The influence of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in elderly adult patients with urinary tract infection.

BACKGROUND: The role of Diabetes mellitus (DM) in the etiology and in the antimicrobial resistance of uropathogens in patients with urinary tract infection has not been well clarified. For this reason we have evaluated the spectrum of uropathogens and the profile of antibiotic resistance in both diabetic and non diabetic patients with asymptomatic urinary tract infection (UTI). METHODS: Urinary isolates and their patterns of susceptibility to the antimicrobials were evaluated in 346 diabetics (229 females and 117 males) and 975 non diabetics (679 females and 296 males) who were screened for significant bacteriuria (> or = 10(5) CFU/mL urine). The mean age of diabetic and non diabetic patients was respectively 73.7 yrs +/- 15 S.D. and 72.7 +/- 24 (p = NS). RESULTS: Most of our patients had asymptomatic UTI. The most frequent causative organisms of bacteriuria in females with and without DM were respectively : E. coli 54.1% vs 58.2% (p = NS), Enterococcus spp 8.3% vs 6.5% (p = NS), Pseudomonas spp 3.9 vs 4.7% (p = NS). The most frequent organisms in diabetic and non diabetic males were respectively E. coli 32.5% vs 31.4% (p = NS), Enterococcus spp 9.4% vs 14.5% (p = NS), Pseudomonas spp 8.5% vs 17.2% (p < or = 0.02). A similar isolation rate of E. coli, Enterococcus spp and Pseudomonas spp was also observed in patients with indwelling bladder catheter with and without DM. No significant differences in resistance rates to ampicillin, nitrofurantoin, cotrimoxazole and ciprofloxacin of E. coli and Enteroccus spp were observed between diabetic and non diabetic patients. CONCLUSION: In our series of patients with asymptomatic UTI (mostly hospital acquired), diabetes mellitus per se does not seem to influence the isolation rate of different uropathogens and their susceptibility patterns to antimicrobials.

Infección Urinaria / Urinary Infection

La infección urinaria (IU) constituye el conjunto de signos y síntomas resultantes de la multiplicación microbiana dentro del tracto urinario

Terms used to describe urinary tract infections--the importance of conceptual clarification.

Inaccuracies in medical language are detrimental to communication and statistics in medicine, and thereby to clinical practice, medical science and public health. The purpose of this article is to explore inconsistencies in the use of some medical terms: urinary tract infection, bacteriuria and urethral syndrome. The investigated literature was collected from medical dictionaries, textbooks, and articles indexed in Medline(R). We found various practices regarding how the medical terms should be defined, and had great difficulty in interpreting the status of the statements under the heading of 'definition'. The lesson to be learned, besides a reminder of the importance of clearly defined medical concepts, is that it must be explicitly stated whether what is presented as a definition is to be considered as defining criterion, as recognising criterion or as characteristic of the disease entity.

[Four-glass or two glass test for chronic prostatitis]. / 4- oder 2-Gläserprobe bei der chronischen Prostatitis?

Chronic pelvic pain syndrome is still an important clinical problem. The NIH prostatitis classification introduced in 1998 for diagnosis and treatment measures is based on extended microbiological analysis of urine and expressed prostate secretion (4-glass test). In 1997 J.C. Nickel proved that the culture and microscopic examination of urine before and after prostatic massage leads to the same results as the 4-glass test. In our prospective study on 143 patients with a diagnosis of chronic prostatitis, we analyzed this statement and came to the same results. We therefore recommend replacing the expensive and time-consuming 4-glass test by a simple preprostatic and postprostatic massage urine culture. Further examinations should only be performed in special cases.

Disuria, infección urinaria, pielonefritis / Dysuria, urinary infection, pyelonephritis

Se describe la capacidad de inducir infección urinaria y los mecanismos que la atenúan o la impide. Se describen los criterios de bacteriuria significativa, destacándose criterios cuantitativos variables según se trate de infecciones sintomáticas o asintomáticas, diferencias por sexo y también según el método de obtención de las muestras. En cuanto al síndrome de disuria, se establecen algunas pautas en la interpretación de los urocultivos y se mencionan sus causas. Se hace una ordenación de esquemas terapéuticos para la cistitis; pielonefritis aguda; profilaxis continua y profilaxis post-coital. En capítulo aparte, se aborda la bacteriuria del embarazo, sus relaciones con la prematurez, hipertensión y preesclampsia y se sugieren algunos esquemas de tratamiento

Definitions, classification, and clinical presentation of urinary tract infections.

Urinary tract infections encompass a spectrum of clinical and pathologic conditions involving various parts of the urinary tract. Each syndrome has its own unique epidemiology, natural history, and clinical manifestations. Basic terminology used in describing urinary tract infections is defined in this article. A classification of these infections and their clinical features is presented.