[The effect of vicasol and pelentan on the biopolymers of the periodontium]. / O vliianii vikasola i pelentana na sostoianie biopolimerov periodonta zubov.

Vitamin K (vikasol) and pelentan were examined for their effects of periodontal tissue levels of collagen, hexosamine-containing biopolymers and sialoglycoproteins. During tooth replantation in dogs, vitamin K was demonstrated to elevate the levels of collagen, hexosamine-containing polymers in periodontal tissue by 25.8, 19.9, and 36.1%, respectively, whereas pelentan lowered the above parameters.

[Activity of menadione reductase and level of cytochrome B5 and P-450 in liver with varying supplies of vitamin K and administration of pelentan to rats]. / Aktivnost' menadionreduktazy i soderzhanie tsitokhormov B5 i P-450 v pecheni pri razlichnoi obespechennosti krys vitaminom K i vvedenii pelentana.

Content of cytochromes b5 and P-450 as well as activity of soluble menadione reductase were estimated in liver microsomes of rats deprived of vitamin K or maintained both on a diet containing excess of vicasol or antivitamin K-pelentan. Deficiency of vitamin K led to an increase in the specific activity of menadione reductase and in content of the cytochrome P-450. Administration of antivitamin K did not alter these parameters but caused an increase in the content of cytochrome b5, which was not changed in vitamin K deficiency. Dissimilar effects of alimentary deficiency in vitamin K and of pelentan administration suggest that administration of antivitamins K (although it allowed to discover alterations developed via the system of vitamin K-dependent carboxylation) could not be completely identified with alimentary vitamin K deficiency.

[Kinetic characteristics of creatine kinase and hexokinase from rat skeletal muscles during dietary deficit of vitamin K and administration of pelentane]. / Kineticheskie kharakteristiki kreatinkinazy i geksokinazy skeletnykh myshts krysy pri pishchevom defitsite vitamina K i vvedenii pelentana.

Kinetic parameters of rat creatine kinase isozymes at different vitamin K supply and treatment with antivitamin K--pelentan have been determined. MM-isozyme (skeletal muscle) has selective sensitivity to the vitamin K deficit, while BB and MB-isozymes (brain, kidney and heart) have not. The value KM for ATP of MM-isozymes increases, while maximal activity decreases. Pelentan treatment does not lead to the change of MM-creatine kinase affinity to ATP. Soluble hexokinase of skeletal muscle in rats with vitamin K deficiency and treated with pelentan has higher affinity to glucose as compared to normal rat enzyme. It has been supposed that skeletal muscle hexokinase exists in a particular molecular form under vitamin K deficiency.

[Effect of protein synthesis inhibitors on the vicasol-induced change in the content of the thermostable antifactor Xa in the blood serum]. / Vliianie ingibitorov sinteza belkov na vyzyvaemoe vikasolom izmenenie soderzhaniia termostabil'nogo antifaktora Xa v syvorotke krovi.

Content of a thermostable inhibitor of thrombinogenesis (antifactor Xa) was decreased in blood serum after administration of pellentan. Subsequent treatment with vicasol normalized at the accelerated rate the antifactor Xa content in blood serum. Administration of the inhibitors of protein synthesis (vincrystine, actinomycin D, toyomycin, tetracycline--inhibitors of RNA polymerase, elongation, posttranscriptional conversions of mRNA and of translation processes, respectively (did not alter distinctly the vicasol effect--decrease in antifactor Xa content of blood serum. Vitamin K appears to participate in formation of the active molecule of the inhibitor of thrombinogenesis at the postribosomal step as shown in study of several other blood plasma procoagulants.