) and excessive lymphoid cell proliferation (CLH).


Assuntos
Foliculite/patologia , Foliculite/virologia , Herpes Zoster/complicações , Pseudolinfoma/patologia , Pseudolinfoma/virologia , Aciclovir/análogos & derivados , Aciclovir/uso terapêutico , Idoso de 80 Anos ou mais , Antivirais/uso terapêutico , Arterite/patologia , Arterite/virologia , Células Clonais , DNA Viral/isolamento & purificação , Feminino , Foliculite/imunologia , Herpes Zoster/imunologia , Herpesvirus Humano 3 , Humanos , Imunofenotipagem , Reação em Cadeia da Polimerase , Pseudolinfoma/imunologia , Valaciclovir , Valina/análogos & derivados , Valina/uso terapêutico
17.
Virchows Arch ; 434(3): 249-54, 1999 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10190306

RESUMO

A 61-year-old woman initially presented with symptoms and findings reminiscent of infectious mononucleosis, and her illness then took a rapidly fatal course. Autopsy revealed widespread granulomatous arteritis, with multinucleated giant cells but without eosinophils and fibrinoid necrosis, affecting small arteries and arterioles and infiltration of haemophagocytic histiocytes into many organs. In situ hybridization with Epstein-Barr virus (EBV)-specific oligonucleotide probes showed positive signals in the infiltrating immune cells and epithelial and endothelial cells of the affected organs. EBV-associated haemophagocytic syndrome (EBV-AHS) with systemic granulomatous arteritis was diagnosed. From the immunophenotypes of the infiltrating immune cells, a possible role of CD4+ T-cells in the pathogenesis of this haemophagocytic syndrome and granulomatous vasculitis was suggested.


Assuntos
Arterite/virologia , Infecções por Vírus Epstein-Barr/complicações , Granuloma/virologia , Arterite/patologia , Infecções por Vírus Epstein-Barr/patologia , Evolução Fatal , Feminino , Granuloma/patologia , Humanos , Imuno-Histoquímica , Hibridização In Situ , Pessoa de Meia-Idade
18.
Neuropediatrics ; 29(4): 202-7, 1998 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9762696

RESUMO

Varicella-zoster associated cerebral vasculitis (VZCV) as a cause of cerebral infarction has hitherto been considered a rare condition. Ischemic stroke in previously healthy children has occurred during recovery from chickenpox or has been attributed to virus reactivation among immunosuppressed patients. The clinical, radiologic and immunologic findings in four children with VZCV will be reported. Clinical manifestations included sudden onset of hemiparesis, motor aphasia and disturbed consciousness in previously healthy children. Only one child had a history of chickenpox six weeks prior to the onset of stroke, whereas a latency period of up to four years between chickenpox and the onset of stroke was found in the other three children. Diagnosis of VZCV was confirmed repeatedly by demonstrating intrathecal production of varicella-zoster IgG antibodies in three children or a four-fold increase of varicella-zoster serum IgA-antibodies in one child. Intrathecal production of antibodies against other latent viruses and borreliosis could be excluded. PCR for varicella on CSF, performed in two patients, remained negative. No intrathecal production of varicella-zoster antibodies has been found in a control group of twenty clinically healthy children (age range from 2-18 years) with a previous varicella infection. During follow-up two children recovered completely whereas two children still suffer from serious neurological deficits. Immunological investigations, performed in three children, showed circulating immune-complexes with slightly lowered complement concentrations in two patients. In addition a lowered T-helper/T-suppressor cell ratio of unknown origin was found in three children. These immunological findings will be discussed in the light of the pathophysiology of VZCV.


Assuntos
Arterite/virologia , Isquemia Encefálica/virologia , Doenças Arteriais Cerebrais/virologia , Varicela/complicações , Adolescente , Arterite/patologia , Arterite/fisiopatologia , Encéfalo/patologia , Isquemia Encefálica/patologia , Isquemia Encefálica/fisiopatologia , Doenças Arteriais Cerebrais/patologia , Doenças Arteriais Cerebrais/fisiopatologia , Artérias Cerebrais/patologia , Criança , Pré-Escolar , Progressão da Doença , Feminino , Seguimentos , Herpesvirus Humano 3/isolamento & purificação , Humanos , Masculino , Resultado do Tratamento , Carga Viral
19.
Arthritis Rheum ; 41(2): 369-73, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9485096

RESUMO

This report describes an autopsy case of large-vessel arteritis associated with chronic active Epstein-Barr virus (EBV) infection in a 10-year-old Japanese girl. All of the 3 main coronary arteries, bilateral common carotid and subclavian arteries, abdominal aorta and its major branches, and bilateral common iliac arteries were involved, and all showed aneurysmal dilation of the lumens. Histopathologic examination revealed mesoarteritis characterized by moth-eaten-appearing destruction of the medial elastic laminae, with T lymphocyte infiltration around the vasa vasorum and severe intimal thickening. The EBV DNA genome was detected in the diseased aortic tissue by polymerase chain reaction, and in the infiltrating lymphocytes by in situ hybridization. The clinical symptoms and histopathologic manifestations of the arterial lesions in this patient were obviously different from those of Kawasaki disease and Takayasu arteritis, and the arteritis was considered to be associated with the EBV infection.


Assuntos
Arterite/virologia , Infecções por Herpesviridae , Herpesvirus Humano 4 , Infecções Tumorais por Vírus , Artérias/patologia , Arterite/patologia , Criança , Tecido Elástico/patologia , Evolução Fatal , Feminino , Humanos , Túnica Média/patologia
20.
Nat Med ; 3(12): 1346-53, 1997 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9396604

RESUMO

Fundamental issues remain unresolved regarding the possible contribution of viruses to vascular pathology, as well as the role of the immune system in regulating these processes. Here we demonstrate that infection of mice with gamma-herpesvirus 68 (gammaHV68) provides a novel model for addressing these issues. Interferon-gamma receptor-deficient (IFNgammaR-/-) mice died weeks to months after gammaHV68 infection from a severe large-vessel panarteritis. GammaHV68-infected B cell-deficient and normal weanling mice exhibited milder large-vessel arteritis. Immunohistochemical analyses demonstrated gammaHV68 antigen in arteritic lesions and revealed a striking tropism of gammaHV68 for smooth muscle cells. These studies demonstrate that IFN-gamma is essential for control of chronic vascular pathology induced by gammaHV68 and suggest gamma-herpesviruses as candidate etiologic agents for human vasculitis.


Assuntos
Arterite/virologia , Gammaherpesvirinae/fisiologia , Infecções por Herpesviridae/complicações , Interferon gama/imunologia , Animais , Antígenos Virais/análise , Arterite/imunologia , Arterite/patologia , Linhagem Celular , Modelos Animais de Doenças , Gammaherpesvirinae/imunologia , Deleção de Genes , Infecções por Herpesviridae/imunologia , Infecções por Herpesviridae/patologia , Humanos , Cinética , Camundongos , Camundongos Endogâmicos C57BL , Coelhos , Receptores de Interferon/deficiência , Receptores de Interferon/genética , Receptores de Interferon/metabolismo , Receptor de Interferon gama
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