RESUMO
Interfacial polymerisation was mainly developed toward the end of the 1960s, leading to applications in microcapsule production by the mid-1970s. The process consists in the dispersion of one phase containing a reactive monomer, into a second immiscible phase to which is added a second monomer. Both monomers react at the droplet surface (interface), forming a polymeric membrane. Over the last 50 years, many studies have been reported, but very few have provided a comprehensive review of this technology. This contribution reviews microcapsule production by interfacial polymerisation from the chemical, physico-chemical and physical perspectives, providing a tool for understanding and mastering this production technology, but also providing guidance toward improvements for future process design.
Assuntos
Cápsulas/síntese química , Membranas Artificiais , Polímeros/síntese química , Animais , Cápsulas/química , Cápsulas/história , História do Século XX , História do Século XXI , Humanos , Polímeros/química , Polímeros/históriaRESUMO
La primera patente para la elaboración de cápsulas gelatinosas fue emitida en Francia en el año 1834. La publicación titulada Torebki albo kapsulki galaretowe, capsulae gelatinosae oraz torebki otwierającesię, envelopes medicamentecises sposób robienia i użyteczność tychże [Cápsulas o cápsulas gelatinosas,capsulae gelatinosae y cápsulas con apertura, envelopes medicamentecises, forma de elaboración y su utilidad] de Aleksander Karwacki (1825-1871) fue publicada veinticinco años después de dicho acontecimiento y contiene información sobre la fabricación de cápsulas gelatinosas y su aplicación (AU)
The first patent regarding the preparation of gelatine capsules was granted in France in 1834. The publication entitled Torebki albo kapsulki galaretowe, capsulae gelatinosae oraz torebki otwierające się,envelopes medicamentecises sposób robienia i użyteczność tychże [Gelatine shells or capsules, capsulae gelatinosae, and shells that can be opened, envelopes medicamentecises, the way of manufacturing and usefulness thereof] by Aleksander Karwacki (18251871) was published 25 years after this event. It contains information regarding the manufacture of gelatine capsules and their application (AU)
Assuntos
Humanos , Preparações Farmacêuticas/história , Cápsulas/história , Gelatina/farmacologia , Farmácia/história , História da MedicinaRESUMO
Set up in Dijon (Côte-d'Or), the pharmacist Charles-Honoré Thévenot (1812-1894) is mainly known as being the inventor of an industrial process for manufacturing and filling the medicamentous capsules. It was also a great art lover which had joined together an important collection of engravings and drawings. It was bequeathed to the town of Dijon and now constitues one of the jewels of its Museum of Fine Arts.
